The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation

Toxicology

Volumn 232, Issue 3, 2007, Pages 268-276

  Skamarauskas, J ^a   Carter, W ^a   Fowler, M ^a   Madjd, A ^b   Lister, T ^a   Mavroudis, G ^a   Ray, D E ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Nikan Clinic   (Iran)

Author keywords

3 chloropropanediol; Astrocyte; Glutathione S transferase; Glyceraldehyde 3 phosphate dehydrogenase; Monochloropropanediol (MCPD); Neurotoxicity

Indexed keywords

ALCOHOL DEHYDROGENASE; ALPHA CHLOROHYDRIN; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LACTIC ACID; PYRUVIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOTOXICITY; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; EXPOSURE; MALE; MOLECULAR MECHANICS; NEOCORTEX; NEUROPATHY; NEUROTOXICITY; NONHUMAN; OCCIPITAL CORTEX; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

ALPHA-CHLOROHYDRIN; ANIMALS; ASTROCYTES; CELL SURVIVAL; ENERGY METABOLISM; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; INFERIOR COLLICULUS; LACTATES; MALE; NERVOUS SYSTEM DISEASES; NEUROTOXINS; PYRUVATES; RATS; RATS, INBRED F344; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

RATTUS;

EID: 33947327729     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.01.013     Document Type: Article

References (36)

1. Barber R.D., Harmer D.W., Coleman R.A., and Clark B.J. GAPDH as a housekeeping gene: analysis of GAPDH mRNA expression in a panel of 72 human tissues. Physiol. Genomics 21 (2005) 389-395
2. Bone W., Jones A.R., Morin C., Nieschlag E., and Cooper T.G. Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro. J. Androl. 22 (2001) 464-470
3. Brookes P.S., Land J.M., Clark J.B., and Heales S.J. Stimulation of glyceraldehyde-3-phosphate dehydrogenase by oxyhemoglobin. FEBS Lett. 416 (1997) 90-92
4. Carlberg I., and Mannervik B. Glutathione reductase. Methods Enzymol. 113 (1985) 484-490
5. Cavanagh J.B. Selective vulnerability in acute energy deprivation syndromes. Neuropathol. Appl. Neurobiol. 19 (1993) 461-470
6. Cavanagh J.B., and Nolan C.C. The neurotoxicity of alpha-chlorohydrin in rats and mice: II. Lesion topography and factors in selective vulnerability in acute energy deprivation syndromes. Neuropathol. Appl. Neurobiol. 19 (1993) 471-479
7. Cavanagh J.B., Nolan C.C., and Seville M.P. The neurotoxicity of alpha-chlorohydrin in rats and mice: I. Evolution of the cellular changes. Neuropathol. Appl. Neurobiol. 19 (1993) 240-252
8. Chung W.C., Hui K.Y., and Cheng S.C. Sensitive method for the determination of 1,3-dichloropropan-2-ol and 3-chloropropane-1,2-diol in soy sauce by capillary gas chromatography with mass spectrometric detection. J. Chromatogr. A 952 (2002) 185-192
9. Firth S., Peters J., and Bulfield G. Activity and electrophoretic mobility of glutathione reductase allozymes in different tissues of the mouse. Biochem. Genet. 17 (1979) 229-232
10. Ford W.C., and Waites G.M. The effect of high doses of 6-chloro-6-deoxyglucose on the rat. Contraception 24 (1981) 577-588
11. Galter D., Carmine A., Buervenich S., Duester G., and Olson L. Distribution of class I, III and IV alcohol dehydrogenase mRNAs in the adult rat, mouse and human brain. Eur. J. Biochem. 270 (2003) 1316-1326
12. Garle M.J., Sinclair C., Thurley P., and Fry J.R. Haloalcohols deplete glutathione when incubated with fortified liver fractions. Xenobiotica 29 (1999) 533-545
13. Heywood R., Sortwell R.J., and Prentice D.E. The toxicity of 1-amino-3-chloro-2-propanol hydrochloride (CL88,236) in the rhesus monkey. Toxicology 9 (1978) 219-225
14. Hissin P.J., and Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74 (1976) 214-226
15. Howland R.D. Biochemical studies of acrylamide neuropathy. Neurotoxicology 6 (1985) 7-15
16. Iozef R., Becker K., Boehme C.C., Schirmer R.H., and Werner D. Assembly and functional expression of murine glutathione reductase cDNA: a sequence missing in expressed sequence tag libraries. Biochim. Biophys. Acta 1500 (2000) 137-141
17. Jakoby W.B. Glutathione transferases. Methods Enzymol. 113 (1985) 499-503
18. Jones A.R. The metabolism of 3-chloro,- 3-bromo- and 3-iodopropan-1,2-diol in rats and mice. Xenobiotica 5 (1975) 155-165
19. Jones A.R., and Ford S.A. The action of (S)-alpha-chlorohydrin and 6-chloro-6-deoxyglucose on the metabolism of guinea pig spermatozoa. Contraception 30 (1984) 261-269
20. Jones A.R., and Porter L.M. Inhibition of glycolysis in boar spermatozoa by alpha-chlorohydrin phosphate appears to be mediated by phosphatase activity. Reprod. Fertil. Dev. 7 (1995) 1089-1094
21. Jones A.R., Mashford P.M., and Murcott C. The metabolism of 3-amino-1-chloropropan-2-ol in relation to its antifertility activity in male rats. Xenobiotica 9 (1979) 253-261
22. Kish S.J., Lopes-Cendes I., Guttman M., Furukawa Y., Pandolfo M., Rouleau G.A., Ross B.M., Nance M., Schut L., Ang L., and DiStefano L. Brain glyceraldehyde-3-phosphate dehydrogenase activity in human trinucleotide repeat disorders. Arch. Neurol. 55 (1998) 1299-1304
23. Kwack S.J., Kim S.S., Choi Y.W., Rhee G.S., Da Lee R., Seok J.H., Chae S.Y., Won Y.H., Lim K.J., Choi K.S., Park K.L., and Lee B.M. Mechanism of antifertility in male rats treated with 3-monochloro-1,2-propanediol (3-MCPD). J. Toxicol. Environ. Health A 67 (2004) 2001-2011
24. Lynch N.J., Willis C.L., Nolan C.C., Roscher S., Fowler M.J., Weihe E., Ray D.E., and Schwaeble W.J. Microglial activation and increased synthesis of complement component C1q precedes blood-brain barrier dysfunction in rats. Mol. Immunol. 40 (2004) 709-716
25. Mavroudis G., Prior M.J., Lister T., Nolan C.C., and Ray D.E. Neurochemical and oedematous changes in 1,3-dinitrobenzene-induced astroglial injury in rat brain from a (1)H-nuclear magnetic resonance perspective. J. Neural. Transm. 113 (2006) 1263-1278
26. Mori O., Haseba T., Kameyama K., Shimizu H., Kudoh M., Ohaki O., Arai Y., Yamazaki M., and Asano G. Histological distribution of class III alcohol dehydrogenase in human brain. Brain Res. 852 (2000) 186-190
27. Porter K.E., and Jones A.R. The renal toxicity of (R)-3-chlorolactate in the rat. Chem. Biol. Interact. 62 (1987) 157-166
28. Ravindranath V., and Pai K.S. The use of rat brain slices as an in vitro model for mechanistic evaluation of neurotoxicity-studies with acrylamide. Neurotoxicology 12 (1991) 225-234
29. Romero I.A., Lister T., Richards H.K., Seville M.P., Wylie S.P., and Ray D.E. Early metabolic changes during m-dinitrobenzene neurotoxicity and the possible role of oxidative stress. Free Radic. Biol. Med. 18 (1995) 311-319
30. Sheline C.T., and Choi D.W. Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase. Neurobiol. Dis. 5 (1998) 47-54
31. Sirover M.A. Role of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in normal cell function and in cell pathology. J. Cell Biochem. 66 (1997) 133-140
32. Sood C., and O'Brien P.J. 2-Chloroacetaldehyde-induced cerebral glutathione depletion and neurotoxicity. Br. J. Cancer Suppl. 27 (1996) S287-S293
33. WHO. 3-Chloro-1.2-propanediolWHO Food Additives series, vol. 48 (2006), World Health Organisation
34. Willis C.L., Leach L., Clarke G.J., Nolan C.C., and Ray D.E. Reversible disruption of tight junction complexes in the rat blood brain barrier, following transitory focal astrocyte loss. Glia 48 (2004) 1-13
35. Willis C.L., Nolan C.C., Reith S.N., Lister T., Prior M.J.W., Guerin C.J., Mavroudis G., and Ray D.E. Focal astrocyte loss is followed by microvascular damage, with subsequent repair of the blood-brain barrier in the apparent absence of direct astrocytic contact. Glia 45 (2004) 325-337
36. Xiao, Y., Zhou, Y., Luo, R.C., Zhang, Z., 2003. Study on the absorption, distribution and excretion of 3-chloro-1,2-propandiol in rats. Zhonghua Yu Fang Yi. Xue. Za Zhi. 37, 426-428.