Impact of a pharmaceutical care program on liver transplant patientsĝ€™ compliance with immunosuppressive medication: A prospective, randomized, controlled trial using electronic monitoring

Transplantation

Volumn 87, Issue 6, 2009, Pages 839-847

  Klein, Anja ^a   Otto, Gerd ^a   Krämer, Irene ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Compliance; Compliance intervention; Compliance measurement; Electronic monitoring; Liver transplantation; Pharmaceutical care

Indexed keywords

CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; TACROLIMUS; DRUG DERIVATIVE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ELECTRONIC MONITORING; FEMALE; HAMILTON SCALE; HEALTH PROGRAM; HOSPITAL PHARMACY; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER DISEASE; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MALE; MEDICATION EVENT MONITORING; MICROELECTROMECHANICAL SYSTEM; MORISKY SCORE; PATIENT CARE; PATIENT COMPLIANCE; PATIENT EDUCATION; PATIENT MONITORING; PHARMACIST; PILL; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SELF REPORT; TABLET; AMBULATORY MONITORING; ANXIETY; DEPRESSION; DRUG COMBINATION; ELECTRONICS; EQUIPMENT DESIGN; FOLLOW UP; IMMUNOLOGY; METHODOLOGY; MICROCAPSULE; PSYCHOLOGICAL ASPECT; STATISTICS;

ANXIETY; CAPSULES; CYCLOSPORINE; DEPRESSION; DRUG THERAPY, COMBINATION; ELECTRONICS, MEDICAL; EQUIPMENT DESIGN; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; MALE; MONITORING, AMBULATORY; MYCOPHENOLIC ACID; PATIENT COMPLIANCE; PROSPECTIVE STUDIES; TACROLIMUS;

EID: 65549116457     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318199d122     Document Type: Article

References (31)

1. Haynes RB, Taylor DW, Sackett DL. Compliance in health care. Baltimore, MD, John Hopkins University Press 1979, p 49.
2. Laederach-Hofmann K, Bunzel B. Noncompliance in organ transplant recipients: A literature review. General Hosp Psychiatry 2000; 22: 412.
3. Rovelli M, Palmeri D, Vossler E, et al. Noncompliance in organ transplant recipients. Transplant Proc 1989; 21: 833.
4. Mor E, Gonwa TA, Husberg BS, et al. Late-onset acute rejection in orthotopic liver transplantation-Associated risk factors and outcome. Transplantation 1992; 54: 821.
5. De Geest S, Borgermans L, Evers G, et al. Incidence, determinants, and consequences of subclinical noncompliance with immunosuppressive therapy in renal transplant recipients. Transplantation 1995; 59: 340.
6. De Geest S, Abraham I, Moons P, et al. Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients. J Heart Lung Transpl 1998; 17: 854.
7. Berlakovich GA, Steininger R, Herbst F, et al. Efficacy of liver transplantation for alcoholic cirrhosis with respect to recidivism and compliance. Transplantation 1994; 58: 560.
8. Van Dulmen S, Sluijs E, van Dijk L, et al. Patient adherence to medical treatment: A review of reviews. BMC Health Services Res 2007; 7: 55.
9. Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharmacists 1990; 47: 533.
10. Schulz M, Verheyen F, Muehlig S, et al. Pharmaceutical care services for asthma patients: A controlled intervention study. J Clin Pharmacol 2001; 41: 668.
11. Blenkinsopp A, Phelan M, Bourne J, et al. Extended adherence support by community pharmacists for patients with hypertension: A randomised controlled trial. Int J Pharmacy Pract 2000; 8: 165.
12. Chisholm MA, Mulloy LL, Jagadeesan M, et al. Impact of clinical pharmacy services on renal transplant patients' compliance with immunosuppressive medications. Clin Transpl 2001; 15: 330.
13. Cramer JA, Mattson RH, Prevey ML, et al. How often is medication taken as prescribed? A novel assessment technique. JAMA 1989; 261: 3273.
14. Cramer JA. Overview of methods to measure and enhance patient compliance. In: Cramer JA, Spilker B, eds. Patient compliance in medical practice and clinical trials, [ed. 1]. New York, Raven Press 1991, p 3.
15. De Geest S, Abraham I, Dunbar-Jacob J. Measuring transplant patients' compliance with immunosuppressive therapy. West J Nursing Res 1996; 18: 595.
16. Zigmond AS, Buss, U, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica 1983; 67: 361.
17. Herrmann C, Buss U, Snaith RP. Hospital and Anxiety Depression Scale- Deutsche Version: Ein Fragebogen zur Erfassung von Angst und Depressivita ̈t in der somatischen Medizin. Bern: Hans Huber, 1995.
18. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005; 353: 487.
19. Gordis L. Conceptual and methodological problems in measuring patient compliance. In: Meichenbaum D, Turk DC, eds. Faciliating treatment adherence [ed. 1]. New York, Plenum Press 1987, p 2.
20. Spilker B. Methods of assessing and improving patient compliance in clinical trials. In: Cramer JA, Spilker B, eds. Patient compliance in medical practice and clinical trials [ed. 1]. New York, Raven Press 1991, p 37.
21. Vrijens B, Goetghebeur E. Comparing compliance patterns between randomized treatments. Controlled Clin Trials 1997; 18: 187.
22. Drent G, Haagsma B, De Geest S, et al. Prevalence of prednisolon (non) compliance in adult liver transplant recipients. Transplant Int 2005; 18: 960.
23. Shemesh E, Schneider B, Savitzky J, et al. Medication adherence in pediatric and adolescent liver transplant recipients. Pediatrics 2004; 113: 825.
24. Berquist RK, Berquist WE, Esquivel CO, et al. Non-adherence to posttransplant care: Prevalence, risk factors and outcomes in adolescent liver transplant recipients. Pediatr Transplant 2008; 12: 194.
25. Chisholm MA, Vollenweider LJ, Mulloy LL, et al. Renal transplant patient compliance with free immunosuppressive medication. Transplantation 2000; 70: 1240.
26. Greenstein G, Siegel B. Odds probabilities of compliance and noncompliance in patients with a functioning renal transplant: A multicenter study. Transplant Proc 1999; 31: 280.
27. Chisholm MA. Enhancing transplant patients' adherence to medication therapy. Clin Transplant 2002; 16: 30.
28. Annunziato RA, Emre S, Schneider B. Adherence and medical outcomes in pediatric liver transplant recipients who transition to adult services. Pediatric Transplant 2007; 11: 578.
29. Van Mil F. Is Hawthorne bothering pharmaceutical care research? Pharmacy World Sci 200;25: 37.
30. Burney KD, Krishnan K, Ruffin MT, et al. Adherence to single daily dose of aspirin in a chemoprevention trial. An evaluation of self-report and microelectronic monitoring. Archives Family Med 1996; 5: 297.
31. Choo PW, Rand CS, Inui TS, et al. Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. Med Care 1999; 37: 846.