Multinucleation of a sibling blastomere on day 2 suggests unsuitability for embryo transfer in IVF-preimplantation genetic screening cycles

Fertility and Sterility

Volumn 96, Issue 4, 2011, Pages 856-859

  Ambroggio, Jennifer ^a   Gindoff, Paul R ^a   Dayal, Molina B ^a   Khaldi, Reem ^a   Peak, Doug ^a   Frankfurter, David ^a   Dubey, Anil K ^a  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Aneuploidy; multinucleated blastomere; preimplantation genetic screening

Indexed keywords

ADULT; ANEUPLOIDY; ARTICLE; BLASTOMERE; CHROMOSOME 13; CHROMOSOME 15; CHROMOSOME 16; CHROMOSOME 17; CHROMOSOME 18; COHORT ANALYSIS; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC ASSOCIATION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; OOCYTE RETRIEVAL; PREGNANCY OUTCOME; PREGNANCY RATE; PREIMPLANTATION GENETIC SCREENING; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; RECURRENT ABORTION; RETROSPECTIVE STUDY; RISK FACTOR; X CHROMOSOME; Y CHROMOSOME;

ADULT; ANEUPLOIDY; BLASTOMERES; CELL NUCLEUS; COHORT STUDIES; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; GENETIC TESTING; HUMANS; ORGAN CULTURE TECHNIQUES; PREGNANCY; PREGNANCY OUTCOME; PREIMPLANTATION DIAGNOSIS; RETROSPECTIVE STUDIES; SIBLINGS;

EID: 80053297329     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.07.1110     Document Type: Article

References (20)

1. S. Munné, S. Chen, J. Fischer, P. Colls, X. Zheng, and J. Stevens Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 years and older with a history of recurrent miscarriages Fertil Steril 84 2005 331 335 (Pubitemid 41125253)
2. S. Munné, C. Magli, M. Bache, J. Fung, M. Legator, and L. Morrrison Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY,13, 14, 15, 16, 18, 21, 22 Prenat Diagn 18 1998 1459 1466 (Pubitemid 29027003)
3. S. Munné, M. Bache, M. Sandalinas, T. Escudero, C. Marquez, and E. Velilla Differences in chromosome susceptibility to aneuploidy and survival to first trimester Repod Biomed Online 8 2004 81 90 (Pubitemid 38100694)
4. S. Munné Chromosome abnormalities and their relationship to morphology and development of human embryos Reprod Biomed Online 12 2006 234 253 (Pubitemid 43263338)
5. S. Munné, M. Sadalinas, T. Escuderai, E. Velilla, R. Walmseley, and W. Sadowy Improved implantation after preimplantation genetics diagnosis of aneuploidy Reprod Biomed Online 7 2003 91 97 (Pubitemid 36874416)
6. L. Gianaroli, C. Magli, A.P. Ferraretti, and S. Munné Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with poor prognosis: Identification of the categories for which it should be proposed Fertil Steril 72 1999 834 844
7. L. Weriln, I. Rodi, A. Dechereny, E. Marello, D. Hill, and S. Munné Preimplantation genetic diagnosis (PGD) as both a therapeutic and diagnostic tool in assisted reproductive technology Fertil Steril 80 2003 467 468 (Pubitemid 36959815)
8. L. Rienzi, F. Ubaldi, M. Iacobelli, S. Romano, M.G. Minasi, and S. Ferrero Significance of morphological attributes of the early embryo Reprod Biomed Online 10 2005 669 681 (Pubitemid 40645551)
9. L. Scott, A. Finn, T. O'Leary, S. McLellan, and J. Hill Morphologic parameters of early cleavage-stage embryos that correlate with fetal development and delivery: prospective and applied data for increased pregnancy rates Hum Reprod 22 2007 230 240 (Pubitemid 44942691)
10. J. Holte, L. Berglund, K. Milton, C. Garello, G. Gennarelli, and A. Revelli Construction of an evidence-based integrated morphology cleavage embryo score for implantation potential of embryos scored and transferred on day 2 after oocyte retrieval Hum Reprod 22 2007 548 557 (Pubitemid 46152580)
11. S. Pickering, A. Taylor, M. Johnson, and P. Braude An analysis of multinucleated blastomere formation in human embryos Hum Reprod 10 1995 1912 1922
12. E. van Royen, K. Mangelschots, M. Vercruyssen, D. de Neubourg, M. Valkenburg, and G. Ryckaert Multinucleation in cleavage stage embryos Hum Reprod 18 2003 1062 1069 (Pubitemid 36592050)
13. R. de Cassia Savio Figueira, A. Souza Setti, D. Paes de Almeida Ferreira Braga, A. Iaconelli Jr., and E. Boregs Jr. Blastomere multinucleation: contributing factors and effects on embryo development and clinical outcome Hum Fertil (Camb) 13 2010 143 150
14. I. Kligman, C. Benadiva, M. Alikani, and S. Munné The presence of multinucleated blastomeres in human embryos correlated with chromosomal abnormalities Hum Reprod 11 1996 1492 1498 (Pubitemid 26335100)
15. S. Silber, T. Escudero, K. Lenahan, I. Abdelhadi, Z. Kilani, and S. Munné Chromosomal abnormalities in embryos derived from testicular sperm extraction Fertil Steril 79 2003 30 38 (Pubitemid 36071235)
16. M. Bache, T. Escudero, M. Sandalinas, J. Fung, L. Morrrison, and M. Legator Improvements of preimplantation disgnosis of aneuplody by using microwave-hybridization, cell recycling and mono-color labeling of probes Mol Hum Reprod 9 2000 849 854 (Pubitemid 30660618)
17. E. Velilla, T. Escudero, and S. Munné Blastomere fixation techniques and risk of misdiagnosis for PGD of aneuploidies Reprod Biomed Online 4 2002 210 217
18. Y. Kayhan, B. Basak, and U. Bulent Impact of the presence of one or more multinucleated blastomeres on the developmental potential of the embryo to the blastocyst stage Fertil Steril 83 2005 243 245
19. S. Munné, and J. Cohen Unsuitability of multinucleated human blastomeres for preimplantation genetic diagnosis Hum Reprod 7 1993 1120 1125 (Pubitemid 23204702)
20. R.T. Scott, X. Tao, D. Tylor, K.M. Ferry, and N.R. Treff A prospective randomized controlled trial demonstrating significantly increased clinical pregnancy rates following 24 chromosome aneuploidy screening: biopsy and analysis on day 5 with fresh transfer Fertil Steril 94 Suppl 2010 S4