Overweight and obesity in children and adolescents

JCRPE Journal of Clinical Research in Pediatric Endocrinology

Volumn 6, Issue 3, 2014, Pages 129-143

  Güngör, Neslihan Koyuncuoğlu ^a  

^a Louisiana State University Health Sciences Center at Shreveport   (United States)

Author keywords

Diabetes; Dyslipidemia; Obesity; Overweight; Pediatric; Prevention; Type 2 diabetes mellitus; Weight management

Indexed keywords

AMYLIN; GHRELIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 2; HEMOGLOBIN A1C; LEPTIN; MELANOCORTIN 4 RECEPTOR; OXYNTOMODULIN; PANCREAS POLYPEPTIDE; PEPTIDE YY;

ALBRIGHT SYNDROME; ARTICLE; BEHAVIOR MODIFICATION; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM DISEASE; CHILDHOOD OBESITY; COMORBIDITY; DIET THERAPY; DISEASE PREDISPOSITION; DNA METHYLATION; ENDOCRINE DISEASE; ENERGY METABOLISM; EPIGENETICS; ETHNICITY; FAMILY HISTORY; GASTROINTESTINAL DISEASE; GENETIC DISORDER; GENETIC VARIABILITY; HISTONE MODIFICATION; HUMAN; HYPOTHYROIDISM; IATROGENIC DISEASE; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LIVER BIOPSY; LIVER FUNCTION TEST; META ANALYSIS (TOPIC); METABOLIC SYNDROME X; MUSCULOSKELETAL SYSTEM EXAMINATION; PHYSICAL ACTIVITY; PRACTICE GUIDELINE; PRENATAL DRUG EXPOSURE; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SOCIAL PSYCHOLOGY; SOCIOECONOMICS; SYSTEMATIC REVIEW (TOPIC); URBAN POPULATION; ADOLESCENT; ADOLESCENT BEHAVIOR; AGE; AGE DISTRIBUTION; ANIMAL; ATTITUDE TO HEALTH; CHILD; CHILD BEHAVIOR; FEMALE; HEALTH BEHAVIOR; LIFESTYLE; MALE; PATHOPHYSIOLOGY; PEDIATRIC OBESITY; PRESCHOOL CHILD; PREVALENCE; PREVENTIVE HEALTH SERVICE; PROGNOSIS; PSYCHOLOGY; RISK REDUCTION;

ADOLESCENT; ADOLESCENT BEHAVIOR; AGE DISTRIBUTION; AGE FACTORS; ANIMALS; CHILD; CHILD BEHAVIOR; CHILD, PRESCHOOL; COMORBIDITY; FEMALE; HEALTH BEHAVIOR; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; LIFE STYLE; MALE; PEDIATRIC OBESITY; PREVALENCE; PREVENTIVE HEALTH SERVICES; PROGNOSIS; RISK FACTORS; RISK REDUCTION BEHAVIOR;

EID: 84908167509     PISSN: 13085727     EISSN: 13085735     Source Type: Journal    
DOI: 10.4274/jcrpe.1471     Document Type: Article

References (109)

1. Han JC, Kimm SYS. Childhood Obesity-2010: Progress and Challenges. Lancet 2010; 375:1737-1748.
2. Lustig RH and Weiss R. Disorders of energy balance. In: Sperling MA (ed) Pediatric Endocrinology (third edition). Saunders Elsevier, Philadelphia, PA 2008:788-838.
3. Hubbard VS. Defining overweight and obesity: what are the issues? Am J Clin Nutr 2000;72:1067-1068.
4. rd ed). W.B Saunders (Elsevier), Philadelphia, PA 2012:364-375.
5. Klish WJ. Clinical evaluation of the obese child and adolescent. In: Motil KJ, Geffner M (section eds) and Hoppin AG (Deputy ed). Up to date. www.uptodate.com©2013UpToDate.
6. BMI curves. http://www.cdc.gov/growthcharts.
7. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: International survey. BMJ 2000;320:1240-1243.
8. Childhood obesity in: http://aspe.hhs.gov/health/reports/child_obesity/
9. Huang JS, Barlow SE, Quiros-Tejeira RE, Scheimann A, Skelton J, Suskind D, Tsai P, Uko V, Warolin JP, Xanthakos SA; The NASPGHAN Obesity Task Force. Consensus Statement: Childhood Obesity for Pediatric Gastroenterologists. J Pediatr Gastroenterol Nutr 2013;56:99-109.
10. Ramachandrappa S, Farooqi IS. Genetic approaches to understanding human obesity. J Clin Invest 2011;121:2080-2086. Epub 2011 Jun 1
11. Karra E, Chandarana K, Batterham RL. The role of peptide YY in appetite regulation and obesity. J Physiol 2009;587:19-25. Epub 2008 Dec 8
12. Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007;117:13-23.
13. Farooqi S, O’Rahilly S. Genetics of obesity in humans. Endocr Rev 2006;27:710-718. Epub 2006 Nov 22
14. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N, Tanaka T, Timpson NJ, Almgren P, Bennett A, Bergman RN, Bingham SA, Bonnycastle LL, Brown M, Burtt NP, Chines P, Coin L, Collins FS, Connell JM, Cooper C, Smith GD, Dennison EM, Deodhar P, Elliott P, Erdos MR, Estrada K, Evans DM, Gianniny L, Gieger C, Gillson CJ, Guiducci C, Hackett R, Hadley D, Hall AS, Havulinna AS, Hebebrand J, Hofman A, Isomaa B, Jacobs KB, Johnson T, Jousilahti P, Jovanovic Z, Khaw KT, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta EG, Luan J, Luben RN, Mangino M, McArdle WL, Meitinger T, Mulas A, Munroe PB, Narisu N, Ness AR, Northstone K, O’Rahilly S, Purmann C, Rees MG, Ridderstråle M, Ring SM, Rivadeneira F, Ruokonen A, Sandhu MS, Saramies J, Scott LJ, Scuteri A, Silander K, Sims MA, Song K, Stephens J, Stevens S, Stringham HM, Tung YC, Valle TT, Van Duijn CM, Vimaleswaran KS, Vollenweider P, Waeber G, Wallace C, Watanabe RM, Waterworth DM, Watkins N; Witteman JC, Zeggini E, Zhai G, Zillikens MC, Altshuler D, Caulfield MJ, Chanock SJ, Farooqi IS, Ferrucci L, Guralnik JM, Hattersley AT, Hu FB, Jarvelin MR, Laakso M, Mooser V, Ong KK, Ouwehand WH, Salomaa V, Samani NJ, Spector TD, Tuomi T, Tuomilehto J, Uda M, Uitterlinden AG, Wareham NJ, Deloukas P, Frayling TM, Groop LC, Hayes RB, Hunter DJ, Mohlke KL, Peltonen L, Schlessinger D, Strachan DP, Wichmann HE, McCarthy MI, Boehnke M, Barroso I, Abecasis GR, Hirschhorn JN Wellcome Trust Case Control Consortium; Genetic Investigation of Anthropometric Traits Consortium. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009;41:25-34. Epub 2008 Dec 14
15. Bouchard L. Epigenetics and fetal metabolic programming: A call for integrated research on larger cohorts. Diabetes 2013;62:1026-10288.
16. Weinstein LS, Chen M, Liu J. Gsaα (alpha) mutations and imprinting defects in human disease. Ann NY Acad Sci 2002;968:173-197.
17. Crocker MK, Yanovski JA. Pediatric obesity: Etiology and treatment. Endocrinol Metab Clin North Am 2009;38:525-548.
18. Lee M, Korner J. Review of physiology, clinical manifestations, and management of hypothalamic obesity in humans. Pituitary 2009;12:87-95.
19. Dabelea D. The predisposition to obesity and diabetes in offspring of diabetic mothers. Diabetes Care 2007;30(Suppl 2):169-174.
20. Kral JG, Biron S, Simard S, Hould FS, Lebel S, Marceau S, Marceau P. Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics 2006;118:1644-1649.
21. Ong KK, Loos RJ. Rapid infancy weight gain and subsequent obesity: systematic reviews and hopeful suggestions. Acta Paediatr 2006;95:904-908.
22. Rogers IS, Ness AR, Steer CD, Wells JC, Emmett PM, Reilly JR, Tobias J, Smith GD. Associations of size at birth and dual-energy X-ray absorptiometry measures of lean and fat mass at 9 to 10 y of age. Am J Clin Nutr 2006;84:739-747.
23. Freedman DS, Kettel Khan L, Serdula MK, Srinivasan SR, Berenson GS. BMI rebound, childhood height and obesity among adults: the Bogalusa Heart Study. Int J Obes Relat Metab Disord 2001;25:543-549.
24. Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Effect of infant feeding on the risk of obesity across the life course: a quantitative review of published evidence. Pediatrics 2005;115:1367-1377.
25. Kramer MS, Matush L, Vanilovich I, Platt RW, Bogdanovich N, Sevkovskaya Z, Dzikovich I, Shishko G, Collet JP, Martin RM, Davey Smith G, Gillman MW, Chalmers B, Hodnett E, Shapiro S; PROBIT Study Group. Effects of prolonged and exclusive breastfeeding on child height, weight, adiposity, and blood pressure at age 6.5 y: evidence from a large randomized trial. Am J Clin Nutr 2007;86:1717-1721.
26. Moreno LA, Rodríguez G. Dietary risk factors for development of childhood obesity. Curr Opin Clin Nutr Metab Care 2007;10:336--341.
27. Al Mamun A, Lawlor DA, Cramb S, O’Callaghan M, Williams G, Najman J. Do childhood sleeping problems predict obesity in young adulthood? Evidence from a prospective birth cohort study. Am J Epidemiol 2007;166:1368-1373.
28. Atkinson RL, Dhurandhar NV, Allison DB, Bowen RL, Israel BA, Albu JB, Augustus AS. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes (Lond) 2005;29:281-286.
29. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI. A core gut microbiome in obese and lean twins. Nature 2009;457:480-484. Epub 2008 Nov 30
30. Freedman DS, Khan LK, Serdula MK, Ogden CL, Dietz WH. Racial and ethnic differences in secular trends for childhood BMI, weight, and height. Obesity (Silver Spring) 2006;14:301--308.
31. Yajnik CS, Lubree HG, Rege SS, Naik SS, Deshpande JA, Deshpande SS, Joglekar CV, Yudkin JS. Adiposity and hyperinsulinemia in Indians are present at birth. J Clin Endocrinol Metab 2002;87:5575-5580.
32. de Onis M, Garza C, Victora CG, Onyango AW, Frongillo EA, Martines J. The WHO Multicentre Growth Reference Study: planning, study design, and methodology. Food Nutr Bull 2004;25(Suppl 1):15-26.
33. Wang Y, Lobstein T. Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes 2006;1:11-25.
34. Li L, deMoira AP, Power C. Changing influences on childhood obesity: a study of two generations of the 1958 British birth cohort. J Epidemiol Community Health 2009;63(Suppl 2):27.
35. Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007-2008. JAMA 2010;303:242-249. Epub 2010 Jan 13
36. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010. JAMA 2012;307:483-490. Epub 2012 Jan 17
37. de Onis M, Blössner M, Borghi E. Global prevalence and trends of overweight and obesity among preschool children. Am J Clin Nutr 2010;92:1257-1264.
38. World Health Organization (WHO) Europe ENHIS Fact Sheet 2.3. December 2009. Code RPG2_hous_E2. Available at euro. who.int.
39. Daniels SR. Complications of obesity in children and adolescents. Int J Obes (Lond) 2009;33(Suppl 1):60-65.
40. Gungor N, Libman I, Arslanian S. Type 2 Diabetes Mellitus in Children and Adolescents. Pescovitz and Eugster (eds) Pediatric Endocrinology: Mechanisms, Manifestations and Management”, Lippincott, Williams and Wilkins 2004:450-466.
41. Staiano AE, Katzmarzyk PT. Ethnic and sex differences in body fat and visceral and subcutaneous adiposity in children and adolescents. Int J Obes (Lond) 2012;36:1261-1269. Epub 2012 Jun 19
42. Kahn SE. Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001;86:4047-4058.
43. Gungor N, Bacha F, Saad R, Janosky J, Arslanian S. Youth Type 2 Diabetes Mellitus: Insulin resistance, beta-cell failure or both? Diabetes Care 2005;28:638-6844.
44. Sinha R, Fisch G, Teague B, Tamborlane WV, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin RS, Caprio S. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002;346(11):802-10.
45. Goran MI, Bergman RN, Avila Q, Watkins M, Ball GD, Shaibi GQ, Weigensberg MJ, Cruz ML. Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes. J Clin Endocrinol Metab 2004;89:207-212.
46. Wiegand S, Maikowski U, Blankenstein O, Biebermann H, Tarnow P, Grüters A. Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity - a problem that is no longer restricted to minority groups. Eur J Endocrinol 2004;151:199-206.
47. Aye T, Levitsky LL. Type 2 diabetes: an epidemic disease in childhood. Curr Opin Pediatr 2003;15:411-415.
48. SEARCH for Diabetes in Youth Study Group, Liese AD, D’Agostino RB Jr, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, Loots B, Linder B, Marcovina S, Rodriguez B, Standiford D, Williams DE. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 2006;118:1510-1518.
49. Lee L, Sanders RA. Metabolic syndrome. Pediatr Rev 2012; 33:459-466.
50. Calles-Escandon J, Cipolla M. Diabetes and endothelial dysfunction: a clinical perspective. Endocr Rev 2001;22:36-52.
51. Meyer AA, Kundt G, Steiner M, Schuff-Werner P, Kienast W. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. Pediatrics 2006;117:1560-1567.
52. Berenson GS, Srinivasan SR, Bao W, Newman WP 3rd, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998;338:1650-1656.
53. Li S, Chen W, Srinivasan SR, Xu J, Berenson GS. Relation of childhood obesity/cardiometabolic phenotypes to adult cardiometabolic profile: the Bogalusa Heart Study. Am J Epidemiol 2012;176(Suppl 7):142-149.
54. Legro RS, Arslanian S., Ehrmann DA, Hoeger KM, Murad MH, Pasquali R, Welt CK; Endocrine Society. Diagnosis and treatment of polycystic ovary syndrome: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2013;98:4565-4592. Epub 2013 Oct 22
55. Kaplowitz P., Slora EJ, Wasserman RC, Pedlow SE, Herman-Giddens ME. Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics 2001;108:347--353.
56. Kaplowitz P. Delayed puberty in obese boys: comparison with constitutional delayed puberty and response to testosterone therapy. J Pediatr 1998;133:745-749.
57. Pacifico L, Anania C, Ferraro F, Andreoli GM, Chiesa C. Thyroid function in childhood obesity and metabolic comorbidity. Clin Chim Acta 2012;413:396-405. Epub 2011 Nov 27
58. Srinivasan SR, Bao W, Wattigney WA, Berenson GS. Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism 1996;45:235-240.
59. Lavine JE1, Schwimmer JB, Van Natta ML, Molleston JP, Murray KF, Rosenthal P, Abrams SH, Scheimann AO, Sanyal AJ, Chalasani N, Tonascia J, Üalp A, Clark JM, Brunt EM, Kleiner DE, Hoofnagle JH, Robuck PR; Nonalcoholic Steatohepatitis Clinical Research Network. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 2011;305:1659-1668.
60. Schwimmer JB, Deutsch R, Rauch JB, Behling C, Newbury R, Lavine JE. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr 2003;143:500-505.
61. de la Eva RC, Baur LA, Donaghue KC, Waters KA. Metabolic correlates with obstructive sleep apnea in obese subjects. J Pediatr 2002;140:654-659.
62. Section on Pediatric Pulmonology, Subcommittee on Obstructive Sleep Apnea Syndrome. American Academy of Pediatrics. Clinical practice guideline: diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics 2002;109:704-712.
63. Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA 2004;291:2013-2016.
64. Gettys FK, Jackson JB, Frick SL. Obesity in pediatric orthopaedics. Orthop Clin North Am. 2011;42:95-105.
65. BalL AK, Clarke CE. Idiopathic intracranial hypertension. Lancet Neurol 2006;5:433-442.
66. August GP, Caprio S, Fennoy I, Freemark M, Kaufman FR, Lustig RH, Silverstein JH, Speiser PW, Styne D., Montori VM; Endocrine Society. Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion. J Clin Endocrinol Metab 2008;93:4576-4599. Epub 2008 Sep 9
67. Lau K, Höger PH. Skin diseases associated with obesity in children [Article in German]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2013;56:539-542.
68. Sinha S, Schwartz RA. Juvenile acanthosis nigricans. J Am Acad Dermatol 2007;57:502-508. Epub 2007 Jun 25
69. Vander Wal JS, Mitchell ER. Psychological complications of pediatric obesity. Pediatr Clin North Am 2011;58:1393-1401. Epub 2011 Oct 14
70. Maloney AE. Pediatric obesity: a review for the child psychiatrist. Child Adolesc Psychiatr Clin N Am 2010;19:353-370.
71. Hebebrand J, Herpertz-Dahlmann B. Psychological and psychiatric aspects of pediatric obesity. Child Adolesc Psychiatr Clin N Am 2009;18:49-65.
72. Wardle J, Cooke L. The impact of obesity on psychological well-being. Best Pract Res Clin Endocrinol Metab 2005;19:421-440.
73. Casazza K, Fontaine KR, Astrup A, Birch LL, Brown AW, Bohan Brown MM, Durant N, Dutton G, Foster EM, Heymsfield SB, McIver K, Mehta T, Menachemi N, Newby PK, Pate R, Rolls BJ, Sen B, Smith DL Jr, Thomas DM, Allison DB. Myths, presumptions, and facts about obesity. N Engl J Med 2013;368:446-454.
74. Cheskin LJ, Bartlett SJ, Zayas R, Twilley CH, Allison DB, Contoreggi C. Prescription medications: a modifiable contributor to obesity. South Med J 1999;92:898-904.
75. Bougnères P, Pantalone L, Linglart A, Rothenbühler A, Le Stunff C. Endocrine manifestations of the rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation, and neural tumor syndrome in childhood. J Clin Endocrinol Metab 2008;93:3971-3980. Epub 2008 Jul 15
76. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997;337:869-873.
77. Blair NJ, Thompson JM, Black PN, Becroft DM, Clark PM, Han DY, Robinson E, Waldie KE, Wild CJ, Mitchell EA. Risk factors for obesity in 7-year-old European children: the Auckland Birthweight Collaborative Study. Arch Dis Child 2007;92:866--871. Epub 2007 Sep 13
78. Reilly JJ, Armstrong J, Dorosty AR, Emmett PM, Ness A, Rogers I, Steer C, Sherriff A. Early life risk factors for obesity in childhood: cohort study. BMJ 2005;330:1357.
79. Rudolf M. Predicting babies’ risk of obesity. Arch Dis Child 2011;96:995-997. Epub 2011 Aug 9
80. Puhl RM, Latner JD. Stigma, obesity and the health of the nation’s children. Psychol Bull 2007;133:557-580.
81. Edmunds L.D. Parents’ perceptions of health professionals’ responses when seeking help for their overweight children. Fam Pract 2005;22:287-292. Epub 2005 Mar 16
82. Rodin RL, Alexander MH, Guillory VJ, Rogers J. Physician counseling to prevent overweight in children and adolescents: American College of Preventive Medicine Position Statement. J Public Health Manag Pract 2007;13:655-661.
83. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114(Suppl 2):555-576.
84. Krebs NF, Himes JH, Jacobson D, Nicklas TA, Guilday P, Styne D. Assessment of child and adolescent overweight and obesity. Pediatrics 2007;120(Suppl 4):193-228.
85. Brara SM, Koebnick C, Porter AH, Langer-Gould A. Pediatric idiopathic intracranial hypertension and extreme childhood obesity. J Pediatr 2012;161:602-607. Epub 2012 May 26
86. Green JS, Parfrey PS, Harnett JD, Farid NR, Cramer BC, Johnson G, Heath O, McManamon PJ, O’Leary E, Pryse-Phillips W. The cardinal manifestations of Bardet-Biedl syndrome, a form of Laurence-Moon-Biedl syndrome. N Engl J Med 1989;321:1002--1009.
87. American Diabetes Association Position Statement. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2010;33:62-69.
88. Kapadia CR. Are the ADA Hemoglobin a1c criteria relevant for the diagnosis of type 2 diabetes in youth? Curr Diab Rep 2013;13:51-55.
89. Lee JM, Eason A, Nelson C, Kazzi NG, Cowan AE, Tarini BA. Screening Practices for Identifying Type 2 Diabetes in Adolescent. J Adolesc Health 2014;54:139-143. Epub 2013 Aug 20
90. Levy-Marchal C, Arslanian S, Cutfield W, Sinaiko A, Druet C, Marcovecchio ML, Chiarelli F; ESPE-LWPES-ISPAD-APPES--APEG-SLEP-JSPE; Insulin Resistance in Children Consensus Conference Group. Insulin resistance in children: consensus, perspective, and future directions. J Clin Endocrinol Metab 2010;95:5189-5198. Epub 2010 Sep 8
91. American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care 2000;23:381-389.
92. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents, National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 2011;128(Suppl 5):213-256.
93. Daniels SR. Management of hyperlipidemia in pediatrics. Curr Opin Cardiol 2012;27:92-97.
94. Bamba V. Update on screening, etiology and treatment of dyslipidemia in children. J Clin Endocrinol Metab 2014:jc20133860. [Epub ahead of print]
95. Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H, Ten S. Prevalence of vitamin D insufficiency in obese children and adolescents. J Pediatr Endocrinol Metab 2007;20:817-823.
96. Botella-Carretero JI, Alvarez-Blasco F, Villafruela JJ, Balsa JA, Vázquez C, Escobar-Morreale HF. Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity. Clin Nutr 2007;26:573-580. Epub 2007 Jul 10
97. Kelly A, Brooks LJ, Dougherty S, Carlow DC, Zemel BS. A cross-sectional study of vitamin D and insulin resistance in children. Arch Dis Child 2011;96:447-452. Epub 2011 Feb 20
98. Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics 2013;131:152.
99. Yanovski JA, Cutler GB Jr. Glucocorticoid action and the clinical features of Cushing’s syndrome. Endocrinol Metab Clin North Am 1994;23:487-509.
100. Dubnov-Raz G, Berry EM. The dietary treatment of obesity. Med Clin North Am 2011;95:939-952.
101. Pediatric overweight: A review of the literature. The Center for Weight and Health College of Natural Resources University of California, Berkeley. June 2001. http://cwh.berkeley.edu/sites/default/files/primary_pdfs/Pediatric_Overweight_LitRev.pdf.
102. Ho M, Garnett SP, Baur LA, Burrows T, Stewart L, Neve M, Collins C. Impact of Dietary and Exercise Interventions on Weight Change and Metabolic Outcomes in Obese Children and Adolescents: A Systematic Review and Meta-analysis of Randomized Trials. JAMA Pediatr 2013;167:759-768.
103. Wald AB, Uli NK. Pharmacotherapy in pediatric obesity: current agents and future directions. Rev Endocr Metab Disord 2009;10:205-214.
104. Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA, O’Rahilly S. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med 1999;341:879-884.
105. Lustig RH, Hinds PS, Ringwald-Smith K, Christensen RK, Kaste SC, Schreiber RE, Rai SN, Lensing SY, Wu S, Xiong X. Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial. J Clin Endocrinol Metab 2003;88:2586-2592.
106. Inge TH, Miyano G, Bean J, Helmrath M, Courcoulas A, Harmon CM, Chen MK, Wilson K, Daniels SR, Garcia VF, Brandt ML, Dolan LM. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents. Pediatrics 2009;123:214-222.
107. Perkin RM, Swift JD, Newton DA, et al. Pediatric Hospital Medicine: Textbook of Inpatient Management. Second ed. Philadelphia, PA: Lippincott Williams & Wilkins 2008:692.
108. Huang JS, Chun S, Sandhu A, Terrones L. Quality Improvement in Childhood Obesity Management through the Maintenance of Certification Process. J Pediatr 2013;163:1313-1316. Epub 2013 Jun 27
109. Barlow SE; Expert Committee. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007;120(Suppl 4):164-192.