Aldol-type compounds from water-soluble indole-3,4-diones: Synthesis, kinetics, and antiviral properties

Molecular Diversity

Volumn 17, Issue 3, 2013, Pages 479-488

  Scala, Angela ^a   Cordaro, Massimiliano ^b   Mazzaglia, Antonino ^a   Risitano, Francesco ^b   Venuti, Assunta ^b   Sciortino, Maria Teresa ^b   Grassi, Giovanni ^b  

^a CNR   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Aldol condensation; Antiviral activity; Indoledione; Kinetics

Indexed keywords

2 METHYL 6 PHENYL 6,7 DIHYDRO 2H INDOLE 3,4 (3A H,5H) DIONE; 2,2' DIMETHYL 6,6' DIPHENYL 6,6',7,7 ' TETRAHYDRO 1H,1' H 2,3' BIINDOLE 3,4,4' (2H,5H,5' H) TRIONE; 2,2' DIMETHYL 6,6',7,7' TETRAHYDRO 1H,1' H 2,3' BIINDOLE 3,4,4' (2H,5H,5' H) TRIONE; 2,2',6,6' TETRAMETHYL 6,6' ,7,7' TETRAHYDRO 1H,1' H 2,3' (2H,5H,5' H) TRIONE; 2,2',6,6,6',6' HEXAMETHYL 6,6',7,7' TETRAHYDRO 1H,1' H 2,3' BIINDOLE 3,4,4' (2H,5H, 5' H) TRIONE; 6 (4 CHLOROPHENYL) 2 METHYL 6,7 DIHYDRO 2H INDOLE 3,4 (3A H,5H) DIONE; 6 (4 FLUOROPHENYL) 2 METHYL 6,7 DIHYDRO 2H INDOLE 3,4 (3A H,5H) DIONE; 6 ISOPROPYL 2 METHYL 6,7 DIHYDRO 2H INDOLE 3,4 (3A H,5H) DIONE; 6,6' BIS (4 CHLOROPHENYL) 2,2' DIMETHYL 6,6',7,7' TETRAHYDRO 1H,1' H 2,3' BIINDOLE 3,4,4' (2H,5H,5' H) TRIONE; 6,6' BIS (4 FLUOROPHENYL) 2,2' DIMETHYL 6,6',7,7' TETRAHYDRO 1H,1' H 2,3' BIINDOLE 3,4,4' (2H,5H,5' H) TRIONE; 6,6' DIISOPROPYL 2,2' DIMETHYL 6,6',7,7' TETRAHYDRO 1H,1' H 2,3' BIINDOLE 3,4,4' (2H,5H,5' H) TRIONE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG; WATER;

ALDOL REACTION; ANTIPROLIFERATIVE ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DEPROTECTION REACTION; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; IN VITRO STUDY; KINETICS; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION;

ALDEHYDES; ANTIVIRAL AGENTS; CYCLIN-DEPENDENT KINASES; DRUG DESIGN; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; INDOLES;

EID: 84880775915     PISSN: 13811991     EISSN: 1573501X     Source Type: Journal    
DOI: 10.1007/s11030-013-9448-8     Document Type: Article

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