Protein redox chemistry: Post-translational cysteine modifications that regulate signal transduction and drug pharmacology

Frontiers in Pharmacology

Volumn 5, Issue OCT, 2014, Pages

  Wani, Revati ^a   Nagata, Asako ^a   Murray, Brion W ^a  

^a PFIZER INC   (United States)

Author keywords

Covalent drugs; Cysteine oxidation; EGFR; Kinase; Redox; ROS; Subcellular trafficking

Indexed keywords

2 CYANO N (2,5 DIBROMOPHENYL) 3 HYDROXYCROTONAMIDE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; AFATINIB; BRUTON TYROSINE KINASE; CANERTINIB; CETUXIMAB; CYSTEINE; DACOMITINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 4; ERLOTINIB; GEFITINIB; IBRUTINIB; JANUS KINASE 3; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; PANITUMUMAB; PERTUZUMAB; PROTEIN BLK; PROTEIN BMX; PROTEIN ITK; PROTEIN KINASE; PROTEIN TEC; PROTEIN TXK; TOFACITINIB; TRASTUZUMAB; TRASTUZUMAB EMTANSINE; UNCLASSIFIED DRUG; VANDETANIB;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CHEMICAL INTERACTION; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; NONHUMAN; ONCOLOGY; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHARMACOLOGY; PROTEIN CONFORMATION; PROTEIN PROCESSING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 84908347405     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2014.00224     Document Type: Article

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