Mechanistic studies of an autonomously pulsing hydrogel/enzyme system for rhythmic hormone delivery

Journal of Controlled Release

Volumn 196, Issue , 2014, Pages 261-271

  Bhalla, Amardeep S ^a   Siegel, Ronald A ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b University of Minnesota   (United States)

Author keywords

Enzyme mediated drug delivery; GnRH; Membrane; Membrane permeability; pH oscillator; pH sensitive hydrogels; Rhythmic hormone delivery

Indexed keywords

ENZYME-MEDIATED; GNRH; MEMBRANE PERMEABILITY; PH-SENSITIVE HYDROGEL; RHYTHMIC HORMONE DELIVERY;

MEMBRANES;

ENZYME; GONADORELIN; ARTIFICIAL MEMBRANE; BUFFER; CALCIUM; CALCIUM CARBONATE; GLUCOSE; HORMONE; HYDROGEL;

ARTICLE; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HYDROGEL; MEMBRANE PERMEABILITY; NEGATIVE FEEDBACK; OSCILLATION; PH; ARTIFICIAL MEMBRANE; CHEMISTRY; METABOLISM;

BUFFERS; CALCIUM; CALCIUM CARBONATE; DRUG DELIVERY SYSTEMS; ENZYMES; GLUCOSE; GONADOTROPIN-RELEASING HORMONE; HORMONES; HYDROGELS; HYDROGEN-ION CONCENTRATION; MEMBRANES, ARTIFICIAL;

EID: 84908452960     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.10.019     Document Type: Article

References (63)

1. G. Brabant, K. Prank, and C. Schöfl Pulsatile patterns in hormone secretion Trends Endocrinol. Metab. 3 1992 183 190
2. L.M. Winer, M.A. Shaw, and G. Baumann Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion J. Clin. Endocrinol. Metab. 70 1990 1678 1686
3. E. Terasawa Cellular mechanisms of pulsatile LHRH release Gen. Comp. Endocrinol. 112 1998 283 295
4. F. Hayes, and W.F. Crowley Jr. Gonadotropin pulsations across development Horm. Res. 49 1998 163 168
5. Y.-X. Li, and A. Goldbeter Frequency specificity in intercellular communication Biophys. J. 1989 125 145
6. E. Terasawa Luteinizing hormone-releasing hormone (LHRH) neurons: mechanisms of pulsatile LHRH release Vitam. Horm. 63 2001 91 129
7. S. Igarashi, and H. Mizunuma Gonadotropins and GnRH Ann. Rev. Naimunpi 2001 179 184
8. N. Porksen The in vivo regulation of pulsatile insulin secretion Diabetologia 45 2002 3 20
9. F.J. Hayes, S.B. Seminara, and W.F. Crowley Jr. Hypogonadotropic hypogonadism Endocr. Metab. Clin. N. Am. 27 1998 739 763
10. P.E. Belchetz, T.M. Plant, Y. Nakai, E.J. Keogh, and E. Knobil Hypophysial responses to continuous and intermittent delivery of hypothalamic gonadotropin-releasing hormone Science 202 1978 631 633
11. E.R. Edelman, J. Kost, H. Bobeck, and R. Langer Regulation of drug release from polymer matrices by oscillating magnetic fields J. Biomed. Mater. Res. 19 1985 67 83
12. N.J. Medlicott, and I.G. Tucker Pulsatile release from subcutaneous implants Adv. Drug Deliv. Rev. 38 1999 139 149
13. A. Goepferich Bioerodible implants with programmable drug Release J. Control Release 44 1997 271 281
14. P. Arunothayanun, T. Sooksawate, and A.T. Florence Extrusion of niosomes from capillaries: approaches to a pulsed delivery device J. Control. Release 60 1999 391 397
15. D.B. Bommannan, J. Tamada, L.P. Leung, and R.O. Potts Effect of electroporation on transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro Pharm. Res. 11 1994 1809 1814
16. K.S. Bhatia, S. Gao, and J. Singh Effect of penetration enhancers and iontophoresis on the FT-IR spectroscopy and LHRH permeability through porcine skin J. Control. Release 47 1997 81 89
17. A. Lemay, and N. Faure Fourteen-day versus twenty-one-day regimens of intermittent intranasal luteinizing hormone-releasing hormone agonist combined with an oral progestogen as antiovulatory contraceptive approach J. Clin. Endocrinol. Metab. 63 1986 1379 1385
18. S. Nakane, M. Kakumoto, K. Yukimatsu, and Y.W. Chien Oramucosal delivery of LHRH: pharmacokinetic studies of controlled and enhanced transmucosal permeation Pharm. Dev. Technol. 1 1996 251 259
19. J.T. Santini, M.J. Cima, and R. Langer A controlled release microchip Nature 397 1999 335 338
20. J. Maloney, S. Uhland, B. Polito, N. Sheppard, C. Pelta, and J. Santini Electrothermally activated microchips for implantable drug delivery and biosensing J. Control. Release 109 2005 244 255
21. A.P. Dhanarajan, G.P. Misra, and R.A. Siegel Autonomous chemomechanical oscillations in a hydrogel/enzyme system driven by glucose J. Phys. Chem. 106 2002 8835 8838
22. G.P. Misra, and R.A. Siegel A new mode of drug delivery: long term autonomous rhythmic hormone release across a hydrogel membrane J. Control. Release 81 2002 1 6
23. P.H.S. Tse, and D.A. Gough Time-dependent inactivation of immobilized glucose oxidase and catalase Biotechnol. Bioeng. 29 1987 705 713
24. J. Bao, K. Furumoto, M. Yoshimoto, K. Fukunaga, and K. Nakao Competitive inhibition by hydrogen peroxide produced in glucose oxidation catalyzed by glucose oxidase Biochem. Eng. J. 13 2003 69 72
25. J.P. Baker, and R.A. Siegel Hysteresis in the glucose permeability versus pH characteristic for a responsive hydrogel membrane Macromol. Rapid Commun. 17 1996 409 415
26. J.-C. Leroux, and R.A. Siegel Autonomous gel-enzyme oscillator fueled by glucose - preliminary evidence for oscillations Chaos 9 1999 267 275
27. A. Dhanarajan, and R.A. Siegel Time-dependent permeabilities of hydrophobic, pH-sensitive hydrogels exposed to pH gradients Macromol. Symp. 227 2005 105 114
28. G. Rábai, and I. Hanazaki pH oscillations in the bromate-sulfite-marble semibatch and flow systems J. Phys. Chem. 100 1996 10615 10619
29. R.A. Siegel, G.P. Misra, and A.P. Dhanarajan Rhythmically pulsing gels based on chemomechanical feedback Y. Osada, A.R. Khokhlov, Polymer Gels and Networks 2002 Marcel Dekker New York 357 372
30. A.S. Bhalla, S.K. Mujumdar, and R.A. Siegel Novel hydrogels for rhythmic pulsatile drug delivery Macromol. Symp. 254 2007 338 344
31. A. Dhanarajan, J. Urban, and R.A. Siegel A model for a hydrogel/enzyme chemomechanical oscillator J.A. Pojman, Q. Tran-Cong-Miyata, Nonlinear Dynamics in Polymeric Systems, American Chemical Society, Washington, DC 2003 44 57
32. A.N. Martin Ionic equilibria P. Sinko, Martin's Physical Pharmacy and Pharmaceutical Sciences 2011 Kluwer Philadelphia 161 185
33. J. Ricka, and T. Tanaka Swelling of ionic gels: quantitative performance of the donnan theory Macromolecules 17 1984 2916 2921
34. F. Horkay, I. Tasaki, and P. Basser Osmotic swelling of polyacrylate hydrogels in physiological salt solutions Biomacromolecules 1 2000 84 90
35. F. Horkay, I. Tasaki, and P.J. Basser Effect of monovalent-divalent cation exchange on the swelling of polyacrylate hydrogels in physiological salt solutions Biomacromolecules 2 2001 195 199
36. P.-Y. Ben Jar, and Y.S. Wu Effect of counter-ions on swelling and shrinkage of polyacrylamide-based ionic gels Polymer 38 1997 2557 2560
37. T.L. Hill An Introduction to Statistical Thermodynamics 1960 Courier Dover Publications Dover, New York
38. J. Boissonade, and P. De Kepper Transition from bistability to limit cycle oscillations. Theoretical analysis and experimental evidence in an open chemical system J. Phys. Chem. 84 1980 501 506
39. I.R. Epstein, and J.A. Pojman An Introduction to Nonlinear Chemical Dynamics: Oscillations, Waves, Patterns and Chaos 1998 Oxford, New York Oxford University Press
40. S.K. Mujumdar, and R.A. Siegel Introduction of pH-sensitivity into mechanically strong nanoclay composite hydrogels based on N-isopropylacrylamide J. Polym. Sci. A Polym. Chem. 46 2008 6630 6640
41. X. Zou, and R.A. Siegel Modeling of oscillatory dynamics of a simple enzyme-gel diffusion systems with hysteresis. The case of lumped permeabilities J. Chem. Phys. 110 1999 2267 2279
42. D.A. Gough, J.Y. Lucisano, and P.H.S. Tse Two-dimensional enzyme electrode sensor for glucose Anal. Chem. 57 1985 2351 2357
43. L.A. Klumb, and T.A. Horbett Design of insulin delivery devices based on glucose sensitive membranes J. Control. Release 18 1992 59 80
44. R. Yoshida, H. Ichijo, T. Hakuta, and T. Yamaguchi Self-oscillating swelling and deswelling of polymer gels Macromol. Rapid Commun. 16 1995 305 310
45. J. Horvath, I. Szalai, J. Boissonade, and P. De Kepper Oscillatory dynamics induced in a responsive gel by non-oscillatory chemical reaction: experimental evidence Soft Matter 7 2011 8462 8472
46. I. Varga, I. Szalai, R. Meszaros, and T. Gilanyi Pulsating pH-responsive nanogels J. Phys. Chem. B 110 2006 20297 20301
47. A.J. Ryan, C.J. Crook, J.R. Howse, P. Topham, R.A.L. Jones, M. Geoghegan, A.J. Parnell, L. Ruiz-Pèrez, S.J. Martin, A. Cadby, A. Menelle, J.R.P. Webster, A.J. Gleeson, and W. Bras Responsive brushes and gels as components of soft nanotechnology Faraday Discuss. 128 2005 55 74
48. J.R. Howse, P. Topham, C.J. Crook, A.J. Gleeson, W. Bras, R.A.L. Jones, and A.J. Ryan Reciprocating power generation in a chemically driven synthetic muscle Nano Lett. 6 2006 73 77
49. J.M.G. Swann, and A.J. Ryan Chemical actuation in responsive hydrogels Polym. Int. 58 2008 285 289
50. R. Yoshida, M. Tanaka, S. Onodera, T. Yamaguchi, and E. Kokofuta In-phase synchronization of chemical and mechanical oscillations in self-oscillating gels J. Phys. Chem. A 104 2000 7549 7555
51. R. Yoshida, and T. Sakai Self-oscillating nanogel particles Langmuir 20 2004 1036 1038
52. S. Sasaki, S. Koga, R. Yoshida, and T. Yamaguchi Mechanical oscillations coupled with the Belousov-Zhabotinsky reaction in gel Langmuir 19 2003 5595 5600
53. R. Yoshida Self-oscillating gels driven by the Belousov-Zhabotinsky reaction as novel smart materials Adv. Mater. 22 2010 3463 3483
54. M.L. Smith, K. Heitfeld, C. Slone, and R.A. Vaia Autonomic hydrogels through postfunctionalization of gelatin Chem. Mater. 24 2012 3074 3080
55. P. Yuan, O. Kuksenok, D.E. Gross, A.C. Balazs, J.S. Moore, and R.G. Nuzzo UV patternable thin film chemistry for shape and functionally versatile self-oscillating gels Soft Matter 9 2013 1231 1243
56. I.Y. Konotop, I.R. Nasimova, N.G. Rambidi, and A.R. Khokhlov Self-oscillatory systems based on polymer gels Polym. Sci. Ser. B 51 2009 383 388
57. I.Y. Konotop, I. Nasimova, N. Rambidi, and A. Khokhlov Chemical oscillations in polymer gels: effect of size of samples Polym. Sci. Ser. B 53 2011 26-23
58. I.C. Chen, O. Kuksenok, V. Yashin, R.M. Moslin, A. Balazs, and K.J. Van Vliet Shape- and size-dependent patterns ion self-oscillating polymer gels Soft Matter 7 2011 3141 3146
59. V. Yashin, O. Kuksenok, P. Dayal, and A. Balazs Mechano-chemical oscillations and waves in reactive gels Rep. Prog. Phys. 75 2013 06601
60. P. Labrot, P. De Kepper, J. Boissonade, I. Szalai, and F. Gauffre Wave patterns driven by chemomechanical instabilities in responsive gels J. Phys. Chem. B 109 2005 21476
61. X. He, M. Aizenberg, O. Kuksenok, L.D. Zarzar, A. Shastri, A.C. Balazs, and J. Aizenberg Synthetic homeostatic materials with chemo-mechano-chemical self-regulation Nature 487 2012 214 218
62. X. He, R.S. Friedlander, L.D. Zarzar, and J. Aizenberg Chemo-mechanically regulated oscillation of an enzymatic reaction Chem. Mater. 25 2013 521 523
63. D.W. Urry Physical chemistry of biological free energy transduction as demonstrated by elastic protein-based polymers J. Phys. Chem. B 101 1997 11007 11028