High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses

Journal of Physiology

Volumn 592, Issue 19, 2014, Pages 4131-4136

  d'Incamps, Boris Lamotte ^a   Ascher, Philippe ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2;

ARTICLE; BINDING AFFINITY; EXCITATORY POSTSYNAPTIC POTENTIAL; MOTONEURON; NERVOUS SYSTEM; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRESYNAPTIC POTENTIAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RECEPTOR AFFINITY; RENSHAW CELL; STOICHIOMETRY; SYNAPTIC POTENTIAL; ANIMAL; BRAIN; METABOLISM; PHYSIOLOGY; SYNAPSE; SYNAPTIC TRANSMISSION;

ANIMALS; BRAIN; EXCITATORY POSTSYNAPTIC POTENTIALS; MOTOR NEURONS; RECEPTORS, NICOTINIC; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 84908568206     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.273128     Document Type: Article

References (34)

1. Alvarez FJ, Dewey DE, McMillin P & Fyffe RE (1999). Distribution of cholinergic contacts on Renshaw cells in the rat spinal cord: a light microscopic study. J Physiol 515, 787-797.
2. Arroyo S, Bennett C, Aziz D, Brown SP & Hestrin S (2012). Prolonged disynaptic inhibition in the cortex mediated by slow, non-α7 nicotinic excitation of a specific subset of cortical interneurons. J Neurosci 32, 3859-3864.
3. Bell KA, Shim H, Chen C-K & McQuiston AR (2011). Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and β2 subunits. Neuropharmacology 61, 1379-1388.
4. Benallegue N, Mazzaferro S, Alcaino C & Bermudez I (2013). The additional ACh binding site at the α4(+)/α4(-) interface of the (α4β2)2α4 nicotinic ACh receptor contributes to desensitization. Br J Pharmacol 170, 304-316.
5. Bennett C, Arroyo S, Berns D & Hestrin S (2012). Mechanisms generating dual-component nicotinic EPSCs in cortical interneurons. J Neurosci 32, 17287-17296.
6. Briggs CA, Gubbins EJ, Marks MJ, Putman CB, Thimmapaya R, Meyer MD & Surowy CS (2006). Untranslated region-dependent exclusive expression of high-sensitivity subforms of α4β2 and α3β2 nicotinic acetylcholine receptors. Mol Pharmacol 70, 227-240.
7. Chavez-Noriega LE, Crona JH, Washburn MS, Urrutia A, Elliott KJ & Johnson EC (1997). Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 expressed in Xenopus oocytes. J Pharmacol Exp Ther 280, 346-356.
8. Descarries L, Gisiger V & Steriade M (1997). Diffuse transmission by acetylcholine in the CNS. Prog Neurobiol 53, 603-625.
9. Dourado M & Sargent PB (2002). Properties of nicotinic receptors underlying Renshaw cell excitation by α-motor neurons in neonatal rat spinal cord. J Neurophysiol 87, 3117-3125.
10. Harpsøe K, Ahring PK, Christensen JK, Jensen ML, Peters D & Balle T (2011). Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors. J Neurosci 31, 10759-10766.
11. Hartzell HC, Kuffler SW & Yoshikami D (1975). Post-synaptic potentiation: interaction between quanta of acetylcholine at the skeletal neuromuscular synapse. J Physiol 251, 427-463.
12. Harvey SC & Luetje CW (1996). Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor β subunits. J Neurosci 16, 3798-3806.
13. Hu B, Steriade M & Deschênes M (1989). The effects of brainstem peribrachial stimulation on neurons of the lateral geniculate nucleus. Neuroscience 31, 13-24.
14. Ishii K, Wong JK & Sumikawa K (2005). Comparison of α2 nicotinic acetylcholine receptor subunit mRNA expression in the central nervous system of rats and mice. J Comp Neurol 493, 241-260.
15. Khiroug SS, Khiroug L & Yakel JL (2004). Rat nicotinic acetylcholine receptor α2β2 channels: comparison of functional properties with α4β2 channels in Xenopus oocytes. Neuroscience 124, 817-822.
16. Lamotte d'Incamps B & Ascher P (2008). Four excitatory postsynaptic ionotropic receptors coactivated at the motoneuron-Renshaw cell synapse. J Neurosci 28, 14121-14131.
17. Lamotte d'Incamps B & Ascher P (2013). Subunit composition and kinetics of the Renshaw cell heteromeric nicotinic receptors. Biochem Pharmacol 86, 1114-1121.
18. Lamotte d'Incamps B, Krejci E & Ascher P (2012). Mechanisms shaping the slow nicotinic synaptic current at the motoneuron-Renshaw cell synapse. J Neurosci 32, 8413-8423.
19. Leão RN, Mikulovic S, Leão KE, Munguba H, Gezelius H, Enjin A, Patra K, Eriksson A, Loew LM, Tort ABL & Kullander K (2012). OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci 15, 1524-1530.
20. Lester RA, Clements JD, Westbrook GL & Jahr CE (1990). Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature 346, 565-567.
21. McQuiston AR & Madison D V (1999). Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus. J Neurosci 19, 2887-2896.
22. Mazzaferro S, Benallegue N, Carbone A, Gasparri F, Vijayan R, Biggin PC, Moroni M & Bermudez I (2011). Additional acetylcholine (ACh) binding site at α4/α4 interface of (α4β2)2α4 nicotinic receptor influences agonist sensitivity. J Biol Chem 286, 31043-31054.
23. Moroni M, Zwart R, Sher E, Cassels BK & Bermudez I (2006). α4β2 Nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol Pharmacol 70, 755-768.
24. Nelson ME, Kuryatov A, Choi CH, Zhou Y & Lindstrom J (2003). Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors. Mol Pharmacol 63, 332-341.
25. Nose I, Higashi H, Inokuchi H & Nishi S (1991). Synaptic responses of guinea pig and rat central amygdala neurons in vitro. J Neurophysiol 65, 1227-1241.
26. Parent M & Descarries L (2008). Acetylcholine innervation of the adult rat thalamus: distribution and ultrastructural features in dorsolateral geniculate, parafascicular, and reticular thalamic nuclei. J Comp Neurol 511, 678-691.
27. Ren J, Qin C, Hu F, Tan J, Qiu L, Zhao S, Feng G & Luo M (2011). Habenula 'cholinergic' neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron 69, 445-452.
28. Sabey K, Paradiso K, Zhang J & Steinbach JH (1999). Ligand binding and activation of rat nicotinic α4β2 receptors stably expressed in HEK293 cells. Mol Pharmacol 55, 58-66.
29. Schofield CM & Huguenard JR (2007). GABA affinity shapes IPSCs in thalamic nuclei. J Neurosci 27, 7954-7962.
30. Sun Y-G, Pita-Almenar JD, Wu C-S, Renger JJ, Uebele VN, Lu H-C & Beierlein M (2013). Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons. J Neurosci 33, 2048-2059.
31. Timmermann DB, Sandager-Nielsen K, Dyhring T, Smith M, Jacobsen A-M, Nielsen EØ, Grunnet M, Christensen JK, Peters D, Kohlhaas K, Olsen GM & Ahring PK (2012). Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of α2- and α4-containing nicotinic acetylcholine receptors. Br J Pharmacol 167, 164-182.
32. Wootz H, Fitzsimons-Kantamneni E, Larhammar M, Rotterman TM, Enjin A, Patra K, André E, Van Zundert B, Kullander K & Alvarez FJ (2013). Alterations in the motor neuron-renshaw cell circuit in the Sod1(G93A) mouse model. J Comp Neurol 521, 1449-1469.
33. Zhang J & Diamond JS (2006). Distinct perisynaptic and synaptic localization of NMDA and AMPA receptors on ganglion cells in rat retina. J Comp Neurol 498, 810-820.
34. Zwart R & Vijverberg HP (1998). Four pharmacologically distinct subtypes of α4ß2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Mol Pharmacol 54, 1124-1131.