Patient-centered interventions to improve medication management and adherence: A qualitative review of research findings

Patient Education and Counseling

Volumn 97, Issue 3, 2014, Pages 310-326

  Kuntz, Jennifer L ^a   Safford, Monika M ^b   Singh, Jasvinder A ^b   Phansalkar, Shobha ^c,d   Slight, Sarah P ^c,d   Her, Qoua Liang ^c   Lapointe, Nancy Allen ^e   Mathews, Robin ^e   O'Brien, Emily ^e   Brinkman, William B ^f   Hommel, Kevin ^f   Farmer, Kevin C ^g   Klinger, Elissa ^d   Maniam, Nivethietha ^c   Sobko, Heather J ^b   Bailey, Stacy C ^h   Cho, Insook ^d   Rumptz, Maureen H ^a   Vandermeer, Meredith L ^a   Hornbrook, Mark C ^a  

^a CENTER FOR HEALTH RESEARCH   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c PARTNERS HEALTHCARE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e DUKE UNIVERSITY   (United States)

^f Division of Pulmonology Medicine Department of Pediatrics Cincinnati Children's Hospital and Medical Center   (United States)

^g UNIVERSITY OF OKLAHOMA COLLEGE OF PHARMACY   (United States)

^h University of North Carolina   (United States)

Author keywords

Adherence; Medications; Patient centered care

Indexed keywords

CASE MANAGEMENT; FEEDBACK SYSTEM; HEALTH BEHAVIOR; HEALTH CARE QUALITY; HUMAN; MEDICATION COMPLIANCE; MEDICATION THERAPY MANAGEMENT; PATIENT CARE; PATIENT COMPLIANCE; PATIENT DECISION MAKING; PATIENT EDUCATION; QUALITATIVE ANALYSIS; REVIEW; DECISION MAKING; DRUG SELF ADMINISTRATION; OUTCOME ASSESSMENT;

DECISION MAKING; HUMANS; MEDICATION ADHERENCE; OUTCOME ASSESSMENT (HEALTH CARE); PATIENT EDUCATION AS TOPIC; PATIENT-CENTERED CARE; SELF ADMINISTRATION;

EID: 84908505729     PISSN: 07383991     EISSN: 18735134     Source Type: Journal    
DOI: 10.1016/j.pec.2014.08.021     Document Type: Review

References (73)

1. Zhong W., Maradit-Kremers H., St Sauver J.L., Yawn B.P., Ebbert J.O., Roger V.L., et al. Age and sex patterns of drug prescribing in a defined american population. Mayo Clin Proc 2013, 88:697-707.
2. Peterson A.M., Takiya L., Finley R. Meta-analysis of trials of interventions to improve medication adherence. Am J Health Syst Pharm 2003, 60:657-665.
3. New England Healthcare Institute Thinking Outside the Pillbox: A System-wide Approach to Improving Patient Medication Adherence for Chronic Disease 2009, NEHI, Cambridge, MA, August.
4. Sokol M.C., McGuigan K.A., Verbrugge R.R., Epstein R.S. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005, 43:521-530.
5. Roebuck M.C., Liberman J.N., Gemmill-Toyama M., Brennan T.A. Medication adherence leads to lower health care use and costs despite increased drug spending. Health Aff (Millwood) 2011, 30:91-99.
6. DiMatteo M.R., Giordani P.J., Lepper H.S., Croghan T.W. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002, 40:794-811.
7. Briesacher B.A., Gurwitz J.H., Soumerai S.B. Patients at-risk for cost-related medication nonadherence: a review of the literature. J Gen Intern Med 2007, 22:864-871.
8. Golin M., Jones C., Ashlok C., Blalock M., Wines S., Coker-Schwimmer R., et al. Medication adherence interventions: comparative effectiveness. Closing the quality gap: revisiting the state of the science. Evidence report no. 208. (Prepared by RTI International-University of North Carolina Evidence-based Practice Center under contract no. 290-2007-10056-I) 2012, (AHRQ Publication No. 12-E010-EF).
9. Viswanathan M., Golin C.E., Jones C.D., Ashok M., Blalock S.J., Wines R.C., et al. Interventions to improve adherence to self-administered medications for chronic diseases in the United States: a systematic review. Ann Intern Med 2012, 157:785-795.
10. Haynes R.B., Ackloo E., Sahota N., McDonald H.P., Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008, 2:CD000011.
11. Committee on Quality of Health Care in America IoM Crossing the quality chasm: a new health system for the 21st century 2001, The National Academies Press, Washington, D.C.
12. Stacey D., Bennett C.L., Barry M.J., Col N.F., Eden K.B., Holmes-Rovner M., et al. Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Rev 2011, 5:CD001431.
13. Pearce K.A., Love M.M., Shelton B.J., Schoenberg N.E., Williamson M.A., Barron M.A., et al. Cardiovascular risk education and social support (CaRESS): report of a randomized controlled trial from the Kentucky Ambulatory Network (KAN). J Am Board Fam Med 2008, 21:269-281.
14. Homer D., Nightingale P., Jobanputra P. Providing patients with information about disease-modifying anti-rheumatic drugs: individually or in groups? A pilot randomized controlled trial comparing adherence and satisfaction. Musculoskeletal Care 2009, 7:78-92.
15. Park J., Jackson J., Skinner E., Ranghell K., Saiers J., Cherney B. Impact of an adherence intervention program on medication adherence barriers, asthma control, and productivity/daily activities in patients with asthma. J Asthma 2010, 47:1072-1077.
16. McCarthy M.L., Ding R., Roderer N.K., Steinwachs D.M., Ortmann M.J., Pham J.C., et al. Does providing prescription information or services improve medication adherence among patients discharged from the emergency department? A randomized controlled trial. Ann Emerg Med 2013, 62:212-223.
17. Hacihasanoglu R., Gozum S. The effect of patient education and home monitoring on medication compliance, hypertension management, healthy lifestyle behaviours and BMI in a primary health care setting. J Clin Nurs 2011, 20:692-695.
18. Grosset K.A., Grosset D.G. Effect of educational intervention on medication timing in Parkinson's disease: a randomized controlled trial. BMC Neurol 2007, 7:20.
19. Edworthy S.M., Baptie B., Galvin D., Brant R.F., Churchill-Smith T., Manyari D., et al. Effects of an enhanced secondary prevention program for patients with heart disease: a prospective randomized trial. Can J Cardiol 2007, 23:1066-1072.
20. Chen S.Y., Sheu S., Chang C.S., Wang T.H., Huang M.S. The effects of the self-efficacy method on adult asthmatic patient self-care behavior. J Nurs Res 2010, 18:266-274.
21. Bocchi E.A., Cruz F., Guimaraes G., Pinho Moreira L.F., Issa V.S., Ayub Ferreira S.M., et al. Long-term prospective, randomized, controlled study using repetitive education at six-month intervals and monitoring for adherence in heart failure outpatients: the REMADHE trial. Circ Heart Fail 2008, 1:115-124.
22. Altiner A., Brockmann S., Sielk M., Wilm S., Wegscheider K., Abholz H.H. Reducing antibiotic prescriptions for acute cough by motivating GPs to change their attitudes to communication and empowering patients: a cluster-randomized intervention study. J Antimicrob Chemother 2007, 60:638-644.
23. Janson S.L., McGrath K.W., Covington J.K., Cheng S.C., Boushey H.A. Individualized asthma self-management improves medication adherence and markers of asthma control. J Allergy Clin Immunol 2009, 123:840-846.
24. Nielsen D., Ryg J., Nielsen W., Knold B., Nissen N., Brixen K. Patient education in groups increases knowledge of osteoporosis and adherence to treatment: a two-year randomized controlled trial. Patient Educ Couns 2010, 81:155-160.
25. Pladevall M., Brotons C., Gabriel R., Arnau A., Suarez C., de la Figuera M., et al. Multicenter cluster-randomized trial of a multifactorial intervention to improve antihypertensive medication adherence and blood pressure control among patients at high cardiovascular risk (the COM99 study). Circulation 2010, 122:1183-1191.
26. Rudd R.E., Blanch D.C., Gall V., Chibnik L.B., Wright E.A., Reichmann W., et al. A randomized controlled trial of an intervention to reduce low literacy barriers in inflammatory arthritis management. Patient Educ Couns 2009, 75:334-339.
27. Moshkovska T., Stone M.A., Smith R.M., Bankart J., Baker R., Mayberry J.F. Impact of a tailored patient preference intervention in adherence to 5-aminosalicylic acid medication in ulcerative colitis: results from an exploratory randomized controlled trial. Inflamm Bowel Dis 2011, 17:1874-1881.
28. Wu J.R., Corley D.J., Lennie T.A., Moser D.K. Effect of a medication-taking behavior feedback theory-based intervention on outcomes in patients with heart failure. J Card Fail 2012, 18:1-9.
29. Adie K., James M.A. Does telephone follow-up improve blood pressure after minor stroke or TIA?. Age Ageing 2010, 39:598-603.
30. Perahia D.G., Quail D., Gandhi P., Walker D.J., Peveler R.C. A randomized, controlled trial of duloxetine alone vs. duloxetine plus a telephone intervention in the treatment of depression. J Affect Disord 2008, 108:33-41.
31. Taitel M., Jiang J., Rudkin K., Ewing S., Duncan I. The impact of pharmacist face-to-face counseling to improve medication adherence among patients initiating statin therapy. Patient Prefer Adherence 2012, 6:323-329.
32. Ho E.Y., D'Agostino T.A., Yadegar V., Burke A., Bylund C.L. Teaching patients how to talk with biomedical providers about their complementary and alternative medicine use. Patient Educ Couns 2012, 89:405-410.
33. Wolever R.Q., Dreusicke M., Fikkan J., Hawkins T.V., Yeung S., Wakefield J., et al. Integrative health coaching for patients with type 2 diabetes: a randomized clinical trial. Diabetes Educ 2010, 36:629-639.
34. Finocchario-Kessler S., Catley D., Thomson D., Bradley-Ewing A., Berkley-Patton J., Goggin K. Patient communication tools to enhance ART adherence counseling in low and high resource settings. Patient Educ Couns 2012, 89:163-170.
35. Rubak S., Sandbaek A., Lauritzen T., Borch-Johnsen K., Christensen B. Effect of "motivational interviewing" on quality of care measures in screen detected type 2 diabetes patients: a one-year follow-up of an RCT. ADDITION Denmark. Scand J Prim Health Care 2011, 29:92-98.
36. Neafsey P.J., M'lan C.E., Ge M., Walsh S.J., Lin C.A., Anderson E. Reducing adverse self-medication behaviors in lder adults with hypertension: results of an e-health Clinical Efficacy Trial. Ageing Int 2011, 36:159-191.
37. Delmas P.D., Vrijens B., Eastell R., Roux C., Pols H.A., Ringe J.D., et al. Effect of monitoring bone turnover markers on persistence with risedronate treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab 2007, 92:1296-1304.
38. Nassaralla C.L., Naessens J.M., Hunt V.L., Bhagra A., Chaudhry R., Hansen M.A., et al. Medication reconciliation in ambulatory care: attempts at improvement. Qual Saf Health Care 2009, 18:402-407.
39. Shimp L.A., Kucukarslan S.N., Elder J., Remington T., Wells T., Choe H.M., et al. Employer-based patient-centered medication therapy management program: evidence and recommendations for future programs. J Am Pharm Assoc: JAPhA 2012, 52:768-776.
40. Calvert S.B., Kramer J.M., Anstrom K.J., Kaltenbach L.A., Stafford J.A., Allen LaPointe N.M. Patient-focused intervention to improve long-term adherence to evidence-based medications: a randomized trial. Am Heart J 2012, 163:657-665.
41. Eussen S.R., van der Elst M.E., Klungel O.H., Rompelberg C.J., Garssen J., Oosterveld M.H., et al. A pharmaceutical care program to improve adherence to statin therapy: a randomized controlled trial. Ann Pharmacother 2010, 44:1905-1913.
42. Hunt J.S., Siemienczuk J., Pape G., Rozenfeld Y., MacKay J., LeBlanc B.H., Touchette D. A randomized controlled trial of team-based care: impact of physician-pharmacist collaboration on uncontrolled hypertension. J Gen Intern Med 2008, 23:1966-1972.
43. Lenaghan E., Holland R., Brooks A. Home-based medication review in a high risk elderly population in primary care-the POLYMED randomised controlled trial. Age Ageing 2007, 36:292-297.
44. Elliott R.A., Barber N., Clifford S., Horne R., Hartley E. The cost effectiveness of a telephone-based pharmacy advisory service to improve adherence to newly prescribed medicines. Pharm World Sci 2008, 30:17-23.
45. Phumipamorn S., Pongwecharak J., Soorapan S., Pattharachayakul S. Effects of the pharmacist's input on glycaemic control and cardiovascular risks in Muslim diabetes. Prim Care Diabetes 2008, 2:31-37.
46. Klein A., Otto G., Kramer I. Impact of a pharmaceutical care program on liver transplant patients' compliance with immunosuppressive medication: a prospective, randomized, controlled trial using electronic monitoring. Transplantation 2009, 87:839-847.
47. Monte S.V., Slazak E.M., Albanese N.P., Adelman M., Rao G., Paladino J.A. Clinical and economic impact of a diabetes clinical pharmacy service program in a university and primary care-based collaboration model. J Am Pharm Assoc: JAPhA 2009, 49:200-208.
48. Pindolia V.K., Stebelsky L., Romain T.M., Luoma L., Nowak S.N., Gillanders F. Mitigation of medication mishaps via medication therapy management. Ann Pharmacother 2009, 43:611-620.
49. Welch E.K., Delate T., Chester E.A., Stubbings T. Assessment of the impact of medication therapy management delivered to home-based Medicare beneficiaries. Ann Pharmacother 2009, 43:603-610.
50. Moore J.M., Shartle D., Faudskar L., Matlin O.S., Brennan T.A. Impact of a patient-centered pharmacy program and intervention in a high-risk group. J Manage Care Pharm 2013, 19:228-236.
51. Wilson S.R., Strub P., Buist A.S., Knowles S.B., Lavori P.W., Lapidus J. Shared treatment decision making improves adherence and outcomes in poorly controlled asthma. Am J Respir Crit Care Med 2010, 181:566-577.
52. Thomson R.G., Eccles M.P., Steen I.N., Greenaway J., Stobbart L., Murtagh M.J., et al. A patient decision aid to support shared decision-making on anti-thrombotic treatment of patients with atrial fibrillation: randomised controlled trial. Qual Saf Health Care 2007, 16:216-223.
53. Mullan R.J., Montori V.M., Shah N.D., Christianson T.J., Bryant S.C., Guyatt G.H., et al. The diabetes mellitus medication choice decision aid: a randomized trial. Arch Intern Med 2009, 169:1560-1568.
54. Montori V.M., Shah N.D., Pencille L.J., Branda M.E., Van Houten H.K., Swiglo B.A., et al. Use of a decision aid to improve treatment decisions in osteoporosis: the osteoporosis choice randomized trial. Am J Med 2011, 124:549-556.
55. Mann D.M., Ponieman D., Montori V.M., Arciniega J., McGinn T. The statin choice decision aid in primary care: a randomized trial. Pat Educ Couns 2010, 80:138-140.
56. Loh A., Simon D., Wills C.E., Kriston L., Niebling W., Harter M. The effects of a shared decision-making intervention in primary care of depression: a cluster-randomized controlled trial. Patient Educ Couns 2007, 67:324-332.
57. Kasper J., Kopke S., Muhlhauser I., Nubling M., Heesen C. Informed shared decision making about immunotherapy for patients with multiple sclerosis (ISDIMS): a randomized controlled trial. Eur J Neurol 2008, 15:1345-1352.
58. Fagerlin A., Zikmund-Fisher B.J., Nair V., Derry H.A., McClure J.B., Greene S., et al. Women's decisions regarding tamoxifen for breast cancer prevention: responses to a tailored decision aid. Breast Cancer Res Treat 2010, 119:613-620.
59. Deinzer A., Veelken R., Kohnen R., Schmieder R.E. Is a shared decision-making approach effective in improving hypertension management?. J Clin Hypertens (Greenwich) 2009, 11:266-270.
60. Gensichen J., von K.M., Peitz M., Muth C., Beyer M., Guthlin C., et al. Case management for depression by health care assistants in small primary care practices: a cluster randomized trial. Ann Intern Med 2009, 151:369-378.
61. Bogner H.R., Morales K.H., de Vries H.F., Cappola A.R. Integrated management of type 2 diabetes mellitus and depression treatment to improve medication adherence: a randomized controlled trial. Ann Fam Med 2012, 10:15-22.
62. Hudson T.J., Owen R.R., Thrush C.R., Armitage T.L., Thapa P. Guideline implementation and patient-tailoring strategies to improve medication adherence for schizophrenia. J Clin Psychiat 2008, 69:74-80.
63. Olsson I.N., Runnamo R., Engfeldt P. Drug treatment in the elderly: an intervention in primary care to enhance prescription quality and quality of life. Scand J Prim Health 2012, 30:3-9.
64. Wakefield B.J., Holman J.E., Ray A., Scherubel M., Adams M.R., Hillis S.L., et al. Effectiveness of home telehealth in comorbid diabetes and hypertension: a randomized, controlled trial. Telemed J E Health 2011, 17:254-261.
65. Stanhope V., Ingoglia C., Schmelter B., Marcus S.C. Impact of person-centered planning and collaborative documentation on treatment adherence. Psychiat Serv 2013, 64:76-79.
66. Chimbanrai B., Fungladda W., Kaewkungwal J., Silachamroon U. Treatment-seeking behaviors and improvement in adherence to treatment regimen of tuberculosis patients using intensive triad-model program, Thailand. Southeast Asian J Trop Med Public Health 2008, 39:526-541.
67. Gelmanova I.Y., Taran D.V., Mishustin S.P., Golubkov A.A., Solovyova A.V., Keshavjee S. 'Sputnik': a programmatic approach to improve tuberculosis treatment adherence and outcome among defaulters. Int J Tuberc Lung Dis 2011, 15:1373-1379.
68. Chang T.E., Jing Y., Yeung A.S., Brenneman S.K., Kalsekar I., Hebden T., et al. Effect of communicating depression severity on physician prescribing patterns: findings from the clinical outcomes in measurement-based treatment (COMET) trial. Gen Hosp Psychiat 2012, 34:105-112.
69. Wilder C.M., Elbogen E.B., Moser L.L., Swanson J.W., Swartz M.S. Medication preferences and adherence among individuals with severe mental illness and psychiatric advance directives. Psychiat Serv 2010, 61:380-385.
70. Christensen A., Christrup L.L., Fabricius P.E., Chrostowska M., Wronka M., Narkiewicz K., et al. The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial. J Hypertens 2010, 28:194-200.
71. Rinfret S., Lussier M.T., Peirce A., Duhamel F., Cossette S., Lalonde L., et al. The impact of a multidisciplinary information technology-supported program on blood pressure control in primary care. Circ Cardiovasc Qual Outcomes 2009, 2:170-177.
72. Simon G.E., Ralston J.D., Savarino J., Pabiniak C., Wentzel C., Operskalski B.H. Randomized trial of depression follow-up care by online messaging. J Gen Intern Med 2011, 26:698-704.
73. Simon S.R., Smith D.H., Feldstein A.C., Perrin N., Yang X., Zhou Y., et al. Computerized prescribing alerts and group academic detailing to reduce the use of potentially inappropriate medications in older people. J Am Geriatr Soc 2006, 54:963-968.