Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth

Molecular Oncology

Volumn 8, Issue 7, 2014, Pages 1220-1230

  Li, Changyou ^a   Egloff, Ann Marie ^b   Sen, Malabika ^b   Grandis, Jennifer R ^a,b   Johnson, Daniel E ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Caspase 8; Extrinsic apoptosis; HNSCC; Invasion; Migration

Indexed keywords

CASPASE 8; DEATH RECEPTOR; FAS ANTIBODY; FAS ASSOCIATED DEATH DOMAIN PROTEIN; MATRIGEL; PROCASPASE 8; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; GENE MUTATION; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; CELL MOTION; FEMALE; GENETICS; HEAD AND NECK TUMOR; METABOLISM; MUTATION; NUDE MOUSE; PATHOLOGY; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CASPASE 8; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MICE, NUDE; MUTATION; NEOPLASM INVASIVENESS; RECEPTORS, DEATH DOMAIN;

EID: 84908556309     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2014.03.018     Document Type: Article

References (34)

1. Agrawal N., Frederick M.J., Pickering C.R., Bettegowda C., Chang K., Li R.J., Fakhry C., Xie T.X., Zhang J., Wang J., Zhang N., El-Naggar A.K., Jasser S.A., Weinstein J.N., Trevino L., Drummond J.A., Muzny D.M., Wu Y., Wood L.D., Hruban R.H., Westra W.H., Koch W.M., Califano J.A., Gibbs R.A., Sidransky D., Vogelstein B., Velculescu V.E., Papadopoulos N., Wheeler D.A., Kinzler K.W., Myers J.N. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011, 333:1154-1157.
2. Ando M., Kawazu M., Ueno T., Fukumura K., Yamato A., Soda M., Yamashita Y., Choi Y.L., Yamasoba T., Mano H. Cancer-associated missense mutations of caspase-8 activate nuclear factor-kappaB signaling. Cancer Sci. 2013, 104:1002-1008.
3. Barbero S., Barila D., Mielgo A., Stagni V., Clair K., Stupack D. Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. J.Biol. Chem. 2008, 283:13031-13034.
4. Bonner J.A., Harari P.M., Giralt J., Cohen R.B., Jones C.U., Sur R.K., Raben D., Baselga J., Spencer S.A., Zhu J., Youssoufian H., Rowinsky E.K., Ang K.K. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 2010, 11:21-28.
5. Cerami E., Gao J., Dogrusoz U., Gross B.E., Sumer S.O., Aksoy B.A., Jacobsen A., Byrne C.J., Heuer M.L., Larsson E., Antipin Y., Reva B., Goldberg A.P., Sander C., Schultz N. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer discov. 2012, 2:401-404.
6. Chaudhary P.M., Eby M.T., Jasmin A., Kumar A., Liu L., Hood L. Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene 2000, 19:4451-4460.
7. Degterev A., Boyce M., Yuan J. A decade of caspases. Oncogene 2003, 22:8543-8567.
8. Dickens L.S., Boyd R.S., Jukes-Jones R., Hughes M.A., Robinson G.L., Fairall L., Schwabe J.W., Cain K., Macfarlane M. A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death. Mol. Cell. 2012, 47:291-305.
9. Finlay D., Vuori K. Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells. Cancer Res. 2007, 67:11704-11711.
10. Frisch S.M. Caspase-8: fly or die. Cancer Res. 2008, 68:4491-4493.
11. Fulda S. Caspase-8 in cancer biology and therapy. Cancer Lett. 2009, 281:128-133.
12. Fung C., Grandis J.R. Emerging drugs to treat squamous cell carcinomas of the head and neck. Expert Opin. Emerg. Drugs 2010, 15:355-373.
13. Helfer B., Boswell B.C., Finlay D., Cipres A., Vuori K., Bong Kang T., Wallach D., Dorfleutner A., Lahti J.M., Flynn D.C., Frisch S.M. Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions. Cancer Res. 2006, 66:4273-4278.
14. Hou W., Han J., Lu C., Goldstein L.A., Rabinowich H. Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis. Autophagy 2010, 6:891-900.
15. Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.L., Schroter M., Burns K., Mattmann C., Rimoldi D., French L.E., Tschopp J. Inhibition of death receptor signals by cellular FLIP. Nature 1997, 388:190-195.
16. Jemal A., Siegel R., Ward E., Hao Y., Xu J., Thun M.J. Cancer statistics, 2009. CA Cancer J. Clin. 2009, 59:225-249.
17. Kim H.S., Lee J.W., Soung Y.H., Park W.S., Kim S.Y., Lee J.H., Park J.Y., Cho Y.G., Kim C.J., Jeong S.W., Nam S.W., Kim S.H., Lee J.Y., Yoo N.J., Lee S.H. Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology 2003, 125:708-715.
18. Li C., Johnson D.E. Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive head and neck squamous cell carcinoma cells promotes apoptosis and cell cycle arrest. Cell Cycle 2013, 12:923-934.
19. Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y. Head and neck squamous cell carcinoma cell lines: established models and rationale for selection. Head Neck 2007, 29:163-188.
20. Mandruzzato S., Brasseur F., Andry G., Boon T., van der Bruggen P. A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma. J.Exp. Med. 1997, 186:785-793.
21. Martin D.A., Siegel R.M., Zheng L., Lenardo M.J. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J.Biol. Chem. 1998, 273:4345-4349.
22. Mehanna H., Paleri V., West C.M., Nutting C. Head and neck cancer-Part 1: epidemiology, presentation, and prevention. Bmj 2010, 341:c4684.
23. Muzio M., Stockwell B.R., Stennicke H.R., Salvesen G.S., Dixit V.M. An induced proximity model for caspase-8 activation. J.Biol. Chem. 1998, 273:2926-2930.
24. Oberst A., Dillon C.P., Weinlich R., McCormick L.L., Fitzgerald P., Pop C., Hakem R., Salvesen G.S., Green D.R. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 2011, 471:363-367.
25. Pickering C.R., Zhang J., Yoo S.Y., Bengtsson L., Moorthy S., Neskey D.M., Zhao M., Ortega Alves M.V., Chang K., Drummond J., Cortez E., Xie T.X., Zhang D., Chung W., Issa J.P., Zweidler-McKay P.A., Wu X., El-Naggar A.K., Weinstein J.N., Wang J., Muzny D.M., Gibbs R.A., Wheeler D.A., Myers J.N., Frederick M.J. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer discov. 2013, 3:770-781.
26. Schleich K., Warnken U., Fricker N., Ozturk S., Richter P., Kammerer K., Schnolzer M., Krammer P.H., Lavrik I.N. Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model. Mol. Cell. 2012, 47:306-319.
27. Senft J., Helfer B., Frisch S.M. Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility. Cancer Res. 2007, 67:11505-11509.
28. Soung Y.H., Lee J.W., Kim S.Y., Jang J., Park Y.G., Park W.S., Nam S.W., Lee J.Y., Yoo N.J., Lee S.H. CASPASE-8 gene is inactivated by somatic mutations in gastric carcinomas. Cancer Res. 2005, 65:815-821.
29. Soung Y.H., Lee J.W., Kim S.Y., Sung Y.J., Park W.S., Nam S.W., Kim S.H., Lee J.Y., Yoo N.J., Lee S.H. Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas. Oncogene 2005, 24:141-147.
30. Stransky N., Egloff A.M., Tward A.D., Kostic A.D., Cibulskis K., Sivachenko A., Kryukov G.V., Lawrence M.S., Sougnez C., McKenna A., Shefler E., Ramos A.H., Stojanov P., Carter S.L., Voet D., Cortes M.L., Auclair D., Berger M.F., Saksena G., Guiducci C., Onofrio R.C., Parkin M., Romkes M., Weissfeld J.L., Seethala R.R., Wang L., Rangel-Escareno C., Fernandez-Lopez J.C., Hidalgo-Miranda A., Melendez-Zajgla J., Winckler W., Ardlie K., Gabriel S.B., Meyerson M., Lander E.S., Getz G., Golub T.R., Garraway L.A., Grandis J.R. The mutational landscape of head and neck squamous cell carcinoma. Science 2011, 333:1157-1160.
31. Stupack D.G., Teitz T., Potter M.D., Mikolon D., Houghton P.J., Kidd V.J., Lahti J.M., Cheresh D.A. Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature 2006, 439:95-99.
32. Torres V.A., Mielgo A., Barbero S., Hsiao R., Wilkins J.A., Stupack D.G. Rab5 mediates caspase-8-promoted cell motility and metastasis. Mol. Biol. Cell. 2010, 21:369-376.
33. Yang X., Chang H.Y., Baltimore D. Autoproteolytic activation of pro-caspases by oligomerization. Mol. Cell. 1998, 1:319-325.
34. Zhao Y., Sui X., Ren H. From procaspase-8 to caspase-8: revisiting structural functions of caspase-8. J.Cell Physiol. 2010, 225:316-320.