Impaired LTP-but not LTD-like cortical plasticity in Alzheimer's disease patients

Journal of Alzheimer's Disease

Volumn 31, Issue 3, 2012, Pages 593-599

  Koch, Giacomo ^a,b   Di Lorenzo, Francesco ^a,b   Bonnì, Sonia ^a   Ponzo, Viviana ^a   Caltagirone, Carlo ^a,b   Martorana, Alessandro ^a,b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Alzheimer's disease; cortical plasticity; long term potentiation; transcranial magnetic stimulation

Indexed keywords

ALZHEIMER DISEASE; ARTICLE; BRAIN DEPTH STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MODEL; FEMALE; HUMAN; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MALE; MUSCLE CONTRACTION; NERVE CELL PLASTICITY; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 84865579936     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120532     Document Type: Article

References (25)

1. Braak H, Braak E (1991) Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections. Brain Pathol 1, 213-216.
2. DeKosky ST, Scheff SW (1990) Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity. Ann Neurol 27, 457-464. (Pubitemid 20149963)
3. Francis PT (2003) Glutamatergic systems in Alzheimer's disease. Int J Geriatr Psychiatry 18, S15-S21. (Pubitemid 37150474)
4. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
5. Klyubin I, Wang Q, Reed MN, Irving EA, Upton N, Hofmeister J, Cleary JP, Anwyl R, Rowan MJ (2009) Protection against Abeta-mediated rapid disruption of synaptic plasticity and memory by memantine. Neurobiol Aging 32, 614-623.
6. Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D (2009) Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 62, 788-801.
7. Palop JJ, Mucke L Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: From synapses toward neural networks. Nat Neurosci 13, 812-818.
8. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14, 837-842.
9. Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, van Leuven F, Lucassen PJ (2006) Improved longterm potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. J Neurosci 26, 3514-3523.
10. Ondrejcak T, Klyubin I, Hu NW, Barry AE, Cullen WK, Rowan MJ (2010) Alzheimer's disease amyloid beta-protein and synaptic function. Neuromolecular Med 12, 13-26.
11. Selkoe DJ (2008) Soluble oligomers of the amyloid betaprotein impair synaptic plasticity and behavior. Behav Brain Res 192, 106-113.
12. Huang YZ, Rothwell JC, Lu CS, Chuang WL, ChenRS (2011) Abnormal bidirectional plasticity-like effects in Parkinson's disease. Brain 134, 2312-2320.
13. Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC (2005) Theta burst stimulation of the human motor cortex. Neuron 45, 201-206. (Pubitemid 40128115)
14. Varma AR, Snowden JS, Lloyd JJ, Talbot PR, Mann DM, Neary D (1999) Evaluation of the NINCDS-ADRDA criteria in the differentiation of Alzheimer's disease and frontotemporal dementia. J Neurol Neurosurg Psychiatry 66, 184-188. (Pubitemid 29103519)
15. Carlesimo GA, Caltagirone C, Gainotti G (1996) The Mental Deterioration Battery: Normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery. Eur Neurol 36, 378-384. (Pubitemid 26343685)
16. Rossini PM, Barker AT, Berardelli A, Caramia MD, Caruso G, Cracco RQ, Dimitrijevic MR, Hallett M, Katayama Y, Lucking CH, et al. (1994) Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: Basic principles and procedures for routine clinical application. Report of an IFCN committee. Electroencephalogr Clin Neurophysiol 91, 79-92. (Pubitemid 24246462)
17. Freitas C, Mondragon-Llorca H, Pascual-Leone A (2011) Noninvasive brain stimulation in Alzheimer's disease: Systematic review and perspectives for the future. Exp Gerontol 46, 611-627.
18. Battaglia F, Wang HY, Ghilardi MF, Gashi E, Quartarone A, Friedman E, Nixon RA (2007) Cortical plasticity in Alzheimer's disease in humans and rodents. Biol Psychiatry 62, 1405-1412. (Pubitemid 350180725)
19. Inghilleri M, Conte A, Frasca V, Scaldaferri N, Gilio F, Santini M, Fabbrini G, Prencipe M, Berardelli A (2006) Altered response to rTMS in patients with Alzheimer's disease. Clin Neurophysiol 117, 103-109. (Pubitemid 43099956)
20. Klyubin I, Betts V, Welzel AT, et al. (2008) Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: Prevention by systemic passive immunization. J Neurosci 28, 4231-4237.
21. Proctor DT, Coulson EJ, Dodd PR (2011) Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer's disease. Prog Neurobiol 93, 509-521.
22. Yan JH, Rountree S, Massman P, Doody RS, Li H (2008) Alzheimer's disease and mild cognitive impairment deteriorate fine movement control. J Psychiatr Res 42, 1203-1212.
23. Thut G, Veniero D, Romei V, Miniussi C, Schyns P, Gross J (2011) Rhythmic TMS causes local entrainment of natural oscillatory signatures. Curr Biol 21, 1176-1185.
24. Kim JH, Anwyl R, Suh YH, Djamgoz MB, Rowan MJ (2001) Use-dependent effects of amyloidogenic fragments of (beta)-amyloid precursor protein on synaptic plasticity in rat hippocampus in vivo. J Neurosci 21, 1327-1333. (Pubitemid 32128777)
25. Koch G, Esposito Z, Kusayanagi H, Monteleone F, Codeca C, Di Lorenzo F, Caltagirone C, Bernardi G, MartoranaA (2011) CSF tau levels influence cortical plasticity in Alzheimer's disease patients. J Alzheimers Dis 26, 181-186.