CD4 Depletion in SIV-Infected Macaques Results in Macrophage and Microglia Infection with Rapid Turnover of Infected Cells

PLoS Pathogens

Volumn 10, Issue 10, 2014, Pages

  Micci, Luca ^a   Alvarez, Xavier ^b   Iriele, Robin I ^a   Ortiz, Alexandra M ^a   Ryan, Emily S ^a   McGary, Colleen S ^a   Deleage, Claire ^c   McAtee, Brigitte B ^b   He, Tianyu ^d   Apetrei, Cristian ^d   Easley, Kirk ^e   Pahwa, Savita ^f   Collman, Ronald G ^g   Derdeyn, Cynthia A ^a   Davenport, Miles P ^h   Estes, Jacob D ^c   Silvestri, Guido ^a   Lackner, Andrew A ^b   Paiardini, Mirko ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e EMORY UNIVERSITY   (United States)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CD163 ANTIGEN; CD20 ANTIGEN; CD3 ANTIGEN; CD4R1 ANTIBODY; CD68 ANTIGEN; CD8 ANTIGEN; CYCLINE; DIETHYL PYROCARBONATE; EMTRICITABINE; HLA DR ANTIGEN; IMMUNOGLOBULIN G1 ANTIBODY; KI 67 ANTIGEN; MONOCLONAL ANTIBODY; RALTEGRAVIR; RECOMBINANT ANTIBODY; TENOFOVIR; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW BIOPSY; CD4+ T LYMPHOCYTE; CELL COUNT; CELL POPULATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; IMAGE ANALYSIS; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LYMPH NODE BIOPSY; MACROPHAGE; MICROGLIA; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECTUM BIOPSY; RHESUS MONKEY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; T CELL DEPLETION; TURNOVER TIME; VIREMIA; VIRUS LOAD; VIRUS REPLICATION; ANIMAL; DISEASE MODEL; IMMUNOLOGY; LYMPHOCYTE DEPLETION; VIROLOGY;

MACACA; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; LYMPHOCYTE DEPLETION; MACACA MULATTA; MACROPHAGES; MICROGLIA; MONOCYTES; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRAL LOAD; VIREMIA;

EID: 84908338546     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004467     Document Type: Article

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