Role of soluble guanylate cyclase in renal hemodynamics and autoregulation in the rat

American Journal of Physiology - Renal Physiology

Volumn 307, Issue 9, 2014, Pages F1003-F1012

  Dautzenberg, Marcel ^a   Kahnert, Antje ^b   Stasch, Johannes Peter ^b   Just, Armin ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

cGMP; Cinaciguat; Glomerular filtration rate; Nitric oxide; Renal blood flow autoregulation; Renal hemodynamics; sGC activation; Soluble guanylate cyclase

Indexed keywords

CINACIGUAT; CYCLIC GMP; GUANYLATE CYCLASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; BENZOIC ACID DERIVATIVE; CELL RECEPTOR; NITRIC OXIDE; SOLUBLE GUANYLYL CYCLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; AUTOREGULATION; CONTROLLED STUDY; ENZYME INHIBITION; GLOMERULUS FILTRATION RATE; HEART RATE; INDUCED HYPOTENSION; KIDNEY BLOOD FLOW; KIDNEY CLEARANCE; KIDNEY PLASMA FLOW; KIDNEY VASCULAR RESISTANCE; MALE; MICTURITION; NONHUMAN; RAT; ANIMAL; DRUG EFFECTS; KIDNEY CIRCULATION; PHYSIOLOGY; WISTAR RAT;

ANIMALS; BENZOATES; GLOMERULAR FILTRATION RATE; GUANYLATE CYCLASE; MALE; NITRIC OXIDE; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RENAL CIRCULATION;

EID: 84908387182     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00229.2014     Document Type: Article

References (67)

1. Baumann JE, Persson PB, Ehmke H, Nafz B, Kirchheim HR. Role of endothelium-derived relaxing factor in renal autoregulation in conscious dogs. Am J Physiol Renal Fluid Electrolyte Physiol 263: F208-F213, 1992.
2. Baylis C, Deen WM, Myers BD, Brenner BM. Effects of some vasodilator drugs on transcapillary fluid exchange in renal cortex. Am J Physiol 230: 1148-1158, 1976.
3. Beierwaltes WH, Sigmon DH, Carretero OA. Endothelium modulates renal blood flow but not autoregulation. Am J Physiol Renal Fluid Electrolyte Physiol 262: F943-F949, 1992.
4. Benz K, Orth SR, Simonaviciene A, Linz W, Schindler U, Rutten H, Amann K. Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator HMR1766 on progression in a model of noninflammatory chronic renal damage. Kidney Blood Press Res 30: 224-233, 2007.
5. Bidani AK, Griffin KA, Williamson G, Wang X, Loutzenhiser R. Protective importance of the myogenic response in the renal circulation. Hypertension 54: 393-398, 2009.
6. Blantz RC, Thomson SC, Peterson OW, Gabbai FB. Physiologic adaptations of the tubuloglomerular feedback system. Kidney Int 38: 577-583, 1990.
7. Boerrigter G, Costello-Boerrigter LC, Cataliotti A, Lapp H, Stasch JP, Burnett JC, Jr. Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure. Hypertension 49: 1128-1133, 2007.
8. Boerrigter G, Costello-Boerrigter LC, Cataliotti A, Tsuruda T, Harty GJ, Lapp H, Stasch JP, Burnett JC, Jr. Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure. Circulation 107: 686- 689, 2003.
9. Bouriquet N, Casellas D. Interaction between cGMP-dependent dilators and autoregulation in rat preglomerular vasculature. Am J Physiol Renal Fluid Electrolyte Physiol 268: F338-F346, 1995.
10. Chatziantoniou C, Boffa JJ, Ardaillou R, Dussaule JC. Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice. Role of endothelin. J Clin Invest 101: 2780-2789, 1998.
11. Cupples WA, Braam B. Assessment of renal autoregulation. Am J Physiol Renal Physiol 292: F1105-F1123, 2007.
12. Dautzenberg M, Just A. Temporal characteristics of nitric oxide-, prostaglandin-, and EDHF-mediated components of endothelium-dependent vasodilation in the kidney. Am J Physiol Regul Integr Comp Physiol 305: R987-R998, 2013.
13. Dautzenberg M, Keilhoff G, Just A. Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOS. J Physiol 589: 4731-4744, 2011.
14. Deng A, Baylis C. Locally produced EDRF controls preglomerular resistance and ultrafiltration coefficient. Am J Physiol Renal Fluid Electrolyte Physiol 264: F212-F215, 1993.
15. Denton KM, Anderson WP. Intrarenal haemodynamic and glomerular responses to inhibition of nitric oxide formation in rabbits. J Physiol 475: 159-167, 1994.
16. Derbyshire ER, Marletta MA. Structure and regulation of soluble guanylate cyclase. Annu Rev Biochem 81: 533-559, 2012.
17. Dumitrascu R, Weissmann N, Ghofrani HA, Dony E, Beuerlein K, Schmidt H, Stasch JP, Gnoth MJ, Seeger W, Grimminger F, Schermuly RT. Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling. Circulation 113: 286- 295, 2006.
18. Edwards RM. Response of isolated renal arterioles to acetylcholine, dopamine, bradykinin. Am J Physiol Renal Fluid Electrolyte Physiol 248: F183-F189, 1985.
19. Erdmann E, Semigran MJ, Nieminen MS, Gheorghiade M, Agrawal R, Mitrovic V, Mebazaa A. Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure. Eur Heart J 34: 57-67, 2013.
20. Evgenov OV, Pacher P, Schmidt PM, Hasko G, Schmidt HH, Stasch JP. NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov 5: 755-768, 2006.
21. Forstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J 33: 829-837, 2012.
22. Frey R, Muck W, Unger S, Artmeier-Brandt U, Weimann G, Wensing G. Pharmacokinetics, pharmacodynamics, tolerability, and safety of the soluble guanylate cyclase activator cinaciguat (BAY 58-2667) in healthy male volunteers. J Clin Pharmacol 48: 1400-1410, 2008.
23. Garvin JL, Herrera M, Ortiz PA. Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications. Annu Rev Physiol 73: 359-376, 2011.
24. Ge Y, Gannon K, Gousset M, Liu R, Murphey B, Drummond HA. Impaired myogenic constriction of the renal afferent arteriole in a mouse model of reduced ENaC expression. Am J Physiol Renal Physiol 302: F1486-F1493, 2012.
25. Gheorghiade M, Greene SJ, Filippatos G, Erdmann E, Ferrari R, Levy PD, Maggioni A, Nowack C, Mebazaa A. Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes. Eur J Heart Fail 14: 1056-1066, 2012.
26. Greenberg SS, Diecke FP, Cantor E, Peevy K, Tanaka TP. Inhibition of sympathetic neurotransmitter release by modulators of cyclic GMP in canine vascular smooth muscle. Eur J Pharmacol 187: 409-423, 1990.
27. Griffin KA, Picken MM, Bidani AK. Deleterious effects of calcium channel blockade on pressure transmission and glomerular injury in rat remnant kidneys. J Clin Invest 96: 793-800, 1995.
28. Hoffend J, Cavarape A, Endlich K, Steinhausen M. Influence of endothelium-derived relaxing factor on renal microvessels and pressuredependent vasodilation. Am J Physiol Renal Fluid Electrolyte Physiol 265: F285-F292, 1993.
29. Ito S, Carretero OA, Abe K. Nitric oxide in the regulation of renal blood flow. New Horiz 3: 615-623, 1995.
30. Ito S, Ren Y. Evidence for the role of nitric oxide in macula densa control of glomerular hemodynamics. J Clin Invest 92: 1093-1098, 1993.
31. Just A. Mechanisms of renal blood flow autoregulation: dynamics and contributions. Am J Physiol Regul Integr Comp Physiol 292: R1-R17, 2007.
32. Just A, Arendshorst WJ. Dynamics and contribution of mechanisms mediating renal blood flow autoregulation. Am J Physiol Regul Integr Comp Physiol 285: R619-R631, 2003.
33. Just A, Arendshorst WJ. Nitric oxide blunts myogenic autoregulation in rat renal but not skeletal muscle circulation via tubuloglomerular feedback. J Physiol 569: 959-974, 2005.
34. Just A, Ehmke H, Wittmann U, Kirchheim HR. Tonic and phasic influences of nitric oxide on renal blood flow autoregulation in conscious dogs. Am J Physiol Renal Physiol 276: F442-F449, 1999.
35. Kalk P, Godes M, Relle K, Rothkegel C, Hucke A, Stasch JP, Hocher B. NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy. Br J Pharmacol 148: 853-859, 2006.
36. Klahr S. The role of nitric oxide in hypertension and renal disease progression. Nephrol Dial Transplant 16, Suppl 1: 60-62, 2001.
37. Kramer HJ, Horacek V, Backer A, Vaneckova I, Heller J. Relative roles of nitric oxide, prostanoids and angiotensin II in the regulation of canine glomerular hemodynamics. A micropuncture study. Kidney Blood Press Res 27: 10-17, 2004.
38. Lapp H, Mitrovic V, Franz N, Heuer H, Buerke M, Wolfertz J, Mueck W, Unger S, Wensing G, Frey R. Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Circulation 119: 2781-2788, 2009.
39. Lettieri JT, Scheerans C, Blunck M, Mazzu AL, Frey R, Muck W, Sundaresan PR. Assessment of the effects of renal impairment on the pharmacokinetics of the soluble guanylate cyclase activator cinaciguat after a single intravenous dose. J Clin Pharmacol 52: 1240-1247, 2012.
40. Liu R, Pittner J, Persson AE. Changes of cell volume and nitric oxide concentration in macula densa cells caused by changes in luminal NaCl concentration. J Am Soc Nephrol 13: 2688-2696, 2002.
41. Lopez B, Moreno C, Salom MG, Roman RJ, Fenoy FJ. Role of guanylyl cyclase and cytochrome P-450 on renal response to nitric oxide. Am J Physiol Renal Physiol 281: F420-F427, 2001.
42. Maack T, Atlas SA, Camargo MJ, Cogan MG. Renal hemodynamic and natriuretic effects of atrial natriuretic factor. Fed Proc 45: 2128-2132, 1986.
43. Majid DS, Navar LG. Suppression of blood flow autoregulation plateau during nitric oxide blockade in canine kidney. Am J Physiol Renal Fluid Electrolyte Physiol 262: F40-F46, 1992.
44. Majid DS, Navar LG. Nitric oxide in the control of renal hemodynamics and excretory function. Am J Hypertens 14: 74S-82S, 2001.
45. Matsumura Y, Tadano K, Yamasaki T. Renal haemodynamic and excretory responses to bradykinin in anaesthetized dogs. Clin Exp Pharmacol Physiol 26: 645-650, 1999.
46. Mueck W, Frey R. Population pharmacokinetics and pharmacodynamics of cinaciguat, a soluble guanylate cyclase activator, in patients with acute decompensated heart failure. Clin Pharmacokinet 49: 119-129, 2010.
47. Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM. Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handb Exp Pharmacol 341-366, 2009.
48. Rees DD, Palmer RMJ, Moncada S. Role of endothelium derived nitric oxide in the regulation of blood pressure. Proc Natl Acad Sci USA 86: 3357-3378, 1989.
49. Ren YL, Garvin JL, Carretero OA. Role of macula densa nitric oxide and cGMP in the regulation of tubuloglomerular feedback. Kidney Int 58: 2053-2060, 2000.
50. Schmidt A, Bayerle-Eder M, Pleiner H, Zeisner C, Wolzt M, Mayer G, Schmetterer L. The renal and systemic hemodynamic effects of a nitric oxide-synthase inhibitor are reversed by a selective endothelin(a) receptor antagonist in men. Nitric Oxide 5: 370-376, 2001.
51. Shi Y, Wang X, Chon KH, Cupples WA. Tubuloglomerular feedbackdependent modulation of renal myogenic autoregulation by nitric oxide. Am J Physiol Regul Integr Comp Physiol 290: R982-R991, 2006.
52. Stasch JP, Pacher P, Evgenov OV. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation 123: 2263-2273, 2011.
53. Stasch JP, Schmidt P, Alonso-Alija C, Apeler H, Dembowsky K, Haerter M, Heil M, Minuth T, Perzborn E, Pleiss U, Schramm M, Schroeder W, Schroder H, Stahl E, Steinke W, Wunder F. NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br J Pharmacol 136: 773-783, 2002.
54. Stasch JP, Schmidt PM, Nedvetsky PI, Nedvetskaya TY, AK HS, Meurer S, Deile M, Taye A, Knorr A, Lapp H, Muller H, Turgay Y, Rothkegel C, Tersteegen A, Kemp-Harper B, Muller-Esterl W, Schmidt HH. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest 116: 2552-2561, 2006.
55. + channel activity and vascular tone in renal arterioles. Circ Res 83: 1069-1079, 1998.
56. Thomas CE, Ott CE, Bell PD, Knox FG, Navar LG. Glomerular filtration dynamics during renal vasodilation with acetylcholine in the dog. Am J Physiol Renal Fluid Electrolyte Physiol 244: F606-F611, 1983.
57. Thomson SC, Deng A. Cyclic GMP mediates influence of macula densa nitric oxide over tubuloglomerular feedback. Kidney Blood Press Res 26: 10-18, 2003.
58. Tolins JP, Palmer RMJ, Moncada S, Raij L. Role of endothelium derived relaxing factor in regulation of renal hemodynamic responses. Am J Physiol Heart Circ Physiol 258: H655-H662, 1990.
59. Turkstra E, Braam B, Koomans HA. Nitric oxide release as an essential mitigating step in the tubuloglomerular feedback: observations during intrarenal nitric oxide clamp. J Am Soc Nephrol 9: 1596-1603, 1998.
60. Wang X, Loutzenhiser R. Determinants of renal microvascular response to ACh: afferent and efferent arteriolar actions of EDHF. Am J Physiol Renal Physiol 282: F124-F132, 2002.
61. Wang X, Salevsky FC, Cupples WA. Nitric oxide, atrial natriuretic factor, and dynamic renal autoregulation. Can J Physiol Pharmacol 77: 777-786, 1999.
62. Wang-Rosenke Y, Neumayer HH, Peters H. NO signaling through cGMP in renal tissue fibrosis and beyond: key pathway and novel therapeutic target. Curr Med Chem 15: 1396-1406, 2008.
63. Welch WJ, Wilcox CS, Thomson SC. Nitric oxide and tubuloglomerular feedback. Semin Nephrol 19: 251-262, 1999.
64. Wilcox CS, Welch WJ, Murad F, Gross SS, Taylor G, Levi R, Schmidt HH. Nitric oxide synthase in macula densa regulates glomerular capillary pressure. Proc Natl Acad Sci USA 89: 11993-11997, 1992.
65. Wronski T, Seeliger E, Persson PB, Forner C, Fichtner C, Scheller J, Flemming B. The step response: a method to characterize mechanisms of renal blood flow autoregulation. Am J Physiol Renal Physiol 285: F758- F764, 2003.
66. Zanzinger J. Role of nitric oxide in the neural control of cardiovascular function. Cardiovasc Res 43: 639-649, 1999.
67. Zatz R, De Nucci G. Effects of acute nitric oxide inhibition on rat glomerular microcirculation. Am J Physiol Renal Fluid Electrolyte Physiol 261: F360-F363, 1991.