Biphasic modulation of paracellular claudin-5 expression in mouse brain endothelial cells is mediated through the phosphoinositide-3-kinase/akt pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 351, Issue 3, 2014, Pages 654-662

  Camire, Ryan B ^a   Beaulac, Holly J ^b   Brule, Stephanie A ^b   McGregor, Annie I ^b   Lauria, Emily E ^a   Willis, Colin L ^a,b  

^a UNIVERSITY OF NEW ENGLAND   (United States)

^b UNIVERSITY OF NEW ENGLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 CHLOROPROPANEDIOL; ALPHA CHLOROHYDRIN; CLAUDIN 5; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P85; UNCLASSIFIED DRUG; [2 (4 MORPHOLINYL) 8 (4 AMINOPHENY)L 4H 1 BENZOPYRAN 4 ONE]; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; CLDN5 PROTEIN, MOUSE; MORPHOLINE DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IMMUNOFLUORESCENCE; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD BRAIN BARRIER; BRAIN; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TIGHT JUNCTION; TRANSFORMED CELL LINE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE, TRANSFORMED; CHROMONES; CLAUDIN-5; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; MICE; MICE, INBRED BALB C; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS;

EID: 84908592681     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.218339     Document Type: Article

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