Identification of Orai1 channel inhibitors by using minimal functional domains to screen small molecule microarrays

Chemistry and Biology

Volumn 21, Issue 10, 2014, Pages 1278-1292

  Sadaghiani, Amir Masoud ^a,d   Lee, Sang Min ^b   Odegaard, Justin I ^a   Leveson Gower, Dennis B ^a   McPherson, Olivia M ^c   Novick, Paul ^a   Kim, Mi Ri ^b   Koehler, Angela N ^c   Negrin, Robert ^a   Dolmetsch, Ricardo E ^a,d   Park, Chan Young ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Ulsan National Institute of Science and Technology   (South Korea)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

12A EPIMILLETOSIN; ANCO4882; ANCOA4; ANCOA5; ANCOF6; ANCOG4; BIOCHANIN A; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; GENISTEIN; IMMUNOSUPPRESSIVE AGENT; ION CHANNEL; LUCIFERASE; NFAT LUCIFERASE; PROTEIN INHIBITOR; RENILLA LUCIFERIN 2 MONOOXYGENASE; STORE OPERATED CALCIUM CHANNEL; STROMAL INTERACTION MOLECULE 1; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; ANCOA4 COMPOUND; CHROMONE DERIVATIVE; DROSOPHILA PROTEIN; FURA 2; MEMBRANE PROTEIN; MOLECULAR LIBRARY; ORAI1 PROTEIN, DROSOPHILA; PROTEIN BINDING; RECOMBINANT PROTEIN; STIM1 PROTEIN, HUMAN; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL VIABILITY; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; EC50; EMBRYO; FOOT PAD; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; LYMPHOCYTE PROLIFERATION; MICROARRAY ANALYSIS; MINIMAL FUNCTIONAL DOMAIN; MOLECULE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MICROARRAY; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; REPORTER GENE; SINGLE DRUG DOSE; SMALL MOLECULE MICROARRAY; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION; TISSUE INJURY; TISSUE SECTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMISTRY; DISEASE MODEL; DROSOPHILA; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HYPERSENSITIVITY, DELAYED; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR DOCKING; MOLECULAR LIBRARY; PATHOLOGY; PHARMACOLOGY; PROTEIN TERTIARY STRUCTURE; T LYMPHOCYTE;

ANIMALS; BENZODIOXOLES; CHROMONES; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; FURA-2; GENE EXPRESSION; HEK293 CELLS; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR DOCKING SIMULATION; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; T-LYMPHOCYTES;

EID: 84908337125     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.08.016     Document Type: Article

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