C-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat

Laboratory Investigation

Volumn 91, Issue 7, 2011, Pages 978-991

  Han, Yingjie ^a   Ma, Frank Y ^a   Tesch, Greg H ^a   Manthey, Carl L ^b   Nikolic Paterson, David J ^a  

^a MONASH UNIVERSITY   (Australia)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

c fms; crescent; dendritic cell; macrophage; podocyte; proteinuria

Indexed keywords

4 CYANO 1H IMIDAZOLE 2 CARBOXYLIC ACID (2 CYCLOHEX 1 ENYL) 4 [1 (2 METHANESULFONYL ETHYL)PIPERIDIN 4 YL]PHENYL]AMIDE; COLONY STIMULATING FACTOR RECEPTOR; ENZYME INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12; MACROPHAGE ELASTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOWMAN CAPSULE; CELL ADHESION; CELL INFILTRATION; CONTROLLED STUDY; DENDRITIC CELL; GLOMERULOSCLEROSIS; HISTOPATHOLOGY; KIDNEY DYSFUNCTION; MACROPHAGE; MALE; MONOCYTE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; RAT;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; GLOMERULONEPHRITIS; IMMUNOHISTOCHEMISTRY; KIDNEY GLOMERULUS; MACROPHAGES; MALE; PROTEINURIA; RATS; RATS, INBRED WKY; RATS, WISTAR; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79959758089     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.61     Document Type: Article

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