Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

Nature Immunology

Volumn 15, Issue 11, 2014, Pages 1046-1054

  Valdor, Rut ^a   Mocholi, Enric ^a   Botbol, Yair ^a   Guerrero Ros, Ignacio ^a   Chandra, Dinesh ^a   Koga, Hiroshi ^a   Gravekamp, Claudia ^a   Cuervo, Ana Maria ^a   Macian, Fernando ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN A; FREUND ADJUVANT; GREEN FLUORESCENT PROTEIN; LAMP2A PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 2; MESSENGER RNA; OVALBUMIN; PEPTIDE VACCINE; RCAN1 PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR NFAT; UBIQUITIN LIGASE ITCH; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CHAPERONE; DSCR1 PROTEIN, MOUSE; DUOX1 PROTEIN, MOUSE; ITCH PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MUSCLE PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SIGNAL PEPTIDE; TCFEB PROTEIN, MOUSE;

ADAPTIVE IMMUNITY; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELLULAR IMMUNITY; CHAPERONE-MEDIATED AUTOPHAGY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; LISTERIA MONOCYTOGENES; LISTERIOSIS; LYMPHOCYTE PROLIFERATION; LYSOSOME; MACROAUTOPHAGY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ANIMAL; AUTOPHAGY; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; GENETICS; IMMUNIZATION; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; RNA INTERFERENCE; TH1 CELL;

AGING; ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CALCINEURIN INHIBITORS; CELLS, CULTURED; FEMALE; HUMANS; IMMUNIZATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LISTERIA MONOCYTOGENES; LISTERIOSIS; LYMPHOCYTE ACTIVATION; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR CHAPERONES; MUSCLE PROTEINS; NADPH OXIDASE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, ANTIGEN, T-CELL; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TH1 CELLS; UBIQUITIN-PROTEIN LIGASES;

EID: 84908207126     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3003     Document Type: Article

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