Toll-like receptor activation: From renal inflammation to fibrosis

Kidney International Supplements

Volumn 4, Issue 1, 2014, Pages 20-25

  Yiu, Wai Han ^a   Lin, Miao ^a   Tang, Sydney C W ^a  

^a QUEEN MARY HOSPITAL   (Hong Kong)

Author keywords

diabetic nephropathy; pro fibrotic; proinflammatory; renal fibrosis; Toll like receptors; unilateral ureteral obstruction

Indexed keywords

HEAT SHOCK PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

CHRONIC KIDNEY DISEASE; DEGRADATION; DIABETIC NEPHROPATHY; EXTRACELLULAR MATRIX; HUMAN; KIDNEY FIBROSIS; KIDNEY INJURY; NEPHRITIS; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; UNILATERAL URETERAL OBSTRUCTION; URETER OBSTRUCTION;

EID: 84908500741     PISSN: 21571724     EISSN: 21571716     Source Type: Journal    
DOI: 10.1038/kisup.2014.5     Document Type: Short Survey

References (50)

1. Liu Y. Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol 2011; 7: 684-696.
2. Farris AB, Colvin RB. Renal interstitial fibrosis: mechanisms and evaluation. Curr Opin Nephrol Hypertens 2012; 21: 289-300.
3. Meran S, Steadman R. Fibroblasts and myofibroblasts in renal fibrosis. Int J Exp Pathol 2011; 92: 158-167.
4. Liu Y. New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol 2010; 21: 212-222.
5. Lebleu VS, Taduri G, O'Connell J et al. Origin and function of myofibroblasts in kidney fibrosis. Nat Med 2013; 19: 1047-1053.
6. Kriz W, Kaissling B, Le Hir M. Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest 2011; 121: 468-474.
7. Johnson DW, Saunders HJ, Baxter RC et al. Paracrine stimulation of human renal fibroblasts by proximal tubule cells. Kidney Int 1998; 54: 747-757.
8. Johnson DW, Saunders HJ, Brew BK et al. Human renal fibroblasts modulate proximal tubule cell growth and transport via the IGF-I axis. Kidney Int 1997; 52: 1486-1496.
9. Shankar A, Sun L, Klein BE et al. Markers of inflammation predict the long-term risk of developing chronic kidney disease: a population-based cohort study. Kidney Int 2011; 80: 1231-1238.
10. Silverstein DM. Inflammation in chronic kidney disease: role in the progression of renal and cardiovascular disease. Pediatr Nephrol 2009; 24: 1445-1452.
11. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511.
12. Gluba A, Banach M, Hannam S et al. The role of Toll-like receptors in renal diseases. Nat Rev Nephrol 2010; 6: 224-235.
13. Robson MG. Toll-like receptors and renal disease. Nephron Exp Nephrol 2009; 113: e1-e7.
14. Yamamoto M, Sato S, Mori K et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol 2002; 169: 6668-6672.
15. Moresco EM, LaVine D, Beutler B. Toll-like receptors. Curr Biol 2011; 21: R488-R493.
16. Gollapudi P, Yoon JW, Gollapudi S et al. Leukocyte toll-like receptor expression in end-stage kidney disease. Am J Nephrol 2010; 31: 247-254.
17. Koc M, Toprak A, Arikan H et al. Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation. Nephrol Dial Transplant 2011; 26: 955-963.
18. Li F, Yang N, Zhang L et al. Increased expression of toll-like receptor 2 in rat diabetic nephropathy. Am J Nephrol 2010; 32: 179-186.
19. Lin M, Yiu WH, Wu HJ et al. Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy. J Am Soc Nephrol 2012; 23: 86-102.
20. Leemans JC, Butter LM, Pulskens WP et al. The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. PLoS One 2009; 4: e5704.
21. Wu H, Chen G, Wyburn KR et al. TLR4 activation mediates kidney ischemia/reperfusion injury. J Clin Invest 2007; 117: 2847-2859.
22. Leelahavanichkul A, Huang Y, Hu X et al. Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1. Kidney Int 2011; 80: 1198-1211.
23. Dasu MR, Devaraj S, Park S et al. Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care 2010; 33: 861-868.
24. Park JS, Gamboni-Robertson F, He Q et al. High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol 2006; 290: C917-C924.
25. Lynch J, Nolan S, Slattery C et al. High-mobility group box protein 1: a novel mediator of inflammatory-induced renal epithelial-mesenchymal transition. Am J Nephrol 2010; 32: 590-602.
26. Valentinis B, Capobianco A, Esposito F et al. Human recombinant heat shock protein 70 affects the maturation pathways of dendritic cells in vitro and has an in vivo adjuvant activity. J Leukoc Biol 2008; 84: 199-206.
27. Calabrese V, Mancuso C, Sapienza M et al. Oxidative stress and cellular stress response in diabetic nephropathy. Cell Stress Chaperones 2007; 12: 299-306.
28. Johnson GB, Brunn GJ, Kodaira Y et al. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 2002; 168: 5233-5239.
29. Termeer C, Benedix F, Sleeman J et al. Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 2002; 195: 99-111.
30. Meng XM, Huang XR, Xiao J et al. Diverse roles of TGF-beta receptor II in renal fibrosis and inflammation in vivo and in vitro. J Pathol 2012; 227: 175-188.
31. Skuginna V, Lech M, Allam R et al. Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction. PLoS One 2011; 6: e19204.
32. Sorensen I, Susnik N, Inhester T et al. Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis. Kidney Int 2011; 80: 1035-1044.
33. Campbell MT, Hile KL, Zhang H et al. Toll-like receptor 4: a novel signaling pathway during renal fibrogenesis. J Surg Res 2009; 168: e61-e69.
34. Meldrum KK, Zhang H, Hile KL et al. Profibrotic effect of interleukin-18 in HK-2 cells is dependent on stimulation of the Toll-like receptor 4 (TLR4) promoter and increased TLR4 expression. J Biol Chem 2012; 287: 40391-40399.
35. Pulskens WP, Rampanelli E, Teske GJ et al. TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury. J Am Soc Nephrol 2010; 21: 1299-1308.
36. Chowdhury P, Sacks SH, Sheerin NS. Endogenous ligands for TLR2 and TLR4 are not involved in renal injury following ureteric obstruction. Nephron Exp Nephrol 2010; 115: e122-e130.
37. Suzuki H, Suzuki Y, Narita I et al. Toll-like receptor 9 affects severity of IgA nephropathy. J Am Soc Nephrol 2008; 19: 2384-2395.
38. Xin BM, Wang XX, Jin W et al. Activation of Toll-like receptor 9 attenuates unilateral ureteral obstruction-induced renal fibrosis. Acta Pharmacol Sin 2010; 31: 1583-1592.
39. Rivero A, Mora C, Muros M et al. Pathogenic perspectives for the role of inflammation in diabetic nephropathy. Clin Sci (Lond) 2009; 116: 479-492.
40. Nogueira-Machado JA, Volpe CM, Veloso CA et al. HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation. Exp Opin Ther Targets 2011; 15: 1023-1035.
41. Devaraj S, Dasu MR, Rockwood J et al. Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. J Clin Endocrinol Metab 2008; 93: 578-583.
42. Devaraj S, Dasu MR, Park SH et al. Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes. Diabetologia 2009; 52: 1665-1668.
43. Dasu MR, Devaraj S, Zhao L et al. High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes 2008; 57: 3090-3098.
44. Mudaliar H, Pollock C, Komala MG et al. The role of Toll-like receptor proteins (TLR) 2 and 4 in mediating inflammation in proximal tubules. Am J Physiol Renal Physiol 2013; 305: F143-F154.
45. Devaraj S, Tobias P, Kasinath BS et al. Knockout of toll-like receptor-2 attenuates both the proinflammatory state of diabetes and incipient diabetic nephropathy. Arterioscler Thromb Vasc Biol 2011; 31: 1796-1804.
46. Kim JJ, Sears DD. TLR4 and insulin resistance. Gastroenterol Res Pract 2010; 2010: pii 212563.
47. Hale LJ, Coward RJ. The insulin receptor and the kidney. Curr Opin Nephrol Hypertens 2013; 22: 100-106.
48. Welsh GI, Hale LJ, Eremina V et al. Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab 2010; 12: 329-340.
49. Cha JJ, Hyun YY, Lee MH et al. Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice. Endocrinology 2013; 154: 2144-2155.
50. Mansouri L, Paulsson JM, Moshfegh A et al. Leukocyte proliferation and immune modulator production in patients with chronic kidney disease. PLoS One 2013; 8: e73141.