Myopia

Garner and Klintworth's Pathobiology of Ocular Disease, Third Edition

Volumn , Issue , 2008, Pages 537-556

  Norton, Thomas T ^a   Metlapally, Ravikanth ^b   Young, Terri L ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b DUKE UNIVERSITY EYE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84908170791     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (252)

1. Adams DW, McBrien NA. Prevalence of myopia and myopic progression in a population of clinical microscopists. Optom Vis Sci 1992; 69:467-73.
2. Angle J, Wissmann DA. The epidemiology of myopia. Am J Epidemiol 1980; 111:220-8.
3. Ashton GC. Segregation analysis of ocular refraction and myopia. Hum Hered 1985; 35:232-9.
4. Atkinson SJ, Crabbe T, Cowell S, et al. Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes. J Biol Chem 1995; 270:30479-85.
5. Austin BA, Coulon C, Liu CY, et al. Altered collagen fibril formation in the sclera of lumican-deficient mice. Invest Ophthalmol Vis Sci 2002; 43:1695-701.
6. Avetisov ES, Savitskaya NF, Vinetskaya MI, et al. A study of biochemical and biomechanical qualities of normal and myopic eye sclera in humans of different age groups. Metab Pediatr Syst Ophthalmol 1983; 7, 183-8.
7. Avila MP, Weiter JJ, Jalkh AE, et al. Natural history of choroidal neovascularization in degenerative myopia. Ophthalmol 1984; 91:1573-81.
8. Baldwin WR. A review of statistical studies of relations between myopia and ethnic, behavioral, and physiological characteristics. Am J Optom Physiol Opt 1981; 58:516-27.
9. Barrington M, Sattayasai J, Zappia J, et al. Excitatory amino acids interfere with normal eye growth in posthatch chick. Curr Eye Res 1989; 8, 781-92.
10. Bertrand E, Fritsch C, Diether S, et al. Identification of Apolipoprotein A1 as a “STOP” signal for myopia. Mol Cell Proteomics 2006.
11. Biino G, Palmas MA, Corona C, et al. Ocular refraction:heritability and genome-wide search for eye morphometry traits in an isolated Sardinian population. Hum Genet 2005; 116:152-9.
12. Bohlandt S, von Kaisenberg CS, Wewetzer K, et al. Hyaluronan in the nuchal skin of chromosomally abnormal fetuses. Hum Reprod 2000; 15:1155-8.
13. Burton TC. The influence of refractive error and lattice degeneration on the incidence of retinal detachment. Trans Am Ophthalmol Soc 1989; 87:143-55.
14. Carney LG, Mainstone JC, Henderson BA. Corneal topography and myopia: a cross-sectional study. Invest Ophthalmol Vis Sci 1997; 38:311-20.
15. Cheng H, Singh OS, Kwong KK, et al. Shape of the myopic eye as seen with high-resolution magnetic resonance imaging. Optom Vis Sci 1992; 69:698-701.
16. Christensen AM, Wallman J. Evidence that increased scleral growth underlies visual deprivation myopia in chicks. Invest Ophthalmol Vis Sci 1991; 32:2143-21.
17. Cohn H. The Hygiene of the Eye in School, an English Translation. London: Simpkin, Marshall, 1886.
18. Cook RC, Glasscock RE. Refractive and ocular findings in the newborn. Am J Ophthalmol 1951; 34:1407-13.
19. Curtin BJ. Myopia: a review of its etiology, pathogenesis and treatment. Surv Ophthalmol 1970; 15:1-17.
20. Curtin BJ. Posterior staphyloma development in pathologic myopia. Ann Ophthalmol 1982; 14:655-8.
21. Curtin BJ. The Myopias: Basic Science and Clinical Management. Philadelphia, PA: Harper & Row, 1985:1-495.
22. Curtin BJ, Iwamoto T, Renaldo DP. Normal and staphylomatous sclera of high myopia. Arch Ophthalmol 1979; 97:912-5.
23. Curtin BJ, Karlin DB. Axial length measurements and fundus changes of the myopic eye. Am J Ophthalmol 1971; 71:42-53.
24. Dandona R, Dandona L. Refractive error blindness. Bulletin of the World Health Organization 2001; 79:237-47.
25. Diether S, Schaeffel F. Local changes in eye growth induced by imposed local refractive error despite active accommodation. Vision Res 1997; 37:659-68.
26. Farbrother JE, Kirov G, Owen MJ, et al. Family aggregation of high myopia: estimation of the sibling recurrence risk ratio. Invest Ophthalmol Vis Sci 2004; 45:2873-8.
27. Fischer AJ, McGuire JJ, Schaeffel F, et al. Light-and focusdependent expression of the transcription factor ZENK in the chick retina. Nat Neurosci 1999; 2, 706-12.
28. Fledelius HC. Myopia prevalence in Scandinavia. A survey, with emphasis on factors of relevance for epidemiological refraction studies in general. Acta Ophthalmol Suppl 1988; 185:44-50.
29. Fledelius HC, Christensen AC. Reappraisal of the human ocular growth curve in fetal life, infancy, and early childhood. Br J Ophthalmol 1996; 80:918-21.
30. Fried M, Siebert A, Meyer-Schwickerath G. A natural history of Fuchs’ spot: a long-term follow up study. Doc Ophthalmol 1981; 28:215-21.
31. Frost MR, Norton TT. Differential protein expression in tree shrew sclera during recovery from lens-induced myopia. Ophthal Physiol Opt 2006; 26(Suppl. 1):52.
32. Garner LF, Owens H, Kinnear RF, et al. Prevalence of myopia in Sherpa and Tibetan children in Nepal. Optom Vis Sci 1999; 76:282-5.
33. Gass JDM. Stereoscopic atlas of macular diseases:diagnosis and treatment, vol. 1. 4th ed. St. Louis: C.V. Mosby, 1997:126-8.
34. Gentle A, Liu Y, Martin JE, et al. Collagen gene expression and the altered accumulation of scleral collagen during the development of high myopia. J Biol Chem 2003; 278:16587-94.
35. Gentle A, McBrien NA. Modulation of scleral DNA synthesis in development of and recovery from induced axial myopia in the tree shrew. Exp Eye Res 1999; 68:155-63.
36. Gentle A, McBrien NA. Retinoscleral control of scleral remodelling in refractive development: a role for endogenous FGF-2? Cytokine 2002; 18:344-8.
37. German A, Baker J, Norton TT. Changes in glycosaminoglycan levels in tree shrew sclera during lens-induced myopia and recovery. Invest Ophthalmol Vis Sci 2002; 43:E-Abstract 215.
38. Ghafour IM, Allan D, Foulds WS. Common causes of blindness and visual handicap in the west of Scotland. Br J Ophthalmol 1983; 67:209-13.
39. Goh WSH, Lam CSY. Changes in refractive trends and optical components of Hong Kong Chinese aged 19-39 years. Ophthalmic Physiol Opt 1994; 14:378-82.
40. Goldschmidt E. On the etiology of myopia: an epidemiological study. Acta Ophthalmol Suppl 1968; 98:1-172.
41. Gordon RA, Donzis PB. Refractive development of the human eye. Arch Ophthalmol 1985; 103:785-9.
42. Goss DA, Hampton MJ, Wickham MG. Selected review on genetic factors in myopia. J Am Optom Assoc 1988; 59:875-84.
43. Goss DA, Jackson TW. Clinical findings before the onset of myopia in youth: parental history of myopia. Optom Vis Sci 1995; 73:279-82.
44. Goss DA, Winkler RL. Progression of myopia in youth:age of cessation. Am J Optom Physiol Opt 1983; 60:651-8.
45. Grierson I, Heathcote L, Hiscott P, et al. Hepatocyte growth factor/scatter factor in the eye. Prog Retin Eye Res 2000; 19:779-802.
46. Grossniklaus HE, Green WR. Pathologic findings in pathologic myopia. Retina 1992; 12:127-33.
47. Grosvenor T. A review and a suggested classification system for myopia on the basis of age-related prevalence and age of onset. Am J Optom Physiol Opt 1987; 64:545-54.
48. Grosvenor T, Goss DA. Role of the cornea in emmetropia and myopia. Optom Vis Sci 1998; 75:132-45.
49. Grosvenor T, Scott R. Role of the axial length/corneal radius ratio in determining the refractive state of the eye. Optom Vis Sci 1994; 71:573-9.
50. Guggenheim JA, Kirov G, Hodson SA. The heritability of high myopia: a reanalysis of Goldschmidt’s data. J Med Genet 2000; 37:227-31.
51. Guggenheim JA, McBrien NA. Form-deprivation myopia induces activation of scleral matrix metalloproteinase-2 in tree shrew. Invest Ophthalmol Vis Sci 1996; 37:1380-95.
52. Gwiazda J, Thorn F, Bauer J, et al. Emmetropization and the progression of manifest refraction in children followed from infancy to puberty. Clin Vision Sci 1993; 8, 337-44.
53. Gwiazda J, Thorn F, Bauer J, et al. Myopic children show insufficient accommodative response to blur. Invest Ophthalmol Vis Sci 1993; 34:690-4.
54. Hammond CJ, Andrew T, Mak YT, et al. A susceptibility locus for myopia in the normal population is linked to the PAX6 gene region on chromosome 11: a genomewide scan of dizygotic twins. Am J Hum Genet 2004; 75:294-304.
55. Hammond CJ, Snieder H, Gilbert CE, et al. Genes and environment in refractive error: the twin eye study. Invest Ophthalmol Vis Sci 2001; 42:1232-6.
56. Hampton GR, Kohen D, Bird AC. Visual prognosis of disciform degeneration in myopia. Ophthalmol 1983; 90:923-6.
57. Han W, Yap MK, Wang J, et al. Family-based association analysis of hepatocyte growth factor (HGF) gene polymorphisms in high myopia. Invest Ophthalmol Vis Sci 2006; 47:2291-9.
58. Hayasaka S, Uchida M, Setogawa T. Subretinal hemorrhages with or without choroidal neovascularization in the maculas of patients with pathologic myopia. Graefes Arch Clin Exp Ophthalmol 1990; 228:277-80.
59. Heath S, Robledo R, Beggs W, et al. A novel approach to search for identity by descent in small samples of patients and controls from the same Mendelian breeding unit: a pilot study on myopia. Hum Hered 2001; 52:183-90.
60. Hirsch M, Weymouth F. Notes on ametropia: a further analysis of Stenstrom’s data. Am J Optom Arch Am Acad Optom 1947; 24:601-3.
61. Hodos W, Kuenzel WJ. Retinal-image degradation produces ocular enlargement in chicks. Invest Ophthalmol Vis Sci 1984; 25:652-9.
62. Holmbeck K, Bianco P, Caterina J, et al. MT1-MMPdeficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Cell 1999; 99:81-92.
63. Hotchkiss ML, Fine SL. Pathologic myopia and choroidal neovascularization. Am J Ophthalmol 1981; 91:177-83.
64. Howland HC, Waite S, Peck L. Early focusing history predicts later refractive state: a longitudinal photorefractive study. Optical Society of America 1993; 3, 210-3.
65. Hoyt CS, Stone RD, Frommer C, et al. Monocular axial myopia associated with neonatal eyelid closure in human infants. Am J Ophthalmol 1981; 91:197-200.
66. Hung LF, Crawford ML, Smith EL. Spectacle lenses alter eye growth and the refractive status of young monkeys. Nat Med 1995; 1, 761-5.
67. Hung LF, Wallman J, Smith EL III. Vision-dependent changes in the choroidal thickness of macaque monkeys. Invest Ophthalmol Vis Sci 2000; 41:1259-69.
68. Hyman L, Gwiazda J, Hussein M, et al. Relationship of age, sex, and ethnicity with myopia progression and axial elongation in the correction of myopia evaluation trial. Arch Ophthalmol 2005; 123:977-87.
69. Ibay G, Doan B, Reider L, et al. Candidate high myopia loci on chromosomes 18p and 12q do not play a major role in susceptibility to common myopia. BMC Med Genet 2004; 5, 20.
70. Irving EL, Callender MG, Sivak JG. Inducing ametropias in hatchling chicks by defocus-aperture effects and cylindrical lenses. Vision Res 1995; 35:1165-74.
71. Irving EL, Callender MG, Sivak JG. Inducing myopia, hyperopia, and astigmatism in chicks. Optom Vis Sci 1991; 68:364-8.
72. Jalkh AE, Weiter JJ, Trempe CL, et al. Choroidal neovascularization in degenerative myopia: role of laser photocoagulation. Ophthalmic Surg 1987; 18:721-5.
73. Jansson F. Measurements of intraocular distances by ultrasound. Acta Ophthalmol (Copenh) 1963; (Suppl 74):1-51.
74. Jobling AI, Nguyen M, Gentle A, et al. Isoform-specific changes in scleral transforming growth factor-beta expression and the regulation of collagen synthesis during myopia progression. J Biol Chem 2004; 279:18121-6.
75. Jones LA, Sinnott L, Mitchell GL, et al. Parental history of myopia, sports and outdoor activities, and future myopa. Invest Ophthalmol Vis Sci 2007; 48:3524-32.
76. Kang RN, Norton TT. Electronmicroscopic examination of tree shrew sclera during normal development, induced myopia, and recovery [ARVO Abstract]. Invest Ophthalmol Vis Sci 1996; 37:S3241.
77. Katz J, Tielsch JM, Sommer A. Prevalence and risk factors for refractive errors in an adult inner city population. Invest Ophthalmol Vis Sci 1997; 38:334-40.
78. Kee C-S, Hung L-F, Qiao-Grider Y, et al. Temporal constraints on experimental emmetropization in infant monkeys. Invest Ophthalmol Vis Sci 2007; 48:957-62.
79. Kee C-S, Ramamirtham R, Qiao-Grider Y, et al. The role of peripheral vision in the refractive-error development of infant monkeys (Macaca mulatta). Invest Ophthalmol Vis Sci 2004; 45: E-Abstract 1157.
80. Kempen JH, Mitchell P, Lee KE, et al. The prevalence of refractive errors among adults in the United States, Western Europe, and Australia. Arch Ophthalmol 2004; 122:495-505.
81. Kempf GA, Collins SD, Jarman BL. Refractive errors in the eyes of children as determined by retinoscopic examination with a cycloplegic-Results of eye examinations of 1,860 white school children in Washington, D.C. In: Treasury Department, ed. United States Public Health Service. Washington: United States Government Printing Office, 1928:1-56.
82. Kenning MS, Gentle A, McBrien NA. Expression and cDNA sequence of matrix metalloproteinase-2 (MMP-2) in a mammalian model of human disease processes:Tupaia belangeri. DNA Seq 2004; 15:332-7.
83. Klein AP, Duggal P, Lee KE, et al. Support for polygenic influences on ocular refractive error. Invest Ophthalmol Vis Sci 2005; 46:442-6.
84. Kleinstein RN, Jones LA, Hullett S, et al. Refractive error and ethnicity in children. Arch Ophthalmol 2003; 121:1141-7.
85. Lam DS, Lee WS, Leung YF, et al. TGFbeta-induced factor: a candidate gene for high myopia. Invest Ophthalmol Vis Sci 2003; 44:1012-5.
86. Lam DS, Tam PO, Fan DS, et al. Familial high myopia linkage to chromosome 18p. Ophthalmologica 2003; 217:115-8.
87. Leibowitz HM, Krueger DE, Maunder LR, et al. The Framingham Eye Study monograph: an ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults, 1973-1975. Surv Ophthalmol 1980; 24:335-610.
88. Levy JH, Pollock HM, Curtin BJ. The Fuchs’ spot: an ophthalmoscopic and fluorescein angiographic study. Annals of Ophthalmology 1977; 1433-43.
89. Liang H, Crewther SG, Crewther DP, et al. Structural and elemental evidence for edema in the retina, retinal pigment epithelium, and choroid during recovery from experimentally induced myopia. Invest Ophthalmol Vis Sci 2004; 45:2463-74.
90. Lim R, Mitchell P, Cumming RG. Refractive associations with cataract: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci 1999; 40:3021-6.
91. Lin HJ, Wan L, Tsai Y, et al. The TGFbeta1 gene codon 10 polymorphism contributes to the genetic predisposition to high myopia. Mol Vis 2006; 12:698-703.
92. Lin LL, Hung PT, Ko LS, et al. Study of myopia among aboriginal school children in Taiwan. Acta Ophthalmol Suppl 1988; 185:34-6.
93. Lin LLK, Chen CJ, Hung PT, et al. Nation-wide survey of myopia among schoolchildren in Taiwan, 1986. Acta Ophthalmol Suppl 1988; 185:29-33.
94. Luckett WP. Comparative Biology and Evolutionary Relationships of Tree Shrews. New York: Plenum Press, 1980:1-314.
95. Lyhne N, Sjolie AK, Kyvik KO, et al. The importance of genes and environment for ocular refraction and its determiners: a population based study among 20-45 year old twins. Br J Ophthalmol 2001; 85:1470-6.
96. Mainstone JC, Carney LG, Anderson CR, et al. Corneal shape in hyperopia. Clin Exp Optom 1998; 81:131-7.
97. Mantyjarvi MI. Changes of refraction in schoolchildren. Arch Ophthalmol 1985; 103:790-2.
98. Marshall GE. Human scleral elastic system: an immunoelectron microscopic study. Br J Ophthalmol 1995; 79:57-64.
99. Marshall GE, Konstas AG, Lee WR. Collagens in ocular tissues. Br J Ophthalmol 1993; 77:515-24.
100. Mayer DL, Hansen RM, Moore BD, et al. Cycloplegic refractions in healthy children aged 1 through 48 months. Arch Ophthalmol 2001; 119:1625-28.
101. McBrien NA, Cornell LM, Gentle A. Structural and ultrastructural changes to the sclera in a mammalian model of high myopia. Invest Ophthalmol Vis Sci 2001; 42:2179-87.
102. McBrien NA, Gentle A. The role of visual information in the control of scleral matrix biology in myopia. Curr Eye Res 2001; 23:313-9.
103. McBrien NA, Gentle A. Role of the sclera in the development and pathological complications of myopia. Prog Retin Eye Res 2003; 22:307-38.
104. McBrien NA, Lawlor P, Gentle A. Scleral remodeling during the development of and recovery from axial myopia in the tree shrew. Invest Ophthalmol Vis Sci 2000; 41:3713-9.
105. McBrien NA, Moghaddam HO, Cottriall CL, et al. The effects of blockade of retinal cell action potentials on ocular growth, emmetropization and form deprivation myopia in young chicks. Vision Res 1995; 35:1141-52.
106. McBrien NA, Moghaddam HO, New R, et al. Experimental myopia in a diurnal mammal (Sciurus carolinensis) with no accommodative ability. J Physiol 1993; 469:427-41.
107. McBrien NA, Norton TT. The development of experimental myopia and ocular component dimensions in monocularly lid-sutured tree shrews (Tupaia belangeri). Vision Res 1992; 32:843-52.
108. McCarty CA, Taylor HR. Myopia and vision 2020. Am J Ophthalmol 2000; 129:525-7.
109. McKanna JA, Casagrande VA, Norton TT, et al. Darkreared tree shrews do not develop lid-suture myopia. Invest Ophthalmol Vis Sci 1983; (Suppl. 24), 226.
110. Mertz JR, Wallman J. Choroidal retinoic acid synthesis: a possible mediator between refractive error and compensatory eye growth. Exp Eye Res 2000; 70:519-27.
111. Metlapally R, Jobling AI, Gentle A, et al. Characterization of the integrin receptor subunit profile in the mammalian sclera. Mol Vis 2006; 12:725-34.
112. Meyer LJ, Stern R. Age-dependent changes of hyaluronan in human skin. J Invest Dermatol 1994; 102:385-9.
113. Michaelides M, Johnson S, Bradshaw K, et al. X-linked cone dysfunction syndrome with myopia and protanopia. Ophthalmol 2005; 112:1448-54.
114. Michaels DD. Visual Optics and Refraction: a Clinical Approach. 3rd ed. St. Louis: Mosby, 1985.
115. Mitchell P, Hourihan F, Sandbach J, et al. The relationship between glaucoma and myopia: the Blue Mountains Eye Study. Ophthalmol 1999; 106:2010-5.
116. Murphy G, Willenbrock F, Ward RV, et al. The Cterminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases. Biochem J 1992; 283 (Pt. 3), 637-41.
117. Murthy GV, Gupta SK, Ellwein LB, et al. Refractive error in children in an urban population in New Delhi. Invest Ophthalmol Vis Sci 2002; 43:623-31.
118. Mutti DO, Mitchell GL, Jones LA, et al. Axial growth and changes in lenticular and corneal power during emmetropization in infants. Invest Ophthalmol Vis Sci 2005; 46:3074-80.
119. Mutti DO, Mitchell GL, Moeschberger ML, et al. Parental myopia, near work, school achievement, and children’s refractive error. Invest Ophthalmol Vis Sci 2002; 43:3633-40.
120. Mutti DO, Semina E, Marazita M, et al. Genetic loci for pathological myopia are not associated with juvenile myopia. Am J Med Genet 2002; 112:355-60.
121. Mutti DO, Zadnik K, Fusaro RE, et al. Optical and structural development of the crystalline lens in childhood. Invest Ophthalmol Vis Sci 1998; 39:120-33.
122. Naidoo KS, Raghunandan A, Mashige KP, et al. Refractive error and visual impairment in African children in South Africa. Invest Ophthalmol Vis Sci 2003; 44:3764-70.
123. Naiglin L, Clayton J, Gazagne C, et al. Familial high myopia: evidence of an autosomal dominant mode of inheritance and genetic heterogeneity. Ann Genet 1999; 42:140-6.
124. Naiglin L, Gazagne C, Dallongeville F, et al. A genome wide scan for familial high myopia suggests a novel locus on chromosome 7q36. J Med Genet 2002; 39:118-24.
125. Nickla DL, Sharda V, Troilo D. Temporal integration characteristics of the axial and choroidal responses to myopic defocus induced by prior form deprivation versus positive spectacle lens wear in chickens. Optom Vis Sci 2005; 82:318-27.
126. Noble KG, Carr RE. Pathologic myopia. Ophthalmol 1982; 89:1099-100.
127. Norton TT. Animal models of myopia: learning how vision controls the size of the eye. ILAR J 1999; 40:59-77.
128. Norton TT, Essinger JA, McBrien NA. Lid-suture myopia in tree shrews with retinal ganglion cell blockade. Vis Neurosci 1994; 11:143-53.
129. Norton TT, Kang RN. Morphology of tree shrew sclera and choroid during normal development, induced myopia, and recovery [ARVO Abstract]. Invest Ophthalmol Vis Sci 1996; 37:S324.
130. Norton TT, Manny R, O’Leary DJ. Myopia-global problem, global research. Optom Vis Sci 2005; 82:223-5.
131. Norton TT, Miller EJ. Collagen and protein levels in sclera during normal development, induced myopia, and recovery in tree shrews [ARVO Abstract]. Invest Ophthalmol Vis Sci 1995; 36:S760.
132. Norton TT, Rada JA. Reduced extracellular matrix accumulation in mammalian sclera with induced myopia. Vision Res 1995; 35:1271-81.
133. Norton TT, Siegwart JT. Local myopia produced by partial visual-field deprivation in tree shrew. Soc Neurosci Abstr 1991; 17:558.
134. O’Leary DJ, Millodot M. Eyelid closure causes myopia in humans. Experientia 1979; 35:1478-9.
135. Ohuchi E, Imai K, Fujii Y, et al. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules. J Biol Chem 1997; 272:2446-51.
136. Overall CM, Wrana JL, Sodek J. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 1989; 264:1860-9.
137. Pacella R, McLellan J, Grice K, et al. Role of genetic factors in the etiology of juvenile-onset myopia based on a longitudinal study of refractive error. Optom Vis Sci 1999; 76:381-6.
138. Paluru P, Ronan SM, Heon E, et al. New locus for autosomal dominant high myopia maps to the long arm of chromosome 17. Invest Ophthalmol Vis Sci 2003; 44:1830-6.
139. Paluru PC, Nallasamy S, Devoto M, et al. Identification of a novel locus on 2q for autosomal dominant high-grade myopia. Invest Ophthalmol Vis Sci 2005; 46:2300-7.
140. Perkins ES. Glaucoma in the younger age groups. Arch Ophthalmol 1960; 64:882-91.
141. Perkins ES. Morbidity from myopia. Sight Sav Rev 1979; 49:11-9.
142. Phillips JR, Khalaj M, McBrien NA. Induced myopia associated with increased scleral creep in chick and tree shrew eyes. Invest Ophthalmol Vis Sci 2000; 41:2028-34.
143. Pierro L, Camesasca FI, Mischi M, et al. Peripheral retinal changes and axial myopia. Retina 1992; 12:12-7.
144. Qiao-Grider Y, Hung LF, Kee CS, et al. Recovery from form-deprivation myopia in rhesus monkeys. Invest Ophthalmol Vis Sci 2004; 45:3361-72.
145. Rabb MF, Garoon I, LaFranco FP. Myopic macular degeneration. Int Ophthalmol Clin 1981; 21:51-9.
146. Rabin J, VanSluyters RC, Malach R. Emmetropization: a vision-dependent phenomenon. Invest Ophthalmol Vis Sci 1981; 20:561-4.
147. Rada JA, Achen VR, Perry CA, et al. Proteoglycans in the human sclera: evidence for the presence of aggrecan. Invest Ophthalmol Vis Sci 1997; 38:1740-51.
148. Rada JA, Huang Y, Rada KG. Identification of choroidal ovotransferrin as a potential ocular growth regulator. Curr Eye Res 2001; 22:121-32.
149. Rada JA, Thoft RA, Hassell JR. Increased aggrecan (cartilage proteoglycan) production in the sclera of myopic chicks. Dev Biol 1991; 147:303-12.
150. Rah MJ, Mitchell GL, Mutti DO, et al. Levels of agreement between parents’ and children’s reports of near work. Ophthalmic Epidemiol 2002; 9, 191-203.
151. Raviola E, Wiesel TN. Effect of dark-rearing on experimental myopia in monkeys. Invest Ophthalmol Vis Sci 1978; 17:485-8.
152. Raviola E, Wiesel TN. An animal model of myopia. New Engl J Med 1985; 312:1609-15.
153. Raviola E, Wiesel TN. Neural control of eye growth and experimental myopia in primates. In: Bock G, Widdows K, eds. Myopia and the Control of Eye Growth. Chichester: Wiley, 1990:22-39.
154. Rodieck RW. The Vertebrate Retina. Principles of Structure and Function. San Francisco: W. H. Freeman and Company, 1973:1-1044.
155. Rohrer B, Stell WK. Basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGF-b) act as stop and go signals to modulate postnatal ocular growth in the chick. Exp Eye Res 1994; 58:553-61.
156. Rose K, Morgan I, Smith W, et al. Myopia: prevalence, risk factors and natural history. Ophthal Physiol Opt 2006; 26:25.
157. Rosner M, Belkin M. Intelligence, education, and myopia in males. Arch Ophthalmol 1987; 105:1508-11.
158. Saw SM, Chua WH, Hong CY, et al. Nearwork in early-onset myopia. Invest Ophthalmol Vis Sci 2002; 43:332-9.
159. Saw SM, Gazzard G, Shih-Yen EC, et al. Myopia and associated pathological complications. Ophthalmic Physiol Opt 2005; 25:381-91.
160. Saw SM, Katz J, Schein OD, et al. Epidemiology of myopia. Epidemiol Rev 1996; 18:175-87.
161. Scavello GS, Paluru PC, Ganter WR, et al. Sequence variants in the transforming growth beta-induced factor (TGIF) gene are not associated with high myopia. Invest Ophthalmol Vis Sci 2004; 45:2091-7.
162. Schaeffel F, Burkhardt E, Howland HC, et al. Measurement of refractive state and deprivation myopia in two strains of mice. Optom Vis Sci 2004; 81:99-110.
163. Schaeffel F, Diether S. The growing eye: an autofocus system that works on very poor images. Vision Res 1999; 39:1585-9.
164. Schaeffel F, Glasser A, Howland HC. Accommodation, refractive error and eye growth in chickens. Vision Res 1988; 28:639-57.
165. Schaeffel F, Howland HC. Properties of the feedback loops controlling eye growth and refractive state in the chicken. Vision Res 1991; 31:717-34.
166. Schaeffel F, Simon P, Feldkaemper M, et al. Molecular biology of myopia. Clin Exp Optom 2003; 86:295-307.
167. Schmid KL, Wildsoet CF. Effects on the compensatory responses to positive and negative lenses of intermittent lens wear and ciliary nerve section in chicks. Vision Res 1996; 36:1023-36.
168. Schwartz M, Haim M, Skarsholm D. X-linked myopia:bornholm eye disease-linkage to DNA markers on the distal part of Xq. Clinical Genetics 1990; 38:281-6.
169. Scott JE. Proteoglycan: collagen interactions and subfibrillar structure in collagen fibrils. Implications in the development and ageing of connective tissues. J Anat 1990; 169:23-35.
170. Seko Y, Tanaka Y, Tokoro T. Influence of bFGF as a potent growth stimulator and TGF-beta as a growth regulator on scleral chondrocytes and scleral fibroblasts invitro. Ophthalmic Res 1995; 27:144-52.
171. Shaikh AW, Siegwart JT, Norton TT. Effect of interrupted lens wear on compensation for a minus lens in tree shrews. Optom Vis Sci 1999; 76:308-15.
172. Shen W, Sivak JG. Eyes of lower vertebrates are susceptible to visual environment. Ophthalmic Physiol Opt 2006; 26:11-12.
173. Sheridan M, Douthwaite WA. Corneal asphericity and refractive error. Ophthalmic Physiol Opt 1989; 9, 235-8.
174. Sherman SM, Norton TT, Casagrande VA. Myopia in the lidsutured tree shrew (Tupaia glis). Brain Res 1977; 124:154-7.
175. Siegwart JT, Norton TT. Refractive and ocular changes in tree shrews raised with plus or minus lenses [ARVO Abstract]. Invest Ophthalmol Vis Sci 1993; 34:S1208.
176. Siegwart JT Jr., Norton TT. The susceptible period for deprivation-induced myopia in tree shrew. Vision Res 1998; 38:3505-15.
177. Siegwart JT Jr., Norton TT. Regulation of the mechanical properties of tree shrew sclera by the visual environment. Vision Res 1999; 39:387-407.
178. Siegwart JT Jr., Norton TT. Steady statemRNAlevels in tree shrew sclera with form-deprivation myopia and during recovery. Invest Ophthalmol Vis Sci 2001; 42:1153-9.
179. Siegwart JT Jr., Norton TT. The time course of changes in mRNA levels in tree shrew sclera during induced myopia and recovery. Invest Ophthalmol Vis Sci 2002; 43:2067-75.
180. Siegwart JT Jr., Norton TT. Proteoglycan mRNA Levels in tree shrew sclera during minus lens treatment and during recovery. Invest Ophthalmol Vis Sci 2005; 46: E-Abstract 3335.
181. Siegwart JT Jr., Norton TT. Selective regulation of MMP and TIMP mRNA levels in tree shrew sclera during minus lens compensation and recovery. Invest Ophthalmol Vis Sci 2005; 46:3484-92.
182. Siegwart JT Jr, Norton TT, Robertson JD. Binocular lens treatment in tree shrews. Investigative Ophthalmology & Visual Science 2003; 44: E-abstract 1984.
183. Siegwart JT, Robertson JD, Norton TT. Changes in MMP and TIMP mRNA levels during minus lens treatment and during recovery in tree shrew. Invest Ophthalmol Vis Sci 2004; 45: E-abstract 1232.
184. Siegwart JT Jr., Norton TT. Plus lens wear in young, hyperopic tree shrews halts progression toward emmetropia. Ophthal Physiol Opt 2006; 26(Suppl. 1):12.
185. Smith EL, III. Environmentally induced refractive errors in animals. In: Rosenfield M, Gilmartin B, eds. Myopia and Nearwork. Oxford: Butterworth-Heinemann, 1998:57-90.
186. Smith EL III, Hung LF. The role of optical defocus in regulating refractive development in infant monkeys. Vision Res 1999; 39:1415-35.
187. Smith EL, III, Kee CS, Ramamirtham R, et al. Peripheral vision can influence eye growth and refractive development in infant monkeys. Invest Ophthalmol Vis Sci 2005; 46:3965-72.
188. Sommers D, Kaiser-Kupfer MI, Kupfer C. Increased axial length of the eye following neonatal lid suture as measured with A-scan ultrasonography. Invest Ophthalmol Vis Sci 1978; (Suppl 17), 295.
189. Sorsby A, Benjamin B, Davey JB, et al. Emmetropia and its aberrations. Med Res Counc Spec Rep Ser 1957; 293:1-69.
190. Sorsby A, Benjamin B, Sheridan M, et al. Refraction and its components during the growth of the eye from the age of three. Med Res Counc Spec Rep Ser 1961; 301:1-67.
191. Sorsby A, Leary GA. A Longitudinal Study of Refraction and its Components during Growth. 309th ed. London:Her Majesty’s Stationery Office, 1970:1-41.
192. Sorsby A, Leary GA, Fraser GR. Family studies on ocular refraction and its components. J Med Genet 1966; 3, 269-73.
193. Sorsby A, Leary GA, Richards MJ. Correlation ametropia and component ametropia. Vision Res 1962; 2, 309-13.
194. Sorsby A, Sheridan M, Leary G. Refraction and its components in twins. Med Res Counc Spec Rep Ser 1962; 303.
195. Sperduto RD, Seigel D, Roberts J, et al. Prevalence of myopia in the United States. Arch Ophthalmol 1983; 101:405-7.
196. Spitznas M, Boker T. Idiopathic posterior subretinal neovascularization (IPSN) is related to myopia. Graefes Arch Clin Exp Ophthalmol 1991; 229:536-8.
197. Stambolian D, Ciner EB, Reider LC, et al. Genome-wide scan for myopia in the Old Order Amish. Am J Ophthalmol 2005; 140:469-76.
198. Stambolian D, Ibay G, Reider L, et al. Genomewide linkage scan for myopia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 22q12. Am J Hum Genet 2004; 75:448-59.
199. Steidl SM, Pruett RC. Macular complications associated with posterior staphyloma. Am J Ophthalmol 1997; 123:181-7.
200. Steiger A. Die Entstehung Der Spharischen Refracktionen Des menschlichen Auges. Berlin: Karger, 1913.
201. Stenstrom S. Investigation of the variation and the correlation of the optical elements of human eyes. Am J Optom Arch Am Acad Optom 1948, Monograph 58, Part I-Part VI.
202. Strang NC, Schmid KL, Carney LG. Hyperopia is predominantly axial in nature. Curr Eye Res 1998; 17:380-3.
203. Strömberg E. Uber refraktion und achsenlänge des menschlichen auges. Acta Ophthalmol Suppl 1936; 14:281.
204. Strongin AY, Collier I, Bannikov G, et al. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease. J Biol Chem 1995; 270:5331-8.
205. Summers Rada JA, Shelton S, Norton TT. The sclera and myopia. Exp Eye Res 2006; 82:185-200.
206. Teikari J, O’Donnell JJ, Kaprio J, et al. Genetic and environmental effects on oculometric traits. Optom Vis Sci 1989; 66:594-9.
207. Teikari JM, O’Donnell J, Kaprio J, et al. Impact of heredity in myopia. Hum Hered 1991; 41:151-6.
208. Tejedor J, del V. Refractive changes induced by form deprivation in the mouse eye. Invest Ophthalmol Vis Sci 2003; 44:32-6.
209. The Eye Disease Case-Control Study Group. Risk factors for idiopathic rhegmatogenous retinal detachment. Am J Epidemiol 1993; 137:749-57.
210. Tokoro T, Sato A. Results of investigation of pathologic myopia in Japan. Report of myopic chorioretinal atrophy. Ministry of Health and Welfare 1982; 32-35. Tokyo, Ministry of Health and Welfare.
211. Torczynski E. Sclera. In: Jakobiec FA, ed. Ocular Anatomy, Embryology, and Teratology. Philadelphia, PA: Harper & Row, 1982:587-99.
212. Troilo D, Gottlieb MD, Wallman J. Visual deprivation causes myopia in chicks with optic nerve section. Curr Eye Res 1987; 6, 993-9.
213. Troilo D, Judge SJ. Ocular development and visual deprivation myopia in the common marmoset (Callithrix jacchus). Vision Res 1993; 33:1311-24.
214. Troilo D, Nickla DL, Wildsoet CF. Choroidal thickness changes during altered eye growth and refractive state in a primate. Invest Ophthalmol Vis Sci 2000; 41:1249-58.
215. Tron EJ. The optical elements of the refractive power of the eye. Graefes Arch Ophthalmol 1929; 122:1-33.
216. van Alphen GWHM. On emmetropia and ametropia. Opt Acta (Lond) 1961; (Suppl. 142), 1-92.
217. Venkataraman S, Nguyen L, McBrien NA. Compensatory ocular growth responses to positive lens defocus in the tree shrew. Invest Ophthalmol Vis Sci 2005; 46: E-Abstract 1973.
218. Vessey KA, Lencses KA, Rushforth DA, et al. Glucagon receptor agonists and antagonists affect the growth of the chick eye: a role for glucagonergic regulation of emmetropization? Invest Ophthalmol Vis Sci 2005; 46:3922-31.
219. Vessey KA, Rushforth DA, Stell WK. Glucagon-and secretin-related peptides differentially alter ocular growth and the development of form-deprivation myopia in chicks. Invest Ophthalmol Vis Sci 2005; 46:3932-42.
220. von Noorden GK, Lewis RA. Ocular axial length in unilateral congenital cataracts and blepharoptosis. Invest Ophthalmol Vis Sci 1987; 28:750-2.
221. Vongphanit J, Mitchell P, Wang JJ. Prevalence and progression of myopic retinopathy in an older population. Ophthalmol 2002; 109:704-11.
222. Wallman J, Adams JI. Developmental aspects of experimental myopia in chicks: susceptibility, recovery and relation to emmetropization. Vision Res 1987; 27:1139-63.
223. Wallman J, Turkel J, Trachtman J. Extreme myopia produced by modest change in early visual experience. Science 1978; 201:1249-51.
224. Wallman J, Wildsoet C, Xu A, et al. Moving the retina:choroidal modulation of refractive state. Vision Res 1995; 35:37-50.
225. Wallman J, Winawer J. Homeostasis of eye growth and the question of myopia. Neuron 2004; 43:447-68.
226. Ward RV, Atkinson SJ, Reynolds JJ, et al. Cell surfacemediated activation of progelatinase A: demonstration of the involvement of the C-terminal domain of progelatinase A in cell surface binding and activation of progelatinase A by primary fibroblasts. Biochem J 1994; 304 (Pt. 1), 263-9.
227. Wickremasinghe S, Foster PJ, Uranchimeg D, et al. Ocular biometry and refraction in Mongolian adults. Invest Ophthalmol Vis Sci 2004; 45:776-83.
228. Wiesel TN, Raviola E. Myopia and eye enlargement after neonatal lid fusion in monkeys. Nature 1977; 266:66-8.
229. Wildsoet CF. Active emmetropization-evidence for its existence and ramifications for clinical practice. Ophthal Physiol Opt 1997; 17:279-90.
230. Wildsoet CF, Pettigrew JD. Kainic acid-induced eye enlargement in chickens: differential effects on anterior and posterior segments. Invest Ophthalmol Vis Sci 1988; 29:311-9.
231. Wilson A, Woo G. A review of the prevalence and causes of myopia. Singapore Medical Journal 1989; 30:479-84.
232. Winawer J, Zhu X, Choi J, et al. Ocular compensation for alternating myopic and hyperopic defocus. Vision Res 2005; 45:1667-77.
233. Wojciechowski R, Moy C, Ciner E, et al. Genomewide scan in Ashkenazi Jewish families demonstrates evidence of linkage of ocular refraction to a QTL on chromosome 1p36. Hum Genet 2006; 119:389-99.
234. Wong TY, Foster PJ, Ng TP, et al. Variations in ocular biometry in an adult Chinese population in Singapore:the Tanjong Pagar Survey. Invest Ophthalmol Vis Sci 2001; 42:73-80.
235. Yap M, Wu M, Liu ZM, et al. Role of heredity in the genesis of myopia. Ophthalmic Physiol Opt 1993; 13:316-9.
236. Young FA. The effects of nearwork illumination level on monkey refraction. Am J Optom Arch Am Acad Optom 1962; 39:60-7.
237. Young FA. Reading, measures of intelligence and refractive errors. Am J Optom Arch Am Acad Optom 1963; 40:257-64.
238. Young FA. The effect of restricted visual space on the refractive error of the young monkey eye. Invest Ophthalmol 1963; 2, 571-7.
239. Young FA. Myopia and personality. Am J Optom Arch Am Acad Optom 1967; 44:192-201.
240. Young TL, Deeb SS, Ronan SM, et al. X-linked high myopia associated with cone dysfunction. Arch Ophthalmol 2004; 122:897-908.
241. Young TL, Ronan SM, Alvear AB, et al. A second locus for familial high myopia maps to chromosome 12q. Am J Hum Genet 1998; 63:1419-24.
242. Young TL, Ronan SM, Drahozal LA, et al. Evidence that a locus for familial high myopia maps to chromosome 18p. Am J Hum Genet 1998; 63:109-19.
243. Zadnik K. Myopia development in childhood. Optom Vis Sci 1997; 74:603-8.
244. Zadnik K, Manny RE, Yu JA, et al. Ocular component data in schoolchildren as a function of age and gender. Optom Vis Sci 2003; 80:226-36.
245. Zadnik K, Satariano WA, Mutti DO, et al. The effect of parental history of myopia on children’s eye size. JAMA 1994; 271:1323-7.
246. Zhang Q, Guo X, Xiao X, et al. A new locus for autosomal dominant high myopia maps to 4q22-q27 between D4S1578 and D4S1612. Mol Vis 2005; 11:554-60.
247. Zhang Q, Guo X, Xiao X, et al. Novel locus for X linked recessive high myopia maps to Xq23-q25 but outside MYP1. J Med Genet 2006; 43:e20.
248. Zhou G, Williams RW. Eye1 and Eye2: gene loci that modulate eye size, lens weight, and retinal area in the mouse. Invest Ophthalmol Vis Sci 1999; 40:817-25.
249. Zhou G, Williams RW. Mouse models for the analysis of myopia: an analysis of variation in eye size of adult mice. Optom Vis Sci 1999; 76:408-18.
250. Zhu X, Park TW, Winawer J, et al. In a matter of minutes, the eye can know which way to grow. Invest Ophthalmol Vis Sci 2005; 46:2238-41.
251. Zhu X, Winawer JA, Wallman J. Potency of myopic defocus in spectacle lens compensation. Invest Ophthalmol Vis Sci 2003; 44:2818-27.
252. Zylbermann R, Landau D, Berson D. The influence of study habits on myopia in Jewish teenagers. J Pediatr Ophthalmol Strabismus 1993; 30:319-22.