Calcium and Magnesium Physiology and Nutrition in Relation to the Prevention of Milk Fever and Tetany (Dietary Management of Macrominerals in Preventing Disease)

Veterinary Clinics of North America - Food Animal Practice

Volumn 30, Issue 3, 2014, Pages 643-670

  Martín Tereso, Javier ^a   Martens, Holger ^b  

^a Nutreco Research and Development   (Netherlands)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Adaptation; Calcium; Hypocalcemia; Hypomagnesemia; Magnesium; Milk fever; Prevention; Tetany

Indexed keywords

CALCIUM; CALCIUM INTAKE; MAGNESIUM;

ADMINISTRATION AND DOSAGE; ANIMAL; BLOOD; BOVINAE; CALCIUM INTAKE; CATTLE DISEASES; DAIRYING; DIET THERAPY; FEMALE; HYPOCALCEMIA; METABOLISM; PARTURIENT PARESIS; PREGNANCY; PROCEDURES; TETANY; VETERINARY;

ANIMALS; CALCIUM; CALCIUM, DIETARY; CATTLE; CATTLE DISEASES; DAIRYING; FEMALE; HYPOCALCEMIA; MAGNESIUM; PARTURIENT PARESIS; PREGNANCY; TETANY;

EID: 84908252012     PISSN: 07490720     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvfa.2014.07.007     Document Type: Review

References (133)

1. +2 channels in kidney disease. Adv Chronic Kidney Dis 2006, 13(2):110-117.
2. Case R.M., Eisner D., Gurney A., et al. Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system. Cell Calcium 2007, 42(4-5):345-350.
3. Günther T. Stoffwechsel und Wirkungen des intrazellulären Magnesium. JClin Chem Clin Biochem 1977, 15:433-438.
4. Stumpff F., Martens H. The rumen and potassium homeostasis: a model. Anim Feed Sci Technol 2007, 16(Suppl 2):436-441.
5. Zhou H., Clapham D.E. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci USA 2009, 106(37):15750-15755.
6. Ramberg C., Johnson E., Fargo R., et al. Calcium homeostasis in cows, with special reference to parturient hypocalcemia. Am J Physiol Regul Integr Comp Physiol 1984, 246(5):698-704.
7. Roche J., Berry D. Periparturient climatic, animal, and management factors influencing the incidence of milk fever in grazing systems. JDairy Sci 2006, 89(7):2775-2783.
8. Reinhardt T.A., Lippolis J.D., McCluskey B.J., et al. Prevalence of subclinical hypocalcemia in dairy herds. Vet J 2011, 188(1):122-124.
9. USDA Dairy 2007, Part II: changes in the U.S. dairy cattle industry, 1991-2007 2008, USDA-APHIS-VS, Fort Collins (CO).
10. Moore S., VandeHaar M., Sharma B., et al. Effects of altering dietary cation-anion difference on calcium and energy metabolism in peripartum cows. JDairy Sci 2000, 83(9):2095-2104.
11. DeGaris P., Lean I. Milk fever in dairy cows: a review of pathophysiology and control principles. Vet J 2008, 176(1):58-69.
12. Barja G. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic Biol Med 2002, 33(9):1167-1172.
13. 2+ content and estrogens. J Am Soc Nephrol 2006, 17(4):1035-1043.
14. Todd J., Horvath D. Magnesium and neuromuscular irritability in calves, with particular reference to hypomagnesaemic tetany. Br Vet J 1970, 126:333-346.
15. Sjollema B. On the nature and therapy of grass staggers. Vet Rec 1930, 10(425-430):450-453.
16. Meyer H., Scholz H. Studies on the pathogenesis of hypomagnesemic tetany. I. Relationships between the magnesium contents in blood and cerebrospinal fluid. Dtsch Tierarztl Wochenschr 1972, 79(3):55. [in German].
17. Allsop T., Pauli J. Responses to the lowering of magnesium and calcium concentrations in the cerebrospinal fluid of unanesthetized sheep. Aust J Biol Sci 1975, 28(5-6):475-481.
18. Reynolds C.K., Bell M.C., Sims M.H. Changes in plasma, red blood cell and cerebrospinal fluid mineral concentrations in calves during magnesium depletion followed by repletion with rectally infused magnesium chloride. JNutr 1984, 114(7):1334-1341.
19. 2+ transport. Livest Prod Sci 2010, 134:4-10.
20. Erben R. Vitamin D analogs and bone. JMusculoskelet Neuronal Interact 2001, 2(1):59-69.
21. Goff J. Macromineral physiology and application to the feeding of the dairy cow for prevention of milk fever and other periparturient mineral disorders. Anim Feed Sci Technol 2006, 126(3-4):237-257.
22. Horst R. Regulation of calcium and phosphorus homeostasis in the dairy cow. JDairy Sci 1986, 69(2):604-616.
23. Schröder B., Breves G. Mechanisms and regulation of calcium absorption from the gastrointestinal tract in pigs and ruminants: comparative aspects with special emphasis on hypocalcemia in dairy cows. Anim Health Res Rev 2007, 7(1-2):31-41.
24. 2+ absorption in health and disease. Annu Rev Physiol 2008, 70:257-271.
25. 2+-sensing receptor from bovine parathyroid. Nature 1993, 366(6455):575-580.
26. Martín-Tereso J., Verstegen M.W. Anovel model to explain dietary factors affecting hypocalcaemia in dairy cattle. Nutr Res Rev 2011, 24:228-243.
27. Schonewille J., van't Klooster A., Wouterse H., et al. Hypocalcemia induced by intravenous administration of disodium ethylenediaminotetraacetate and its effects on excretion of calcium in urine of cows fed a high chloride diet. JDairy Sci 1999, 82(6):1317-1324.
28. Martín-Tereso J., Derks M., van Laar H., et al. Urinary calcium excretion in non-lactating dairy cows in relation to intake of fat-coated rice bran. JAnim Physiol Anim Nutr (Berl) 2010, 94:129-136.
29. Armbrecht H.J., Boltz M.A., Christakos S., et al. Capacity of 1,25-dihydroxyvitamin D to stimulate expression of calbindin D changes with age in the rat. Arch Biochem Biophys 1998, 352(2):159-164.
30. Martín-Tereso J., van Puijenbroek R., van Laar H., et al. Effect of feeding rumen protected rice bran on calcium homeostasis of non-lactating multiparous cows. JAnim Physiol Anim Nutr (Berl) 2011, 95:236-244.
31. Schröder B., Rittmann I., Pfeffer E., et al. Invitro studies on calcium absorption from the gastrointestinal tract in small ruminants. JComp Physiol B 1997, 167(1):43-51.
32. Wilkens M.R., Kunert-Keil C., Brinkmeier H., et al. Expression of calcium channel TRPV6 in ovine epithelial tissue. Vet J 2009, 182(2):294-300.
33. Wilkens M.R., Mrochen N., Breves G., et al. Gastrointestinal calcium absorption in sheep is mostly insensitive to an alimentary induced challenge of calcium homeostasis. Comp Biochem Physiol B Biochem Mol Biol 2011, 158:199-207.
34. Sidler-Lauff K., Boos A., Kraenzlin M., et al. Influence of different calcium supplies and a single vitamin D injection on vitamin D receptor and calbindin D9k immunoreactivities in the gastrointestinal tract of goat kids. JAnim Sci 2010, 88(11):3598-3610.
35. 3 before parturition. JDairy Sci 2008, 91(6):2408-2416.
36. Liesegang A., Eicher R., Sassi M.L., et al. The course of selected bone resorption marker concentrations in response to short-term hypocalcemia experimentally induced with disodium EDTA infusions in dairy cows. JVet Med A Physiol Pathol Clin Med 2000, 47(8):477-487.
37. Parfitt A. The actions of parathyroid hormone on bone. Relation to bone remodelling and turnover, calcium homeostasis, and metabolic bone disease. Part II. Metabolism 1976, 25:909-955.
38. Hadjidakis D., Androullakis I. Bone remodeling. Ann N Y Acad Sci 2006, 1092(1 women's health and disease: gynecologic, endocrine, and reproductive issues):385-396.
39. Lemaire V., Tobin F., Greller L., et al. Modeling the interactions between osteoblast and osteoclast activities in bone remodeling. JTheor Biol 2004, 229(3):293-309.
40. Schonewille J., Everts H., Jittakhot S., et al. Quantitative prediction of magnesium absorption in dairy cows. JDairy Sci 2008, 91(1):271-278.
41. Ruckebusch Y., Thivend P. Magnesium metabolism and hypomagnesaemia. Digestive physiology and metabolism in ruminants 1980, 447-466. MTP Press, Clermont-Ferrand.
42. Martens H., Schweigel M. Pathophysiology of grass tetany and other hypomagnesemias. Implications for clinical management. Vet Clin North Am Food Anim Pract 2000, 16(2):339.
43. Tomas F., Potter B. The effect and site of action of potassium upon magnesium absorption in sheep. Aust J Agric Res 1976, 27(6):873-880.
44. Pfeffer E., Rahman K. Untersuchungen zur Lokalisierung der Magnesium-Absorption beim Wiederkäuer. ZTierphysiol Tierernahr Futtermittelkd 1974, 33:209-210.
45. Smith R. Absorption of major minerals in the small and large intestines of the ruminant. Proc Nutr Soc 1969, 28(1):151-160.
46. Meyer H., Busse F. Zur rektalen absorption von magnesium beim wiederkaeuer. Dtsch Tierarztl Wochenschr 1975, 82:140-141.
47. Bell M., Oluokun J., Ramsey N., et al. Magnesium treatment of cows for grass tetany [Hypomagnesemia] 1978, 24-32. Feedstuffs, 50.
48. Martens H., Stössel E.M. Magnesium absorption from the temporarily isolated rumen of sheep: no effect of hyper- or hypomagnesaemia. Exp Physiol 1988, 73(2):217-223.
49. Kemp A. The effect of fertilizer treatment of grassland on the biological availability of magnesium to ruminants. Role of magnesium in animal nutrition 1983, 143-157. Polytechnic Institute State University Blacksburg, Blacksburg (VA). J.P. Fontenot (Ed.).
50. Hoenderop J.G., Nilius B., Bindels R.J. Calcium absorption across epithelia. Physiol Rev 2005, 85(1):373-422.
51. Pérez A., Picotto G., Carpentieri A., et al. Minireview on regulation of intestinal calcium absorption. Emphasis on molecular mechanisms of transcellular pathway. Digestion 2008, 77(1):22-34.
52. Wasserman R. Vitamin D and the dual processes of intestinal calcium absorption. JNutr 2004, 134(11):3137-3139.
53. Bouillon R., Van Cromphaut S., Carmeliet G. Intestinal calcium absorption: molecular vitamin D mediated mechanisms. JCell Biochem 2003, 88(2):332-339.
54. Bronner F. Mechanisms of intestinal calcium absorption. JCell Biochem 2003, 88(2):387-393.
55. Khanal R., Nemere I. Regulation of intestinal calcium transport. Annu Rev Nutr 2008, 28:179-196.
56. 2+ transport proteins by parathyroid hormone. Kidney Int 2005, 68(4):1708-1721.
57. Scott D. Factors influencing the secretion and absorption of calcium and magnesium in the small intestine of the sheep. Exp Physiol 1965, 50(3):312-329.
58. Care A., Brown R., Farrar A., et al. Magnesium absorption from the digestive tract of sheep. Exp Physiol 1984, 69(3):577-587.
59. Leonhard-Marek S., Martens H. Effects of potassium on magnesium transport across rumen epithelium. Am J Physiol Gastrointest Liver Physiol 1996, 271(6):G1034-G1038.
60. Schweigel M., Kolisek M., Nikolic Z., et al. Expression and functional activity of the Na/Mg exchanger, TRPM7 and MagT1 are changed to regulate Mg homeostasis and transport in rumen epithelial cells. Magnesium Res. 2008, 21:1-6.
61. 2+ channel TRPM6: insight into the molecular regulation. Magnes Res 2009, 22(3):127-132.
62. 2+ exchanger. Am J Physiol Cell Physiol 2012, 302(1):C318-C326.
63. Ram L., Schonewille J.T., Martens H., et al. Magnesium absorption by wethers fed potassium bicarbonate in combination with different dietary magnesium concentrations. JDairy Sci 1998, 81(9):2485-2492.
64. Martinez N., Sinedino L., Bisinotto R., et al. Effect of induced subclinical hypocalcemia on physiological responses and neutrophil function in dairy cows. JDairy Sci 2014, 97(2):874-887.
65. Chattopadhyay N., Vassilev P., Brown E. Calcium-sensing receptor: roles in and beyond systemic calcium homeostasis. Biol Chem 1997, 378(8):759-768.
66. 2+ transport: a guided tour along the nephron. Curr Opin Nephrol Hypertens 2010, 19(5):456-462.
67. Schonewille J.T., van't Klooster A.T., Wouterse H., et al. Time courses of plasma magnesium concentrations and urinary magnesium excretion in cows subjected to acute changes in potassium intake. Vet Q 2000, 22(3):136-140.
68. NRC Nutrient requirements of dairy cattle 2001, National Academy Press, Washington, DC. 7th revised edition.
69. Taylor M., Knowlton K., McGilliard M., et al. Dietary calcium has little effect on mineral balance and bone mineral metabolism through twenty weeks of lactation in Holstein cows. JDairy Sci 2009, 92(1):223-237.
70. Pivonka P., Zimak J., Smith D., et al. Model structure and control of bone remodeling: a theoretical study. Bone 2008, 43(2):249-263.
71. Bieglmayer C., Prager G., Niederle B. Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy. Clin Chem 2002, 48(10):1731-1738.
72. Norman A., Friedlander E., Henry H. Determination of the rates of synthesis and degradation of vitamin D-dependent chick intestinal and renal calcium-binding proteins. Arch Biochem Biophys 1981, 206(2):305-317.
73. Creamer B., Shorter R., Bamforth J. The turnover and shedding of epithelial cells. Gut 1961, 2(2):110-118.
74. Vogetseder A., Karadeniz A., Kaissling B., et al. Tubular cell proliferation in the healthy rat kidney. Histochem Cell Biol 2005, 124(2):97-104.
75. Walters J., Weiser M. Calcium transport by rat duodenal villus and crypt basolateral membranes. Am J Physiol Gastrointest Liver Physiol 1987, 252(2):170-177.
76. Halloran B.P., De Luca H.F. Intestinal calcium transport: Evidence for two distinct mechanisms of action of 1, 25-dihydroxyvitamin D3. Arch Biochem Biophys 1981, 208(2):477-486.
77. Greenfield E., Bi Y., Miyauchi A. Regulation of osteoclast activity. Life Sci 1999, 65(11):1087-1102.
78. Goff J., Littledike E., Horst R. Effect of synthetic bovine parathyroid hormone in dairy cows: prevention of hypocalcemic parturient paresis. JDairy Sci 1986, 69(9):2278-2289.
79. Lean I., DeGaris P., McNeil D., et al. Hypocalcemia in dairy cows: meta-analysis and dietary cation anion difference theory revisited. JDairy Sci 2006, 89(2):669-684.
80. Roche J., Dalley D., Moate P., et al. Dietary cation-anion difference and the health and production of pasture-fed dairy cows 2. Nonlactating periparturient cows. JDairy Sci 2003, 86(3):979-987.
81. de Groot T., Bindels R.J., Hoenderop J.G. TRPV5: an ingeniously controlled calcium channel. Kidney Int 2008, 74(10):1241-1246.
82. Lambers T.T., Oancea E., de Groot T., et al. Extracellular pH dynamically controls cell surface delivery of functional TRPV5 channels. Mol Cell Biol 2007, 27(4):1486-1494.
83. 2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. JClin Invest 2003, 112(12):1906-1914.
84. Martens H., Blume I. Effect of intraruminal sodium and potassium concentrations and of the transmural potential difference on magnesium absorption from the temporarily isolated rumen of sheep. Exp Physiol 1986, 71(3):409-415.
85. Martens H., Gäbel G., Strozyk H. The effect of potassium and the transmural potential difference on magnesium transport across an isolated preparation of sheep rumen epithelium. Exp Physiol 1987, 72(2):181-188.
86. Weiss W. Macromineral digestion by lactating dairy cows: factors affecting digestibility of magnesium. JDairy Sci 2004, 87(7):2167-2171.
87. Martens H., Stumpff F. Ruminal Mg transport and assessment of Mg intake in dairy cows. Two sides of one coin. JDairy Sci 2011, 94(Suppl 1):510. [abstract].
88. Schonewille J., Beynen A. Reviews on the mineral provision in ruminants (III): magnesium metabolism and requirement in ruminants 2005, 14. CVB Documentation Report Nr. 35, Central Veevoederbureau, Lelystad (The Netherlands).
89. 2 on the net absorption of magnesium from the temporarily isolated rumen of heifers. Zentralbl Veterinarmed A 1988, 35(1):73-80.
90. Gäbel G., Martens H. The effect of ammonia on magnesium metabolism in sheep. JAnim Physiol Anim Nutr (Berl) 1986, 55(1-5):278-287.
91. Fontenot J., Wise M., Webb K. Interrelationships of potassium, nitrogen, and magnesium in ruminants. Fed Proc 1973, 32:1925-1928.
92. Butler E. The mineral element content of spring pasture in relation to the occurrence of grass tetany and hypomagnesaemia in dairy cows. JAgric Sci 1963, 60:329-340.
93. Boda J., Cole H. Calcium metabolism with special reference to parturient paresis (milk fever) in dairy cattle: a review. JDairy Sci 1956, 39(7):1027-1054.
94. Thilsing-Hansen T., Jørgensen R., Østergaard S. Milk fever control principles: a review. Acta Vet Scand 2002, 43(1):1-19.
95. Horst R., Goff J., Reinhardt T. Role of vitamin D in calcium homeostasis and its use in prevention of bovine periparturient paresis. Acta Vet Scand Suppl 2003, 97:35-50.
96. 3 toxicity in dairy cows. JDairy Sci 1982, 65(5):749-759.
97. Gast D., Horst R., Jorgensen N., et al. Potential use of 1, 25-dihydroxycholecalciferol for prevention of parturient paresis1. JDairy Sci 1979, 62(6):1009-1013.
98. 3 on mineral metabolism and 1, 25-dihydroxyvitamin D concentrations in dairy cows. JDairy Sci 1983, 66(1):59-66.
99. Hibbs J., Conrad H. Studies of milk fever in dairy cows. VI. Effect of three prepartal dosage levels of vitamin D on milk fever incidence. JDairy Sci 1960, 43(8):1124-1129.
100. Albright J., Blosser T. Blood levels and urinary excretion of calcium in normal cows and cows with parturient paresis after intravenous injections with calcium borogluconate. JDairy Sci 1957, 40(5):477-486.
101. Goings R., Jacobson N., Beitz D., et al. Prevention of parturient paresis by a prepartum, calcium-deficient diet. JDairy Sci 1974, 57(10):1184-1188.
102. Wiggers K., Nelson D., Jacobson N. Prevention of parturient paresis by a low-calcium diet prepartum: a field study. JDairy Sci 1975, 58(3):430-431.
103. Yarrington J., Capen C., Black H., et al. Effects of a low calcium prepartal diet on calcium homeostatic mechanisms in the cow: morphologic and biochemical studies. JNutr 1977, 107(12):2244-2256.
104. Green H., Horst R., Beitz D., et al. Vitamin D metabolites in plasma of cows fed a prepartum low-calcium diet for prevention of parturient hypocalcemia. JDairy Sci 1981, 64(2):217-226.
105. Kichura T., Horst R., Beitz D., et al. Relationships between prepartal dietary calcium and phosphorus, vitamin D metabolism, and parturient paresis in dairy cows. JNutr 1982, 112(3):480-487.
106. Shappell N., Herbein J., Deftos L., et al. Effects of dietary calcium and age on parathyroid hormone, calcitonin and serum and milk minerals in the periparturient dairy cow. JNutr 1987, 117(1):201-207.
107. Oetzel G. Meta-analysis of nutritional risk factors for milk fever in dairy cattle. JDairy Sci 1991, 74(11):3900-3912.
108. Thilsing-Hansen T., Jorgensen R., Enemark J., et al. The effect of zeolite A supplementation in the dry period on periparturient calcium, phosphorus, and magnesium homeostasis. JDairy Sci 2002, 85(7):1855-1862.
109. Enemark J., Frandsen A., Thilsing-Hansen T., et al. Aspects of physiological effects of sodium zeolite A supplementation in dry, non-pregnant dairy cows fed grass silage. Acta Vet Scand Suppl 2003, 97:97-117.
110. Enemark J., Kirketerp-Møller C., Jørgensen R. Effect of prepartum zeolite A supplementation on renal calcium excretion in dairy cows around calving and evaluation of a field test kit for monitoring it. Acta Vet Scand Suppl 2003, 97:119-136.
111. Thilsing-Hansen T., Jørgensen R., Enemark J., et al. The effect of zeolite A supplementation in the dry period on blood mineral status around calving. Acta Vet Scand Suppl 2003, 97:87-95.
112. Katsoulos P., Roubies N., Panousis N., et al. Effects of long-term dietary supplementation with clinoptilolite on incidence of parturient paresis and serum concentrations of total calcium, phosphate, magnesium, potassium, and sodium in dairy cows. Am J Vet Res 2005, 66(12):2081-2085.
113. Thilsing T., Larsen T., Jorgensen R., et al. The effect of dietary calcium and phosphorus supplementation in zeolite A treated dry cows on periparturient calcium and phosphorus homeostasis. JVet Med A Physiol Pathol Clin Med 2007, 54(2):82-91.
114. Grabherr H., Spolders M., Flachowsky G., et al. Influence of zeolite A supplementation during the dry period of dairy cows on feed intake, on the macro and trace element metabolism around calving and milk yield in the following lactation. Berl Munch Tierarztl Wochenschr 2008, 121(1-2):41-52.
115. Grabherr H., Spolders M., Furll M., et al. Effect of several doses of zeolite A on feed intake, energy metabolism and on mineral metabolism in dairy cows around calving. JAnim Physiol Anim Nutr (Berl) 2009, 93(2):221-236.
116. Pallesen A., Pallesen F., Jørgensen R., et al. Effect of pre-calving zeolite, magnesium and phosphorus supplementation on periparturient serum mineral concentrations. Vet J 2008, 175(2):234-239.
117. 45Ca. JAgric Food Chem 2001, 49(9):4397-4401.
118. Clark W., Wohlt J., Gilbreath R., et al. Phytate phosphorus intake and disappearance in the gastrointestinal tract of high producing dairy cows. JDairy Sci 1986, 69(12):3151-3155.
119. Martín-Tereso J., Gonzalez A., Van Laar H., et al. In situ ruminal degradation of phytic acid in formaldehyde-treated rice bran. Anim Feed Sci Tech 2009, 152(3-4):286-297.
120. Martín-Tereso J., Wijlen H., Laar H., et al. Peripartal calcium homoeostasis of multiparous dairy cows fed rumen-protected rice bran or a lowered dietary cation/anion balance diet before calving. JAnim Physiol Anim Nutr (Berl) 2014, 98(4):775-784.
121. Block E. Manipulating dietary anions and cations for prepartum dairy cows to reduce incidence of milk fever. JDairy Sci 1984, 67(12):2939-2948.
122. Oetzel G., Fettman M., Hamar D., et al. Screening of anionic salts for palatability, effects on acid-base status, and urinary calcium excretion in dairy cows. JDairy Sci 1991, 74(3):965-971.
123. Charbonneau E., Pellerin D., Oetzel G. Impact of lowering dietary cation-anion difference in nonlactating dairy cows: a meta-analysis. JDairy Sci 2006, 89(2):537-548.
124. Goff J., Horst R. Effects of the addition of potassium or sodium, but not calcium, to prepartum rations on milk fever in dairy cows. JDairy Sci 1997, 80(1):176-186.
125. Goff J., Horst R., Mueller F., et al. Addition of chloride to a prepartal diet high in cations increases 1, 25-dihydroxyvitamin d response to hypocalcemia preventing milk fever. JDairy Sci 1991, 74(11):3863-3871.
126. Goff J. The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. Vet J 2008, 176(1):50-57.
127. Goff J., Liesegang A., Horst R. Diet-induced pseudohypoparathyroidism: a hypocalcemia and milk fever risk factor. JDairy Sci 2014, 97(3):1520-1528.
128. Horst R., Goff J., Reinhardt T. Calcium and vitamin D metabolism in the dairy cow. JDairy Sci 1994, 77(7):1936-1951.
129. Hu W., Murphy M. Dietary cation-anion difference effects on performance and acid-base status of lactating dairy cows: a meta-analysis. JDairy Sci 2004, 87(7):2222-2229.
130. Oetzel G. Management of dry cows for the prevention of milk fever and other mineral disorders. Vet Clin North Am Food Anim Pract 2000, 16(2):369-386.
131. Anast C.S., Mohs J.M., Kaplan S.L., et al. Evidence for parathyroid failure in magnesium deficiency. Science 1972, 177(4049):606-608.
132. Sansom B., Manston R., Vagg M. Magnesium and milk fever. Vet Rec 1983, 112(19):447-449.
133. Kehoe S., Jayarao B., Heinrichs A. Asurvey of bovine colostrum composition and colostrum management practices on Pennsylvania dairy farms. JDairy Sci 2007, 90(9):4108-4116.