Over-expression of Oct4 and Sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo

Biochemical and Biophysical Research Communications

Volumn 451, Issue 4, 2014, Pages 503-509

  Guseva, Daria ^a,b   Rizvanov, Albert A ^c   Salafutdinov, Ilnur I ^c   Kudryashova, Nezhdana V ^c   Palotás, András ^c,d   Islamov, Rustem R ^a  

^a KAZAN STATE MEDICAL UNIVERSITY   (Russian Federation)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c KAZAN FEDERAL UNIVERSITY   (Russian Federation)

^d Asklepios Med (private medical practice and research center)   (Hungary)

Author keywords

Amyotrophic lateral sclerosis; Differentiation; Pluripotency; Transcription factor; Umbilical cord blood mono nuclear cell

Indexed keywords

KRUPPEL LIKE FACTOR 4; MESSENGER RNA; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; POU5F1 PROTEIN, HUMAN; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENDOTHELIAL PROGENITOR CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALIGNANT TRANSFORMATION; MESENCHYMAL STEM CELL; MONONUCLEAR CELL; NERVE CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SKELETAL MUSCLE; UMBILICAL CORD BLOOD; ANIMAL; BIOSYNTHESIS; CELL DEDIFFERENTIATION; CYTOLOGY; DIFFERENTIATION; DISEASE MODEL; FETUS BLOOD; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE; PLURIPOTENCY; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; UMBILICAL CORD BLOOD MONO-NUCLEAR CELL;

AMYOTROPHIC LATERAL SCLEROSIS; DIFFERENTIATION; PLURIPOTENCY; TRANSCRIPTION FACTOR; UMBILICAL CORD BLOOD MONO-NUCLEAR CELL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; FETAL BLOOD; HUMANS; MICE; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; REGENERATIVE MEDICINE; SOXB1 TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84908367410     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.07.132     Document Type: Article

References (34)

1. N. Maherali Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution Cell Stem Cell 1 1 2007 55 70
2. K. Okita, T. Ichisaka, and S. Yamanaka Generation of germline-competent induced pluripotent stem cells Nature 448 7151 2007 313 317
3. M. Wernig In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state Nature 448 7151 2007 318 324
4. J. Hanna Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin Science 318 5858 2007 1920 1923
5. K. Takahashi Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 5 2007 861 872
6. J. Yu Induced pluripotent stem cell lines derived from human somatic cells Science 318 5858 2007 1917 1920
7. J.T. Dimos Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons Science 321 5893 2008 1218 1221
8. I.V. Chestkov Patient-specific induced pluripotent stem cells for SOD1-associated amyotrophic lateral sclerosis pathogenesis studies Acta Nat. 6 1 2014 54 60
9. M.P. Kashyap Differentiating neurons derived from human umbilical cord blood stem cells work as a test system for developmental neurotoxicity Mol. Neurobiol. 2014
10. A.A. Rizvanov Genetically modified human umbilical cord blood cells expressing vascular endothelial growth factor and fibroblast growth factor 2 differentiate into glial cells after transplantation into amyotrophic lateral sclerosis transgenic mice Exp. Biol. Med. (Maywood) 236 1 2011 91 98
11. A.A. Rizvanov Human umbilical cord blood cells transfected with VEGF and L(1)CAM do not differentiate into neurons but transform into vascular endothelial cells and secrete neuro-trophic factors to support neuro-genesis-a novel approach in stem cell therapy Neurochem. Int. 53 6-8 2008 389 394
12. M.E. Yalvac Isolation and characterization of stem cells derived from human third molar tooth germs of young adults: implications in neo-vascularization, osteo-, adipo- and neurogenesis Pharmacogenom. J. 10 2 2010 105 113
13. D. Guseva Ablation of adhesion molecule L1 in mice favours Schwann cell proliferation and functional recovery after peripheral nerve injury Brain: J. Neurol. 132 Pt 8 2009 2180 2195
14. D.T. Harris, and I. Rogers Umbilical cord blood: a unique source of pluripotent stem cells for regenerative medicine Curr. Stem Cell Res. Ther. 2 4 2007 301 309
15. Y.H. Loh The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells Nat. Genet. 38 4 2006 431 440
16. S. Garbuzova-Davis Intravenous administration of human umbilical cord blood cells in a mouse model of amyotrophic lateral sclerosis: distribution, migration, and differentiation J. Hematother. Stem Cell Res. 12 3 2003 255 270
17. C.E. Ang, and M. Wernig Induced neuronal reprogramming J. Comp. Neurol. 2014
18. I. Wilmut Viable offspring derived from fetal and adult mammalian cells Nature 385 6619 1997 810 813
19. C.A. Cowan Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells Science 309 5739 2005 1369 1373
20. J. Nichols Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4 Cell 95 3 1998 379 391
21. A.A. Avilion Multipotent cell lineages in early mouse development depend on SOX2 function Genes Dev. 17 1 2003 126 140
22. K. Mitsui The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells Cell 113 5 2003 631 642
23. H. Niwa Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3 Genes Dev. 12 13 1998 2048 2060
24. K. Takahashi, K. Mitsui, and S. Yamanaka Role of ERas in promoting tumour-like properties in mouse embryonic stem cells Nature 423 6939 2003 541 545
25. P. Cartwright LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism Development 132 5 2005 885 896
26. Y. Li Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4 Blood 105 2 2005 635 637
27. M.F. Kielman Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling Nat. Genet. 32 4 2002 594 605
28. S. Yamanaka Strategies and new developments in the generation of patient-specific pluripotent stem cells Cell Stem Cell 1 1 2007 39 49
29. N. Yang Induced neuronal cells: how to make and define a neuron Cell Stem Cell 9 6 2011 517 525
30. M. Caiazzo Direct generation of functional dopaminergic neurons from mouse and human fibroblasts Nature 476 7359 2011 224 227
31. T. Vierbuchen Direct conversion of fibroblasts to functional neurons by defined factors Nature 463 7284 2010 1035 1041
32. K. Shimozaki Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures Development 130 11 2003 2505 2512
33. T. Wang Derivation of neural stem cells from human adult peripheral CD34+ cells for an autologous model of neuroinflammation PLoS One 8 11 2013 e81720
34. F.K. Lin, and Y.L. Chui Generation of induced pluripotent stem cells from mouse cancer cells Cancer Biother. Radiopharm. 27 10 2012 694 700