Exercise changes regional vascular control by commissural NTS in spontaneously hypertensive rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 299, Issue 1, 2010, Pages

  Ogihara, Cristiana A ^a   Schoorlemmer, Gerhardus H M ^a   Levada, Adriana C ^b   Pithon Curi, Tania C ^b   Curi, Rui ^b   Lopes, Oswaldo Ubriaco ^a   Colombari, Eduardo ^a,c   Sato, Monica A ^c  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c FACULDADE DE MEDICINA DO ABC   (Brazil)

Author keywords

Cardiovascular; Citrate synthase; GABA

Indexed keywords

4 AMINOBUTYRIC ACID; CITRATE SYNTHASE;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ARTERY CATHETERIZATION; ARTICLE; BODY WEIGHT; CARDIOVASCULAR EFFECT; CONDUCTANCE; CONTROLLED STUDY; DOPPLER FLOWMETRY; ENZYME ACTIVITY; EVOKED RESPONSE; EXERCISE; FEMORAL ARTERY; HEART RATE; HEMODYNAMICS; LEG BLOOD FLOW; LEG BLOOD VESSEL; MALE; MEAN ARTERIAL PRESSURE; NERVE CELL INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; SITTING; SOLITARY TRACT NUCLEUS; SPONTANEOUSLY HYPERTENSIVE RAT; SUPERIOR MESENTERIC ARTERY; SWIMMING; VASODILATATION; WISTAR KYOTO RAT;

ANIMALS; BLOOD PRESSURE; BLOOD VESSELS; BODY WEIGHT; CHLORALOSE; ENERGY METABOLISM; GAMMA-AMINOBUTYRIC ACID; HEART RATE; HINDLIMB; MALE; MICROINJECTIONS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SOLITARY NUCLEUS; SPINAL CORD; SYMPATHETIC NERVOUS SYSTEM;

EID: 77954417006     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00055.2009     Document Type: Article

References (48)

1. +-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates. Biochem J 154: 689-700, 1976.
2. Alvarez de Sotomayor M, Pérez-Guerrero C, Herrera MD, Marhuenda E. Effects of chronic treatment with simvastatin on endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 17: 769-776, 1999.
3. Arakawa K. Hypertension and exercise. Clin Exp Hypertens 15: 1171-1179, 1993.
4. Bauersachs J, Bouloumie' A, Mülsch A, Wiemer G, Fleming I, Busse R. Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production. Cardiovasc Res 37: 772-779, 1998.
5. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976.
6. Catelli JM, Sved AF. Enhanced pressor response to GABA in the nucleus tractus solitarii of the spontaneously hypertensive rat. Eur J Pharmacol 151: 243-248, 1988.
7. Chandler MP, DiCarlo SE. Sinoaortic denervation prevents postexercise reductions in arterial pressure and cardiac sympathetic tonus. Am J Physiol Heart Circ Physiol 273: H1627-H1634, 1997.
8. Chitravanshi VC, Kachroo A, Sapru HN. A midline area in the nucleus commissuralis of NTS mediates the phrenic nerve responses to carotid chemoreceptor simulation. Am J Physiol Regul Integr Comp Physiol 264: R41-R50, 1993.
9. Chitravanshi VC, Sapru HN. Chemoreceptor-sensitive neurons in the commissural subnucleus of nucleus tractus solitarius of the rat. Am J Physiol Regul Integr Comp Physiol 268: R851-R858, 1995.
10. Ciriello J, Hochstenbach SL, Roder S. Central projections of baroreceptor and chemoreceptor afferent fibers in the rat. In: Nucleus of the Solitary Tract, edited by Robin I and Barroco A. Boca Raton, FL: CRC, 1994, p. 35-50.
11. Colombari E, Menani JV, Talman WT. Commissural NTS contributes to pressor responses to glutamate injected into the medial NTS of awake rats. Am J Physiol Regul Integr Comp Physiol 270: R1220-R1225, 1996. (Pubitemid 26298616)
12. DiCarlo SE, Bishop VS. Exercise training attenuates baroreflex regulation of nerve activity in rabbits. Am J Physiol Heart Circ Physiol 255: H974-H979, 1988.
13. DiCarlo SE, Bishop VS. Exercise training enhances cardiac afferent inhibition of baroreflex function. Am J Physiol Heart Circ Physiol 258: H212-H220, 1990. (Pubitemid 20063131)
14. Fernstrom M, Tonkonogi M, Sahlin K. Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle. J Physiol 554: 755-763, 2004.
15. Finley JCW, Katz DM. The central organization of carotid afferent projections to the brainstem of the rat. Brain Res 572: 108-116, 1992.
16. Fitzgerald W. Labile hypertension and jogging: new diagnostic tool or spurious discovery. Br Med J 282: 542-544, 1981. (Pubitemid 11188772)
17. Gava NS, Veras-Silva AS, Negrao CE, Krieger EM. Low-intensity exercise training attenuates cardiac β-adrenergic tone during exercise in spontaneously hypertensive rats. Hypertension 26: 1129-1133, 1995.
18. Graham DA, Rush JWE. Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats. J Appl Physiol 96: 2088-2096, 2004.
19. Hannum SM, Kash FW. Acute postexercise blood pressure response of hypertensive and normotensive men. Scand J Sports Sci 3: 11-15, 1981. (Pubitemid 12185873)
20. Hayakawa H, Raij L. The link among nitric oxide synthase activity, endothelial function, and aortic and ventricular hypertrophy in hypertension. Hypertension 29: 235-241, 1997.
21. Haywood JR, Shaffer RA, Fastenow C, Fink GD, Brody MJ. Regional blood flow measurement with pulsed Doppler flowmeter in conscious rats. Am J Physiol Heart Circ Physiol 241: H273-H278, 1981.
22. Holloszy JO, Oscai LB, Don IJ, Mole PA. Mitochondrial citric acid cycle and related enzymes: adaptive response to exercise. Biochem Biophys Res Commun 40: 1368-1373, 1970.
23. Ji LL, Stratman FW, Lardy HA. Enzymatic down regulation with exercise in rat skeletal muscle. Arch Biochem Biophys 263: 137-149, 1988.
24. Kauser K, Rubanyi GM. Gender difference in endothelial dysfunction in the aorta of spontaneously hypertensive rats. Hypertension 25: 517-523, 1995.
25. Konishi M, Su C. Role of endothelium in dilator responses of spontaneously hypertensive rat arteries. Hypertension 5: 881-886, 1983. (Pubitemid 14214822)
26. Koshiya N, Guyenet PG. NTS neurons with carotid chemoreceptor inputs arborize in the rostral ventrolateral medulla. Am J Physiol Regul Integr Comp Physiol 270: R1273-R1278, 1996.
27. Krieger M, Brum PC, Negrao CE. Role of arterial baroreceptor function on cardiovascular adjustments to acute and chronic dynamic exercise. Biol Res 31: 273-279, 1998.
28. Krieger EM, Da Silva GJ, Negrao CE. Effect of exercise training on baroreflex control of the cardiovascular system. Ann NY Acad Sci 940: 338-347, 2001. (Pubitemid 32623406)
29. Lambertucci RH, Levada-Pires AC, Rossoni LV, Curi R, Pithon-Curi TC. Effects of aerobic exercise training on antioxidant enzyme activities and mRNA levels in soleus muscle from young and aged rats. Mech Ageing Dev 128: 267-275, 2007.
30. Medeiros A, Oliveira EM, Gianolla R, Casarini DE, Negrao CE, Brum PC. Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats. Braz J Med Biol Res 37: 1909-1917, 2004.
31. Mifflin SW. What does the brain know about blood pressure? News Physiol Sci 16: 266-271, 2001.
32. Mueller PJ, Hasser EM. Putative role of the NTS in alterations in neural control of the circulation following exercise training rats. Am J Physiol Regul Integr Comp Physiol 290: R383-R392, 2006.
33. Nelson DO, Cohen HL, Feldman JL, McCrimmon DR. Cardiovascular function is altered by picomole injections of glutamate into rat medulla. J Neurosci 8: 1684-1693, 1988.
34. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Sydney, Australia: Academic, 1986.
35. Pereira B, Curi R, Kokubun E, Bechara EJ. 5-Aminolevulinic acid-induced alterations of oxidative metabolism in sedentary and exercisetrained rats. J Appl Physiol 72: 226-230, 1992.
36. Pimenta AS, Lambertucci RH, Gorjao R, Silveira RS, Curi R. Effect of a single session of electrical stimulation on activity and expression of citrate synthase and antioxidant enzymes in rat soleus muscle. Eur J Appl Physiol 102: 119-126, 2007.
37. Potts JT, Fuchs IE, Li J, Leshnower B, Mitchell JE. Skeletal muscle afferent fibres release substance P in the nucleus tractus solitarii of anesthetized cats. J Physiol 514: 829-841, 1999.
38. Potts JT, Paton JF, Mitchell JH, Garry MG, Kline G, Anguelo PT, Lee SM. Contraction-sensitive skeletal muscle afferents inhibit arterial baroreceptor signalling in the nucleus of the solitary tract: role of intrinsic GABA interneurons. Neuroscience 119: 201-214, 2003.
39. Rupp H. Differential effects of physical exercise routines on ventricular myosin and peripheral catecholamine stores in normotensive and spontaneously hypertensive rats. Circ Res 65: 370-377, 1989. (Pubitemid 19194623)
40. Sato MA, Menani JV, Lopes OU, Colombari E. Lesions of the commissural nucleus of the solitary tract reduce arterial pressure in spontaneously hypertensive rats. Hypertension 38: 560-564, 2001.
41. Sato MA, Colombari E, Morrison SF. Inhibition of neurons in commissural nucleus of the solitary tract reduces sympathetic nerve activity in SHR. Am J Physiol Heart Circ Physiol 282: H1679-H1684, 2002.
42. Sturek ML, Bedford TG, Tipton CM, Newcomer L. Acute cardiorespiratory responses of hypertensive rats to swimming and treadmill exercise. J Appl Physiol 57: 1328-1332, 1984. (Pubitemid 15216420)
43. Suzuki K, Machida K. Effectiveness of lower-level voluntary exercise in disease prevention of mature rats. Cardiovascular risk factor modification. Eur J Appl Physiol Occup Physiol 71: 240-244, 1995.
44. Tipton CM. Exercise training, hypertension: an update. Exerc Sport Sci Rev 32: 107-111, 2004.
45. Tsukamoto K, Sved AF. Enhanced γ-aminobutyric acid-mediated responses in nucleus tractus solitarius of hypertensive rats. Hypertension 22: 819-825, 1993. (Pubitemid 2012132)
46. Veras-Silva AC, Mattos KC, Gava NL, Brum PC, Negrao CE, Krieger EM. Low intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 273: H2627-H2631, 1997.
47. Zhang W, Herrera-Rosales M, Mifflin S. Chronic hypertension enhances the postsynaptic effect of baclofen in the nucleus tractus solitarius. Hypertension 49: 659-663, 2007.
48. Wiegand G, Remington SJ. Citrate synthase: structure control, mechanism. Annu Rev Biophys Biophys Chem 15: 97-117, 1986.