Enzymatic resolution of racemates with a 'remote' stereogenic center as an efficient tool in drug, flavor and vitamin synthesis

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 20, 2014, Pages 5539-5546

  Alfaro Blasco, Maria ^a   Gröger, Harald ^a,b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

Author keywords

Biocatalysis; Enzymatic resolution; Enzyme catalysis; Racemic resolution; Remote chiral center; Remote stereogenic center

Indexed keywords

ALPHA TOCOPHEROL; ENZYME; FLAVORING AGENT; FUNCTIONAL GROUP; HEXOBARBITAL; LASOFOXIFENE; METHYLPHENOBARBITAL; MONASTROL; PELITREXOL; VITAMIN;

ALPHA CHAIN; ARTICLE; BETA CHAIN; BIOCATALYSIS; BIOTRANSFORMATION; CANDIDA ANTARCTICA; CANDIDA RUGOSA; CHEMICAL BOND; CHEMICAL STRUCTURE; CHIRALITY; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; ENZYMATIC RESOLUTION; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME SUBSTRATE; ESTERIFICATION; HYDROLYSIS; MOLECULAR RECOGNITION; NONHUMAN; PHASE SEPARATION; PLANAR AROMATIC MOIETY; PSEUDOMONAS FLUORESCENS; RACEMIC MIXTURE; REMOTE STEREOGENIC CENTER; RHIZOMUCOR MIEHEI; STEREOISOMERISM; SYNTHESIS; THERMOMYCES LANUGINOSUS; VITAMIN SYNTHESIS; BIOSYNTHESIS; CHEMISTRY; CONFORMATION; METABOLISM;

BIOCATALYSIS; ENZYMES; MOLECULAR CONFORMATION; STEREOISOMERISM; VITAMINS;

EID: 84908463161     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.06.024     Document Type: Article

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