Rational design of a transition state analogue with picomolar affinity for pseudomonas aeruginosa PvdQ, a siderophore biosynthetic enzyme

ACS Chemical Biology

Volumn 8, Issue 10, 2013, Pages 2192-2200

  Clevenger, Kenneth D ^a   Wu, Rui ^b   Er, Joyce A V ^a   Liu, Dali ^b   Fast, Walter ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; SIDEROPHORE; ENZYME INHIBITOR; LIGAND;

ARTICLE; BACTERIAL GROWTH; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; BIOASSAY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; IC50; MEDICINAL CHEMISTRY; METABOLISM; X RAY CRYSTALLOGRAPHY;

PSEUDOMONAS AERUGINOSA;

BIOLOGICAL ASSAY; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME ACTIVATION; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, MOLECULAR; PSEUDOMONAS AERUGINOSA; SIDEROPHORES; SUBSTRATE SPECIFICITY;

EID: 84886572862     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400345h     Document Type: Article

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