Mechanisms and regulation of epithelial Ca2+ absorption in health and disease

Annual Review of Physiology

Volumn 70, Issue , 2008, Pages 257-271

  Suzuki, Yoshiro ^a   Landowsky, Christopher P ^a   Hediger, Matthias A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Calcium homeostasis; Hypercalciuria; Intestinal absorption; TRPV5; TRPV6

Indexed keywords

CALCIUM; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6; VANILLOID RECEPTOR;

CALCIUM ABSORPTION; CALCIUM BALANCE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; HUMAN; HYPERCALCIURIA; HYPERPARATHYROIDISM; HYPOPHOSPHATEMIC RICKETS; INTESTINE; INTESTINE ABSORPTION; KIDNEY; KNOCKOUT MOUSE; NEPHROLITHIASIS; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; ANIMAL; EPITHELIUM; HOMEOSTASIS; METABOLIC BONE DISEASE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BONE DISEASES, METABOLIC; CALCIUM; EPITHELIUM; HOMEOSTASIS; HUMANS; HYPERCALCIURIA; INTESTINAL ABSORPTION; TRPV CATION CHANNELS;

EID: 43549124563     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.69.031905.161003     Document Type: Review

References (84)

1. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, et al. 1999. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J. Biol. Chem. 274:22739-46
2. 2+ transport and beyond. J. Physiol. 551:729-40
3. Bianco SDC, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, et al. 2007. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J. Bone Miner. Res. 22:274-85
4. Hoenderop JG, Nilius B, Bindels RJ. 2005. Calcium absorption across epithelia. Physiol. Rev. 85:373-422
5. 2+ channel in 1,25-dihydroxyvitamin D-3-responsive epithelia. J. Biol. Chem. 274:8375-78
6. Bronner F, Pansu D. 1999. Nutritional aspects of calcium absorption. J. Nutr. 129:9-12
7. Christakos S, Gill R, Lee S, Li H. 1992. Molecular aspects of the calbindins. J. Nutr. 122:678-82
8. Gross M, Kumar R. 1990. Physiology and biochemistry of vitamin D-dependent calcium binding proteins. Am. J. Physiol. 259:F195-209
9. Heizmann CW. 1992. Calcium-binding proteins: basic concepts and clinical implications. Gen. Physiol. Biophys. 11:411-25
10. Wasserman RH, Chandler JS, Meyer SA, Smith CA, Brindak ME, et al. 1992. Intestinal calcium transport and calcium extrusion processes at the basolateral membrane. J. Nutr. 122:662-71
11. Nicolaysen R, Eeg-Larsen N, Malm OJ. 1953. Physiology of calcium metabolism. Physiol. Rev. 33:424-44
12. Kimberg DV, Schachter D, Schenker H. 1961. Active transport of calcium by intestine: effects of dietary calcium. Am. J. Physiol. 200:1256-62
13. Fullmer CS, Wasserman RH. 1981. The amino acid sequence of bovine intestinal calcium-binding protein. J. Biol. Chem. 256:5669-74
14. Hofmann T, Kawakami M, Hitchman AJ, Harrison JE, Dorrington KJ. 1979. The amino acid sequence of porcine intestinal calcium-binding protein. Can. J. Biochem. 57:737-48
15. Costanzo LS, Windhager EE. 1978. Calcium and sodium transport by the distal convoluted tubule of the rat. Am. J. Physiol. 235:F492-506
16. Greger R, Lang F, Oberleithner H. 1978. Distal site of calcium reabsorption in the rat nephron. Pflügers Arch. 374:153-57
17. Shareghi GR, Stoner LC. 1978. Calcium transport across segments of the rabbit distal nephron in vitro. Am. J. Physiol. 235:F367-75
18. Roth J, Thorens B, Hunziker W, Norman AW, Orci L. 1981. Vitamin D-dependent calcium binding protein: immunocytochemical localization in chick kidney. Science 214:197-200
19. Thorens B, Roth J, Norman AW, Perrelet A, Orci L. 1982. Immunocytochemical localization of the vitamin D-dependent calcium binding protein in chick duodenum. J. Cell Biol. 94:115-22
20. Doucet A, Katz AI. 1982. High-affinity Ca-Mg-ATPase along the rabbit nephron. Am. J. Physiol. 242:F346-52
21. Nellans HN, Popovitch JE. 1981. Calmodulin-regulated, ATP-driven calcium transport by basolateral membranes of rat small intestine. J. Biol. Chem. 256:9932-36
22. Miller A III, Bronner F. 1981. Calcium uptake in isolated brush-border vesicles from rat small intestine. Biochem. J. 196:391-401
23. 3 and calcium channel blockers on cecal calcium transport in the rat. Am. J. Physiol. 248:G676-81
24. 2+ channels in renal epithelial cells by parathyroid hormone. Nature 347:388-91
25. 2+ channels sensitive to dihydropyridines and activated by hyperpolarizing voltages. Am. J. Physiol. 267:C157-65
26. 2+ channel modulators and membrane potential examined with fluorescent dye, fura-2. Pflügers Arch. 419:184-89
27. Romero MF, Kanai Y, Gunshin H, Hediger MA. 1998. Expression cloning using Xenopus laevis oocytes. Methods Enzymol. 296:17-52
28. Yue L, Peng JB, Hediger MA, Clapham DE. 2001. CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410:705-9
29. Goyer RA. 1997. Toxic and essential metal interactions. Annu. Rev. Nutr. 17:37-50
30. Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, et al. 2002. Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab. Invest. 82:1755-64
31. Weber K, Erben RG, Rump A, Adamski J. 2001. Gene structure and regulation of the murine epithelial calcium channels ECaC1 and 2. Biochem. Biophys. Res. Commun. 289:1287-94
32. Peng JB, Chen XZ, Berger UV, Weremowicz S, Morton CC, et al. 2000. Human calcium transport protein CaT1. Biochem. Biophys. Res. Commun. 278:326-32
33. Peng JB, Zhuang L, Berger UV, Adam RM, Williams BJ, et al. 2001. CaT1 expression correlates with tumor grade in prostate cancer. Biochem. Biophys. Res. Commun. 282:729-34
34. 3 in the intestine and kidney of mice. Endocrinology 144:3885-94
35. Spencer R, Charman M, Wilson PW, Lawson EM. 1978. The relationship between vitamin D-stimulated calcium transport and intestinal calcium-binding protein in the chicken. Biochem. J. 170:93-101
36. 3-1α-hydroxylase knockout mice. Kidney Int. 66:1082-89
37. Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, Van Herck E, et al. 2001. Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc. Natl. Acad. Sci. USA 98:13324-29
38. 3 target genes. Mol. Endocrinol. 19:2685-95
39. 3 in intestinal cells. Mol. Endocrinol. 20:1447-61
40. Parekh AB, Putney JW Jr. 2005. Store-operated calcium channels. Physiol. Rev. 85:757-810
41. Kahr H, Schindl R, Fritsch R, Heinze B, Hofbauer M, et al. 2004. CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells. J. Physiol. 557:121-32
42. 2+ transporter type 1. J. Biol. Chem. 278:15381-89
43. 2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 22:7858-61
44. 2+ channel expression. Biochem. Biophys. Res. Commun. 322:1359-63
45. Loffing J, Loffing-Cueni D, Valderrabano V, Klausli L, Hebert SC, et al. 2001. Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am. J. Physiol. Renal Physiol. 281:F1021-27
46. den Dekker E, Schoeber J, Topala CN, van de Graaf SF, Hoenderop JG, Bindels RJ. 2005. Characterization of a Madin-Darby canine kidney cell line stably expressing TRPV5. Pflügers Arch. 450:236-44
47. Hoenderop JG, Muller D, Van Der Kemp AW, Hartog A, Suzuki M, et al. 2001. Calcitriol controls the epithelial calcium channel in kidney. J. Am. Soc. Nephrol. 12:1342-49
48. 2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J. Clin. Invest. 112:1906-14
49. 2+ channel (ECAC1). Genomics 67:48-53
50. Peng JB, Brown EM, Hediger MA. 2001. Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics 76:99-109
51. Qiu A, Hogstrand C. 2004. Functional characterisation and genomic analysis of an epithelial calcium channel (ECaC) from pufferfish, Fugu rubripes. Gene 342:113-23
52. 2+ hyperabsorption in TRPV5 knockout mice. J. Am. Soc. Nephrol. 16:3188-95
53. Procino G, Carmosino M, Tamma G, Gouraud S, Laera A, et al. 2004. Extracellular calcium antagonizes forskolin-induced aquaporin 2 trafficking in collecting duct cells. Kidney Int. 66:2245-55
54. Valenti G, Procino G, Tamma G, Carmosino M, Svelto M. 2005. Minireview: aquaporin 2 trafficking. Endocrinology 146:5063-70
55. 2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc. Natl. Acad. Sci. USA 102:17507-12
56. 2+ channel TRPV6 in the kidney. J. Am. Soc. Nephrol. 14:2731-40
57. Lloyd SE, Pearce SH, Fisher SE, Steinmeyer K, Schwappach B, et al. 1996. A common molecular basis for three inherited kidney stone diseases. Nature 379:445-49
58. Prie D, Huart V, Bakouh N, Planelles G, Dellis O, et al. 2002. Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2 a sodium-phosphate cotransporter. N Engl. J. Med. 347:983-91
59. Vezzoli G, Tanini A, Ferrucci L, Soldati L, Bianchin C, et al. 2002. Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. J. Am. Soc. Nephrol. 13:2517-23
60. Lerolle N, Coulet F, Lantz B, Paillard F, Houillier P, et al. 2001. No evidence for point mutations of the calcium-sensing receptor in familial idiopathic hypercalciuria. Nephrol. Dial. Transplant. 16:2317-22
61. Scott P, Ouimet D, Valiquette L, Guay G, Proulx Y, et al. 1999. Suggestive evidence for a susceptibility gene near the vitamin D receptor locus in idiopathic calcium stone formation. J. Am. Soc. Nephrol. 10:1007-13
62. Rendina D, Mossetti G, Viceconti R, Sorrentino M, Castaldo R, et al. 2004. Association between vitamin D receptor gene polymorphisms and fasting idiopathic hypercalciuria in recurrent stone-forming patients. Urology 64:833-38
63. Soylemezoglu O, Ozkaya O, Gonen S, Misirlioglu M, Kalman S, Buyan N. 2004. Vitamin D receptor gene polymorphism in hypercalciuric children. Pediatr. Nephrol. 19:724-27
64. Lau K, Thomas D, Langman C, Eby B. 1985. Pathophysiology of spontaneous hypercalciuria in laboratory rats. Role of deranged vitamin D metabolism. J. Clin. Invest. 76:420-25
65. Karnauskas AJ, van Leeuwen JP, Van Den Bemd GJ, Kathpalia PP, Deluca HF, et al. 2005. Mechanism and function of high vitamin D receptor levels in genetic hypercalciuric stone-forming rats. J. Bone Miner. Res. 20:447-54
66. Hoopes RR Jr, Reid R, Sen S, Szpirer C, Dixon P, et al. 2003. Quantitative trait loci for hypercalciuria in a rat model of kidney stone disease. J. Am. Soc. Nephrol. 14:1844-50
67. Achard JM, Disse-Nicodeme S, Fiquet-Kempf B, Jeunemaitre X. 2001. Phenotypic and genetic heterogeneity of familial hyperkalaemic hypertension (Gordon syndrome). Clin. Exp. Pharmacol. Physiol. 28:1048-52
68. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Willams C, et al. 2001. Human hypertension caused by mutations in WNK kinases. Science 293:1107-12
69. Yang CL, Angell J, Mitchell R, Ellison DH. 2003. WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J. Clin. Inv. 111:1039-45
70. + secretion. Nat. Genet. 35:372-76
71. Jiang Y, Ferguson WB, Peng JB. 2007. WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. Am. J. Physiol. Renal Physiol. 292:F545-54
72. 2+ channel (ECAC1) in autosomal dominant idiopathic hypercalciuria. Nephrol. Dial. Transplant. 17:1614-20
73. Pak CY. 1979. Physiological basis for absorptive and renal hypercalciurias. Am. J. Physiol. 237:F415-23
74. Uitterlinden AG, Fang Y, van Meurs JB, Pols HA, van Leeuwen JP. 2004. Genetics and biology of vitamin D receptor polymorphisms. Gene 338:143-56
75. Pacifici R. 1996. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J. Bone Miner. Res. 11:1043-51
76. Albagha OM, Pettersson U, Stewart A, McGuigan FE, MacDonald HM, et al. 2005. Association of oestrogen receptor alpha gene polymorphisms with postmenopausal bone loss, bone mass, and quantitative ultrasound properties of bone. J. Med. Genet. 42:240-46
77. Brunkow ME, Gardner JC, Van Ness J, Paeper BW, Kovacevich BR, et al. 2001. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein. Am. J. Hum. Genet. 68:577-89
78. Uitterlinden AG, Arp PP, Paeper BW, Charmley P, Proll S, et al. 2004. Polymorphisms in the sclerosteosis/van Buchem disease gene (SOST) region are associated with bone-mineral density in elderly whites. Am. J. Hum. Genet. 75:1032-45
79. Giannini S, Nobile M, Dalle CL, Lodetti MG, Sella S, et al. 2003. Hypercalciuria is a common and important finding in postmenopausal women with osteoporosis. Eur. J. Endocrinol. 149:209-13
80. Van Cromphaut SJ, Rummens K, Stockmans I, Van Herck E, Dijcks FA, et al. 2003. Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms. J. Bone Miner. Res. 18:1725-36
81. Malloy PJ, Pike JW, Feldman D. 1999. The vitamin D receptor and the syndrome of hereditary 1,25-dihydroxyvitamin D-resistant rickets. Endocr. Rev. 20:156-88
82. Hughes MR, Malloy PJ, Kieback DG, Kesterson RA, Pike JW, et al. 1988. Point mutations in the human vitamin D receptor gene associated with hypocalcemic rickets. Science 242:1702-5
83. Hewison M, Rut AR, Kristjansson K, Walker RE, Dillon MJ, et al. 1993. Tissue resistance to 1,25-dihydroxyvitamin D without a mutation of the vitamin D receptor gene. Clin. Endocrinol. 39:663-70
84. Giraldo A, Pino W, Garcia-Ramirez LF, Pineda M, Iglesias A. 1995. Vitamin D dependent rickets type II and normal vitamin D receptor cDNA sequence. A cluster in a rural area of Cauca, Colombia, with more than 200 affected children. Clin. Genet. 48:57-65