메뉴 건너뛰기




Volumn 16, Issue , 2014, Pages 26-32

Brain glucose sensing, glucokinase and neural control of metabolism and islet function

Author keywords

Glucokinase; Glucose sensing; Glucose stimulated insulin secretion; Hypoglycaemia; Hypothalamus; Insulin

Indexed keywords

GLUCOKINASE; HEXOKINASE; GLUCOSE; INSULIN; NERVE PROTEIN;

EID: 84908547619     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12334     Document Type: Review
Times cited : (34)

References (63)
  • 1
    • 76649124522 scopus 로고    scopus 로고
    • Hypoglycaemia
    • Wass J, Shalet S, eds. Oxford: Oxford University Press
    • Evans ML, Amiel SA. Hypoglycaemia. In: Wass J, Shalet S, eds. Oxford Textbook of Endocrinology. Oxford: Oxford University Press, 2002.
    • (2002) Oxford Textbook of Endocrinology
    • Evans, M.L.1    Amiel, S.A.2
  • 2
    • 0027327113 scopus 로고
    • Counterregulation during hypoglycemia is directed by widespread brain regions
    • Frizzell RT, Jones EM, Davis SN et al. Counterregulation during hypoglycemia is directed by widespread brain regions. Diabetes 1993; 42: 1253-1261.
    • (1993) Diabetes , vol.42 , pp. 1253-1261
    • Frizzell, R.T.1    Jones, E.M.2    Davis, S.N.3
  • 3
    • 0024520153 scopus 로고
    • Role of brain in counterregulation of insulin-induced hypoglycemia in dogs
    • Biggers DW, Myers SR, Neal D et al. Role of brain in counterregulation of insulin-induced hypoglycemia in dogs. Diabetes 1989; 38: 7-16.
    • (1989) Diabetes , vol.38 , pp. 7-16
    • Biggers, D.W.1    Myers, S.R.2    Neal, D.3
  • 4
    • 0028931891 scopus 로고
    • Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release
    • Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 1995; 44: 180-184.
    • (1995) Diabetes , vol.44 , pp. 180-184
    • Borg, W.P.1    Sherwin, R.S.2    During, M.J.3    Borg, M.A.4    Shulman, G.I.5
  • 5
    • 0028296222 scopus 로고
    • Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia
    • Borg WP, During MJ, Sherwin RS, Borg MA, Brines ML, Shulman GI. Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia. J Clin Invest 1994; 93: 1677-1682.
    • (1994) J Clin Invest , vol.93 , pp. 1677-1682
    • Borg, W.P.1    During, M.J.2    Sherwin, R.S.3    Borg, M.A.4    Brines, M.L.5    Shulman, G.I.6
  • 6
    • 0031038124 scopus 로고    scopus 로고
    • Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats
    • Borg MA, Sherwin RS, Borg WP, Tamborlane WV, Shulman GI. Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats. J Clin Invest 1997; 99: 361-365.
    • (1997) J Clin Invest , vol.99 , pp. 361-365
    • Borg, M.A.1    Sherwin, R.S.2    Borg, W.P.3    Tamborlane, W.V.4    Shulman, G.I.5
  • 7
    • 0019794835 scopus 로고
    • Glucoreceptors controlling feeding and blood glucose: location in the hindbrain
    • Ritter RC, Slusser PG, Stone S. Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 1981; 213: 451-453.
    • (1981) Science , vol.213 , pp. 451-453
    • Ritter, R.C.1    Slusser, P.G.2    Stone, S.3
  • 8
    • 0035795199 scopus 로고    scopus 로고
    • Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation
    • Ritter S, Bugarith K, Dinh TT. Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation. J Comp Neurol 2001; 43: 197-216.
    • (2001) J Comp Neurol , vol.43 , pp. 197-216
    • Ritter, S.1    Bugarith, K.2    Dinh, T.T.3
  • 9
    • 0033976228 scopus 로고    scopus 로고
    • Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose
    • Ritter S, Dinh TT, Zhang Y. Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res 2000; 856: 37-47.
    • (2000) Brain Res , vol.856 , pp. 37-47
    • Ritter, S.1    Dinh, T.T.2    Zhang, Y.3
  • 10
    • 34247616021 scopus 로고    scopus 로고
    • Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
    • Tong Q, Ye C, McCrimmon RJ et al. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 2007; 5: 383-393.
    • (2007) Cell Metab , vol.5 , pp. 383-393
    • Tong, Q.1    Ye, C.2    McCrimmon, R.J.3
  • 11
    • 0033957338 scopus 로고    scopus 로고
    • Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia
    • Hevener AL, Bergman RN, Donovan CM. Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia. Diabetes 2000; 49: 8-12.
    • (2000) Diabetes , vol.49 , pp. 8-12
    • Hevener, A.L.1    Bergman, R.N.2    Donovan, C.M.3
  • 12
    • 48449097409 scopus 로고    scopus 로고
    • The locus for hypoglycemic detection shifts with the rate of fall in glycemia: the role of portal-superior mesenteric vein glucose sensing
    • Saberi M, Bohland M, Donovan CM. The locus for hypoglycemic detection shifts with the rate of fall in glycemia: the role of portal-superior mesenteric vein glucose sensing. Diabetes 2008; 57: 1380-1386.
    • (2008) Diabetes , vol.57 , pp. 1380-1386
    • Saberi, M.1    Bohland, M.2    Donovan, C.M.3
  • 13
    • 34548420968 scopus 로고    scopus 로고
    • Portal vein hypoglycemia is essential for full induction of hypoglycemia-associated autonomic failure with slow-onset hypoglycemia
    • Matveyenko AV, Bohland M, Saberi M, Donovan CM. Portal vein hypoglycemia is essential for full induction of hypoglycemia-associated autonomic failure with slow-onset hypoglycemia. Am J Physiol Endocrinol Metab 2007; 293: E857-864.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. E857-E864
    • Matveyenko, A.V.1    Bohland, M.2    Saberi, M.3    Donovan, C.M.4
  • 14
    • 84887824523 scopus 로고    scopus 로고
    • Portal glucose influences the sensory, cortical and reward systems in rats
    • Delaere F, Akaoka H, De Vadder F, Duchampt A, Mithieux G. Portal glucose influences the sensory, cortical and reward systems in rats. Eur J Neurosci 2013; 38: 3476-3486.
    • (2013) Eur J Neurosci , vol.38 , pp. 3476-3486
    • Delaere, F.1    Akaoka, H.2    De Vadder, F.3    Duchampt, A.4    Mithieux, G.5
  • 15
    • 17844379717 scopus 로고    scopus 로고
    • Hypothalamic K(ATP) channels control hepatic glucose production
    • Pocai A, Lam TK, Gutierrez-Juarez R et al. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 2005; 434: 1026-1031.
    • (2005) Nature , vol.434 , pp. 1026-1031
    • Pocai, A.1    Lam, T.K.2    Gutierrez-Juarez, R.3
  • 16
    • 0027143882 scopus 로고
    • Cephalic-phase insulin in obese and normal-weight men: relation to postprandial insulin
    • Teff KL, Mattes RD, Engelman J, Mattern J. Cephalic-phase insulin in obese and normal-weight men: relation to postprandial insulin. Metabolism 1993; 42: 1600-1608.
    • (1993) Metabolism , vol.42 , pp. 1600-1608
    • Teff, K.L.1    Mattes, R.D.2    Engelman, J.3    Mattern, J.4
  • 18
    • 0014061137 scopus 로고
    • Effects of stimulation of the vagus nerve on insulin secretion
    • Kaneto A, Kosaka K, Nakao K. Effects of stimulation of the vagus nerve on insulin secretion. Endocrinology 1967; 80: 530-536.
    • (1967) Endocrinology , vol.80 , pp. 530-536
    • Kaneto, A.1    Kosaka, K.2    Nakao, K.3
  • 19
    • 0014515508 scopus 로고
    • Increased insulin output following stimulation of the vagal supply to the perfused rabbit pancreas
    • Findlay JA, Gill JR, Lever JD, Randle PJ, Spriggs TL. Increased insulin output following stimulation of the vagal supply to the perfused rabbit pancreas. J Anat 1969; 104: 580.
    • (1969) J Anat , vol.104 , pp. 580
    • Findlay, J.A.1    Gill, J.R.2    Lever, J.D.3    Randle, P.J.4    Spriggs, T.L.5
  • 20
    • 0014104226 scopus 로고
    • Effect of vagotomy and vagal stimulation on insulin secretion
    • Frohman LA, Ezdinli EZ, Javid R. Effect of vagotomy and vagal stimulation on insulin secretion. Diabetes 1967; 16: 443-448.
    • (1967) Diabetes , vol.16 , pp. 443-448
    • Frohman, L.A.1    Ezdinli, E.Z.2    Javid, R.3
  • 21
    • 0016732951 scopus 로고
    • Pancreatic endocrine responses to stimulation via the sympathetic innervation
    • Bloom SR, Edwards AV. Pancreatic endocrine responses to stimulation via the sympathetic innervation. J Physiol 1975; 245: 120P-121P.
    • (1975) J Physiol , vol.245 , pp. 120P-121P
    • Bloom, S.R.1    Edwards, A.V.2
  • 22
    • 2942553044 scopus 로고    scopus 로고
    • Acute intracarotid glucose injection towards the brain induces specific c-fos activation in hypothalamic nuclei: involvement of astrocytes in cerebral glucose-sensing in rats
    • Guillod-Maximin E, Lorsignol A, Alquier T, Pénicaud L. Acute intracarotid glucose injection towards the brain induces specific c-fos activation in hypothalamic nuclei: involvement of astrocytes in cerebral glucose-sensing in rats. J Neuroendocrinol 2004; 16: 464-471.
    • (2004) J Neuroendocrinol , vol.16 , pp. 464-471
    • Guillod-Maximin, E.1    Lorsignol, A.2    Alquier, T.3    Pénicaud, L.4
  • 23
    • 33747039288 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing
    • Leloup C, Magnan C, Benani A et al. Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing. Diabetes 2006; 55: 2084-2090.
    • (2006) Diabetes , vol.55 , pp. 2084-2090
    • Leloup, C.1    Magnan, C.2    Benani, A.3
  • 24
    • 84892919259 scopus 로고    scopus 로고
    • Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis
    • Tarussio D, Metref S, Seyer P et al. Nervous glucose sensing regulates postnatal β cell proliferation and glucose homeostasis. J Clin Invest 2014; 124: 413-424.
    • (2014) J Clin Invest , vol.124 , pp. 413-424
    • Tarussio, D.1    Metref, S.2    Seyer, P.3
  • 25
    • 0025843629 scopus 로고
    • Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats
    • Le Feuvre RA, Woods AJ, Stock MJ, Rothwell NJ. Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats. Brain Res 1991; 547: 110-114.
    • (1991) Brain Res , vol.547 , pp. 110-114
    • Le Feuvre, R.A.1    Woods, A.J.2    Stock, M.J.3    Rothwell, N.J.4
  • 26
    • 0001643038 scopus 로고
    • Activity of single neurons in the hypothalamic feeding centers: effect of glucose
    • Anand BK, Chhina GS, Sharma KN, Dua S, Singh B. Activity of single neurons in the hypothalamic feeding centers: effect of glucose. Am J Physiol 1964; 207: 1146-1154.
    • (1964) Am J Physiol , vol.207 , pp. 1146-1154
    • Anand, B.K.1    Chhina, G.S.2    Sharma, K.N.3    Dua, S.4    Singh, B.5
  • 27
    • 0021249617 scopus 로고
    • Neural network of glucose monitoring system
    • Oomura Y, Yoshimatsu H. Neural network of glucose monitoring system. J Auton Nerv Syst 1984; 10: 359-372.
    • (1984) J Auton Nerv Syst , vol.10 , pp. 359-372
    • Oomura, Y.1    Yoshimatsu, H.2
  • 28
    • 2642641299 scopus 로고    scopus 로고
    • Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons
    • Silver IA, Erecinska M. Glucose-induced intracellular ion changes in sugar-sensitive hypothalamic neurons. J Neurophysiol 1998; 79: 1733-1745.
    • (1998) J Neurophysiol , vol.79 , pp. 1733-1745
    • Silver, I.A.1    Erecinska, M.2
  • 29
    • 0021367606 scopus 로고
    • Convergence of hepatoportal glucose-sensitive afferents signal to glucose sensitive units within the nucleus of the solitary tract
    • Adachi A, Shimizu N, Oomura Y, Kobashi M. Convergence of hepatoportal glucose-sensitive afferents signal to glucose sensitive units within the nucleus of the solitary tract. Neurosci Lett 1984; 46: 215-218.
    • (1984) Neurosci Lett , vol.46 , pp. 215-218
    • Adachi, A.1    Shimizu, N.2    Oomura, Y.3    Kobashi, M.4
  • 30
    • 0033588532 scopus 로고    scopus 로고
    • A solitary tract nucleus sensitivity to moderate changes in glucose level
    • Dallaporta M, Himmi T, Perrin J, Orsini JC. A solitary tract nucleus sensitivity to moderate changes in glucose level. Neuroreport 1999; 10: 1-4.
    • (1999) Neuroreport , vol.10 , pp. 1-4
    • Dallaporta, M.1    Himmi, T.2    Perrin, J.3    Orsini, J.C.4
  • 32
    • 33845516690 scopus 로고    scopus 로고
    • Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing
    • O'Malley D, Reimann F, Simpson AK, Gribble FM. Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensing. Diabetes 2006; 55: 3381-3386.
    • (2006) Diabetes , vol.55 , pp. 3381-3386
    • O'Malley, D.1    Reimann, F.2    Simpson, A.K.3    Gribble, F.M.4
  • 33
    • 33646914929 scopus 로고    scopus 로고
    • Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose
    • Burdakov D, Jensen LT, Alexopoulos H et al. Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron 2006; 50: 711-722.
    • (2006) Neuron , vol.50 , pp. 711-722
    • Burdakov, D.1    Jensen, L.T.2    Alexopoulos, H.3
  • 34
    • 4644298411 scopus 로고    scopus 로고
    • Hypothalamic ATP-sensitive K+ channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses
    • Evans ML, McCrimmon RJ, Flanagan DE et al. Hypothalamic ATP-sensitive K+ channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes 2004; 53: 2542-2551.
    • (2004) Diabetes , vol.53 , pp. 2542-2551
    • Evans, M.L.1    McCrimmon, R.J.2    Flanagan, D.E.3
  • 35
    • 33644696261 scopus 로고    scopus 로고
    • Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats
    • McCrimmon RJ, Evans ML, Fan X et al. Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats. Diabetes 2005; 54: 3169-3174.
    • (2005) Diabetes , vol.54 , pp. 3169-3174
    • McCrimmon, R.J.1    Evans, M.L.2    Fan, X.3
  • 36
    • 0035042796 scopus 로고    scopus 로고
    • ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis
    • Miki T, Liss B, Minami K et al. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci 2001; 4: 507-512.
    • (2001) Nat Neurosci , vol.4 , pp. 507-512
    • Miki, T.1    Liss, B.2    Minami, K.3
  • 37
    • 34047114378 scopus 로고    scopus 로고
    • ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia
    • Chan O, Lawson M, Zhu W, Beverly JL, Sherwin RS. ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia. Diabetes 2007; 56: 1120-1126.
    • (2007) Diabetes , vol.56 , pp. 1120-1126
    • Chan, O.1    Lawson, M.2    Zhu, W.3    Beverly, J.L.4    Sherwin, R.S.5
  • 38
    • 33745327159 scopus 로고    scopus 로고
    • Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia
    • Chan O, Zhu W, Ding Y, McCrimmon RJ, Sherwin RS. Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia. Diabetes 2006; 55: 1080-1087.
    • (2006) Diabetes , vol.55 , pp. 1080-1087
    • Chan, O.1    Zhu, W.2    Ding, Y.3    McCrimmon, R.J.4    Sherwin, R.S.5
  • 39
    • 77950805120 scopus 로고    scopus 로고
    • Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia
    • Zhu W, Czyzyk D, Paranjape SA et al. Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia. Am J Physiol Endocrinol Metab 2010; 298: E971-977.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E971-E977
    • Zhu, W.1    Czyzyk, D.2    Paranjape, S.A.3
  • 40
    • 0034604731 scopus 로고    scopus 로고
    • Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion
    • Thorens B, Guillam MT, Beermann F, Burcelin R, Jaquet M. Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 2000; 275: 23751-23758.
    • (2000) J Biol Chem , vol.275 , pp. 23751-23758
    • Thorens, B.1    Guillam, M.T.2    Beermann, F.3    Burcelin, R.4    Jaquet, M.5
  • 41
    • 31044444108 scopus 로고    scopus 로고
    • Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors
    • Marty N, Dallaporta M, Foretz M et al. Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors. J Clin Invest 2005; 115: 3545-3553.
    • (2005) J Clin Invest , vol.115 , pp. 3545-3553
    • Marty, N.1    Dallaporta, M.2    Foretz, M.3
  • 42
    • 1442276966 scopus 로고    scopus 로고
    • Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons
    • Kang L, Routh VH, Kuzhikandathil EV, Gaspers LD, Levin BE. Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes 2004; 53: 549-559.
    • (2004) Diabetes , vol.53 , pp. 549-559
    • Kang, L.1    Routh, V.H.2    Kuzhikandathil, E.V.3    Gaspers, L.D.4    Levin, B.E.5
  • 43
    • 84866113299 scopus 로고    scopus 로고
    • Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour
    • Beall C, Hamilton DL, Gallagher J et al. Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. Diabetologia 2012; 55: 2432-2444.
    • (2012) Diabetologia , vol.55 , pp. 2432-2444
    • Beall, C.1    Hamilton, D.L.2    Gallagher, J.3
  • 44
    • 40749132626 scopus 로고    scopus 로고
    • Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
    • McCrimmon RJ, Shaw M, Fan X et al. Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia. Diabetes 2008; 57: 444-450.
    • (2008) Diabetes , vol.57 , pp. 444-450
    • McCrimmon, R.J.1    Shaw, M.2    Fan, X.3
  • 45
    • 33748296106 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation
    • McCrimmon RJ, Fan X, Cheng H et al. Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation. Diabetes 2006; 55: 1755-1760.
    • (2006) Diabetes , vol.55 , pp. 1755-1760
    • McCrimmon, R.J.1    Fan, X.2    Cheng, H.3
  • 46
    • 0028101926 scopus 로고
    • Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut
    • Jetton TL, Liang Y, Pettepher CC et al. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J Biol Chem 1994; 269: 3641-3654.
    • (1994) J Biol Chem , vol.269 , pp. 3641-3654
    • Jetton, T.L.1    Liang, Y.2    Pettepher, C.C.3
  • 48
    • 0036303140 scopus 로고    scopus 로고
    • Glucokinase Is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons
    • Dunn-Meynell AA, Routh VH, Kang L, Gaspers L, Levin BE. Glucokinase Is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons. Diabetes 2002; 51: 2056-2065.
    • (2002) Diabetes , vol.51 , pp. 2056-2065
    • Dunn-Meynell, A.A.1    Routh, V.H.2    Kang, L.3    Gaspers, L.4    Levin, B.E.5
  • 49
    • 77956257822 scopus 로고    scopus 로고
    • Glial glucokinase expression in adult and post-natal development of the hypothalamic region
    • Millán C, Martínez F, Cortés-Campos C et al. Glial glucokinase expression in adult and post-natal development of the hypothalamic region. ASN Neuro 2010; 2: e00035.
    • (2010) ASN Neuro , vol.2 , pp. e00035
    • Millán, C.1    Martínez, F.2    Cortés-Campos, C.3
  • 50
    • 84885145339 scopus 로고    scopus 로고
    • Profiling of glucose-sensing neurons reveals that GHRH neurons are activated by hypoglycemia
    • Stanley S, Domingos A, Kelly L et al. Profiling of glucose-sensing neurons reveals that GHRH neurons are activated by hypoglycemia. Cell Metab 2013; 18: 596-607.
    • (2013) Cell Metab , vol.18 , pp. 596-607
    • Stanley, S.1    Domingos, A.2    Kelly, L.3
  • 51
    • 33644773627 scopus 로고    scopus 로고
    • Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing
    • Kang L, Dunn-Meynell AA, Routh VH et al. Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing. Diabetes 2006; 55: 412-420.
    • (2006) Diabetes , vol.55 , pp. 412-420
    • Kang, L.1    Dunn-Meynell, A.A.2    Routh, V.H.3
  • 52
    • 0032829063 scopus 로고    scopus 로고
    • Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms
    • Yang XJ, Kow LM, Funabashi T, Mobbs CV. Hypothalamic glucose sensor: similarities to and differences from pancreatic beta-cell mechanisms. Diabetes 1999; 48: 1763-1772.
    • (1999) Diabetes , vol.48 , pp. 1763-1772
    • Yang, X.J.1    Kow, L.M.2    Funabashi, T.3    Mobbs, C.V.4
  • 53
    • 0347360368 scopus 로고    scopus 로고
    • Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose
    • Yang XJ, Kow LM, Pfaff DW, Mobbs CV. Metabolic pathways that mediate inhibition of hypothalamic neurons by glucose. Diabetes 2004; 53: 67-73.
    • (2004) Diabetes , vol.53 , pp. 67-73
    • Yang, X.J.1    Kow, L.M.2    Pfaff, D.W.3    Mobbs, C.V.4
  • 54
    • 48449103821 scopus 로고    scopus 로고
    • Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia
    • Levin BE, Becker TC, Eiki J-I, Zhang BB, Dunn-Meynell AA. Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia. Diabetes 2008; 57: 1371-1379.
    • (2008) Diabetes , vol.57 , pp. 1371-1379
    • Levin, B.E.1    Becker, T.C.2    Eiki, J.-I.3    Zhang, B.B.4    Dunn-Meynell, A.A.5
  • 55
    • 77957608055 scopus 로고    scopus 로고
    • The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemia
    • Zhou L, Podolsky N, Sang Z et al. The medial amygdalar nucleus: a novel glucose-sensing region that modulates the counterregulatory response to hypoglycemia. Diabetes 2010; 59: 2646-2652.
    • (2010) Diabetes , vol.59 , pp. 2646-2652
    • Zhou, L.1    Podolsky, N.2    Sang, Z.3
  • 56
    • 77950270393 scopus 로고    scopus 로고
    • Brain glucosamine boosts protective glucoprivic feeding
    • Osundiji MA, Zhou L, Shaw J et al. Brain glucosamine boosts protective glucoprivic feeding. Endocrinology 2010; 151: 1499-1508.
    • (2010) Endocrinology , vol.151 , pp. 1499-1508
    • Osundiji, M.A.1    Zhou, L.2    Shaw, J.3
  • 57
    • 79955758359 scopus 로고    scopus 로고
    • Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons
    • Zhou L, Yueh CY, Lam DD et al. Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons. Behav Brain Res 2011; 12: 274-278.
    • (2011) Behav Brain Res , vol.12 , pp. 274-278
    • Zhou, L.1    Yueh, C.Y.2    Lam, D.D.3
  • 58
    • 0033670425 scopus 로고    scopus 로고
    • Counterregulatory responses to hypoglycemia in patients with glucokinase gene mutations
    • Guenat E, Seematter G, Philippe J, Temler E, Jequier E, Tappy L. Counterregulatory responses to hypoglycemia in patients with glucokinase gene mutations. Diabetes Metab 2000; 26: 377-384.
    • (2000) Diabetes Metab , vol.26 , pp. 377-384
    • Guenat, E.1    Seematter, G.2    Philippe, J.3    Temler, E.4    Jequier, E.5    Tappy, L.6
  • 59
    • 82655180434 scopus 로고    scopus 로고
    • BAD modulates counterregulatory responses to hypoglycemia and protective glucoprivic feeding
    • Osundiji MA, Godes ML, Evans ML, Danial NN. BAD modulates counterregulatory responses to hypoglycemia and protective glucoprivic feeding. PLoS One 2011; 6: e28016.
    • (2011) PLoS One , vol.6 , pp. e28016
    • Osundiji, M.A.1    Godes, M.L.2    Evans, M.L.3    Danial, N.N.4
  • 60
    • 84856536388 scopus 로고    scopus 로고
    • Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion
    • Osundiji MA, Lam DD, Shaw JS et al. Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion. Diabetes 2012; 61: 321-328.
    • (2012) Diabetes , vol.61 , pp. 321-328
    • Osundiji, M.A.1    Lam, D.D.2    Shaw, J.S.3
  • 61
    • 40449134788 scopus 로고    scopus 로고
    • Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons
    • Kang L, Sanders NM, Dunn-Meynell AA et al. Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons. Am J Physiol Regul Integr Comp Physiol 2008; 294: R784-792.
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.294 , pp. R784-R792
    • Kang, L.1    Sanders, N.M.2    Dunn-Meynell, A.A.3
  • 62
    • 79952985152 scopus 로고    scopus 로고
    • Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats
    • Osundiji MA, Hurst P, Moore SP et al. Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats. Metabolism 2011; 60: 550-556.
    • (2011) Metabolism , vol.60 , pp. 550-556
    • Osundiji, M.A.1    Hurst, P.2    Moore, S.P.3
  • 63
    • 84866164993 scopus 로고    scopus 로고
    • Glucokinase activators AZD6370 and AZD1656 do not affect the central counterregulatory response to hypoglycemia in healthy males
    • Norjavaara E, Ericsson H, Sjöberg F et al. Glucokinase activators AZD6370 and AZD1656 do not affect the central counterregulatory response to hypoglycemia in healthy males. J Clin Endocrinol Metab 2012; 97: 3319-3325.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3319-3325
    • Norjavaara, E.1    Ericsson, H.2    Sjöberg, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.