Novel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity

Biochemical Pharmacology

Volumn 92, Issue 2, 2014, Pages 192-205

  Henary, Maged ^a   Narayana, Lakshminarayana ^a   Ahad, Shazia ^b   Gundala, Sushma R ^a   Mukkavilli, Rao ^c   Sharma, Vibhuti ^a   Owens, Eric A ^a   Yadav, Yogesh ^a   Nagaraju, Mulpuri ^a   Hamelberg, Donald ^a   Tandon, Vibha ^d,e   Panda, Dulal ^b   Aneja, Ritu ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^c Advinus Therapeutics Private Limited Bangalore   (India)

^d UNIVERSITY OF DELHI   (India)

^e JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Antiproliferative; Noscapine; Pharmacokinetics; Tubulin binding; Water solubility

Indexed keywords

3 ( 9 BROMO 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 7 HYDROXY 6 METHOXYISOBENZOFURAN 1(3H) ONE; 3 9 AMINO 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 6,7 DIMETHOXYISOBENZOFURAN 1 (3H) ONE; 3 9 BROMO 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 6,7 DIMETHOXYISOBENZOFURAN 1 (3H) ONE; 3 [ 5 METHOXY 1 [( 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL]OXY] N,N,N TRIMETHYLPROPAN 1 AMINIUM BROMIDE; 3 [[ 1 ( 9 BROMO 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL]OXY]PROPANE 1 SULFONIC ACID; 3 [[ 1 (9 BROMO 4 METHOXY 6 METHYL-5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 5 METHOXY 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL]OXY] N,N,N TRIMETHYLPROPAN 1 AMINIUM BROMIDE; 3 [[5 (4,5 DIMETHOXY 3 OXO 1,3 DIHYDROISOBENZOFURAN 1 YL) 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 9 YL]AMINO] N,N,N TRIMETHYLPROPAN 1 AMINIUM BROMIDE; 3 [[5 (4,5 DIMETHOXY 3 OXO 1,3 DIHYDROISOBENZOFURAN 1 YL) 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 9 YL]AMINO]PROPANE 1 SULFONIC ACID; 4 [[ 1 (9 BROMO 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL]OXY]BUTANE 1 SULFONIC ACID; 4 [[ 5 METHOXY 1 (4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL]OXY]BUTANE 1 SULFONIC ACID; 4 [[ 5 METHOXY 1 (4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL) 3 OXO 1,3 DIHYDROISOBENZOFURAN 4 YL]OXY]PROPANE 1 SULFONIC ACID; 4 [[5 (4,5 DIMETHOXY 3 OXO 1,3 DIHYDROISOBENZOFURAN 1 YL) 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 9 YL]AMINO]BUTANE 1 SULFONIC ACID; 7 HYDROXY 6 METHOXY 3 (4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO[4,5 G]ISOQUINOLIN 5 YL)ISOBENZOFURAN 1(3H) ONE; NOSCAPINE; QUINOLINE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; GROWTH INHIBITOR; TUBULIN MODULATOR; WATER;

ANIMAL EXPERIMENT; ANTIPROLIFERATIVE ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; COMPUTER MODEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; ELIMINATION RATE CONSTANT; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS INHIBITION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PANCREAS CANCER; PHYSICAL CHEMISTRY; PREDICTION; PROSTATE CANCER; SOLVATION; TIME TO MAXIMUM PLASMA CONCENTRATION; UTERINE CERVIX CANCER; VOLUME OF DISTRIBUTION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GOAT; HELA CELL LINE; MICROTUBULE; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; SOLUBILITY;

ANIMALS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GOATS; GROWTH INHIBITORS; HELA CELLS; HUMANS; MALE; MICE; MICROTUBULES; NOSCAPINE; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY; TUBULIN MODULATORS; WATER;

EID: 84908335936     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.07.020     Document Type: Article

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