A new erythrocyte-based biochemical approach to predict the antiproliferative effects of heterocyclic scaffolds: The case of indolone

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 1, 2015, Pages 73-79

  Scala, Angela ^a   Ficarra, Silvana ^a   Russo, Annamaria ^a   Barreca, Davide ^a   Giunta, Elena ^b   Galtieri, Antonio ^a   Grassi, Giovanni ^a   Tellone, Ester ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b Virology and Microbiology AOOR Papardo Piemonte   (Italy)

Author keywords

Anion transport; Antiproliferation; ATP transport; Caspase 3; Heterocycle; Red blood cell

Indexed keywords

2,2' DIMETHYL 6,6',7,7' TETRAHYDRO 1H,1'H 2,3' BIINDOLE 3,4,4' (2H,5H,5'H) TRIONE; 2,2'-DIMETHYL-6,6'-DIPHENYL-6,6',7,7'-TETRAHYDRO-1H,1'H-2,3'-BIINDOLE-3,4,4'(2H,5H,5'H)-TRIONE; ADENOSINE TRIPHOSPHATE; ANTIMITOTIC AGENT; CASPASE 3; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; PHARMACOLOGY; SUPEROXIDE; UNCLASSIFIED DRUG;

ANION EXCHANGE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL MODEL; CANCER CELL; CELL DIVISION; CELL FUNCTION; CELL MEMBRANE; CELL PH; CELL PROLIFERATION; CELL STRUCTURE; CHEMICAL STRUCTURE; CHEMISTRY; CONTROLLED STUDY; CYTOLOGY; CYTOSOL; DOSE RESPONSE; DRUG EFFECTS; ENERGY METABOLISM; ENZYME ACTIVATION; ERYTHROCYTE; ERYTHROCYTE METABOLISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; LIPID PEROXIDATION; METABOLISM; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHOSPHOLIPID BILAYER; PROTEIN STABILITY; PROTEIN TRANSPORT;

ADENOSINE TRIPHOSPHATE; CASPASE 3; CELL MEMBRANE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EFFECTS; ENERGY METABOLISM; ERYTHROCYTES; FLOW CYTOMETRY; HETEROCYCLIC COMPOUNDS; HUMANS; INDOLES; LIPID PEROXIDATION; METABOLISM; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; OXIDATIVE STRESS; PHARMACOLOGY; SUPEROXIDES;

EID: 84908388655     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.09.022     Document Type: Article

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