Th17 cells and related cytokines in unexplained recurrent spontaneous miscarriage at the implantation window

Reproductive BioMedicine Online

Volumn 29, Issue 4, 2014, Pages 481-489

  Saifi, Bita ^a   Rezaee, Seyed Abdolrahim ^b   Tajik, Nader ^a   Ahmadpour, Mahmood Erfanian ^c   Ashrafi, Mahnaz ^d   Vakili, Rosita ^b   Soleimaniasl, Sara ^e   Aflatoonian, Reza ^d   Mehdizadeh, Mehdi ^f  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^e HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

IL 17; IL 21; IL 23; IL 6; TGF ; unexplained recurrent spontaneous miscarriage

Indexed keywords

CYTOKINE; INTERLEUKIN 17; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; MESSENGER RNA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOMODULATION; LUTEAL PHASE; LYMPHOCYTE; LYMPHOCYTE SUBPOPULATION; NIDATION; PATHOGENESIS; PERIPHERAL LYMPHOCYTE; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPONTANEOUS ABORTION; TH17 CELL; ADULT; BLOOD; CELL CULTURE; CROSS-SECTIONAL STUDY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IRAN; METABOLISM; PATHOLOGY; PREGNANCY; RECURRENT ABORTION; REPRODUCIBILITY; STATISTICAL MODEL;

ABORTION, HABITUAL; ADULT; CELLS, CULTURED; CROSS-SECTIONAL STUDIES; CYTOKINES; EMBRYO IMPLANTATION; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; IRAN; LINEAR MODELS; LUTEAL PHASE; PREGNANCY; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84908211692     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2014.06.008     Document Type: Article

References (35)

1. Arruvito L., Billordo A., Capucchio M., Prada M.E., and Fainboim L. IL-6 trans-signaling and the frequency of CD4+FOXP3+ cells in women with reproductive failure J. Reprod. Immunol 82 2009 158 165
2. Arruvito L., Sotelo A.I., Billordo A., and Fainboim L. A physiological role for inducible FOXP3(+) Treg cells. Lessons from women with reproductive failure Clin. Immunol 136 2010 432 441
3. Bansal A.S., Bajardeen B., and Thum M.Y. The basis and value of currently used immunomodulatory therapies in recurrent miscarriage J. Reprod. Immunol 93 2012 41 51
4. Chen H.-H., Chen D.-Y., Chen M.-J., Chen M.-F., and Chueh P.-J. Decreased Ratios of Serum Th17/Treg-related Cytokines in Women with a Defect in Implantation after in vitro Fertilization Formos. J. Rheumatol 23 2009 66 71
5. Chen Z., Lin F., Gao Y., Li Z., Zhang J., Xing Y., Deng Z., Yao Z., Tsun A., and Li B. FOXP3 and RORgammat: transcriptional regulation of Treg and Th17 Int. Immunopharmacol 11 2011 536 542
6. Corthay A. How do regulatory T cells work? Scand. J. Immunol 70 2009 326 336
7. Du M.R., Dong L., Zhou W.H., Yan F.T., and Li D.J. Cyclosporin a improves pregnancy outcome by promoting functions of trophoblasts and inducing maternal tolerance to the allogeneic fetus in abortion-prone matings in the mouse Biol. Reprod 76 2007 906 914
8. Guerin L.R., Prins J.R., and Robertson S.A. Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum. Reprod. Update 15 2009 517 535
9. Iwakura Y., and Ishigame H. The IL-23/IL-17 axis in inflammation J. Clin. Invest 116 2006 1218 1222
10. Kishimoto T. IL-6: from its discovery to clinical applications Int. Immunol 22 2010 347 352
11. Kwak-Kim J.Y., Chung-Bang H.S., Ng S.C., Ntrivalas E.I., Mangubat C.P., Beaman K.D., Beer A.E., and Gilman-Sachs A. Increased T helper 1 cytokine responses by circulating T cells are present in women with recurrent pregnancy losses and in infertile women with multiple implantation failures after IVF Hum. Reprod 18 2003 767 773
12. Kwak-Kim J., Yang K.M., and Gilman-Sachs A. Recurrent pregnancy loss: a disease of inflammation and coagulation J. Obstet. Gynaecol. Res 35 2009 609 622
13. Lee J.Y., Lee M., and Lee S.K. Role of endometrial immune cells in implantation Clin. Exp. Reprod. Med 38 2011 119 125
14. Lee S.K., Kim J.Y., Hur S.E., Kim C.J., Na B.J., Lee M., Gilman-Sachs A., and Kwak-Kim J. An imbalance in interleukin-17-producing T and Foxp3(+) regulatory T cells in women with idiopathic recurrent pregnancy loss Hum. Reprod 26 2011 2964 2971
15. Lee S.K., Kim J.Y., Lee M., Gilman-Sachs A., and Kwak-Kim J. Th17 and regulatory T cells in women with recurrent pregnancy loss Am. J. Reprod. Immunol 67 2012 311 318
16. Liu Y.S., Wu L., Tong X.H., Wu L.M., He G.P., Zhou G.X., Luo L.H., and Luan H.B. Study on the relationship between Th17 cells and unexplained recurrent spontaneous abortion Am. J. Reprod. Immunol 65 2011 503 511
17. Makhseed M., Raghupathy R., Azizieh F., Farhat R., Hassan N., and Bandar A. Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions Hum. Reprod 15 2000 2011 2017
18. Medicine P.C.O.T.A.S.F.R. The clinical relevance of luteal phase deficiency: a committee opinion Fertil. Steril 98 2012 1112 1117
19. Mei S., Tan J., Chen H., Chen Y., and Zhang J. Changes of CD4+CD25high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients Fertil. Steril 94 2010 2244 2247
20. Nakashima A., Ito M., Shima T., Bac N.D., Hidaka T., and Saito S. Accumulation of IL-17-positive cells in decidua of inevitable abortion cases Am. J. Reprod. Immunol 64 2010 4 11
21. Prins J.R., Gomez-Lopez N., and Robertson S.A. Interleukin-6 in pregnancy and gestational disorders J. Reprod. Immunol 95 2012 1 14
22. Robertson S.A., Care A.S., and Skinner R.J. Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice Biol. Reprod 76 2007 738 748
23. Roses R.E., Xu S., Xu M., Koldovsky U., Koski G., and Czerniecki B.J. Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists J. Immunol 181 2008 5120 5127
24. Saini V., Arora S., Yadav A., and Bhattacharjee J. Cytokines in recurrent pregnancy loss Clin. Chim. Acta 412 2011 702 708
25. Saito S., Nakashima A., Shima T., and Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy Am. J. Reprod. Immunol 63 2010 601 610
26. Saito S., Nakashima A., Ito M., and Shima T. Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology Expert. Rev. Clin. Immunol 7 2011 649 657
27. Schumacher A., Brachwitz N., Sohr S., Engeland K., Langwisch S., Dolaptchieva M., Alexander T., Taran A., Malfertheiner S.F., Costa S.D., Zimmermann G., Nitschke C., Volk H.D., Alexander H., Gunzer M., and Zenclussen A.C. Human chorionic gonadotropin attracts regulatory T cells into the fetal-maternal interface during early human pregnancy J. Immunol 182 2009 5488 5497
28. Steinborn A., Schmitt E., Kisielewicz A., Rechenberg S., Seissler N., Mahnke K., Schaier M., Zeier M., and Sohn C. Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs Clin. Exp. Immunol 167 2012 84 98
29. Unfried G., Bocskor S., Endler G., Nagele F., Huber J.C., and Tempfer C.B. A polymorphism of the interleukin-6 gene promoter and idiopathic recurrent miscarriage Hum. Reprod 18 2003 267 270
30. Uz Y.H., Murk W., Yetkin C.E., Kayisli U.A., and Arici A. Expression and role of interleukin-23 in human endometrium throughout the menstrual cycle and early pregnancy J. Reprod. Immunol 87 2010 21 27
31. Wang W.J., Hao C.F., Qu Q.L., Wang X., Qiu L.H., and Lin Q.D. The deregulation of regulatory T cells on interleukin-17-producing T helper cells in patients with unexplained early recurrent miscarriage Hum. Reprod 25 2010 2591 2596
32. Wang W.J., Hao C.F., Yi L., Yin G.J., Bao S.H., Qiu L.H., and Lin Q.D. Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients J. Reprod. Immunol 84 2010 164 170
33. World Health Organization WHO Laboratory Manual for The Examination of Human Semen and Sperm-Cervical Mucus Interaction 1999 Cambridge university press
34. Wu Z., You Z., Zhang C., Li Z., Su X., Zhang X., and Li Y. Association between functional polymorphisms of Foxp3 gene and the occurrence of unexplained recurrent spontaneous abortion in a Chinese Han population Clin. Dev. Immunol 2012 2012 896458
35. Yang H., Qiu L., Chen G., Ye Z., Lu C., and Lin Q. Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients Fertil. Steril 89 2008 656 661