Macrophages promote renal fibrosis through direct and indirect mechanisms

Kidney International Supplements

Volumn 4, Issue 1, 2014, Pages 34-38

  Nikolic Paterson, David J ^a   Wang, Shuang ^b   Lan, Hui Yao ^b  

^a MONASH MEDICAL CENTRE   (Australia)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

fibrosis; M1 and M2 macrophages; MMT; myofibroblast; transition

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD45 ANTIGEN; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CXCL16 CHEMOKINE; FIBROBLAST GROWTH FACTOR 2; GALECTIN 3; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 13; INTERLEUKIN 4; MACROPHAGE ELASTASE; MACROPHAGE MIGRATION INHIBITION FACTOR; PLATELET DERIVED GROWTH FACTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANTIGEN ANTIBODY COMPLEX; BONE MARROW DERIVED MACROPHAGE; CELL HETEROGENEITY; CELL INFILTRATION; CELL PROLIFERATION; CELL TRANSFORMATION; CYTOKINE PRODUCTION; ENDOTHELIAL MYOFIBROBLAST TRANSITION; FLOW CYTOMETRY; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY FIBROSIS; LEUKOPENIA; MACROPHAGE; MACROPHAGE MYOFIBROBLAST TRANSITION; MONOCYTE; MYOFIBROBLAST; NONHUMAN; PERICYTE; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; URETER OBSTRUCTION;

EID: 84908544895     PISSN: 21571724     EISSN: 21571716     Source Type: Journal    
DOI: 10.1038/kisup.2014.7     Document Type: Short Survey

References (37)

1. Anders HJ, Ryu M. Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis. Kidney Int 2011; 80: 915-925.
2. Martinez FO, Sica A, Mantovani A et al. Macrophage activation and polarization. Front Biosci 2008; 13: 453-461.
3. Ma FY, Ikezumi Y, Nikolic-Paterson DJ. Macrophage signaling pathways: a novel target in renal disease. Sem Nephrol 2010; 30: 334-344.
4. Eardley KS, Kubal C, Zehnder D et al. The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease. Kidney Int 2008; 74: 495-504.
5. Nikolic-Paterson DJ, Atkins RC. The role of macrophages in glomerulonephritis. Nephrol Dialysis Transplant 2001; 16(Suppl 5): 3-7.
6. Yang N, Isbel NM, Nikolic-Paterson DJ et al. Local macrophage proliferation in human glomerulonephritis. Kidney Int 1998; 54: 143-151.
7. Yang N, Wu LL, Nikolic-Paterson DJ et al. Local macrophage and myofibroblast proliferation in progressive renal injury in the rat remnant kidney. Nephrol Dialysis Transplant 1998; 13: 1967-1974.
8. Han Y, Ma FY, Tesch GH et al. c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat. Lab Invest 2011; 91: 978-991.
9. Ma FY, Flanc RS, Tesch GH et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest 2009; 89: 470-484.
10. Tan RJ, Liu Y. Macrophage-derived TGF-beta in renal fibrosis: not a macroimpact after all. Am J Physiol Renal Physiol 2013; 305: F821-F822.
11. Ikezumi Y, Suzuki T, Karasawa T et al. Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion. Histopathology 2011; 58: 198-210.
12. Bellon T, Martinez V, Lucendo B et al. Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis. Nephrol Dialysis Transplant 2011; 26: 2995-3005.
13. Han Y, Ma FY, Tesch GH et al. Role of macrophages in the fibrotic phase of rat crescentic glomerulonephritis. Am J Physiol Renal Physiol 2013; 304: F1043-F1053.
14. Ikezumi Y, Suzuki T, Karasawa T et al. Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulonephritis. Am J Nephrol 2010; 31: 273-282.
15. Anders HJ, Vielhauer V, Frink M et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest 2002; 109: 251-259.
16. Henderson NC, Mackinnon AC, Farnworth SL et al. Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol 2008; 172: 288-298.
17. Kitagawa K, Wada T, Furuichi K et al. Blockade of CCR2 ameliorates progressive fibrosis in kidney. Am J Pathol 2004; 165: 237-246.
18. Kitamoto K, Machida Y, Uchida J et al. Effects of liposome clodronate on renal leukocyte populations and renal fibrosis in murine obstructive nephropathy. J Pharmacol Sci 2009; 111: 285-292.
19. Ma FY, Liu J, Kitching AR et al. Targeting renal macrophage accumulation via c-fms kinase reduces tubular apoptosis but fails to modify progressive fibrosis in the obstructed rat kidney. Am J Physiol Renal Physiol 2009; 296: F177-F185.
20. Nishida M, Okumura Y, Fujimoto S et al. Adoptive transfer of macrophages ameliorates renal fibrosis in mice. Biochem Biophys Res Commun 2005; 332: 11-16.
21. Ferenbach DA, Sheldrake TA, Dhaliwal K et al. Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice. Kidney Int 2012; 82: 928-933.
22. Wang Y, Wang YP, Zheng G et al. Ex vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease. Kidney Int 2007; 72: 290-299.
23. Humphreys BD, Lin SL, Kobayashi A et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2010; 176: 85-97.
24. Iwano M, Plieth D, Danoff TM et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002; 110: 341-350.
25. LeBleu VS, Taduri G, O'Connell J et al. Origin and function of myofibroblasts in kidney fibrosis. Nat Med 2013; 19: 1047-1053.
26. Li J, Qu X, Bertram JF. Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. Am J Pathol 2009; 175: 1380-1388.
27. Zeisberg EM, Potenta SE, Sugimoto H et al. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 2008; 19: 2282-2287.
28. Broekema M, Harmsen MC, van Luyn MJ et al. Bone marrow-derived myofibroblasts contribute to the renal interstitial myofibroblast population and produce procollagen I after ischemia/reperfusion in rats. J Am Soc Nephrol 2007; 18: 165-175.
29. Grimm PC, Nickerson P, Jeffery J et al. Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection. N Engl J Med 2001; 345: 93-97.
30. Lin SL, Kisseleva T, Brenner DA et al. Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 2008; 173: 1617-1627.
31. Roufosse C, Bou-Gharios G, Prodromidi E et al. Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis. J Am Soc Nephrol 2006; 17: 775-782.
32. Bucala R, Spiegel LA, Chesney J et al. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med 1994; 1: 71-81.
33. Chen G, Lin SC, Chen J et al. CXCL16 recruits bone marrow-derived fibroblast precursors in renal fibrosis. J Am Soc Nephrol 2011; 22: 1876-1886.
34. Reich B, Schmidbauer K, Rodriguez Gomez M et al. Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model. Kidney Int 2013; 84: 78-89.
35. Pilling D, Gomer RH. Differentiation of circulating monocytes into fibroblast-like cells. Methods Mol Biol 2012; 904: 191-206.
36. Bertrand S, Godoy M, Semal P et al. Transdifferentiation of macrophages into fibroblasts as a result of Schistosoma mansoni infection. Int J Dev Biol 1992; 36: 179-184.
37. Mooney JE, Rolfe BE, Osborne GW et al. Cellular plasticity of inflammatory myeloid cells in the peritoneal foreign body response. Am J Pathol 2010; 176: 369-380.