Synthesis and antimycobacterial evaluation of natural oridonin and its enmein-type derivatives

Fitoterapia

Volumn 99, Issue 1, 2014, Pages 300-306

  Xu, Shengtao ^a   Pei, Lingling ^a   Li, Dahong ^a,b   Yao, Hong ^a   Cai, Hao ^a   Yao, Hequan ^a   Wu, Xiaoming ^a   Xu, Jinyi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antimycobacterial activity; Enmein type; Natural product; Oridonin; Tuberculosis

Indexed keywords

ANTIMYCOBACTERIAL AGENT; ENT (14ALPHA O 2 CHLORO 3 PYRIDOYL) 1,7 EPOXY 6,7,15 TRIOXO 6, 20 EPOXY 6,7 SECO 16 KAURENE; ENT (14ALPHA O BENZOYL) 1,7 EPOXY 6,7,15 TRIOXO 6,20 EPOXY 6,7 SECO 16 KAURENE; ENT (14ALPHA O CYCLOPENTOYL) 1,7 EPOXY 6,7,15 TRIOXO 6,20 EPOXY 6,7 SECO 16 KAURENE; ENT (14ALPHA O O INDOLOYL) 1,7 EPOXY 6,7,15 TRIOXO 6,20 EPOXY 6,7 SECO 16 KAURENE; ENT (14ALPHA O O PYRAZINOYL) 1,7 EPOXY 6,7,15 TRIOXO 6,20 EPOXY 6,7 SECO 16 KAURENE; ENT (14ALPHA O PARA FLUOROPHENYLVINOYL) 1,7 EPOXY 6,7,15 TRIOXO 6, 20 EPOXY 6,7 SECO 16 KAURENE; ENT (14ALPHA O PARA FLUROBENZOYL) 1,7 EPOXY 6,7,15 TRIOXO 6,20 EPOXY 6,7 SECO 16 KAURENE; ENT (14ALPHA O PARA METHXOYLBENZOYL) 1,7 EPOXY 6,7,15 TRIOXO 6,20 EPOXY 6,7 SECO 16 KAURENE; ENT (14ALPHA PARA META PYRIDOYL) 1,7 EPOXY 6,7,15 TRIOXO 6,20 EPOXY 6,7 SECO 16 KAURENE; ENT 1ALPHA O ACETYL 6BETA,7BETA , DIHYDROXY (14BETA O PARA FLOROBENZOYL) 15 OXO 7,20 EPOXY 16 KAURENE; ENT 1ALPHA,6BETA,7BETA TRIHYDROXY (14BETA O PARA METHOXYCINNAMOYL) 15 OXO 7,20 EPOXY 16 KAURENE; ENT 6BETA HYDROXY (14ALPHA O 2 CHLORO 3 PYRIDOYL) 1,7 EPOXY 7,15 DIOXO 6,20 HEMIKETAL 6,7 SECO 16 KAURENE; ENT 6BETA HYDROXY (14ALPHA O 2 CHLORO 4 PYRIDOYL) 1,7 EPOXY 7,15 DIOXO 6,20 HEMIKETAL 6,7 SECO 16 KAURENE; ENT 6BETA HYDROXY (14ALPHA O 2 INDOLOYL) 1,7 EPOXY 7,15 DIOXO 6, 20 HEMIKETAL 6,7 SECO 16 KAURENE; ENT 6BETA HYDROXY (14ALPHA O BENZOYL) 1,7 EPOXY 7,15 DIOXO 6,20 HEMIKETAL 6,7 SECO 16 KAURENE; ENT 6BETA HYDROXY (14ALPHA O O PYRAZINOYL) 1,7 EPOXY 7,15 DIOXO 6,20 HEMIKETAL 6,7 SECO 16 KAURENE; ENT 6BETA HYDROXY (14ALPHA O OQUINOLOYL) 1,7 EPOXY 7,15 DIOXO 6,20 HEMIKETAL 6,7 SECO 16 KAURENE; ENT 6BETA HYDROXY (14ALPHA O PARA FLUROBENZOYL) 1,7 EPOXY 7,15 DIOXO 6,20 HEMIKETAL 6,7 SECO 16 KAURENE; ENT 6BETA HYDROXY (14ALPHA OCYCLOPENTOYL) 1,7 EPOXY 7,15 DIOXO 6,20 HEMIKETAL 6,7 SECO 16 KAURENE; ORIDONIN; STREPTOMYCIN; UNCLASSIFIED DRUG; DITERPENE; ENMEIN; KAURANE DERIVATIVE; TUBERCULOSTATIC AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IC50; MASS SPECTROMETRY; MYCOBACTERIUM MARINUM; MYCOBACTERIUM PHLEI; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; MYCOBACTERIUM; SYNTHESIS;

MYCOBACTERIUM MARINUM; MYCOBACTERIUM PHLEI; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

ANTITUBERCULAR AGENTS; DITERPENES; DITERPENES, KAURANE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM;

EID: 84908400222     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.10.005     Document Type: Article

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