Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice

Cancer Letters

Volumn 353, Issue 1, 2014, Pages 32-40

  Huang, Minzhao ^a   Tang, Su Ni ^a   Upadhyay, Ghanshyam ^a   Marsh, Justin L ^b   Jackman, Christopher P ^b   Srivastava, Rakesh K ^a   Shankar, Sharmila ^c  

^a UNIVERSITY OF KANSAS CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Akt; Cancer prevention; Notch; Pancreatic cancer; Rottlerin; Sonic Hedgehog

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLOOXYGENASE 2; GELATINASE A; GELATINASE B; INTERLEUKIN 8; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH RECEPTOR; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; ROTTLERIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; ACETOPHENONE DERIVATIVE; ANGIOGENESIS INHIBITOR; ANGIOGENIC PROTEIN; APOPTOSIS REGULATORY PROTEIN; BENZOPYRAN DERIVATIVE; PROTEIN KINASE INHIBITOR; SHH PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; EPITHELIAL MESENCHYMAL TRANSITION; IMMUNOHISTOCHEMISTRY; METASTASIS INHIBITION; MITOSIS INHIBITION; MOUSE; NICK END LABELING; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; WESTERN BLOTTING; AKT; ANIMAL; BAGG ALBINO MOUSE; CANCER PREVENTION; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENETICS; HUMAN; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NOTCH; NUDE MOUSE; ONCOGENE RAS; PANCREAS TUMOR; PATHOLOGY; TIME; TRANSGENIC MOUSE; TUMOR CELL LINE; TUMOR VOLUME;

ERINACEIDAE; GASTROPODA; MUS; MUS MUSCULUS;

AKT; CANCER PREVENTION; NOTCH; PANCREATIC CANCER; ROTTLERIN; SONIC HEDGEHOG;

ACETOPHENONES; ANGIOGENESIS INHIBITORS; ANGIOGENIC PROTEINS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BENZOPYRANS; CELL LINE, TUMOR; CELL PROLIFERATION; EPITHELIAL-MESENCHYMAL TRANSITION; GENES, RAS; HEDGEHOG PROTEINS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MICE, TRANSGENIC; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR BURDEN; TUMOR MICROENVIRONMENT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84908375754     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.06.021     Document Type: Article

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