메뉴 건너뛰기




Volumn 158, Issue 4, 2014, Pages 738-744.e1

Serum and plasma vascular endothelial growth factor concentrations before and after intravitreal injection of aflibercept or ranibizumab for age-related macular degeneration

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; RANIBIZUMAB; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; HYBRID PROTEIN; MONOCLONAL ANTIBODY; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR; VEGFA PROTEIN, HUMAN;

EID: 84908553704     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2014.06.009     Document Type: Article
Times cited : (83)

References (39)
  • 1
    • 1942542429 scopus 로고    scopus 로고
    • Age-related macular degeneration is the leading cause of blindness
    • Bressler NM. Age-related macular degeneration is the leading cause of blindness. JAMA 2004;291(15):1900-1901.
    • (2004) JAMA , vol.291 , Issue.15 , pp. 1900-1901
    • Bressler, N.M.1
  • 2
    • 1842530296 scopus 로고    scopus 로고
    • Causes and prevalence of visual impairment among adults in the united states
    • Congdon N, O'Colmain B, Klaver CC, et al. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol 2004;122(4):477-485.
    • (2004) Arch Ophthalmol , vol.122 , Issue.4 , pp. 477-485
    • Congdon, N.1    O'Colmain, B.2    Klaver, C.C.3
  • 3
  • 4
    • 0028786651 scopus 로고
    • Suppression of retinal neo vascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
    • Aiello LP, Pierce EA, Foley ED, et al. Suppression of retinal neo vascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A 1995;92(23):10457-10461.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , Issue.23 , pp. 10457-10461
    • Aiello, L.P.1    Pierce, E.A.2    Foley, E.D.3
  • 5
    • 0029879849 scopus 로고    scopus 로고
    • Trans differentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neo vascular membranes
    • Lopez PF, Sippy BD, Lambert HM, Thach AB, Hinton DR. Trans differentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neo vascular membranes. Invest Ophthalmol Vis Sci 1996; 37(5):855-868.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , Issue.5 , pp. 855-868
    • Lopez, P.F.1    Sippy, B.D.2    Lambert, H.M.3    Thach, A.B.4    Hinton, D.R.5
  • 6
    • 0029831672 scopus 로고    scopus 로고
    • Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor
    • Kvanta A, Algvere PV, Berglin L, Seregard S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest Ophthalmol Vis Sci 1996;37(9):1929-1934.
    • (1996) Invest Ophthalmol Vis Sci , vol.37 , Issue.9 , pp. 1929-1934
    • Kvanta, A.1    Algvere, P.V.2    Berglin, L.3    Seregard, S.4
  • 7
    • 0031050126 scopus 로고    scopus 로고
    • Increased expression of angiogenic growth factors in age-related maculopathy
    • Kliffen M, Sharma HS, Mooy CM, Kerkvliet S, de Jong PT. Increased expression of angiogenic growth factors in age-related maculopathy. Br J Ophthalmol 1997;81(2): 154-162.
    • (1997) Br J Ophthalmol , vol.81 , Issue.2 , pp. 154-162
    • Kliffen, M.1    Sharma, H.S.2    Mooy, C.M.3    Kerkvliet, S.4    De Jong, P.T.5
  • 8
    • 34250887456 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema
    • Jonas JB, Neumaier M. Vascular endothelial growth factor and basic fibroblast growth factor in exudative age-related macular degeneration and diffuse diabetic macular edema. Ophthalmic Res 2007;39(3):139-142.
    • (2007) Ophthalmic Res , vol.39 , Issue.3 , pp. 139-142
    • Jonas, J.B.1    Neumaier, M.2
  • 9
    • 70350741503 scopus 로고    scopus 로고
    • Changes in aqueous vascular endothelial growth factor and pigment epithelium-derived factor after ranibizumab alone or combined with verteporfin for exudative age-related macular degeneration
    • Ahn JK, Moon HJ. Changes in aqueous vascular endothelial growth factor and pigment epithelium-derived factor after ranibizumab alone or combined with verteporfin for exudative age-related macular degeneration. Am J Ophthalmol 2009;148(5):718-724.
    • (2009) Am J Ophthalmol , vol.148 , Issue.5 , pp. 718-724
    • Ahn, J.K.1    Moon, H.J.2
  • 10
    • 70649094281 scopus 로고    scopus 로고
    • Neo vascular age related macular degeneration: Intraocular cytokines and growth factors and the influence of therapy with ranibizumab
    • Funk M, Karl D, Georgopoulos M, et al. Neo vascular age related macular degeneration: Intraocular cytokines and growth factors and the influence of therapy with ranibizumab. Ophthalmology 2009;116(12):2393-2399.
    • (2009) Ophthalmology , vol.116 , Issue.12 , pp. 2393-2399
    • Funk, M.1    Karl, D.2    Georgopoulos, M.3
  • 11
    • 77954722637 scopus 로고    scopus 로고
    • Aqueous vascular endothelial growth factor after intra vitreal injection of pegaptanib or ranibizumab in patients with age-related macular degeneration
    • Sawada O, Miyake T, Kakinoki M, Sawada T, Kawamura H, Ohji M. Aqueous vascular endothelial growth factor after intra vitreal injection of pegaptanib or ranibizumab in patients with age-related macular degeneration. Retina 2010; 30(7):1034-1038.
    • (2010) Retina , vol.30 , Issue.7 , pp. 1034-1038
    • Sawada, O.1    Miyake, T.2    Kakinoki, M.3    Sawada, T.4    Kawamura, H.5    Ohji, M.6
  • 12
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • Rosenfeld PJ, Brown DM, Heier JS, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 2006;355(14):1419-1431.
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 13
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown DM, Kaiser PK, Michels M, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006;355(14):1432-1444.
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3
  • 14
    • 57949094834 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin photodynamic therapy for neo vascular age related macular degeneration: Two-year results of the anchor study
    • Brown DM, Michels M, Kaiser PK, et al. Ranibizumab versus verteporfin photodynamic therapy for neo vascular age related macular degeneration: Two-year results of the ANCHOR study. Ophthalmology 2009;116(1):57-65.
    • (2009) Ophthalmology , vol.116 , Issue.1 , pp. 57-65
    • Brown, D.M.1    Michels, M.2    Kaiser, P.K.3
  • 15
    • 84870723704 scopus 로고    scopus 로고
    • Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration
    • Heier JS, Brown DM, Chong V, et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology 2012;119(12):2537-2548.
    • (2012) Ophthalmology , vol.119 , Issue.12 , pp. 2537-2548
    • Heier, J.S.1    Brown, D.M.2    Chong, V.3
  • 16
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: A VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A 2002;99(17):11393-11398.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.17 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 17
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989;246(4935):1306-1309.
    • (1989) Science , vol.246 , Issue.4935 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 18
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9(6):669-676.
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 19
    • 32944466693 scopus 로고    scopus 로고
    • Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
    • Baffert F, Le T, Sennino B, et al. Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol 2006; 290(2):H547-H559.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , Issue.2 , pp. H547-H559
    • Baffert, F.1    Le, T.2    Sennino, B.3
  • 20
    • 0036191926 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-mediated, endothelium-dependent relaxation in human internal mammary artery
    • Liu MH, Jin H, Floten HS, Ren Z, Yim AP, He GW. Vascular endothelial growth factor-mediated, endothelium-dependent relaxation in human internal mammary artery. Ann Thorac Surg 2002;73(3):819-824.
    • (2002) Ann Thorac Surg , vol.73 , Issue.3 , pp. 819-824
    • Liu, M.H.1    Jin, H.2    Floten, H.S.3    Ren, Z.4    Yim, A.P.5    He, G.W.6
  • 21
    • 84904357863 scopus 로고    scopus 로고
    • Aqueous vascular endothelial growth factor and ranibizumab concentrations after monthly and bimonthly intravitreal injections of ranibizumab for age-related macular degeneration
    • Wang X, Sawada T, Kakinoki M, et al. Aqueous vascular endothelial growth factor and ranibizumab concentrations after monthly and bimonthly intravitreal injections of ranibizumab for age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2014;252(7):1033-1039.
    • (2014) Graefes Arch Clin Exp Ophthalmol , vol.252 , Issue.7 , pp. 1033-1039
    • Wang, X.1    Sawada, T.2    Kakinoki, M.3
  • 22
    • 80054849404 scopus 로고    scopus 로고
    • Influence of ranibizumab on vascular endothelial growth factor plasma level and endothelial progenitor cell mobilization in age-related macular degeneration patients: Safety of intravitreal treatment for vascular homeostasis
    • Machaliñska A, Paczkowska E, Pabin T, Safranow K, Karczewicz D, Machaliñski B. Influence of ranibizumab on vascular endothelial growth factor plasma level and endothelial progenitor cell mobilization in age-related macular degeneration patients: safety of intravitreal treatment for vascular homeostasis. J Ocul Pharmacol Ther 2011;27(5):471-475.
    • (2011) J Ocul Pharmacol Ther , vol.27 , Issue.5 , pp. 471-475
    • Machaliñska, A.1    Paczkowska, E.2    Pabin, T.3    Safranow, K.4    Karczewicz, D.5    Machaliñski, B.6
  • 23
    • 84875213214 scopus 로고    scopus 로고
    • Plasma levels of vascular endothelial growth factor before and after intravitreal injection of bevacizumab, ranibizumab and pegaptanib in patients with age-related macular degeneration, and in patients with diabetic macular oedema
    • Zehetner C, Kirchmair R, Huber S, Kralinger MT, Kieselbach GF. Plasma levels of vascular endothelial growth factor before and after intravitreal injection of bevacizumab, ranibizumab and pegaptanib in patients with age-related macular degeneration, and in patients with diabetic macular oedema. Br J Ophthalmol 2013;97(4):454-459.
    • (2013) Br J Ophthalmol , vol.97 , Issue.4 , pp. 454-459
    • Zehetner, C.1    Kirchmair, R.2    Huber, S.3    Kralinger, M.T.4    Kieselbach, G.F.5
  • 24
    • 84871683928 scopus 로고    scopus 로고
    • Effect of vitrectomy on aqueous VEGF concentration and pharmacokinetics of bevacizumab in macaque monkeys
    • Kakinoki M, Sawada O, Sawada T, Saishin Y, Kawamura H, Ohji M. Effect of vitrectomy on aqueous VEGF concentration and pharmacokinetics of bevacizumab in macaque monkeys. Invest Ophthalmol Vis Sci 2012;53(9):5877-5880.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , Issue.9 , pp. 5877-5880
    • Kakinoki, M.1    Sawada, O.2    Sawada, T.3    Saishin, Y.4    Kawamura, H.5    Ohji, M.6
  • 25
    • 0032831462 scopus 로고    scopus 로고
    • Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: A key to study an angiogenic marker in vivo?
    • Wynendaele W, Derua R, Hoylaerts MF, et al. Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: A key to study an angiogenic marker in vivo? Ann Oncol 1999; 10(8):965-971.
    • (1999) Ann Oncol , vol.10 , Issue.8 , pp. 965-971
    • Wynendaele, W.1    Derua, R.2    Hoylaerts, M.F.3
  • 26
    • 84898490267 scopus 로고    scopus 로고
    • Intravitreal injection of ranibizumab for treatment of age-related macular degeneration: Effects on serum vegf concentration
    • Gu X, Yu X, Dai H. Intravitreal injection of ranibizumab for treatment of age-related macular degeneration: effects on serum VEGF concentration. Curr Eye Res 2014;39(5): 518-521.
    • (2014) Curr Eye Res , vol.39 , Issue.5 , pp. 518-521
    • Gu, X.1    Yu, X.2    Dai, H.3
  • 27
    • 79551519219 scopus 로고    scopus 로고
    • Serum VEGF and CFH in exudative age-related macular degeneration
    • Haas P, Steindl K, Aggermann T, et al. Serum VEGF and CFH in exudative age-related macular degeneration. Curr Eye Res 2011;36(2):143-148.
    • (2011) Curr Eye Res , vol.36 , Issue.2 , pp. 143-148
    • Haas, P.1    Steindl, K.2    Aggermann, T.3
  • 29
    • 77949887728 scopus 로고    scopus 로고
    • Pharmacokinetics of bevacizumab and its effect on vascular endothelial growth factor after intravitreal injection of bevacizumab in macaque eyes
    • Miyake T, Sawada O, Kakinoki M, et al. Pharmacokinetics of bevacizumab and its effect on vascular endothelial growth factor after intravitreal injection of bevacizumab in macaque eyes. Invest Ophthalmol Vis Sci 2010;51(3):1606-1608.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , Issue.3 , pp. 1606-1608
    • Miyake, T.1    Sawada, O.2    Kakinoki, M.3
  • 30
    • 0000146003 scopus 로고
    • A theoretical model of gamma-globulin catabolism
    • Brambell FW, Hemmings WA, Morris IGA. A theoretical model of gamma-globulin catabolism. Nature 1964;203: 1352-1354.
    • (1964) Nature , vol.203 , pp. 1352-1354
    • Brambell, F.W.1    Hemmings, W.A.2    Morris, I.G.A.3
  • 31
    • 0036201914 scopus 로고    scopus 로고
    • Transcytosis and catabolism of antibody
    • Ghetie V, Ward ES. Transcytosis and catabolism of antibody. Immunol Res 2002;25(2):97-113.
    • (2002) Immunol Res , vol.25 , Issue.2 , pp. 97-113
    • Ghetie, V.1    Ward, E.S.2
  • 33
    • 84861722422 scopus 로고    scopus 로고
    • What are the half-lives of ranibizumab and aflibercept (VEGF trap-eye) in human eyes? Calculations with a mathematical model
    • Stewart MW. What are the half-lives of ranibizumab and aflibercept (VEGF Trap-Eye) in human eyes? Calculations with a mathematical model. Eye Reports 2011;1(1):e5.
    • (2011) Eye Reports , vol.1 , Issue.1 , pp. e5
    • Stewart, M.W.1
  • 34
    • 84889755254 scopus 로고    scopus 로고
    • Available at:, Accessed November 2011
    • US Food and Drug Administration. FDA labeling information: Eylea 2011. Available at: http://www.accessdata.fda.gov/drugsatfda-docs/label/2011/125387lbl.pdf.Accessed November 2011.
    • (2011) FDA Labeling Information: Eylea
  • 35
    • 13944266313 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics of ranibizumab (rhufabv2) after a single intravitreal administration
    • Gaudreault J, Fei D, Rusit J, Suboc P, Shiu V. Preclinical pharmacokinetics of ranibizumab (rhuFabV2) after a single intravitreal administration. Invest Ophthalmol Vis Sci 2005; 46(2):726-733.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , Issue.2 , pp. 726-733
    • Gaudreault, J.1    Fei, D.2    Rusit, J.3    Suboc, P.4    Shiu, V.5
  • 36
    • 0032864292 scopus 로고    scopus 로고
    • Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125i-labeled full-length and fab antibodies in rhesus monkeys following intravitreal administration
    • Mordenti J, Cuthbertson RA, Ferrara N, et al. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol Pathol 1999;27(5):536-544.
    • (1999) Toxicol Pathol , vol.27 , Issue.5 , pp. 536-544
    • Mordenti, J.1    Cuthbertson, R.A.2    Ferrara, N.3
  • 37
    • 84875435647 scopus 로고    scopus 로고
    • Pharmacokinetics of ranibizumab in patients with neo vascular age-related macular degeneration: A population approach
    • Xu L, Lu T, Tuomi L, Jumbe N, Lu J, Eppler S. Pharmacokinetics of ranibizumab in patients with neo vascular age-related macular degeneration: A population approach. Invest Ophthalmol Vis Sci 2013;54(3):1616-1624.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , Issue.3 , pp. 1616-1624
    • Xu, L.1    Lu, T.2    Tuomi, L.3    Jumbe, N.4    Lu, J.5    Eppler, S.6
  • 38
    • 34548141828 scopus 로고    scopus 로고
    • Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab
    • Scappaticci FA, Skillings JR, Holden SN, et al. Arterial thromboembolic events in patients with metastatic carcinoma treated with chemotherapy and bevacizumab. J Natl Cancer Inst 2007;99:1232-1239.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1232-1239
    • Scappaticci, F.A.1    Skillings, J.R.2    Holden, S.N.3
  • 39
    • 56649123212 scopus 로고    scopus 로고
    • Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis
    • Nalluri SR, Chu D, Keresztes R, Zhu X, Wu S. Risk of venous thromboembolism with the angiogenesis inhibitor bevacizumab in cancer patients: A meta-analysis. JAMA 2008; 300(19):2277-2285.
    • (2008) JAMA , vol.300 , Issue.19 , pp. 2277-2285
    • Nalluri, S.R.1    Chu, D.2    Keresztes, R.3    Zhu, X.4    Wu, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.