메뉴 건너뛰기




Volumn 9, Issue 10, 2014, Pages

Pro-inflammatory and pro-oxidant status of pancreatic islet in vitro is controlled by TLR-4 and HO-1 pathways

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; HEME OXYGENASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTOPORPHYRIN COBALT; REACTIVE OXYGEN METABOLITE; RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR;

EID: 84908409406     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107656     Document Type: Article
Times cited : (30)

References (74)
  • 1
    • 0036303015 scopus 로고    scopus 로고
    • Successful islet transplantation: Continued insulin reserve provides long-term glycemic control
    • Ryan EA, Lakey JR, Paty BW, Imes S, Korbutt GS, et al. (2002) Successful islet transplantation: continued insulin reserve provides long-term glycemic control. Diabetes 51: 2148-2157.
    • (2002) Diabetes , vol.51 , pp. 2148-2157
    • Ryan, E.A.1    Lakey, J.R.2    Paty, B.W.3    Imes, S.4    Korbutt, G.S.5
  • 2
    • 0035085643 scopus 로고    scopus 로고
    • Clinical outcomes and insulin secretion after islet transplantation with the edmonton protocol
    • Ryan EA, Lakey JR, Rajotte RV, Korbutt GS, Kin T, et al. (2001) Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 50: 710-719.
    • (2001) Diabetes , vol.50 , pp. 710-719
    • Ryan, E.A.1    Lakey, J.R.2    Rajotte, R.V.3    Korbutt, G.S.4    Kin, T.5
  • 3
    • 0035181201 scopus 로고    scopus 로고
    • Clinical results after islet transplantation
    • Ryan EA, Lakey JR, Shapiro AM (2001) Clinical results after islet transplantation. J Investig Med 49: 559-562.
    • (2001) J Investig Med , vol.49 , pp. 559-562
    • Ryan, E.A.1    Lakey, J.R.2    Shapiro, A.M.3
  • 4
    • 0034721255 scopus 로고    scopus 로고
    • Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
    • Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, et al. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343: 230-238.
    • (2000) N Engl J Med , vol.343 , pp. 230-238
    • Shapiro, A.M.1    Lakey, J.R.2    Ryan, E.A.3    Korbutt, G.S.4    Toth, E.5
  • 6
    • 33645997027 scopus 로고    scopus 로고
    • Current indications for pancreas or islet transplant
    • Ryan EA, Bigam D, Shapiro AM (2006) Current indications for pancreas or islet transplant. Diabetes Obes Metab 8: 1-7.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 1-7
    • Ryan, E.A.1    Bigam, D.2    Shapiro, A.M.3
  • 9
    • 56749160150 scopus 로고    scopus 로고
    • Islet transplantation-the imperative need for continued clinical trials
    • Shapiro AM (2008) Islet transplantation-the imperative need for continued clinical trials. Nat Clin Pract Nephrol 4: 662-663.
    • (2008) Nat Clin Pract Nephrol , vol.4 , pp. 662-663
    • Shapiro, A.M.1
  • 10
    • 80755189324 scopus 로고    scopus 로고
    • State of the art of clinical islet transplantation and novel protocols of immunosuppression
    • Shapiro AM (2011) State of the art of clinical islet transplantation and novel protocols of immunosuppression. Curr Diab Rep 11: 345-354.
    • (2011) Curr Diab Rep , vol.11 , pp. 345-354
    • Shapiro, A.M.1
  • 11
    • 0029821899 scopus 로고    scopus 로고
    • Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function
    • Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, et al. (1996) Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 45: 1161-1167.
    • (1996) Diabetes , vol.45 , pp. 1161-1167
    • Davalli, A.M.1    Scaglia, L.2    Zangen, D.H.3    Hollister, J.4    Bonner-Weir, S.5
  • 12
    • 33644870417 scopus 로고    scopus 로고
    • Liver ischemia contributes to early islet failure following intraportal transplantation: Benefits of liver ischemic-preconditioning
    • Yin D, Ding JW, Shen J, Ma L, Hara M, et al. (2006) Liver ischemia contributes to early islet failure following intraportal transplantation: benefits of liver ischemic-preconditioning. Am J Transplant 6: 60-68.
    • (2006) Am J Transplant , vol.6 , pp. 60-68
    • Yin, D.1    Ding, J.W.2    Shen, J.3    Ma, L.4    Hara, M.5
  • 13
    • 0036097472 scopus 로고    scopus 로고
    • Beta-cell death and mass in syngeneically transplanted islets exposed to short- and longterm hyperglycemia
    • Biarnes M, Montolio M, Nacher V, Raurell M, Soler J, et al. (2002) Beta-cell death and mass in syngeneically transplanted islets exposed to short- and longterm hyperglycemia. Diabetes 51: 66-72.
    • (2002) Diabetes , vol.51 , pp. 66-72
    • Biarnes, M.1    Montolio, M.2    Nacher, V.3    Raurell, M.4    Soler, J.5
  • 14
    • 0027201618 scopus 로고
    • Protection of islet cells from inflammatory cell death in vitro
    • Burkart V, Kolb H (1993) Protection of islet cells from inflammatory cell death in vitro. Clin Exp Immunol 93: 273-278.
    • (1993) Clin Exp Immunol , vol.93 , pp. 273-278
    • Burkart, V.1    Kolb, H.2
  • 15
    • 0041376742 scopus 로고    scopus 로고
    • Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents
    • Gysemans C, Stoffels K, Giulietti A, Overbergh L, Waer M, et al. (2003) Prevention of primary non-function of islet xenografts in autoimmune diabetic NOD mice by anti-inflammatory agents. Diabetologia 46: 1115-1123.
    • (2003) Diabetologia , vol.46 , pp. 1115-1123
    • Gysemans, C.1    Stoffels, K.2    Giulietti, A.3    Overbergh, L.4    Waer, M.5
  • 16
    • 0032870660 scopus 로고    scopus 로고
    • Structural and functional changes resulting from islet isolation lead to islet cell death
    • Rosenberg L, Wang R, Paraskevas S, Maysinger D (1999) Structural and functional changes resulting from islet isolation lead to islet cell death. Surgery 126: 393-398.
    • (1999) Surgery , vol.126 , pp. 393-398
    • Rosenberg, L.1    Wang, R.2    Paraskevas, S.3    Maysinger, D.4
  • 17
    • 0037080975 scopus 로고    scopus 로고
    • Prevention of primary nonfunction of canine islet autografts by treatment with pravastatin
    • Arita S, Nagai T, Ochiai M, Sakamoto Y, Shevlin LA, et al. (2002) Prevention of primary nonfunction of canine islet autografts by treatment with pravastatin. Transplantation 73: 7-12.
    • (2002) Transplantation , vol.73 , pp. 7-12
    • Arita, S.1    Nagai, T.2    Ochiai, M.3    Sakamoto, Y.4    Shevlin, L.A.5
  • 18
    • 0031890972 scopus 로고    scopus 로고
    • Transplantation of allogeneic islets of langerhans in the rat liver: Effects of macrophage depletion on graft survival and microenvironment activation
    • Bottino R, Fernandez LA, Ricordi C, Lehmann R, Tsan MF, et al. (1998) Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 47: 316-323.
    • (1998) Diabetes , vol.47 , pp. 316-323
    • Bottino, R.1    Fernandez, L.A.2    Ricordi, C.3    Lehmann, R.4    Tsan, M.F.5
  • 19
    • 4644233237 scopus 로고    scopus 로고
    • Response of human islets to isolation stress and the effect of antioxidant treatment
    • Bottino R, Balamurugan AN, Tse H, Thirunavukkarasu C, Ge X, et al. (2004) Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes 53: 2559-2568.
    • (2004) Diabetes , vol.53 , pp. 2559-2568
    • Bottino, R.1    Balamurugan, A.N.2    Tse, H.3    Thirunavukkarasu, C.4    Ge, X.5
  • 20
    • 0043167780 scopus 로고    scopus 로고
    • Inflammatory mediators expressed in human islets of langerhans: Implications for islet transplantation
    • Johansson U, Olsson A, Gabrielsson S, Nilsson B, Korsgren O (2003) Inflammatory mediators expressed in human islets of Langerhans: implications for islet transplantation. Biochem Biophys Res Commun 308: 474-479.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 474-479
    • Johansson, U.1    Olsson, A.2    Gabrielsson, S.3    Nilsson, B.4    Korsgren, O.5
  • 21
    • 34547402496 scopus 로고    scopus 로고
    • Rapid loss of intraportally transplanted islets: An overview of pathophysiology and preventive strategies
    • van der Windt DJ, Bottino R, Casu A, Campanile N, Cooper DK (2007) Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies. Xenotransplantation 14: 288-297.
    • (2007) Xenotransplantation , vol.14 , pp. 288-297
    • Van Der Windt, D.J.1    Bottino, R.2    Casu, A.3    Campanile, N.4    Cooper, D.K.5
  • 22
    • 0036094994 scopus 로고    scopus 로고
    • Human pancreatic islets produce and secrete MCP-1/CCL2: Relevance in human islet transplantation
    • Piemonti L, Leone BE, Nano R, Saccani A, Monti P, et al. (2002) Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation. Diabetes 51: 55-65.
    • (2002) Diabetes , vol.51 , pp. 55-65
    • Piemonti, L.1    Leone, B.E.2    Nano, R.3    Saccani, A.4    Monti, P.5
  • 24
    • 20044390358 scopus 로고    scopus 로고
    • Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function
    • Matsuda T, Omori K, Vuong T, Pascual M, Valiente L, et al. (2005) Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function. Am J Transplant 5: 484-493.
    • (2005) Am J Transplant , vol.5 , pp. 484-493
    • Matsuda, T.1    Omori, K.2    Vuong, T.3    Pascual, M.4    Valiente, L.5
  • 25
    • 0036014899 scopus 로고    scopus 로고
    • Inhibition of interleukin-1betainduced COX-2 AND EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function
    • Tran PO, Gleason CE, Robertson RP (2002) Inhibition of interleukin-1betainduced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function. Diabetes 51: 1772-1778.
    • (2002) Diabetes , vol.51 , pp. 1772-1778
    • Tran, P.O.1    Gleason, C.E.2    Robertson, R.P.3
  • 26
    • 0028271718 scopus 로고
    • The role of nitric oxide in IL-1 beta-mediated dysfunction of rodent islets of langerhans. Implications for the function of intrahepatic islet grafts
    • Xenos ES, Stevens RB, Sutherland DE, Lokeh A, Ansite JD, et al. (1994) The role of nitric oxide in IL-1 beta-mediated dysfunction of rodent islets of Langerhans. Implications for the function of intrahepatic islet grafts. Transplantation 57: 1208-1212.
    • (1994) Transplantation , vol.57 , pp. 1208-1212
    • Xenos, E.S.1    Stevens, R.B.2    Sutherland, D.E.3    Lokeh, A.4    Ansite, J.D.5
  • 28
    • 1342302624 scopus 로고    scopus 로고
    • The effect of innate immunity on autoimmune diabetes and the expression of toll-like receptors on pancreatic islets
    • Wen L, Peng J, Li Z, Wong FS (2004) The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol 172: 3173-3180.
    • (2004) J Immunol , vol.172 , pp. 3173-3180
    • Wen, L.1    Peng, J.2    Li, Z.3    Wong, F.S.4
  • 29
    • 0043168062 scopus 로고    scopus 로고
    • Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells
    • Vives-Pi M, Somoza N, Fernandez-Alvarez J, Vargas F, Caro P, et al. (2003) Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells. Clin Exp Immunol 133: 208-218.
    • (2003) Clin Exp Immunol , vol.133 , pp. 208-218
    • Vives-Pi, M.1    Somoza, N.2    Fernandez-Alvarez, J.3    Vargas, F.4    Caro, P.5
  • 30
    • 34548516368 scopus 로고    scopus 로고
    • Toll-like receptor 4 suppression leads to islet allograft survival
    • Goldberg A, Parolini M, Chin BY, Czismadia E, Otterbein LE, et al. (2007) Toll-like receptor 4 suppression leads to islet allograft survival. FASEB J 21: 2840-2848.
    • (2007) FASEB J , vol.21 , pp. 2840-2848
    • Goldberg, A.1    Parolini, M.2    Chin, B.Y.3    Czismadia, E.4    Otterbein, L.E.5
  • 31
    • 77957125749 scopus 로고    scopus 로고
    • Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation
    • Kruger B, Yin N, Zhang N, Yadav A, Coward W, et al. (2010) Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation. Eur J Immunol 40: 2914-2924.
    • (2010) Eur J Immunol , vol.40 , pp. 2914-2924
    • Kruger, B.1    Yin, N.2    Zhang, N.3    Yadav, A.4    Coward, W.5
  • 32
    • 22844436646 scopus 로고    scopus 로고
    • Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury
    • Shen XD, Ke B, Zhai Y, Gao F, Busuttil RW, et al. (2005) Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J - Transplant 5: 1793-1800.
    • (2005) Am J - Transplant , vol.5 , pp. 1793-1800
    • Shen, X.D.1    Ke, B.2    Zhai, Y.3    Gao, F.4    Busuttil, R.W.5
  • 33
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines MD (1997) The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37: 517-554.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 35
  • 36
    • 11144356654 scopus 로고    scopus 로고
    • Activation of human macrophages by allogeneic islets preparations: Inhibition by AOP-RANTES and heparinoids
    • Sigrist S, Oberholzer J, Bohbot A, Esposito G, Mandes K, et al. (2004) Activation of human macrophages by allogeneic islets preparations: inhibition by AOP-RANTES and heparinoids. Immunology 111: 416-421.
    • (2004) Immunology , vol.111 , pp. 416-421
    • Sigrist, S.1    Oberholzer, J.2    Bohbot, A.3    Esposito, G.4    Mandes, K.5
  • 37
    • 77950205756 scopus 로고    scopus 로고
    • Losartan prevents portal hypertension-induced, redox-mediated endothelial dysfunction in the mesenteric artery in rats
    • Dal-Ros S, Oswald-Mammosser M, Pestrikova T, Schott C, Boehm N, et al. (2010) Losartan prevents portal hypertension-induced, redox-mediated endothelial dysfunction in the mesenteric artery in rats. Gastroenterology 138: 1574-1584.
    • (2010) Gastroenterology , vol.138 , pp. 1574-1584
    • Dal-Ros, S.1    Oswald-Mammosser, M.2    Pestrikova, T.3    Schott, C.4    Boehm, N.5
  • 38
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T))
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Method. Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 39
    • 81255168048 scopus 로고    scopus 로고
    • Control of instant blood-mediated inflammatory reaction to improve islets of langerhans engraftment
    • Nilsson B, Ekdahl KN, Korsgren O (2011) Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment. Curr Opin Organ Transplant 16: 620-626.
    • (2011) Curr Opin Organ Transplant , vol.16 , pp. 620-626
    • Nilsson, B.1    Ekdahl, K.N.2    Korsgren, O.3
  • 40
  • 41
    • 15644379473 scopus 로고    scopus 로고
    • A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1beta
    • Ye J, Laychock SG (1998) A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1beta. Endocrinology 139: 4155-4163.
    • (1998) Endocrinology , vol.139 , pp. 4155-4163
    • Ye, J.1    Laychock, S.G.2
  • 42
    • 0038283161 scopus 로고    scopus 로고
    • Interleukin-10 therapy-review of a new approach
    • Asadullah K, Sterry W, Volk HD (2003) Interleukin-10 therapy-review of a new approach. Pharmacol Rev 55: 241-269.
    • (2003) Pharmacol Rev , vol.55 , pp. 241-269
    • Asadullah, K.1    Sterry, W.2    Volk, H.D.3
  • 43
    • 0027791754 scopus 로고
    • Reactive oxygen species and inflammation
    • Hakim J (1993) [Reactive oxygen species and inflammation]. C R Seances Soc Biol Fil 187: 286-295.
    • (1993) C R Seances Soc Biol Fil , vol.187 , pp. 286-295
    • Hakim, J.1
  • 44
    • 33645097021 scopus 로고    scopus 로고
    • A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cy-clohex- 1-Ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4- mediated cytokine production through suppression of intracellular signaling
    • Ii M, Matsunaga N, Hazeki K, Nakamura K, Takashima K, et al. (2006) A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cy-clohex- 1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4- mediated cytokine production through suppression of intracellular signaling. Mol Pharmacol 69: 1288-1295.
    • (2006) Mol Pharmacol , vol.69 , pp. 1288-1295
    • Ii, M.1    Matsunaga, N.2    Hazeki, K.3    Nakamura, K.4    Takashima, K.5
  • 45
    • 41149131096 scopus 로고    scopus 로고
    • TAK-242 selectively suppresses toll-like receptor 4-Signaling mediated by the intracellular domain
    • Kawamoto T, Ii M, Kitazaki T, Iizawa Y, Kimura H (2008) TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain. Eur J Pharmacol 584: 40-48.
    • (2008) Eur J Pharmacol , vol.584 , pp. 40-48
    • Kawamoto, T.1    Ii, M.2    Kitazaki, T.3    Iizawa, Y.4    Kimura, H.5
  • 46
    • 0035458338 scopus 로고    scopus 로고
    • Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation
    • Pileggi A, Molano RD, Berney T, Cattan P, Vizzardelli C, et al. (2001) Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 50: 1983-1991.
    • (2001) Diabetes , vol.50 , pp. 1983-1991
    • Pileggi, A.1    Molano, R.D.2    Berney, T.3    Cattan, P.4    Vizzardelli, C.5
  • 48
    • 17844402768 scopus 로고    scopus 로고
    • Donor treatment with carbon monoxide can yield islet allograft survival and tolerance
    • Wang H, Lee SS, Gao W, Czismadia E, McDaid J, et al. (2005) Donor treatment with carbon monoxide can yield islet allograft survival and tolerance. Diabetes 54: 1400-1406.
    • (2005) Diabetes , vol.54 , pp. 1400-1406
    • Wang, H.1    Lee, S.S.2    Gao, W.3    Czismadia, E.4    McDaid, J.5
  • 49
    • 33749322644 scopus 로고    scopus 로고
    • Carbon monoxide differentially inhibits TLR signaling pathways by regulating rosinduced trafficking of tlrs to lipid rafts
    • Nakahira K, Kim HP, Geng XH, Nakao A, Wang X, et al. (2006) Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROSinduced trafficking of TLRs to lipid rafts. J Exp Med 203: 2377-2389.
    • (2006) J Exp Med , vol.203 , pp. 2377-2389
    • Nakahira, K.1    Kim, H.P.2    Geng, X.H.3    Nakao, A.4    Wang, X.5
  • 50
    • 61449255986 scopus 로고    scopus 로고
    • Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity
    • Remy S, Blancou P, Tesson L, Tardif V, Brion R, et al. (2009) Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity. J Immunol 182: 1877-1884.
    • (2009) J Immunol , vol.182 , pp. 1877-1884
    • Remy, S.1    Blancou, P.2    Tesson, L.3    Tardif, V.4    Brion, R.5
  • 51
    • 78751475245 scopus 로고    scopus 로고
    • Protective effect of heme oxygenase-1 to pancreas islet xenograft
    • Chen X, Zhang Z, Su C, Gu W, Li H, et al. (2010) Protective effect of heme oxygenase-1 to pancreas islet xenograft. J Surg Res 164: 336-343.
    • (2010) J Surg Res , vol.164 , pp. 336-343
    • Chen, X.1    Zhang, Z.2    Su, C.3    Gu, W.4    Li, H.5
  • 53
    • 84866647873 scopus 로고    scopus 로고
    • Regulation of toll-like receptor 4-Mediated immune responses through pasteurella multocida toxin-induced G protein signalling
    • Hildebrand D, Sahr A, Wolfle SJ, Heeg K, Kubatzky KF (2012) Regulation of Toll-like receptor 4-mediated immune responses through Pasteurella multocida toxin-induced G protein signalling. Cell Commun Signal 10: 22.
    • (2012) Cell Commun Signal , vol.10 , pp. 22
    • Hildebrand, D.1    Sahr, A.2    Wolfle, S.J.3    Heeg, K.4    Kubatzky, K.F.5
  • 54
    • 25444463829 scopus 로고    scopus 로고
    • Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with abocompatible blood
    • Moberg L, Korsgren O, Nilsson B (2005) Neutrophilic granulocytes are the predominant cell type infiltrating pancreatic islets in contact with ABOcompatible blood. Clin Exp Immunol 142: 125-131.
    • (2005) Clin Exp Immunol , vol.142 , pp. 125-131
    • Moberg, L.1    Korsgren, O.2    Nilsson, B.3
  • 55
    • 40949114668 scopus 로고    scopus 로고
    • Influence of rapamycin on rat macrophage viability and chemotaxis toward allogenic pancreatic islet supernates
    • Danner S, Sigrist S, Moreau F, Mandes K, Vodouhe C, et al. (2008) Influence of rapamycin on rat macrophage viability and chemotaxis toward allogenic pancreatic islet supernates. Transplant Proc 40: 470-472.
    • (2008) Transplant Proc , vol.40 , pp. 470-472
    • Danner, S.1    Sigrist, S.2    Moreau, F.3    Mandes, K.4    Vodouhe, C.5
  • 56
    • 27844561126 scopus 로고    scopus 로고
    • Role of chemokine signaling pathways in pancreatic islet rejection during allo- and xenotransplantation
    • Sigrist S, Ebel N, Langlois A, Bosco D, Toso C, et al. (2005) Role of chemokine signaling pathways in pancreatic islet rejection during allo- and xenotransplantation. Transplant Proc 37: 3516-3518.
    • (2005) Transplant Proc , vol.37 , pp. 3516-3518
    • Sigrist, S.1    Ebel, N.2    Langlois, A.3    Bosco, D.4    Toso, C.5
  • 58
    • 18244364592 scopus 로고    scopus 로고
    • Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: Implications for intrahepatic grafts
    • Barshes NR, Wyllie S, Goss JA (2005) Inflammation-mediated dysfunction and apoptosis in pancreatic islet transplantation: implications for intrahepatic grafts. J Leukoc Biol 77: 587-597.
    • (2005) J Leukoc Biol , vol.77 , pp. 587-597
    • Barshes, N.R.1    Wyllie, S.2    Goss, J.A.3
  • 59
    • 0842284787 scopus 로고    scopus 로고
    • Glucose-induced regulation of COX-2 expression in human islets of langerhans
    • Suppl 1
    • Persaud SJ, Burns CJ, Belin VD, Jones PM (2004) Glucose-induced regulation of COX-2 expression in human islets of Langerhans. Diabetes 53 Suppl 1: S190-192.
    • (2004) Diabetes , vol.53 , pp. S190-S192
    • Persaud, S.J.1    Burns, C.J.2    Belin, V.D.3    Jones, P.M.4
  • 60
    • 0028399309 scopus 로고
    • Role of inducible cyclooxygenase (COX-2) in inflammation
    • Seibert K, Masferrer JL (1994) Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor 4: 17-23.
    • (1994) Receptor , vol.4 , pp. 17-23
    • Seibert, K.1    Masferrer, J.L.2
  • 61
    • 0032539608 scopus 로고    scopus 로고
    • Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet
    • Sorli CH, Zhang HJ, Armstrong MB, Rajotte RV, Maclouf J, et al. (1998) Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet. Proc Natl Acad Sci U S A 95: 1788-1793.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 1788-1793
    • Sorli, C.H.1    Zhang, H.J.2    Armstrong, M.B.3    Rajotte, R.V.4    Maclouf, J.5
  • 62
    • 11144238593 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets
    • Heitmeier MR, Kelly CB, Ensor NJ, Gibson KA, Mullis KG, et al. (2004) Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets. J Biol Chem 279: 53145-53151.
    • (2004) J Biol Chem , vol.279 , pp. 53145-53151
    • Heitmeier, M.R.1    Kelly, C.B.2    Ensor, N.J.3    Gibson, K.A.4    Mullis, K.G.5
  • 63
    • 78650426510 scopus 로고    scopus 로고
    • Effects of cyclooxygenase-2 inhibitor and adenosine triphosphate-sensitive potassium channel opener in syngeneic mouse islet transplantation
    • Juang JH, Kuo CH (2010) Effects of cyclooxygenase-2 inhibitor and adenosine triphosphate-sensitive potassium channel opener in syngeneic mouse islet transplantation. Transplant Proc 42: 4221-4224.
    • (2010) Transplant Proc , vol.42 , pp. 4221-4224
    • Juang, J.H.1    Kuo, C.H.2
  • 64
    • 84869856414 scopus 로고    scopus 로고
    • Human islets express a marked proinflammatory molecular signature prior to transplantation
    • Cowley MJ, Weinberg A, Zammit NW, Walters SN, Hawthorne WJ, et al. (2012) Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplant 21: 2063-2078.
    • (2012) Cell Transplant , vol.21 , pp. 2063-2078
    • Cowley, M.J.1    Weinberg, A.2    Zammit, N.W.3    Walters, S.N.4    Hawthorne, W.J.5
  • 65
    • 33845667532 scopus 로고    scopus 로고
    • Quantification of basal and stimulated ROS levels as predictors of islet potency and function
    • Armann B, Hanson MS, Hatch E, Steffen A, Fernandez LA (2007) Quantification of basal and stimulated ROS levels as predictors of islet potency and function. Am J Transplant 7: 38-47.
    • (2007) Am J Transplant , vol.7 , pp. 38-47
    • Armann, B.1    Hanson, M.S.2    Hatch, E.3    Steffen, A.4    Fernandez, L.A.5
  • 66
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S, Drinkgern J, Tiedge M (1996) Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 20: 463-466.
    • (1996) Free Radic Biol Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 67
    • 0029401861 scopus 로고
    • Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: Implications for the pathogenesis of insulindependent diabetes mellitus
    • Welsh N, Margulis B, Borg LA, Wiklund HJ, Saldeen J, et al. (1995) Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulindependent diabetes mellitus. Mol Med 1: 806-820.
    • (1995) Mol Med , vol.1 , pp. 806-820
    • Welsh, N.1    Margulis, B.2    Borg, L.A.3    Wiklund, H.J.4    Saldeen, J.5
  • 68
    • 77954291466 scopus 로고    scopus 로고
    • Redox modulation protects islets from transplant-related injury
    • Sklavos MM, Bertera S, Tse HM, Bottino R, He J, et al. (2010) Redox modulation protects islets from transplant-related injury. Diabetes 59: 1731-1738.
    • (2010) Diabetes , vol.59 , pp. 1731-1738
    • Sklavos, M.M.1    Bertera, S.2    Tse, H.M.3    Bottino, R.4    He, J.5
  • 69
    • 0036127426 scopus 로고    scopus 로고
    • Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
    • Lee TS, Chau LY (2002) Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 8: 240-246.
    • (2002) Nat Med , vol.8 , pp. 240-246
    • Lee, T.S.1    Chau, L.Y.2
  • 70
    • 0344642932 scopus 로고    scopus 로고
    • Adenoassociated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice
    • Zhang YC, Pileggi A, Agarwal A, Molano RD, Powers M, et al. (2003) Adenoassociated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes 52: 708-716.
    • (2003) Diabetes , vol.52 , pp. 708-716
    • Zhang, Y.C.1    Pileggi, A.2    Agarwal, A.3    Molano, R.D.4    Powers, M.5
  • 71
    • 77954072462 scopus 로고    scopus 로고
    • TLR4 mediates early graft failure after intraportal islet transplantation
    • Gao Q, Ma LL, Gao X, Yan W, Williams P, et al. (2010) TLR4 mediates early graft failure after intraportal islet transplantation. Am J Transplant 10: 1588-1596.
    • (2010) Am J Transplant , vol.10 , pp. 1588-1596
    • Gao, Q.1    Ma, L.L.2    Gao, X.3    Yan, W.4    Williams, P.5
  • 72
    • 84855460360 scopus 로고    scopus 로고
    • Heparan sulfate and heparanase play key roles in mouse beta cell survival and autoimmune diabetes
    • Ziolkowski AF, Popp SK, Freeman C, Parish CR, Simeonovic CJ (2012) Heparan sulfate and heparanase play key roles in mouse beta cell survival and autoimmune diabetes. J Clin Invest 122: 132-141.
    • (2012) J Clin Invest , vol.122 , pp. 132-141
    • Ziolkowski, A.F.1    Popp, S.K.2    Freeman, C.3    Parish, C.R.4    Simeonovic, C.J.5
  • 73
    • 80455128946 scopus 로고    scopus 로고
    • Establishment of a prolonged pancreas preservation model for islet isolation research in mice
    • Itoh T, Sugimoto K, Shimoda M, Chujo D, Takita M, et al. (2011) Establishment of a prolonged pancreas preservation model for islet isolation research in mice. Islets 3: 376-380.
    • (2011) Islets , vol.3 , pp. 376-380
    • Itoh, T.1    Sugimoto, K.2    Shimoda, M.3    Chujo, D.4    Takita, M.5
  • 74
    • 80051529660 scopus 로고    scopus 로고
    • Effect of a combined treatment with growth hormone and melatonin in the cardiological aging on male SAMP8 mice
    • Forman K, Vara E, Garcia C, Kireev R, Cuesta S, et al. (2011) Effect of a combined treatment with growth hormone and melatonin in the cardiological aging on male SAMP8 mice. J Gerontol A Biol Sci Med Sci 66: 823-834.
    • (2011) J Gerontol A Biol Sci Med Sci , vol.66 , pp. 823-834
    • Forman, K.1    Vara, E.2    Garcia, C.3    Kireev, R.4    Cuesta, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.