A peptide targeting an interaction interface disrupts the dopamine D1-D2 receptor heteromer to block signaling and function in vitro and in vivo: Effective selective antagonism

FASEB Journal

Volumn 28, Issue 11, 2014, Pages 4806-4820

  Hasbi, Ahmed ^a,b   Perreault, Melissa L ^a,b   Shen, Maurice Y F ^a,b   Zhang, Lucia ^b   To, Ryan ^b   Fan, Theresa ^a,b   Nguyen, Tuan ^a,b   Ji, Xiaodong ^b   O'Dowd, Brian F ^a,b   George, Susan R ^a,b,c  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Behavioral despair; Depression; GPCR Oligomerization; Heterooligomer

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; GLUTAMIC ACID; DOPAMINE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; PEPTIDE;

ADULT; AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CELL SURFACE; CONTROLLED STUDY; CORPUS STRIATUM; DENDRITE; EXTRACELLULAR CALCIUM; FLUORESCENCE RESONANCE ENERGY TRANSFER; FORCED SWIM TEST; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL CULTURE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; DRUG EFFECTS; METABOLISM; NERVE CELL; PHYSIOLOGY; PROTEIN MULTIMERIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN; CALCIUM SIGNALING; DOPAMINE; DOPAMINE D2 RECEPTOR ANTAGONISTS; MALE; NEURONS; PEPTIDES; PROTEIN MULTIMERIZATION; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2;

EID: 84908352984     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-254037     Document Type: Article

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