Dietary phosphate binding and loading alter kidney angiotensin-converting enzyme mRNA and protein content in 5/6 nephrectomized rats

American Journal of Nephrology

Volumn 35, Issue 5, 2012, Pages 401-408

  Eräranta, Arttu ^a   Riutta, Asko ^a   Fan, Meng ^a   Koskela, Jenni ^a   Tikkanen, Ilkka ^c   Lakkisto, Päivi ^c   Niemelä, Onni ^d   Parkkinen, Jyrki ^b   Mustonen, Jukka ^a,b   Pörsti, Ilkka ^a,b  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d Department of Clinical Chemistry   (Finland)

Author keywords

Angiotensin converting enzyme; Calcium; Chronic renal insufficiency; Phosphate; Renin angiotensin system

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II [3-8]; ANGIOTENSIN RECEPTOR; CALCIUM CARBONATE; DIPEPTIDYL CARBOXYPEPTIDASE; FIBROBLAST GROWTH FACTOR 23; MESSENGER RNA; PARATHYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CALCIUM INTAKE; CONTROLLED STUDY; CREATININE CLEARANCE; ENZYME INDUCTION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLOMERULOSCLEROSIS; INTERSTITIAL NEPHRITIS; KIDNEY INJURY; MALE; NEPHRECTOMY; NONHUMAN; NUTRIENT LOADING; PARATHYROID HORMONE BLOOD LEVEL; PHOSPHATE BLOOD LEVEL; PHOSPHATE INTAKE; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; RECEPTOR DOWN REGULATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SHAM PROCEDURE;

ANIMALS; AUTORADIOGRAPHY; BLOTTING, WESTERN; KIDNEY; MALE; NEPHRECTOMY; PEPTIDYL-DIPEPTIDASE A; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RENIN-ANGIOTENSIN SYSTEM; RNA, MESSENGER;

EID: 84859869360     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000337942     Document Type: Article

References (27)

1. Koizumi T, Murakami K, Nakayama H, Ku-wa ha ra T, Yoshinari O: Role of dietary phosphorus in the progression of renal failure. Biochem Biophys Res Commun 2002; 295: 917-921.
2. Kestenbaum B, Sampson JN, Rudser KD, Patterson DJ, Seliger SL, Young B, Sherrard DJ, Andress DL: Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 2005; 16: 520-528. (Pubitemid 41725150)
3. Foley RN, Collins AJ, Herzog CA, Ishani A, Kalra PA: Serum phosphorus levels associate with coronary atherosclerosis in young adults. J Am Soc Nephrol 2009; 20: 397-404.
4. Slatopolsky E, Brown A, Dusso A: Role of phosphorus in the pathogenesis of secondary hyperparathyroidism. Am J Kidney Dis 2001; 37:S54-S57. (Pubitemid 32048024)
5. Nolan CR, Qunibi WY: Treatment of hyper-phosphatemia in patients with chronic kidney disease on maintenance hemodialysis. Kidney Int Suppl 2005;S13-S20. (Pubitemid 43361551)
6. Cannata-Andia JB, Rodriguez-Garcia M: Hyperphosphataemia as a cardiovascular risk factor-how to manage the problem. Nephrol Dial Transplant 2002; 17(suppl 11): 16-19. (Pubitemid 35277057)
7. Cozzolino M, Dusso AS, Liapis H, Finch J, Lu Y, Burke SK, Slatopolsky E: The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats. J Am Soc Nephrol 2002; 13: 2299-2308. (Pubitemid 34925240)
8. Fyhrquist F, Saijonmaa O: Renin-angioten-sin system revisited. J Intern Med 2008; 264: 224-236.
9. Siragy HM, Carey RM: Role of the intrarenal renin-angiotensin-aldosterone system in chronic kidney disease. Am J Nephrol 2010; 31:541-550.
10. Porsti I, Fan M, Koobi P, Jolma P, Kal-liovalkama J, Vehmas TI, Helin H, Holthofer H, Mervaala E, Nyman T, Tikkanen I: High calcium diet down-regulates kidney angio-tensin-converting enzyme in experimental renal failure. Kidney Int 2004; 66:2155-2166. (Pubitemid 41115279)
11. Koobi P, Kalliovalkama J, Jolma P, Rysa J, Ruskoaho H, Vuolteenaho O, Kahonen M, Tikkanen I, Fan M, Ylitalo P, Porsti I: AT1 receptor blockade improves vasorelaxation in experimental renal failure. Hypertension 2003; 41:1364-1371. (Pubitemid 36706091)
12. Lakkisto P, Palojoki E, Backlund T, Saraste A, Tikkanen I, Voipio-Pulkki LM, Pulkki K: Expression of heme oxygenase-1 in response to myocardial infarction in rats. J Mol Cell Cardiol 2002; 34: 135 7-13 65. (Pubitemid 35244413)
13. Bäcklund T, Palojoki E, Grönholm T, Eriksson A, Vuolteenaho O, Laine M, Tikkanen I: Dual inhibition of angiotensin converting enzyme and neutral endopeptidase by omapatrilat in rat in vivo. Pharmacol Res 2001; 44: 411-418. (Pubitemid 33105081)
14. Zhuo J, Ohishi M, Mendelsohn FA: Roles of AT1 and AT2 receptors in the hypertensive Ren-2 gene transgenic rat kidney. Hypertension 1999; 33: 347-353. (Pubitemid 29065683)
15. 3 and phosphorus in vivo. J Biol Chem 2005; 280:2543-2549. (Pubitemid 40189356)
16. Hatton DC, McCarron DA: Dietary calcium and blood pressure in experimental models of hypertension. A review. Hypertension 1994; 23: 513-530. (Pubitemid 24102049)
17. Gingold H, Pilpel Y: Determinants of translation efficiency and accuracy. Mol Syst Biol 2011; 7:481.
18. Ferrario CM: Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation. Hypertension 2006; 47: 515-521. (Pubitemid 43843868)
19. Pinheiro SV, Ferreira AJ, Kitten GT, da Sil-veira KD, da Silva DA, Santos SH, Gava E, Castro CH, Magalhaes JA, da Mota RK, Botelho-Santos GA, Bader M, Alenina N, Santos RA, Simoes e Silva AC: Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and mi-croalbuminuria. Kidney Int 2009; 75: 1184-1193.
20. Carey RM: Update on the role of the AT2 receptor. Curr Opin Nephrol Hypertens 2005; 14: 67-71.
21. Nguyen G: The (pro)renin receptor: patho-physiological roles in cardiovascular and renal pathology. Curr Opin Nephrol Hyper-tens 2007; 16:129-133.
22. Riediger F, Quack I, Qadri F, Hartleben B, Park JK, Potthoff SA, Sohn D, Sihn G, Rous-selle A, Fokuhl V, Maschke U, Purfurst B, Schneider W, Rump LC, Luft FC, Dechend R, Bader M, Huber TB, Nguyen G, Muller DN: Prorenin receptor is essential for podocyte autophagy and survival. J Am Soc Nephrol 2011; 22:2193-2202.
23. Gupta S, Clarkson MR, Duggan J, Brady HR: Connective tissue growth factor: potential role in glomerulosclerosis and tubulointer-stitial fibrosis. Kidney Int 2000; 58: 1389-1399.
24. Ruperez M, Ruiz-Ortega M, Esteban V, Lorenzo O, Mezzano S, Plaza JJ, Egido J: An-giotensin II increases connective tissue growth factor in the kidney. Am J Pathol 2003; 163: 1937-1947. (Pubitemid 37310024)
25. Abraham NG, Kappas A: Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 2008; 60:79-127. (Pubitemid 351439218)
26. Mizobuchi M, Towler D, Slatopolsky E: Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol 2009; 20:1453-1464.
27. Wu-Wong JR, Nakane M, Ma J, Ruan X, Kroeger PE: Elevated phosphorus modulates vitamin D receptor-mediated gene expression in human va scu la r smooth muscle cel ls. Am J Physiol Renal Physiol 2007; 293:F1592-F1604. (Pubitemid 350085996)