Hyperplasticity in Autism Spectrum Disorder confers protection from Alzheimer's disease

Medical Hypotheses

Volumn 83, Issue 3, 2014, Pages 337-342

  Oberman, Lindsay M ^a   Pascual Leone, Alvaro ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; ALZHEIMER DISEASE; ARTICLE; ASPERGER SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPERPLASTICITY; INTELLIGENCE QUOTIENT; MALE; NERVE CELL PLASTICITY; NERVE EXCITABILITY; NEUROMODULATION; PREDICTOR VARIABLE; PROTECTION; TRANSCRANIAL MAGNETIC STIMULATION; ADOLESCENT; AGING; AUTISM; BRAIN; CASE CONTROL STUDY; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; COMPLICATION; MIDDLE AGED; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; REGRESSION ANALYSIS; YOUNG ADULT;

ANIMALIA;

ADOLESCENT; ADULT; AGING; ALZHEIMER DISEASE; AUTISM SPECTRUM DISORDER; BRAIN; CASE-CONTROL STUDIES; COGNITION; COGNITION DISORDERS; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEURONAL PLASTICITY; PHENOTYPE; REGRESSION ANALYSIS; TRANSCRANIAL MAGNETIC STIMULATION; YOUNG ADULT;

EID: 84908356197     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2014.06.008     Document Type: Article

References (21)

1. Baio J. Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities Monitoring Network, 11 Sites, United States, 2010. MMWR Surveillance Summary 2014, 63(SS02):1-21.
2. Folstein S.E., Rosen-Sheidley B. Genetics of autism: complex aetiology for a heterogeneous disorder. Nat Rev Genet 2001, 2(12):943-955.
3. Veenstra-VanderWeele J., Cook E.H. Molecular genetics of autism spectrum disorder. Mol Psychiatry 2004, 9(9):819-832.
4. APA Diagnostic and Statistical Manual of Mental Disorders (4th Edition) (DSM-IV) 1994, American Psychiatric Association, Washington DC.
5. Walsh C.A., Morrow E.M., Rubenstein J.L. Autism and brain development. Cell 2008, 135(3):396-400.
6. Markram H., Rinaldi T., Markram K. The intense world syndrome - an alternative hypothesis for autism. Front Neurosci 2007, 1(1):77-96.
7. Dolen G., Bear M.F. Fragile x syndrome and autism: from disease model to therapeutic targets. J Neurodev Disord 2009, 1(2):133-140.
8. Rubenstein J.L., Merzenich M.M. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav 2003, 2(5):255-267.
9. Oberman LM, Rotenberg A, Pascual-Leone A, editors. Aberrant brain plasticity in autism spectrum disorders. Tracy BHJ, Sathian K, editors. Plasticity of cognition in neurologic disorders, New York: Oxford University Press; in press.
10. Pascual-Leone A., et al. The plastic human brain cortex. Annu Rev Neurosci 2005, 28:377-401.
11. Pascual-Leone A., et al. Characterizing brain cortical plasticity and network dynamics across the age-span in health and disease with TMS-EEG and TMS-fMRI. Brain Topogr 2011, 24(3-4):302-315.
12. Freitas C., et al. Changes in cortical plasticity across the lifespan. Front Aging Neurosci 2011, 3:5.
13. Freitas C., Mondragon-Llorca H., Pascual-Leone A. Noninvasive brain stimulation in Alzheimer's disease: systematic review and perspectives for the future. Exp Gerontol 2011, 46(8):611-627.
14. Koch G., et al. Impaired LTP- but not LTD-like cortical plasticity in Alzheimer's disease patients. J Alzheimers Dis 2012, 31(3):593-599.
15. Oberman L., et al. Abnormal modulation of corticospinal excitability in adults with Asperger's syndrome. Eur J Neurosci 2012, 36(6):2782-2788.
16. Rossi S., et al. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 2009, 120(12):2008-2039.
17. Huang Y.Z., Edwards M.J., Rounis E., Bhatia K.P., Rothwell J.C. Theta burst stimulation of the human motor cortex. Neuron 2005, 45:201-206.
18. Borghetti D., et al. Transcranial magnetic stimulation mapping: a model based on spline interpolation. Brain Res Bull 2008, 77(2-3):143-148.
19. Freitas C., Farzan F., Pascual-Leone A. Assessing brain plasticity across the lifespan with transcranial magnetic stimulation: why, how, and what is the ultimate goal?. Front Neurosci 2013, 7:42.
20. Hebert L.E., Scherr P.A., Bienias J.L., Bennett D.A., Evans D.A. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 2003, 60:1119-1122.
21. Oberman L., Pascual-Leone A. Cortical plasticity: a proposed mechanism by which genomic factors lead to the behavioral and neurological phenotype of autism spectrum and psychotic spectrum disorders. Behav Brain Sci 2008, 31:241-320.