Antinociceptive effects of amiloride and benzamil in neuropathic pain model rats

Journal of Korean Medical Science

Volumn 28, Issue 8, 2013, Pages 1238-1243

  Jeong, Seongtae ^a   Lee, Seong Heon ^a   Kim, Yeo Ok ^a   Yoon, Myung Ha ^a  

^a Chonnam National University   (South Korea)

Author keywords

Acid sensing ion channels; Amiloride; Benzamil; Spinal cord dorsal horn; Spinal nerve ligation

Indexed keywords

ACID SENSING ION CHANNEL; AMILORIDE; ANALGESIC AGENT; BENZAMIL; DRUG DERIVATIVE; MESSENGER RNA;

ANIMAL; ARTICLE; DISEASE MODEL; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETICS; MALE; METABOLISM; NEURALGIA; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL NERVE LIGATION; SPRAGUE DAWLEY RAT;

ACID SENSING ION CHANNELS; AMILORIDE; BENZAMIL; SPINAL CORD DORSAL HORN; SPINAL NERVE LIGATION;

ACID SENSING ION CHANNELS; AMILORIDE; ANALGESICS; ANIMALS; DISEASE MODELS, ANIMAL; MALE; NEURALGIA; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD; TRANSCRIPTION, GENETIC;

EID: 84884358397     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2013.28.8.1238     Document Type: Article

References (40)

1. Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 2008; 70: 1630-5.
2. Wallace JM. Update on pharmacotherapy guidelines for treatment of neuropathic pain. Curr Pain Headache Rep 2007; 11: 208-14.
3. Rocha-González HI, Castañeda-Corral G, Araiza-Saldaña CI, Ambriz-Tututi M, Caram-Salas NL, Torres-López JE, Murbartián J, Granados-Soto V. Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception. Neuroscience 2009; 160: 156-64.
4. Page AJ, Brierley SM, Martin CM, Hughes PA, Blackshaw LA. Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain 2007; 133: 150-60.
5. Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, Shimada S. Amilorideblockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J Clin Invest 2002; 110: 1185-90.
6. Colombo E, Francisconi S, Faravelli L, Izzo E, Pevarello P. Ion channel blockers for the treatment of neuropathic pain. Future Med Chem 2010; 2: 803-42.
7. Krishtal O. The ASICs: signaling molecules? modulators? Trends Neurosci 2003; 26: 477-83.
8. Dubé GR, Elagoz A, Mangat H. Acid sensing ion channels and acid nociception. Curr Pharm Des 2009; 15: 1750-66.
9. Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu TL. Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem 2004; 279: 43716-24.
10. Mazzuca M, Heurteaux C, Alloui A, Diochot S, Baron A, Voilley N, Blondeau N, Escoubas P, Gélot A, Cupo A, et al. A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat Neurosci 2007; 10: 943-5.11. Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci 2007; 27: 11139-48.
11. Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci 2007; 27:11139-48.
12. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983; 16: 109-10.
13. Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 1992; 50: 355-63.
14. Calcutt NA, Jorge MC, Yaksh TL, Chaplan SR. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain 1996; 68: 293-9.
15. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 17: 1031-6.
16. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994; 53: 55-63.
17. Tallarida RJ. Drug synergism and dose-effect data analysis. New York: Chapman & Hall/CRC, 2000.
18. Lee HG, Park SK, Yoon MH. Potentiation of morphine antiallodynic efficacy by ACPT-III, a group III metabotropic glutamate receptor agonist, in rat spinal nerve ligation-induced neuropathic pain. Pharmacol Biochem Behav 2010; 96: 108-13.
19. Kellenberger S, Schild L. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev 2002; 82: 735-67.
20. Lingueglia E. Acid-sensing ion channels in sensory perception. J Biol Chem 2007; 282: 17325-9.
21. Rocha-González HI, Herrejon-Abreu EB, López-Santillán FJ, García-López BE, Murbartián J, Granados-Soto V. Acid increases inflammatory pain in rats: effect of local peripheral ASICs inhibitors. Eur J Pharmacol 2009; 603: 56-61.
22. Walder RY, Rasmussen LA, Rainier JD, Light AR, Wemmie JA, Sluka KA. ASIC1 and ASIC3 play different roles in the development of hyperalgesia after inflammatory muscle injury. J Pain 2010; 11: 210-8.
23. Wultsch T, Painsipp E, Shahbazian A, Mitrovic M, Edelsbrunner M, Lazdunski M, Waldmann R, Holzer P. Deletion of the acid-sensing ion channel ASIC3 prevents gastritis-induced acid hyperresponsiveness of the stomach-brainstem axis. Pain 2008; 134: 245-53.
24. Baron A, Voilley N, Lazdunski M, Lingueglia E. Acid sensing ion channels in dorsal spinal cord neurons. J Neurosci 2008; 28: 1498-508.
25. Matricon J, Gelot A, Etienne M, Lazdunski M, Muller E, Ardid D. Spinal cord plasticity and acid-sensing ion channels involvement in a rodent model of irritable bowel syndrome. Eur J Pain 2011; 15: 335-43.
26. Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem 2004; 279: 46962-8.
27. Deval E, Noël J, Lay N, Alloui A, Diochot S, Friend V, Jodar M, Lazdunski M, Lingueglia E. ASIC3 a sensor of acidic and primary inflammatory pain. EMBO J 2008; 27: 3047-55.
28. Ikeuchi M, Kolker SJ, Sluka KA. Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis. J Pain 2009; 10: 336-42.
29. Sluka KA, Radhakrishnan R, Benson CJ, Eshcol JO, Price MP, Babinski K, Audette KM, Yeomans DC, Wilson SP. ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation. Pain 2007; 129: 102-12.
30. Yuan FL, Chen FH, Lu WG, Li X. Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis. Mol Biol Rep 2010; 37: 3233-8.
31. Borzan J, Zhao C, Meyer RA, Raja SN. A role for acid-sensing ion channel 3, but not acid-sensing ion channel 2, in sensing dynamic mechanical stimuli. Anesthesiology 2010; 113: 647-54.
32. Alexander SP, Mathie A, Peters JA. Guide to Receptors and Channels (GRAC), 3rd edition. Br J Pharmacol 2008; 153: S1-209.
33. Craner MJ, Hains BC, Lo AC, Black JA, Waxman SG. Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE. Brain 2004; 127: 294-303.
34. Stys PK, Waxman SG, Ransom BR. Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger. J Neurosci 1992; 12: 430-9.
35. Muthuraman A, Jaggi AS, Singh N, Singh D. Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats. Eur J Pharmacol 2008; 587: 104-11.
36. Jagodic MM, Pathirathna S, Joksovic PM, Lee W, Nelson MT, Naik AK, Su P, Jevtovic-Todorovic V, Todorovic SM. Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol 2008; 99: 3151-6.
37. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res 2002; 951: 336-40.
38. Wen XJ, Xu SY, Chen ZX, Yang CX, Liang H, Li H. The roles of T-type calcium channel in the development of neuropathic pain following chronic compression of rat dorsal root ganglia. Pharmacology 2010; 85: 295-300.
39. Li WG, Yu Y, Zhang ZD, Cao H, Xu TL. ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol Pain 2010; 6: 88.
40. Yu Y, Chen Z, Li WG, Cao H, Feng EG, Yu F, Liu H, Jiang H, Xu TL. A nonproton ligand sensor in the acid-sensing ion channel. Neuron 2010; 68: 61-72