Direct synthesis of C3-mono-functionalized oxindoles from N-unprotected 2-oxindole and their antileishmanial activity

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 3, 2014, Pages 1063-1069

  Scala, Angela ^a   Cordaro, Massimiliano ^a   Grassi, Giovanni ^a   Piperno, Anna ^a   Barberi, Giuseppina ^a   Cascio, Antonio ^a   Risitano, Francesco ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

Cyclization; Diastereoselectivity; Leishmania; Leishmanicidal activity; Michael addition; Oxindoles

Indexed keywords

2,6 BIS(4 CHLOROPHENYL)SPIRO(CYCLOHEXANE 1,3' INDOLINE) 2',4 DIONE; 2,6 BIS(4 METHOXYPHENYL)SPIRO(CYCLOHEXANE 1,3' INDOLINE) 2',4 DIONE; 2,6 DIPHENYLSPIRO(CYCLOHEXANE 1,30 INDOLINE) 2',4 DIONE; 2,6 DIPTOLYLSPIRO(CYCLOHEXANE 1,30 INDOLINE) 2',4 DIONE; 3 (1 (4 CHLOROPHENYL) 3 OXO 3 PHENYLPROPYL)INDOLIN 2 ONE; 3 (1,3 DIPHENYLPROPYL)INDOLIN 2 ONE; 3 (3 OXO 3 PHENYL 1 PARATOLYLPROPYL)INDOLIN 2 ONE; 3 [1 (3 CHLOROPHENYL) 3 OXO 3 PHENYLPROPYL]INDOLIN 2 ONE; 3 [1 (4 METHOXYPHENYL) 3 OXO 3 PHENYPROPYL]INDOLIN 2 ONE; AMPHOTERICIN B; ANTILEISHMANIAL AGENT; OXINDOLE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LEISHMANIA INFANTUM; NONHUMAN; PROMASTIGOTE;

LEISHMANIA INFANTUM; PROTOZOA;

CYCLIZATION; DIASTEREOSELECTIVITY; LEISHMANIA; LEISHMANICIDAL ACTIVITY; MICHAEL ADDITION; OXINDOLES;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; CHALCONE; CHEMISTRY TECHNIQUES, SYNTHETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; INDOLES; LEISHMANIA INFANTUM; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TOXICITY TESTS;

EID: 84892794694     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.039     Document Type: Article

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