Contribution of renin-angiotensin system to exercise-induced attenuation of aortic remodeling and improvement of endothelial function in spontaneously hypertensive rats

Cardiovascular Pathology

Volumn 23, Issue 5, 2014, Pages 298-305

  Gu, Qi ^a   Wang, Bing ^a   Zhang, Xiao Feng ^b   Ma, Yan Ping ^b   Liu, Jian Dong ^c   Wang, Xiao Ze ^d  

^a XI'AN TECHNOLOGICAL UNIVERSITY   (China)

^b Chengyang People's Hospital   (China)

^c The Third People's Hospital Of Datong   (China)

^d TSINGHUA UNIVERSITY YUQUAN HOSPITAL   (China)

Author keywords

Aortic remodeling; Endothelial function; Exercise training; MicroRNA; Renin angiotensin system; Spontaneously hypertensive rats

Indexed keywords

APELIN RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; ELASTIN; HYDROXYPROLINE; MESSENGER RNA; MICRORNA; MICRORNA 143; MICRORNA 155; MICRORNA 27A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTIC LENGTH; AORTIC WEIGHT; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD VESSEL PARAMETERS; BODY WEIGHT; CELL FUNCTION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENDOTHELIUM CELL; ESSENTIAL HYPERTENSION; EXERCISE; GENE CONTROL; HEART RATE; HEMODYNAMIC PARAMETERS; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; AORTA; HYPERTENSION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM; VASCULAR REMODELING; WESTERN BLOTTING; WISTAR KYOTO RAT;

ANIMALS; AORTA; BLOTTING, WESTERN; ENDOTHELIUM, VASCULAR; HYPERTENSION; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REAL-TIME POLYMERASE CHAIN REACTION; RENIN-ANGIOTENSIN SYSTEM; VASCULAR REMODELING;

EID: 84908492485     PISSN: 10548807     EISSN: 18791336     Source Type: Journal    
DOI: 10.1016/j.carpath.2014.05.006     Document Type: Article

References (43)

1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217-23.
2. Panza JA, García CE, Kilcoyne CM, Quyyumi AA, Cannon RO. Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation 1995;91:1732-8.
3. Konishi M, Su C. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension 1983;5:881-6.
4. Yu TT, Guo K, Chen HC, Lan CZ, Wang J, Huang LL, Wang XH, Zhang Z, Gao S. Effects of traditional Chinese medicine Xin-Ji-Er-Kang formula on 2K1C hypertensive rats: role of oxidative stress and endothelial dysfunction. BMC Complement Altern Med 2013;13:173.
5. Ghiadoni L, Taddei S, Virdis A. Hypertension and endothelial dysfunction: therapeutic approach. Curr Vasc Pharmacol 2012;10:42-60.
6. Shantsila A, Shantsila E. Arterial stiffening in hypertension: beyond blood pressure levels. J Hum Hypertens 2010;24:303-5.
7. Lavoie JL, Sigmund CD. Minireview: overview of the renin-angiotensin system - an endocrine and paracrine system. Endocrinology 2003;144:2179-83.
8. Li L, Yi-Ming W, Li ZZ, Zhao L, Yu YS, Li DJ, Xia CY, Liu JG, Su DF. Local RAS and inflammatory factors are involved in cardiovascular hypertrophy in spontaneously hypertensive rats. Pharmacol Res 2008;58:196-201.
9. Touyz RM, Schiffrin EL. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000;52:639-72.
10. Warner FJ, Smith AI, Hooper NM, Turner AJ. Angiotensin-converting enzyme-2: a molecular and cellular perspective. Cell Mol Life Sci 2004;61:2704-13.
11. Yen MH, Yang JH, Sheu JR, Lee YM, Ding YA. Chronic exercise enhances endothelium-mediated dilation in spontaneously hypertensive rats. Life Sci 1995;57:2205-13.
12. Gu Q, Wang B, Zhang XF, Ma YP, Liu JD, Wang XZ. Contribution of hydrogen sulfide and nitric oxide to exercise-induced attenuation of aortic remodeling and improvement of endothelial function in spontaneously hypertensive rats. Mol Cell Biochem 2013;375:199-206.
13. Yung LM, Laher I, Yao X, Chen ZY, Huang Y, Leung FP. Exercise, vascular wall and cardiovascular diseases: an update (part 2). Sports Med 2009;39:45-63.
14. Izawa T, Morikawa M, Inoue M, Mizuta T, Yamashita H, Ohno H, Komabayashi T. Acute or chronic exercise alters angiotensin II-induced contraction of rat aorta. Jpn J Physiol 1995;45:1093-100.
15. Barretti DL, Magalhães Fde C, Fernandes T, do Carmo EC, Rosa KT, Irigoyen MC, Negrão CE, Oliveira EM. Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain. PLoS One 2012;7:e46114.
16. Wan W, Powers AS, Li J, Ji L, Erikson JM, Zhang JQ. Effect of post-myocardial infarction exercise training on the renin-angiotensin-aldosterone system and cardiac function. Am J Med Sci 2007;334:265-73.
17. Fernandes T, Hashimoto NY, Magalhães FC, Fernandes FB, Casarini DE, Carmona AK, Krieger JE, Phillips MI, Oliveira EM. Aerobic exercise training-induced left ventricular hypertrophy involves regulatory microRNAs, decreased angiotensin-converting enzyme-angiotensin II, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7). Hypertension 2011;58:182-9.
18. Silva DM, Gomes-Filho A, Olivon VC, Santos TM, Becker LK, Santos RA, Lemos VS. Swimming training improves the vasodilator effect of angiotensin-(1-7) in the aorta of spontaneously hypertensive rat. J Appl Physiol 2011;111:1272-7.
19. McDonald RA, Hata A, MacLean MR, Morrell NW, Baker AH. MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovasc Res 2012;93:594-604.
20. Wei Y, Schober A, Weber C. Pathogenic arterial remodeling: the good and bad of microRNAs. Am J Physiol Heart Circ Physiol 2013;304:H1050-9.
21. Goyal R, Goyal D, Leitzke A, Gheorghe CP, Longo LD. Brain renin-angiotensin system: fetal epigenetic programming by maternal protein restriction during pregnancy. Reprod Sci 2010;17:227-38.
22. Boettger T, Beetz N, Kostin S, Schneider J, Krüger M, Hein L, Braun T. Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest 2009;119:2634-47.
23. Cheng W, Liu T, Jiang F, Liu C, Zhao X, Gao Y, Wang H, Liu Z. microRNA-155 regulates angiotensin II type 1 receptor expression in umbilical vein endothelial cells from severely pre-eclamptic pregnant women. Int J Mol Med 2011;27:393-9.
24. Chen NX, Kiattisunthorn K, O'Neill KD, Chen X, Moorthi RN, Gattone VH, Allen MR, Moe SM. Decreased microRNA is involved in the vascular remodeling abnormalities in chronic kidney disease (CKD). PLoS One 2013;8:e64558.
25. Husain K. Physical conditioningmodulates rat cardiac VEGF gene expression in nitric oxide-deficient hypertension. Biochem Biophys Res Commun 2004;320:1169-74.
26. Zheng H, Yu YS. Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochem Pharmacol 2012;83:1269-77.
27. Ogihara CA, Schoorlemmer GH, Levada AC, Pithon-Curi TC, Curi R, Lopes OU, Colombari E, Sato MA. Exercise changes regional vascular control by commissural NTS in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 2010;299:R291-7.
28. Moraes-Teixeira JA, Felix A, Fernandes-Santos C, Moura AS, Mandarim-de-Lacerda CA, Carvalho JJ. Exercise training enhances elastin, fibrillin and nitric oxide in the aorta wall of spontaneously hypertensive rats. Exp Mol Pathol 2010;89:351-7.
29. Tomita N, Yamasaki K, Izawa K, Kunugiza Y, Osako MK, Ogihara T, Morishita R. Improvement of organ damage by a non-depressor dose of imidapril in diabetic spontaneously hypertensive rats. Int J Mol Med 2007;19:571-9.
30. Touyz RM. Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II. Exp Physiol 2005;90:449-55.
31. Sharifi AM, Akbarloo N, Heshmatian B, Ziai A. Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertension. Pharmacol Res 2003;47:201-9.
32. Lee J. Reciprocal regulation of angiotensin converting enzyme and neutral endopeptidase in rats with experimental hypertension. Physiol Res 2004;53:365-8.
33. Xie HH, Chen YY, Miao CY, Shen FM, Su DF. Effects of long-term treatment with candesartan on hemodynamics and organ damage in spontaneously hypertensive rats. Cardiovasc Drugs Ther 2005;19:391-7.
34. Carey RM, Wang ZQ, Siragy HM. Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function. Hypertension 2000;35:155-63.
35. Bosnyak S, Welungoda IK, Hallberg A, Alterman M, Widdop RE, Jones ES. Stimulation of angiotensin AT2 receptors by the non-peptide agonist, compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats. Br J Pharmacol 2010;159:709-16.
36. Jones ES, Black MJ, Widdop RE. Influence of angiotensin II subtype 2 receptor (AT(2)R) antagonist, PD123319, on cardiovascular remodelling of aged spontaneously hypertensive rats duringchronic angiotensin II subtype 1 receptor (AT(1)R) blockade. Int J Hypertens 2012;2012:543062.
37. Freeman EJ, Chisolm GM, Ferrario CM, Tallant EA. Angiotensin-(1-7) inhibits vascular smooth muscle cell growth. Hypertension 1996;28:104-8.
38. Rentzsch B, Todiras M, Iliescu R, Popova E, Campos LA, Oliveira ML, Baltatu OC, Santos RA, Bader M. Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function. Hypertension 2008;52:967-73.
39. Yamada K, Iyer SN, Chappell MC, Ganten D, Ferrario CM. Converting enzyme determines plasma clearance of angiotensin-(1-7). Hypertension 1998;32:496-502.
40. Kohara K, Brosnihan KB, Ferrario CM. Angiotensin(1-7) in the spontaneously hypertensive rat. Peptides 1993;14:883-91.
41. Rangrez AY, Massy ZA, Metzinger-Le Meuth V, Metzinger L. miR-143 and miR-145: molecular keys to switch the phenotype of vascular smooth muscle cells. Circ Cardiovasc Genet 2011;4:197-205.
42. Elia L, Quintavalle M, Zhang J, Contu R, Cossu L, Latronico MV, Peterson KL, Indolfi C, Catalucci D, Chen J, Courtneidge SA, Condorelli G. The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ 2009;16:1590-8.
43. Yang LX, Liu G, Zhu GF, Liu H, Guo RW, Qi F, Zou JH. MicroRNA-155 inhibits angiotensin II-induced vascular smooth muscle cell proliferation. J Renin Angiotensin Aldosterone Syst 2014 [in press].