N-alkylboronic acid inhibitors reveal determinants of ligand specificity in the quorum-quenching and siderophore biosynthetic enzyme PvdQ

Biochemistry

Volumn 53, Issue 42, 2014, Pages 6679-6686

  Clevenger, Kenneth D ^a   Wu, Rui ^b   Liu, Dali ^b   Fast, Walter ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; ENZYMES; IRON COMPOUNDS; QUENCHING;

BIOSYNTHETIC ENZYMES; BIOSYNTHETIC PRECURSORS; DISCRIMINATION MODEL; ENZYME ENGINEERING; GRAM-NEGATIVE PATHOGENS; HOMOSERINE LACTONES; PSEUDOMONAS AERUGINOSA; X RAY CRYSTAL STRUCTURES;

LIGANDS;

ALKYL GROUP; AMIDE; ANTIBIOTIC AGENT; BACTERIAL ENZYME; BORONIC ACID DERIVATIVE; ENZYME INHIBITOR; HYDROLASE; IRON; LIGAND; N ACYLHOMOSERINE LACTONE; N ALKYLBORONIC ACID; NUCLEOPHILE; PROTEIN PVDQ; PYOVERDINE; SERINE; SIDEROPHORE; UNCLASSIFIED DRUG; AMIDASE; BACTERIAL PROTEIN; N-TERMINAL NUCLEOPHILE HYDROLASE;

ARTICLE; BETA CHAIN; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME ENGINEERING; GRAM NEGATIVE BACTERIUM; LIGAND BINDING; PROTEIN STABILITY; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

AMIDOHYDROLASES; BACTERIAL PROTEINS; BORONIC ACIDS; CRYSTALLOGRAPHY, X-RAY; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; SIDEROPHORES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84908281790     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501086s     Document Type: Article

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