Protective effect of heme oxygenase-1 to pancreas islet xenograft

Journal of Surgical Research

Volumn 164, Issue 2, 2010, Pages 336-343

  Chen, Xi ^a   Zhang, Zhengyun ^a,c   Su, Chang ^a   Gu, Weiqiong ^b   Li, Hongwei ^a   Zhou, Guangwen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SHANGHAI CHILDREN S MEDICAL CENTER   (China)

Author keywords

Cobalt protoporphyrin (CoPP); Heme oxygenase; IL 10; Pancreatic islet transplantation; Xenograft

Indexed keywords

C PEPTIDE; GAMMA INTERFERON; GLUCOSE; HEME OXYGENASE 1; HEMOGLOBIN A1C; INTERLEUKIN 10; INTERLEUKIN 1BETA; MESSENGER RNA; PROTOPORPHYRIN COBALT; PROTOPORPHYRIN ZINC; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GRAFT SURVIVAL; HEMOGLOBIN BLOOD LEVEL; IMMUNOMODULATION; IN VITRO STUDY; INSULIN RELEASE; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PANCREAS FUNCTION; PANCREAS ISLET TRANSPLANTATION; PATHOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REVIEW; STREPTOZOCIN DIABETES; SURVIVAL TIME; XENOGRAFT; ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; PHYSIOLOGY; SECRETION; SPRAGUE DAWLEY RAT; TRANSPLANTATION TOLERANCE;

ANIMALS; BLOOD GLUCOSE; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEME OXYGENASE-1; INSULIN; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HETEROLOGOUS;

EID: 78751475245     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.08.016     Document Type: Article

References (14)

1. Chang Su, Zhengyun Zhang, Xi Chen, et al. Technical improvement for separation and purification of rat islets. J Surg Concepts Practice 2007;12:460.
2. Pileggi A, Damaris Molano R, Berney T, et al. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 2001; 50:1983.
3. Hao ZH, Zhang QH, Shi W, et al. Experimental study on islets transplantation positions of diabetes receptor mice. Chin J Exp Surg 2006;23:612.
4. SoaresMP,LinY,Anrather J, et al.Expressionofhemeoxygenase- 1 can determine cardiac xenograft survival.NatMed 1998;4:1073.
5. Lundquist I, Alm P, Salehi A, et al. Carbon monoxide stimulates insulin release and propagates Ca2 signals between pancreatic b-cells. Am J Physiol Endocrinol Metab 2003;285:E1055.
6. Moore KW, De Waal Malefyt R, Coffman RL, et al. Interleukin- 10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19:683.
7. Montolio M, Biarnes M, Tellez N, et al. Interleukin-1b and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation. J Endocrinol 2007;192:169.
8. Otterbein LE, Soares MP, Yamashita K, et al. Heme oxygenase- 1: Unleashing the protective properties of heme. Trends Immunol 2003;24:449.
9. Wang HJ, Lee SS, Gao W, et al. Donor treatment with carbon monoxide can yield islet allograft survival and tolerance. Diabetes 2005;54:1400.
10. Wang HJ, Lee SS, Dell'Agnello C, et al. Bilirubin can induce tolerance to islet allografts. Endocrinology 2005;147:762.
11. Lee T, Chau L. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002;8:240.
12. Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen activated protein kinase pathway. Nat Med 2000;6:422.
13. McDaid J, Yamashita K, Chora A, et al. Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells. FASEB J 2005;19:458.
14. Woo J, Iyer S, Mori N, et al. Alleviation of graft- versus-host disease after conditioning with cobalt-protoporphyrin, an inducer of heme oxygenase-1. Transplantation 2000;69:623.