Dock3 overexpression and p38 MAPK inhibition synergistically stimulate neuroprotection and axon regeneration after optic nerve injury

Neuroscience Letters

Volumn 581, Issue , 2014, Pages 89-93

  Semba, Kentaro ^a,b   Namekata, Kazuhiko ^a   Kimura, Atsuko ^a   Harada, Chikako ^a   Katome, Takashi ^a,b   Yoshida, Hiroshi ^c   Mitamura, Yoshinori ^b   Harada, Takayuki ^a,b,c  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c TOKYO METROPOLITAN NEUROLOGICAL HOSPITAL   (Japan)

Author keywords

Axon regeneration; Dock3; Neuroprotection; Optic nerve injury; P38

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; APOPTOSIS SIGNAL REGULATING KINASE 1; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; CARRIER PROTEIN; DOCK3 PROTEIN, MOUSE; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; NERVE PROTEIN; NEUROPROTECTIVE AGENT; PYRIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINESIS; DRUG TARGETING; ENZYME INHIBITION; IN VIVO STUDY; MOUSE; NERVE CELL; NERVE FIBER REGENERATION; NEUROPROTECTION; NONHUMAN; OPTIC NERVE INJURY; OPTICAL COHERENCE TOMOGRAPHY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RETINA DEGENERATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL COUNT; ENZYMOLOGY; METABOLISM; NERVE FIBER; OPTIC NERVE INJURIES; PHOSPHORYLATION; PHYSIOLOGY; REGENERATION; RETINA GANGLION CELL; TRANSGENIC MOUSE;

ANIMALS; AXONS; CARRIER PROTEINS; CELL COUNT; ENZYME INHIBITORS; IMIDAZOLES; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; OPTIC NERVE INJURIES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRIDINES; REGENERATION; RETINAL GANGLION CELLS;

EID: 84908430602     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.08.034     Document Type: Article

References (24)

1. Bai N., Hayashi H., Aida T., Namekata K., Harada T., Mishina M., Tanaka K. Dock3 interaction with a glutamate-receptor NR2D subunit protects neurons from excitotoxicity. Mol. Brain 2013, 6:22.
2. de Lima S., Koriyama Y., Kurimoto T., Oliveira J.T., Yin Y., Li Y., Gilbert H.Y., Fagiolini M., Martinez A.M., Benowitz L. Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:9149-9154.
3. Guo X., Harada C., Namekata K., Kimura A., Mitamura Y., Yoshida H., Matsumoto Y., Harada T. Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis. Invest. Ophthalmol. Vis. Sci. 2011, 52:2696-2703.
4. Guo X., Harada C., Namekata K., Matsuzawa A., Camps M., Ji H., Swinnen D., Jorand-Lebrun C., Muzerelle M., Vitte P., Ruckle T., Kimura A., Kohyama K., Matsumoto Y., Ichijo H., Harada T. Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Mol. Med. 2010, 2:504-515.
5. Harada C., Nakamura K., Namekata K., Okumura A., Mitamura Y., Iizuka Y., Kashiwagi K., Yoshida K., Ohno S., Matsuzawa A., Tanaka K., Ichijo H., Harada T. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am. J. Pathol. 2006, 168:261-269.
6. Harada C., Namekata K., Guo X., Yoshida H., Mitamura Y., Matsumoto Y., Ichijo H., Harada T. ASK1 deficiency attenuates neural cell death in GLAST-deficient mice, a model of normal tension glaucoma. Cell Death Differ. 2010, 17:1751-1759.
7. Katome T., Namekata K., Guo X., Semba K., Kittaka D., Kawamura K., Kimura A., Harada C., Ichijo H., Mitamura Y., Harada T. Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury. Cell Death Differ. 2013, 20:270-280.
8. Kikuchi M., Tenneti L., Lipton S.A. Role of p38 mitogen-activated protein kinase in axotomy induced apoptosis of rat retinal ganglion cells. J. Neurosci. 2000, 20:5037-5044.
9. Krementsov D.N., Thornton T.M., Teuscher C., Rincon M. The emerging role of p38 mitogen-activated protein kinase in multiple sclerosis and its models. Mol. Cell. Biol. 2013, 33:3728-3734.
10. Leon S., Yin Y., Nguyen J., Irwin N., Benowitz L.I. Lens injury stimulates axon regeneration in the mature rat optic nerve. J. Neurosci. 2000, 20:4615-4626.
11. Matsuzawa A., Ichijo H. Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid. Redox Signal. 2005, 7:472-481.
12. Munemasa Y., Ahn J.H., Kwong J.M., Caprioli J., Piri N. Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma. Gene Ther. 2009, 16:17-25.
13. Munoz L., Ammit A.J. Targeting p38 MAPK pathway for the treatment of Alzheimer's disease. Neuropharmacology 2010, 58:561-568.
14. Namekata K., Harada C., Guo X., Kimura A., Kittaka D., Watanabe H., Harada T. Dock3 stimulates axonal outgrowth via GSK-3β-mediated microtubule assembly. J. Neurosci. 2012, 32:264-274.
15. Namekata K., Harada C., Taya C., Guo X., Kimura H., Parada L.F., Harada T. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:7586-7591.
16. Namekata K., Kimura A., Kawamura K., Guo X., Harada C., Tanaka K., Harada T. Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma. Cell Death Differ. 2013, 20:1250-1256.
17. Namekata K., Kimura A., Kawamura K., Harada C., Harada T. Dock GEFs and their therapeutic potential: neuroprotection and axon regeneration. Prog. Retin. Eye Res. 2014, 10.1016/j.preteyeres.2014.06.005.
18. Namekata K., Watanabe H., Guo X., Kittaka D., Kawamura K., Kimura A., Harada C., Harada T. Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG. Genes Cells 2012, 17:688-697.
19. Osborne N.N., del Olmo-Aguado S. Maintenance of retinal ganglion cell mitochondrial functions as a neuroprotective strategy in glaucoma. Curr. Opin. Pharmacol. 2013, 13:16-22.
20. Pernet V., Schwab M.E. Lost in the jungle: new hurdles for optic nerve axon regeneration. Trends Neurosci. 2014, 37:381-387.
21. Quigley H.A., Broman A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol. 2006, 90:262-267.
22. Semba K., Namekata K., Kimura A., Harada C., Harada T., Mitamura Y. Renin-angiotensin system regulates neurodegeneration in a mouse model of normal tension glaucoma. Cell Death Dis. 2014, 5:e1333.
23. Steinsapir K.D., Goldberg R.A. Traumatic optic neuropathy. Surv. Ophthalmol. 1994, 38:487-518.
24. van Velthoven M.E., Faber D.J., Verbraak F.D., van Leeuwen T.G., de Smet M.D. Recent developments in optical coherence tomography for imaging the retina. Prog. Retin. Eye Res. 2007, 26:57-77.