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Volumn 9, Issue 10, 2014, Pages

Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AS160; COMPOUND C; ENZYME INHIBITOR; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; URSOLIC ACID; WORTMANNIN; ANTIINFECTIVE AGENT; PROTEIN KINASE INHIBITOR; SLC2A4 PROTEIN, MOUSE; TRITERPENE;

EID: 84908180953     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110711     Document Type: Article
Times cited : (30)

References (40)
  • 1
    • 0033533596 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease: A statement for healthcare professionals from the American heart association
    • Grundy SM, Benjamin IJ, Burke GL, Chait A, Eckel RH, et al. (1999) Diabetes and cardiovascular disease: a statement for healthcare professionals from the American Heart Association. Circulation 100: 1134-1146.
    • (1999) Circulation , vol.100 , pp. 1134-1146
    • Grundy, S.M.1    Benjamin, I.J.2    Burke, G.L.3    Chait, A.4    Eckel, R.H.5
  • 2
    • 29244462334 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose transport
    • Chang L, Chiang SH, Saltiel AR (2004) Insulin signaling and the regulation of glucose transport. Mol Med 10: 65-71.
    • (2004) Mol Med , vol.10 , pp. 65-71
    • Chang, L.1    Chiang, S.H.2    Saltiel, A.R.3
  • 3
    • 0036434431 scopus 로고    scopus 로고
    • Insulin regulation of glucose uptake: A complex interplay of intracellular signalling pathways
    • Khan AH, Pessin JE (2002) Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 45: 1475-1483.
    • (2002) Diabetologia , vol.45 , pp. 1475-1483
    • Khan, A.H.1    Pessin, J.E.2
  • 4
    • 0035430576 scopus 로고    scopus 로고
    • Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance
    • de Souza CJ, Eckhardt M, Gagen K, Dong M, Chen W, et al. (2001) Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes 50: 1863-1871.
    • (2001) Diabetes , vol.50 , pp. 1863-1871
    • De Souza, C.J.1    Eckhardt, M.2    Gagen, K.3    Dong, M.4    Chen, W.5
  • 7
    • 38949149637 scopus 로고    scopus 로고
    • Ursolic acid: An anti- and pro-inflammatory triterpenoid
    • Ikeda Y, Murakami A, Ohigashi H (2008) Ursolic acid: an anti- and pro-inflammatory triterpenoid. Mol Nutr Food Res 52: 26-42.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 26-42
    • Ikeda, Y.1    Murakami, A.2    Ohigashi, H.3
  • 8
    • 23044440041 scopus 로고    scopus 로고
    • Oleanolic acid and ursolic acid: Research perspectives
    • Liu J (2005) Oleanolic acid and ursolic acid: research perspectives. J Ethnopharmacol 100: 92-94.
    • (2005) J Ethnopharmacol , vol.100 , pp. 92-94
    • Liu, J.1
  • 9
    • 31044449046 scopus 로고    scopus 로고
    • Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in cornelian cherry (Cornus mas)
    • Jayaprakasam B, Olson LK, Schutzki RE, Tai MH, Nair MG (2006) Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). J Agric Food Chem 54: 243-248.
    • (2006) J Agric Food Chem , vol.54 , pp. 243-248
    • Jayaprakasam, B.1    Olson, L.K.2    Schutzki, R.E.3    Tai, M.H.4    Nair, M.G.5
  • 10
    • 80755175244 scopus 로고    scopus 로고
    • Ursolic acid, a pentacyclic triterpene from sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet
    • Rao VS, de Melo CL, Queiroz MG, Lemos TL, Menezes DB, et al. (2011) Ursolic acid, a pentacyclic triterpene from Sambucus australis, prevents abdominal adiposity in mice fed a high-fat diet. J Med Food 14: 1375-1382.
    • (2011) J Med Food , vol.14 , pp. 1375-1382
    • Rao, V.S.1    De Melo, C.L.2    Queiroz, M.G.3    Lemos, T.L.4    Menezes, D.B.5
  • 11
    • 68649103280 scopus 로고    scopus 로고
    • Anti-lipase and lipolytic activities of ursolic acid isolated from the roots of actinidia arguta
    • Kim J, Jang DS, Kim H, Kim JS (2009) Anti-lipase and lipolytic activities of ursolic acid isolated from the roots of Actinidia arguta. Arch Pharm Res 32: 983-987.
    • (2009) Arch Pharm Res , vol.32 , pp. 983-987
    • Kim, J.1    Jang, D.S.2    Kim, H.3    Kim, J.S.4
  • 12
    • 78349294211 scopus 로고    scopus 로고
    • Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes
    • Li Y, Kang Z, Li S, Kong T, Liu X, et al. (2010) Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes. Mol Nutr Food Res 54: 1609-1617.
    • (2010) Mol Nutr Food Res , vol.54 , pp. 1609-1617
    • Li, Y.1    Kang, Z.2    Li, S.3    Kong, T.4    Liu, X.5
  • 13
    • 84880770584 scopus 로고    scopus 로고
    • Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway
    • He Y, Li Y, Zhao T, Wang Y, Sun C (2013) Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. PLoS One 8: e70135.
    • (2013) PLoS One , vol.8
    • He, Y.1    Li, Y.2    Zhao, T.3    Wang, Y.4    Sun, C.5
  • 14
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444: 840-846.
    • (2006) Nature , vol.444 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 15
    • 77949433071 scopus 로고    scopus 로고
    • Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice
    • Jang SM, Kim MJ, Choi MS, Kwon EY, Lee MK (2010) Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice. Metabolism 59: 512-519.
    • (2010) Metabolism , vol.59 , pp. 512-519
    • Jang, S.M.1    Kim, M.J.2    Choi, M.S.3    Kwon, E.Y.4    Lee, M.K.5
  • 16
    • 58149464690 scopus 로고    scopus 로고
    • Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet
    • Jang SM, Yee ST, Choi J, Choi MS, Do GM, et al. (2009) Ursolic acid enhances the cellular immune system and pancreatic beta-cell function in streptozotocin-induced diabetic mice fed a high-fat diet. Int Immunopharmacol 9: 113-119.
    • (2009) Int Immunopharmacol , vol.9 , pp. 113-119
    • Jang, S.M.1    Yee, S.T.2    Choi, J.3    Choi, M.S.4    Do, G.M.5
  • 17
    • 83055184172 scopus 로고    scopus 로고
    • Anti-diabetic potential of ursolic acid stearoyl glucoside: A new triterpenic gycosidic ester from lantana camara
    • Kazmi I, Rahman M, Afzal M, Gupta G, Saleem S, et al. (2012) Anti-diabetic potential of ursolic acid stearoyl glucoside: a new triterpenic gycosidic ester from Lantana camara. Fitoterapia 83: 142-146.
    • (2012) Fitoterapia , vol.83 , pp. 142-146
    • Kazmi, I.1    Rahman, M.2    Afzal, M.3    Gupta, G.4    Saleem, S.5
  • 18
    • 79958072409 scopus 로고    scopus 로고
    • MRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass
    • Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, et al. (2011) mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell Metab 13: 627-638.
    • (2011) Cell Metab , vol.13 , pp. 627-638
    • Kunkel, S.D.1    Suneja, M.2    Ebert, S.M.3    Bongers, K.S.4    Fox, D.K.5
  • 19
    • 78149466792 scopus 로고    scopus 로고
    • Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice
    • Lee J, Yee ST, Kim JJ, Choi MS, Kwon EY, et al. (2010) Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice. Chem Biol Interact 188: 635-642.
    • (2010) Chem Biol Interact , vol.188 , pp. 635-642
    • Lee, J.1    Yee, S.T.2    Kim, J.J.3    Choi, M.S.4    Kwon, E.Y.5
  • 20
    • 84862665187 scopus 로고    scopus 로고
    • Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease
    • Kunkel SD, Elmore CJ, Bongers KS, Ebert SM, Fox DK, et al. (2012) Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS One 7: e39332.
    • (2012) PLoS One , vol.7
    • Kunkel, S.D.1    Elmore, C.J.2    Bongers, K.S.3    Ebert, S.M.4    Fox, D.K.5
  • 21
    • 33748882713 scopus 로고    scopus 로고
    • Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake
    • Zhang W, Hong D, Zhou Y, Zhang Y, Shen Q, et al. (2006) Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake. Biochim Biophys Acta 1760: 1505-1512.
    • (2006) Biochim Biophys Acta , vol.1760 , pp. 1505-1512
    • Zhang, W.1    Hong, D.2    Zhou, Y.3    Zhang, Y.4    Shen, Q.5
  • 22
    • 77953884960 scopus 로고    scopus 로고
    • Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3
    • Azevedo MF, Camsari C, Sa CM, Lima CF, Fernandes-Ferreira M, et al. (2010) Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. Phytother Res 24 Suppl 2: S220-224.
    • (2010) Phytother Res , vol.24 , pp. S220-224
    • Azevedo, M.F.1    Camsari, C.2    Sa, C.M.3    Lima, C.F.4    Fernandes-Ferreira, M.5
  • 23
    • 33845864967 scopus 로고    scopus 로고
    • Adipocytes as regulators of energy balance and glucose homeostasis
    • Rosen ED, Spiegelman BM (2006) Adipocytes as regulators of energy balance and glucose homeostasis. Nature 444: 847-853.
    • (2006) Nature , vol.444 , pp. 847-853
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 24
    • 84879606038 scopus 로고    scopus 로고
    • Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes
    • He Y, Li Y, Zhang S, Perry B, Zhao T, et al. (2013) Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 436: 169-174.
    • (2013) Biochem Biophys Res Commun , vol.436 , pp. 169-174
    • He, Y.1    Li, Y.2    Zhang, S.3    Perry, B.4    Zhao, T.5
  • 25
    • 3042851621 scopus 로고    scopus 로고
    • Sending the signal: Molecular mechanisms regulating glucose uptake
    • Krook A, Wallberg-Henriksson H, Zierath JR (2004) Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc 36: 1212-1217.
    • (2004) Med Sci Sports Exerc , vol.36 , pp. 1212-1217
    • Krook, A.1    Wallberg-Henriksson, H.2    Zierath, J.R.3
  • 26
    • 84897382346 scopus 로고    scopus 로고
    • Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats
    • Li S, Liao X, Meng F, Wang Y, Sun Z, et al. (2014) Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. PLoS One 9: e86724.
    • (2014) PLoS One , vol.9
    • Li, S.1    Liao, X.2    Meng, F.3    Wang, Y.4    Sun, Z.5
  • 27
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, et al. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115: 1343-1351.
    • (2005) J Clin Invest , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5
  • 28
    • 1842454705 scopus 로고    scopus 로고
    • Adipose tissue and adipokines: For better or worse
    • Guerre-Millo M (2004) Adipose tissue and adipokines: for better or worse. Diabetes Metab 30: 13-19.
    • (2004) Diabetes Metab , vol.30 , pp. 13-19
    • Guerre-Millo, M.1
  • 29
    • 33646161443 scopus 로고    scopus 로고
    • Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2
    • Haukeland JW, Damas JK, Konopski Z, Loberg EM, Haaland T, et al. (2006) Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2. J Hepatol 44: 1167-1174.
    • (2006) J Hepatol , vol.44 , pp. 1167-1174
    • Haukeland, J.W.1    Damas, J.K.2    Konopski, Z.3    Loberg, E.M.4    Haaland, T.5
  • 30
    • 33644825288 scopus 로고    scopus 로고
    • Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance
    • Pagano C, Soardo G, Pilon C, Milocco C, Basan L, et al. (2006) Increased serum resistin in nonalcoholic fatty liver disease is related to liver disease severity and not to insulin resistance. J Clin Endocrinol Metab 91: 1081-1086.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1081-1086
    • Pagano, C.1    Soardo, G.2    Pilon, C.3    Milocco, C.4    Basan, L.5
  • 31
    • 0035825643 scopus 로고    scopus 로고
    • Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    • Abel ED, Peroni O, Kim JK, Kim YB, Boss O, et al. (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409: 729-733.
    • (2001) Nature , vol.409 , pp. 729-733
    • Abel, E.D.1    Peroni, O.2    Kim, J.K.3    Kim, Y.B.4    Boss, O.5
  • 32
    • 0031038052 scopus 로고    scopus 로고
    • Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport
    • Bandyopadhyay G, Standaert ML, Zhao L, Yu B, Avignon A, et al. (1997) Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. J Biol Chem 272: 2551-2558.
    • (1997) J Biol Chem , vol.272 , pp. 2551-2558
    • Bandyopadhyay, G.1    Standaert, M.L.2    Zhao, L.3    Yu, B.4    Avignon, A.5
  • 33
    • 0141815503 scopus 로고    scopus 로고
    • Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both glut4 translocation and p38 MAPK activity
    • Bazuine M, Ouwens DM, Gomes de Mesquita DS, Maassen JA (2003) Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity. Eur J Biochem 270: 3891-3903.
    • (2003) Eur J Biochem , vol.270 , pp. 3891-3903
    • Bazuine, M.1    Ouwens, D.M.2    Gomes De Mesquita, D.S.3    Maassen, J.A.4
  • 34
    • 0035504158 scopus 로고    scopus 로고
    • GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: Potential activation of GLUT4 via p38 mitogen-activated protein kinase
    • Somwar R, Kim DY, Sweeney G, Huang C, Niu W, et al. (2001) GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase. Biochem J 359: 639-649.
    • (2001) Biochem J , vol.359 , pp. 639-649
    • Somwar, R.1    Kim, D.Y.2    Sweeney, G.3    Huang, C.4    Niu, W.5
  • 35
    • 25144470594 scopus 로고    scopus 로고
    • Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes
    • Yamaguchi S, Katahira H, Ozawa S, Nakamichi Y, Tanaka T, et al. (2005) Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 289: E643-649.
    • (2005) Am J Physiol Endocrinol Metab , vol.289 , pp. E643-649
    • Yamaguchi, S.1    Katahira, H.2    Ozawa, S.3    Nakamichi, Y.4    Tanaka, T.5
  • 36
    • 4344559467 scopus 로고    scopus 로고
    • The glucose transporter families SGLT and GLUT: Molecular basis of normal and aberrant function
    • Scheepers A, Joost HG, Schurmann A (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr 28: 364-371.
    • (2004) JPEN J Parenter Enteral Nutr , vol.28 , pp. 364-371
    • Scheepers, A.1    Joost, H.G.2    Schurmann, A.3
  • 37
    • 0033595121 scopus 로고    scopus 로고
    • Glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus
    • Shepherd PR, Kahn BB (1999) Glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus. N Engl J Med 341: 248-257.
    • (1999) N Engl J Med , vol.341 , pp. 248-257
    • Shepherd, P.R.1    Kahn, B.B.2
  • 38
    • 28544435205 scopus 로고    scopus 로고
    • Full intracellular retention of GLUT4 requires AS160 rab GTPase activating protein
    • Eguez L, Lee A, Chavez JA, Miinea CP, Kane S, et al. (2005) Full intracellular retention of GLUT4 requires AS160 Rab GTPase activating protein. Cell Metab 2: 263-272.
    • (2005) Cell Metab , vol.2 , pp. 263-272
    • Eguez, L.1    Lee, A.2    Chavez, J.A.3    Miinea, C.P.4    Kane, S.5
  • 39
    • 27844528870 scopus 로고    scopus 로고
    • Characterization of the role of the rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking
    • Larance M, Ramm G, Stockli J, van Dam EM, Winata S, et al. (2005) Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking. J Biol Chem 280: 37803-37813.
    • (2005) J Biol Chem , vol.280 , pp. 37803-37813
    • Larance, M.1    Ramm, G.2    Stockli, J.3    Van Dam, E.M.4    Winata, S.5
  • 40
    • 10644289369 scopus 로고    scopus 로고
    • Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes
    • Bosch RR, Bazuine M, Span PN, Willems PH, Olthaar AJ, et al. (2004) Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes. Biochem J 384: 349-355.
    • (2004) Biochem J , vol.384 , pp. 349-355
    • Bosch, R.R.1    Bazuine, M.2    Span, P.N.3    Willems, P.H.4    Olthaar, A.J.5


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