Novel, potent, and selective phosphodiesterase 5 inhibitors: Synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives

Journal of Medicinal Chemistry

Volumn 44, Issue 13, 2001, Pages 2204-2218

  Ukita, T ^a,b   Nakamura, Y ^a,b   Kubo, A ^a,b   Yamamoto, Y ^a,b   Moritani, Y ^a,b   Saruta, K ^a,b   Higashijima, T ^a,b   Kotera, J ^a,b   Takagi, M ^a,b   Kikkawa, K ^a,b   Omori, K ^a,b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 AMINOPHENYL) 1,2 DIHYDRO 1 OXO 7 (2 PYRIDINYLMETHOXY) 4 (3,4,5 TRIMETHOXYPHENYL) 3 ISOQUINOLINECARBOXYLIC ACID METHYL ESTER; ISOENZYME; ISOQUINOLINE DERIVATIVE; METHYL 2 (4 AMINOPHENYL) 1,2 DIHYDRO 1 OXO 7 (2 PYRIDINYLMETHOXY) 4 (3,4,5 TRIMETHOXYPHENYL) 3 ISOQUINOLINE CARBOXYLATE; METHYL 2 (4 AMINOPHENYL) 1,2 DIHYDRO 1 OXO 7 (2 PYRIDINYLMETHOXY) 4 (3,4,5 TRIMETHOXYPHENYL) 3 ISOQUINOLINE CARBOXYLATE SULFATE; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CORPUS CAVERNOSUM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ERECTILE DYSFUNCTION; IC 50; MALE; MUSCLE RELAXATION; NONHUMAN; RABBIT; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; CATTLE; DOGS; ENZYME INHIBITORS; ISOQUINOLINES; LUNG; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; MYOCARDIUM; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; RABBITS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035927445     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000558h     Document Type: Article

References (29)

1. Cyclic nucleotide phosphodiesterases: Relating structure and function
2. Multiple cyclic nucleotide phophodiesterase
3. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
4. Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)
5. The molecular biology of cyclic nucleotide phosphodiesterases
6. Cloning and characterizaion of a novel human phosphodiesterase that hydrolyze both cAMP and cGMP
7. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
8. Cyclic GMP phosphodiesterase-5: Target of sildenafil
9. Inhibitors of types I and V phophodiesterase: Elevation of cGMP as a therapeutic strategy
10. The role of phosphodiesterase inhibitors in impotence
11. Sildenafil. A review of its use in erectile dysfunction
12. Synthesis and cyclic GMP phosphodiesterase inhibitory activity of 6-phenylpyrazolo[3,4-d]-pyrimidones
13. SILDENAFIL (VIAGRA), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
14. N-3-substituted imidazoquinazolinones: Potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction
15. Cyclic GMP phophodiesterase inhibitors. 2. Replacement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity
16. Cyclic GMP phophodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline
17. Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phophodiesterase and thromboxane synthesis inhibitory activities
18. 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5
19. 4-Benzyl-1-chloro-6-substituted phthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5
20. Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans
21. Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: Synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives
22. 1-Arylnaphthalene lignan: A novel scaffold for type 5 phosphodiesterase inhibitor
23. Novel, potent, and orally active substance P antagonist activity of N-benzylcarboxamide derivatives of pyrido[3,4b]-pyridine
24. Isocoumarins. Part-XXIII. Synthesis of some 6,7-dimethoxy-3-phenylisocoumarins
25. Sildenafil (Viagra) and Ophthalmology
26. Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzyme