Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation

Neurobiology of Disease

Volumn 71, Issue 1, 2014, Pages 305-316

  Andresen, Lauren ^a,b   Hampton, David ^a   Taylor Weiner, Amaro ^c   Morel, Lydie ^a   Yang, Yongjie ^a   Maguire, Jamie ^a   Dulla, Chris G ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

Cortex; Developmental cortical malformation; Epilepsy; Freeze lesion; Gabapentin; Glutamate; Thrombospondin

Indexed keywords

CALCIUM CHANNEL; GABAPENTIN; KAINIC ACID; THROMBOSPONDIN; 4 AMINOBUTYRIC ACID; AMINE; AMINO ACID RECEPTOR STIMULATING AGENT; ANTICONVULSIVE AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; ASTROCYTOSIS; BRAIN MALFORMATION; CONTROLLED STUDY; DEVELOPMENTAL CORTICAL MALFORMATION; DRUG MECHANISM; ENZYMIC BIOSENSOR; EXCITABILITY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; SEIZURE; SIGNAL TRANSDUCTION; UPREGULATION; ADVERSE EFFECTS; AGE; ANIMAL; C57BL MOUSE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ELECTROSTIMULATION; EPILEPSY; EVOKED RESPONSE; FREEZING; GROWTH, DEVELOPMENT AND AGING; INJURIES; MALFORMATIONS OF CORTICAL DEVELOPMENT; METABOLISM; NEUROIMAGING; NEWBORN; PATCH CLAMP TECHNIQUE; SOMATOSENSORY CORTEX;

AGE FACTORS; AMINES; ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; CALCIUM CHANNELS; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EPILEPSY; EVOKED POTENTIALS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; FREEZING; GAMMA-AMINOBUTYRIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; IN VITRO TECHNIQUES; KAINIC ACID; MALFORMATIONS OF CORTICAL DEVELOPMENT; MICE; MICE, INBRED C57BL; NEUROIMAGING; PATCH-CLAMP TECHNIQUES; SOMATOSENSORY CORTEX; THROMBOSPONDINS;

EID: 84908216036     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.08.022     Document Type: Article

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