Transdermal delivery of highly lipophilic drugs: In vitro fluxes of antiestrogens, permeation enhancers, and solvents from liquid formulations

Pharmaceutical Research

Volumn 19, Issue 5, 2002, Pages 661-668

  Funke, A P ^a   Schiller, R ^a   Motzkus, H W ^a   Ginther, C ^a   Miller, R H ^b   Lipp, R ^a  

^a BAYER PHARMA AG   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Antiestrogens; Differential scanning calorimetry (DSC); Highly lipophilic drug; Lauric acid; Permeation enhancers; Propylene glycol; Transdermal drug delivery

Indexed keywords

ANTIESTROGEN; LAURIC ACID; PROPYLENE GLYCOL; SOLVENT; 11 FLUORO 7 (5 (METHYL(3 ((4,4,5,5,5 PENTAFLUOROPENTYL)SULFANYL)PROPYL)AMINO)PENTYL)ESTRA 1,3,5(10) TRIENE 3,17 DIOL; 11 FLUORO 7 (5 (METHYL(7,7,8,8,9,9,10,10,10 NONAFLUORODECYL)AMINO)PENTYL)ESTRA 1,3,5(10) TRIENE 3,17 DIOL; 11-FLUORO-7-(5-(METHYL(3-((4,4,5,5,5-PENTAFLUOROPENTYL)SULFANYL)PROPYL)AMINO)PENTYL)ESTRA-1,3,5(10)-TRIENE-3,17-DIOL; 11-FLUORO-7-(5-(METHYL(7,7,8,8,9,9,10,10,10-NONAFLUORODECYL)AMINO)PENTYL)ESTRA-1,3,5(10)-TRIENE-3,17-DIOL; 2,5 DIMETHYLISOSORBIDE; 2,5-DIMETHYLISOSORBIDE; DIMETHYL SULFOXIDE; DRUG DERIVATIVE; ESTRADIOL; ISOSORBIDE; LAURIC ACID DERIVATIVE; PHARMACEUTICAL VEHICLES AND ADDITIVES; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SULFUR DERIVATIVE;

ANIMAL TISSUE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG FORMULATION; DRUG PENETRATION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; STRATUM CORNEUM; TEMPERATURE; TRANSDERMAL DRUG ADMINISTRATION; ANIMAL; CHEMISTRY; DIFFUSION; DOSE RESPONSE; HAIRLESS MOUSE; IN VITRO STUDY; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; SKIN; SKIN ABSORPTION; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ADJUVANTS, PHARMACEUTIC; ADMINISTRATION, CUTANEOUS; ANIMAL; BIOLOGICAL TRANSPORT; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DIFFUSION; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN RECEPTOR MODULATORS; IN VITRO; ISOSORBIDE; LAURIC ACIDS; MALE; MICE; MICE, INBRED HRS; PROPYLENE GLYCOL; SKIN; SKIN ABSORPTION; SOLVENTS; TIME FACTORS; ANIMALS; SULFUR COMPOUNDS;

EID: 0036001399     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015314314796     Document Type: Article

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