Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats

Ecotoxicology and Environmental Safety

Volumn 74, Issue 7, 2011, Pages 2105-2111

  Shagirtha, Kalist ^a   Pari, Leelavinothan ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidants; ATPases; Cadmium; Hesperetin; Testis

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (MAGNESIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIOXIDANT; CADMIUM; CATALASE; GLUCOSE 6 PHOSPHATE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HESPERETIN; MEMBRANE ENZYME; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THYROTROPIN;

ANTIOXIDANT; CADMIUM; HISTOPATHOLOGY; MEMBRANE; RODENT; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CLINICAL EVALUATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MEMBRANE BINDING; NONHUMAN; OXIDATIVE STRESS; RAT; TESTICULAR TOXICITY; TESTIS DISEASE; TESTIS WEIGHT;

ANIMALS; ANTIOXIDANTS; CADMIUM; CADMIUM CHLORIDE; CITRUS; HESPERIDIN; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; RATS; RATS, WISTAR; TESTICULAR DISEASES; TESTIS;

CITRUS; RATTUS;

EID: 80053130244     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2011.06.002     Document Type: Article

References (55)

1. Ameer B., Weintraub R.A., Johnson J.V., Yost R.A., Rouseff R.L. Flavanone absorption after naringin, hesperidin, and citrus administration. Clin. Pharmacol. Ther. 1996, 60:34-40.
2. Aranganathan S., Nalini N. Efficacy of the potential chemopreventive agent, hesperetin (citrus flavonone) on 1,2-dimethylhydrazine induced colon carcinogenesis. Food Chem. Toxicol. 2009, 47:2594-2600.
3. Bartsch H., Nair J. Ultrasensitive and specific detection method for exocyclic DNA adducts: markers for lipid peroxidation and oxidative stress. Toxicology 2000, 153:105-114.
4. Beutler E. Active transport of glutathione disulfide from erythrocytes. Functions of Glutathione, Biochemical Physiological, Toxicological and Clinical Aspects 1983, 65. Raven Press, New York, USA. A. Larson, S. Orrenius, A. Holmgren, B. Mannerwik (Eds.).
5. Bonting S.L. Presence of enzyme system in mammalian tissues. Membrane and Ion Transport 1970, 257-263. Wiley Inter Science, London. E.E. Bilter (Ed.).
6. Cai Y.Z., Luo Q., Sun M., Corke H. Antioxidant activity and phenolic compounds of 112 traditional. Life Sci. 2004, 74:2157-2184.
7. Casalino E., Calzaretti G., Sblano L., Landriscina C. Cadmium dependent enzyme activity alteration is not imputable to lipid peroxidation. Arch. Biochem. Biophys. 2000, 383:288-295.
8. Duncan B.D. Multiple range test for correlated and heteroscedastic means. Biometrics 1957, 13:359-364.
9. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
10. Evans D.J. Membrane adenosine triphosphatase of E. coli activation by calcium ions and inhibition by monovalent cations. J. Bacteriol. 1969, 100:914-922.
11. Fiske C.H., Subbarow Y. The colorimetric determination of phosphorus. J. Biol. Chem. 1925, 66:375-400.
12. Galati E.M., Trovato A., Kirjavainen S., Forestieri A.M., Rossitto A., Monforte M.T. Biological effects of hesperidin, a citrus flavonoid. (Note III): antihypertensive and diuretic activity in rat. Farmaco 1996, 51:219-221.
13. Garg A., Garg S., Zaneveld L.J., Singla A.K. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother. Res. 2001, 15:655-669.
14. Gil-Izquierdo A., Gil M.I., Ferreres F., Tomas-Barberan F.A. In vitro availability of flavonoids and other phenolics in orange juice. J. Agric. Food Chem. 2001, 49:1035-1041.
15. Habig W.H., Pabst M.L., Jakpoly W.B. Glutathione transferase: a first enxymatic step in mercapturic acid and formation. J. Biol. Chem. 1974, 249:7130-7139.
16. Heim K.E., Tagliafero A.R., Bobilya D.J. Flavonoid antioxidants: chemistry, metabolism and structure activity relationship. J. Nutr. Biochem. 2002, 13:572-584.
17. +-ATPase activity possibly regulated by a specific serotonin receptor. Brain Res. 1989, 408:399-402.
18. 2+-ATPase from erythrocyte membranes. Biochem. Biophys. Acta 1983, 728:281-288.
19. Horn H.D., Burns F.H. Assay of glutathione reductase activity. Methods of Enzymatic Analysis 1978, 142-146. Academic Press, New York, USA. H.V. Bergemeyer (Ed.).
20. Jiang Z.Y., Hunt J.V., Wolff S.D. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal. Biochem. 1992, 202:384-389.
21. Kakkar P., Das B., Viswanathan P.N. A modified spectroscopic assay of superoxide dismutase. Indian J. Biochem. Biophys. 1984, 21:130-132.
22. Kim J.Y., Jung K.J., Choi J.S., Chong H.Y. Hesperetin: potent antioxidant against peroxynitrite. Free Radical Res. 2004, 38:761-769.
23. Koyuturk M., Yanardag R., Bolkent S., Tunali S. Influence of combined antioxidants against cadmium induced testicular damage. Environ. Toxicol. Pharmacol. 2006, 21:235-240.
24. Lauwerys R. Cadmium in man. Chemistry, Biochemistry and Biology of Cadmium 1979, Elsevier, Biomedical Press, Amsterdam, North Holand. M. Webb (Ed.).
25. Lee N.K., Choi S.H., Park S.H., Park E.K., Kim D.H. Antiallergic activity of hesperidin is activated by intestinal microflora. Pharmacology 2004, 71:174-180.
26. Levine R.L., Garland D., Oliver C.N., Amic A., Climent I., Lenz A.G. Determination of carbonyl content in oxidatively modified proteins. Method Enzymol. 1999, 186:464-478.
27. Li L., Heindel J. Sertoli cell toxicants. Reprod. Dev. Toxicol. 1998, Marcel Dekker, New York. K. Korach (Ed.).
28. Lowry O.H., Rosenbrough N.J., Farr A.I., Ramdall R.J. Protein measurement with folin-phenol reagent. J. Biol. Chem. 1951, 193:265-275.
29. Martin L.J., Chen H., Liao X., Allayee H., Shih D.M., Lee G.S., Hoyland D.N., Robbins W.A., Carnes K., Hess R.A., Lusis A.J., Collins M.D. FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice. Toxicol. Sci. 2007, 100:474-485.
30. Mata M., Fink D.J., Gainer H., Smith C.B., Davidsen L., Savakis H., Schwartz W.J., Sokoloff L. Activity-dependent energy metabolism in rat posterior pituitary, primarily reflects sodium pump activity. J. Neurochem. 1980, 34:214-215.
31. Milton Prabu S., Shagirtha K., Muthumani M. The protective role of S-allylmercaptocysteine against cadmium induced changes in sperm characteristics and testicular oxidative damage in rats. J. Pharm. Res. 2010, 3(11):2717-2721.
32. Moron M.S., Despierre J.W., Minnervik B. Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim. Biophys. Acta 1979, 582:67-78.
33. Murugavel P., Pari L. Protective role of diallyl tetrasulfide on cadmium induced testicular damage in adult rats: a biochemical and histological study. Toxicol. Ind. Health 2011, 27:407-416.
34. Niehius W.G., Samuelson B. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur. J. Biochem. 1968, 6:126-130.
35. 2+-ATPase activities in normal, regenerating and malignant cells. Biochem. Biophys. Acta 1982, 684:67-74.
36. Oteiza P.I., Adonaylo V.N., Keen C.L. Cadmium-induced testes oxidative damage in rats can be influenced by dietary zinc intake. Toxicology 1999, 137:13-22.
37. Pari L., Murugavel P. Role of diallyl tetrasulfide in ameliorating the cadmium induced biochemical changes in rats. Environ. Toxicol. Pharmacol. 2005, 20:493-500.
38. Pari L., Shagirtha K. Hesperetin protects against oxidative stress related hepatic dysfunction by cadmium in rats. Exp. Toxicol. Pathol 2010, 10.1016/j.etp.2010.11.007.
39. Pollard S.E., Whiteman M., Spencer J.P. Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signaling. Biochem. Biophys. Res. Commun. 2006, 347:916-923.
40. Quig D. Cysteine metabolism and metal toxicity. Altern. Med. Rev. 1998, 3:262-270.
41. Rotruck J.T., Pope A.L., Ganther H.E. Selenium: biochemical role as a component of glutathione peroxidase purification assay. Science 1973, 179:588-590.
42. Santos F.W., Oro T., Zeni G., Rocha J.B., do Nascimento P.C., Nogueira C.W. Cadmium induced testicular damage and its response to administration of succimer and diphenyl diselenide in mice. Toxicol. Lett. 2004, 152:255-263.
43. Selvakumar E., Prahalathan E., Mythili Y., Varalakshmi P. Protective effect of dl-α-lipoic acid in cyclophosphamide induced oxidative injury in rat testis. Reprod. Toxicol. 2004, 19:163-167.
44. Shagirtha, K., Pari, L. Hesperetin, a citrus flavonone, attenuates cadmium-induced nephrotoxicity in rat. Biomed. Prev. Nutr., in press. doi:. http://10.1016/j.bionut.2011.02.005.
45. Sharma R.K., Agarwal A. Role of reactive oxygen species in male infertility. Urology 1996, 48:835-850.
46. Sikka S.C. Relative impact of oxidative stress on male reproductive function. Curr. Med. Chem. 2001, 8:851-862.
47. Sinha A.K. Colorimetric assay of catalase. Anal. Biochem. 1972, 47:389-394.
48. Spencer J.P., Abd-el-Mohsen M.M., Rice-Evans C. Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity. Arch. Biochem. Biophys. 2004, 423:148-161.
49. Szuster-Ciesielska A., Stachura A., Slotwinska M., Kaminska T., Sneizko R., Paduch R., Abramczyk D., Filar J., Kandefer-Szerszen M. The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology 2000, 145:159-171.
50. Thompson J., Bannigan J. Cadmium: toxic effects on the reproductive system and the embryo. Reprod. Toxicol. 2008, 25:304-315.
51. Trivedi P.P., Tripathi D.N., Jena G.B. Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFk{cyrillic}B, p38 and caspase-3. Food Chem. Toxicol. 2011, 49(4):838-847.
52. Watjen W., Beyersmann D. Cadmium-induced apoptosis in C6 glioma cells: influence of oxidative stress. Biometals 2004, 17:65-68.
53. Yadav N., Dogra R.K., Khan M.Y., Khandelwal S. Prevention of acute cadmium toxicity by picroliv. Hum. Exp. Toxicol. 2005, 24:529-536.
54. Yang H.S., Han D.K., Kim J.R., Sin J.C. Effect of a-tocopherol on cadmium induced toxicity in rat testis and spermatogenesis. J. Korean Med. Sci. 2006, 21:445-451.
55. Yasuda M., Miwa A., Kitagawa M. Morphotometric studies of renal lesions in itai-itai disease: chronic cadmium nephropathy. Nephron 1995, 69:14-19.