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Volumn 10, Issue , 2014, Pages 2021-2030

Optimal management of seizures associated with tuberous sclerosis complex: Current and emerging options

Author keywords

Adrenocorticotropic hormone; Epilepsy; Ketogenic diet; Mammalian target of rapamycin; Vagus nerve stimulation; Vigabatrin

Indexed keywords


EID: 84908155222     PISSN: None     EISSN: 11782021     Source Type: Journal    
DOI: 10.2147/NDT.S51789     Document Type: Review
Times cited : (35)

References (90)
  • 1
    • 84908195827 scopus 로고    scopus 로고
    • Tuberous sclerosis fact sheet. NIH publication number 07-1846 2014 [webpage on the Internet]. Bethesda, MD: National Institutes of Health; 2014 [updated April 16, 2014]. Available from
    • National Institute of Neurological Disorders and Stroke. Tuberous sclerosis fact sheet. NIH publication number 07-1846 2014 [webpage on the Internet]. Bethesda, MD: National Institutes of Health; 2014 [updated April 16, 2014]. Available from: http://www.ninds.nih.gov/disorders/tuberous_sclerosis/detail_tuberous_sclerosis.htm
  • 3
    • 8844231735 scopus 로고    scopus 로고
    • Diagnosis of tuberous sclerosis complex
    • Roach ES, Sparagana SP. Diagnosis of tuberous sclerosis complex. J Child Neurol. 2004;19(9):643-649.
    • (2004) J Child Neurol , vol.19 , Issue.9 , pp. 643-649
    • Roach, E.S.1    Sparagana, S.P.2
  • 4
    • 33847057994 scopus 로고    scopus 로고
    • Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States
    • Au KS, Williams AT, Roach ES, et al. Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States. Genet Med. 2007;9(2):88-100.
    • (2007) Genet Med , vol.9 , Issue.2 , pp. 88-100
    • Au, K.S.1    Williams, A.T.2    Roach, E.S.3
  • 6
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
    • Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008;412(2):179-190.
    • (2008) Biochem J , vol.412 , Issue.2 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 7
    • 10044259616 scopus 로고    scopus 로고
    • Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: Biallelic inactivation of TSC1 or TSC2 leads to mTOR activation
    • Chan JA, Zhang H, Roberts PS, et al. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. J Neuropathol Exp Neurol. 2004;63(12):1236-1242.
    • (2004) J Neuropathol Exp Neurol , vol.63 , Issue.12 , pp. 1236-1242
    • Chan, J.A.1    Zhang, H.2    Roberts, P.S.3
  • 8
    • 80054773182 scopus 로고    scopus 로고
    • Tuberous Sclerosis 2000 Study Group. The Tuberous Sclerosis 2000 Study: Presentation, initial assessments and implications for diagnosis and management
    • Yates JR, Maclean C, Higgins JN, et al; Tuberous Sclerosis 2000 Study Group. The Tuberous Sclerosis 2000 Study: presentation, initial assessments and implications for diagnosis and management. Arch Dis Child. 2011;96(11):1020-1025.
    • (2011) Arch Dis Child , vol.96 , Issue.11 , pp. 1020-1025
    • Yates, J.R.1    Maclean, C.2    Higgins, J.N.3
  • 9
    • 0032052110 scopus 로고    scopus 로고
    • CT and MR imaging of cerebral tuberous sclerosis
    • Inoue Y, Nemoto Y, Murata R, et al. CT and MR imaging of cerebral tuberous sclerosis. Brain Dev. 1998;20(4):209-221.
    • (1998) Brain Dev , vol.20 , Issue.4 , pp. 209-221
    • Inoue, Y.1    Nemoto, Y.2    Murata, R.3
  • 10
    • 12244298162 scopus 로고    scopus 로고
    • Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex
    • Joinson C, O’Callaghan FJ, Osborne JP, Martyn C, Harris T, Bolton PF. Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex. Psychol Med. 2003;33(2):335-344.
    • (2003) Psychol Med , vol.33 , Issue.2 , pp. 335-344
    • Joinson, C.1    O’callaghan, F.J.2    Osborne, J.P.3    Martyn, C.4    Harris, T.5    Bolton, P.F.6
  • 11
    • 84890118994 scopus 로고    scopus 로고
    • Epilepsy in TSC: Certain etiology does not mean certain prognosis
    • Vignoli A, La Briola F, Turner K, et al. Epilepsy in TSC: certain etiology does not mean certain prognosis. Epilepsia. 2013;54(12):2134-2142.
    • (2013) Epilepsia , vol.54 , Issue.12 , pp. 2134-2142
    • Vignoli, A.1    La Briola, F.2    Turner, K.3
  • 13
    • 0025099253 scopus 로고
    • Tuberous sclerosis and infantile spasms
    • Riikonen R, Simell O. Tuberous sclerosis and infantile spasms. Dev Med Child Neurol. 1990;32(3):203-209.
    • (1990) Dev Med Child Neurol , vol.32 , Issue.3 , pp. 203-209
    • Riikonen, R.1    Simell, O.2
  • 14
    • 79958238943 scopus 로고    scopus 로고
    • Neurodevelopmental, psychiatric and cognitive aspects of tuberous sclerosis complex
    • In: Kwiatkowsi DJ, Whittemore VH, Thiele EA, editors, Weinheim: Wiley-Blackwell
    • de Vries P. Neurodevelopmental, psychiatric and cognitive aspects of tuberous sclerosis complex. In: Kwiatkowsi DJ, Whittemore VH, Thiele EA, editors. Tuberous Sclerosis Complex: Genes, Clinical Features. Weinheim: Wiley-Blackwell. 2010:229-267.
    • (2010) Tuberous Sclerosis Complex: Genes, Clinical Features , pp. 229-267
    • De Vries, P.1
  • 15
    • 82955184567 scopus 로고    scopus 로고
    • Long-term neurological outcome in children with early-onset epilepsy associated with tuberous sclerosis
    • Cusmai R, Moavero R, Bombardieri R, Vigevano F, Curatolo P. Long-term neurological outcome in children with early-onset epilepsy associated with tuberous sclerosis. Epilepsy Behav. 2011;22(4):735-739.
    • (2011) Epilepsy Behav , vol.22 , Issue.4 , pp. 735-739
    • Cusmai, R.1    Moavero, R.2    Bombardieri, R.3    Vigevano, F.4    Curatolo, P.5
  • 16
    • 84899817790 scopus 로고    scopus 로고
    • Sleep alterations in children with refractory epileptic encephalopathies: A polysomnographic study
    • Carotenuto M, Parisi P, Esposito M, Cortese S, Elia M. Sleep alterations in children with refractory epileptic encephalopathies: a polysomnographic study. Epilepsy Behav. 2014;35:50-53.
    • (2014) Epilepsy Behav , vol.35 , pp. 50-53
    • Carotenuto, M.1    Parisi, P.2    Esposito, M.3    Cortese, S.4    Elia, M.5
  • 17
    • 84867101893 scopus 로고    scopus 로고
    • TSC Consensus Meeting for SEGA and Epilepsy Management. Management of epilepsy associated with tuberous sclerosis complex (TSC): Clinical recommendations
    • Curatolo P, Jóźwiak S, Nabbout R; TSC Consensus Meeting for SEGA and Epilepsy Management. Management of epilepsy associated with tuberous sclerosis complex (TSC): clinical recommendations. Eur J Paediatr Neurol. 2012;16(6):582-586.
    • (2012) Eur J Paediatr Neurol , vol.16 , Issue.6 , pp. 582-586
    • Curatolo, P.1    Jóźwiak, S.2    Nabbout, R.3
  • 18
    • 84884511014 scopus 로고    scopus 로고
    • International Tuberous Sclerosis Complex Consensus Group. Tuberous sclerosis complex surveillance and management: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference
    • Krueger DA, Northrup H; International Tuberous Sclerosis Complex Consensus Group. Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatr Neurol. 2013;49(4):255-265.
    • (2013) Pediatr Neurol , vol.49 , Issue.4 , pp. 255-265
    • Krueger, D.A.1    Northrup, H.2
  • 19
    • 7044245656 scopus 로고    scopus 로고
    • Subependymal giant cell tumors in tuberous sclerosis complex
    • Goh S, Butler W, Thiele EA. Subependymal giant cell tumors in tuberous sclerosis complex. Neurology. 2004;63(8):1457-1461.
    • (2004) Neurology , vol.63 , Issue.8 , pp. 1457-1461
    • Goh, S.1    Butler, W.2    Thiele, E.A.3
  • 20
    • 33846247923 scopus 로고    scopus 로고
    • Subependymal giant-cell astrocytomas in pediatric tuberous sclerosis disease: When should we operate?
    • discussion 89–90
    • de Ribaupierre S, Dorfmüller G, Bulteau C, et al. Subependymal giant-cell astrocytomas in pediatric tuberous sclerosis disease: when should we operate? Neurosurgery. 2007;60(1):83-89; discussion 89-90.
    • (2007) Neurosurgery , vol.60 , Issue.1 , pp. 83-89
    • De Ribaupierre, S.1    Dorfmüller, G.2    Bulteau, C.3
  • 21
    • 0030942875 scopus 로고    scopus 로고
    • Cortical tuber count: A biomarker indicating neurologic severity of tuberous sclerosis complex
    • Goodman M, Lamm SH, Engel A, Shepherd CW, Houser OW, Gomez MR. Cortical tuber count: a biomarker indicating neurologic severity of tuberous sclerosis complex. J Child Neurol. 1997;12(2):85-90.
    • (1997) J Child Neurol , vol.12 , Issue.2 , pp. 85-90
    • Goodman, M.1    Lamm, S.H.2    Engel, A.3    Shepherd, C.W.4    Houser, O.W.5    Gomez, M.R.6
  • 22
    • 41149159158 scopus 로고    scopus 로고
    • Cognitive impairment in tuberous sclerosis complex is a multifactorial condition
    • Jansen FE, Vincken KL, Algra A, et al. Cognitive impairment in tuberous sclerosis complex is a multifactorial condition. Neurology. 2008;70(12):916-923.
    • (2008) Neurology , vol.70 , Issue.12 , pp. 916-923
    • Jansen, F.E.1    Vincken, K.L.2    Algra, A.3
  • 23
    • 65249116322 scopus 로고    scopus 로고
    • Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex
    • Chu-Shore CJ, Major P, Montenegro M, Thiele E. Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex. Neurology. 2009;72(13):1165-1169.
    • (2009) Neurology , vol.72 , Issue.13 , pp. 1165-1169
    • Chu-Shore, C.J.1    Major, P.2    Montenegro, M.3    Thiele, E.4
  • 24
    • 0025118628 scopus 로고
    • MR and CT of tuberous sclerosis: Linear abnormalities in the cerebral white matter
    • Iwasaki S, Nakagawa H, Kichikawa K, et al. MR and CT of tuberous sclerosis: linear abnormalities in the cerebral white matter. AJNR Am J Neuroradiol. 1990;11(5):1029-1034.
    • (1990) AJNR Am J Neuroradiol , vol.11 , Issue.5 , pp. 1029-1034
    • Iwasaki, S.1    Nakagawa, H.2    Kichikawa, K.3
  • 25
    • 75349112539 scopus 로고    scopus 로고
    • Early control of seizures improves long-term outcome in children with tuberous sclerosis complex
    • Bombardieri R, Pinci M, Moavero R, Cerminara C, Curatolo P. Early control of seizures improves long-term outcome in children with tuberous sclerosis complex. Eur J Paediatr Neurol. 2010;14(2):146-149.
    • (2010) Eur J Paediatr Neurol , vol.14 , Issue.2 , pp. 146-149
    • Bombardieri, R.1    Pinci, M.2    Moavero, R.3    Cerminara, C.4    Curatolo, P.5
  • 26
    • 47249112141 scopus 로고    scopus 로고
    • Vigabatrin in the treatment of childhood epilepsy: A retrospective chart review of efficacy and safety profile
    • Camposano SE, Major P, Halpern E, Thiele EA. Vigabatrin in the treatment of childhood epilepsy: a retrospective chart review of efficacy and safety profile. Epilepsia. 2008;49(7):1186-1191.
    • (2008) Epilepsia , vol.49 , Issue.7 , pp. 1186-1191
    • Camposano, S.E.1    Major, P.2    Halpern, E.3    Thiele, E.A.4
  • 27
    • 80053003178 scopus 로고    scopus 로고
    • Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex
    • Jóźwiak S, Kotulska K, Domańska-Pakieła D, et al. Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex. Eur J Paediatr Neurol. 2011;15(5):424-431.
    • (2011) Eur J Paediatr Neurol , vol.15 , Issue.5 , pp. 424-431
    • Jóźwiak, S.1    Kotulska, K.2    Domańska-Pakieła, D.3
  • 28
    • 0036368031 scopus 로고    scopus 로고
    • ACTH treatment of infantile spasms: Mechanisms of its effects in modulation of neuronal excitability
    • Brunson KL, Avishai-Eliner S, Baram TZ. ACTH treatment of infantile spasms: mechanisms of its effects in modulation of neuronal excitability. Int Rev Neurobiol. 2002;49:185-197.
    • (2002) Int Rev Neurobiol , vol.49 , pp. 185-197
    • Brunson, K.L.1    Avishai-Eliner, S.2    Baram, T.Z.3
  • 29
    • 0032842693 scopus 로고    scopus 로고
    • A comparative study of high-dose and low-dose ACTH therapy for West syndrome
    • Yanagaki S, Oguni H, Hayashi K, et al. A comparative study of high-dose and low-dose ACTH therapy for West syndrome. Brain Dev. 1999;21(7):461-467.
    • (1999) Brain Dev , vol.21 , Issue.7 , pp. 461-467
    • Yanagaki, S.1    Oguni, H.2    Hayashi, K.3
  • 30
    • 0028227353 scopus 로고
    • High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms
    • Hrachovy RA, Frost JD, Glaze DG. High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. J Pediatr. 1994;124(5 Pt 1):803-806.
    • (1994) J Pediatr , vol.124 , Issue.5 , pp. 803-806
    • Hrachovy, R.A.1    Frost, J.D.2    Glaze, D.G.3
  • 31
    • 78649241016 scopus 로고    scopus 로고
    • Infantile spasms: A U.S. consensus report
    • Pellock JM, Hrachovy R, Shinnar S, et al. Infantile spasms: a U.S. consensus report. Epilepsia. 2010;51(10):2175-2189.
    • (2010) Epilepsia , vol.51 , Issue.10 , pp. 2175-2189
    • Pellock, J.M.1    Hrachovy, R.2    Shinnar, S.3
  • 32
    • 2442641463 scopus 로고    scopus 로고
    • American Academy of Neurology; Child Neurology Society. Practice parameter: Medical treatment of infantile spasms: Report of the American Academy of Neurology and the Child Neurology Society
    • Mackay MT, Weiss SK, Adams-Webber T, et al; American Academy of Neurology; Child Neurology Society. Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. Neurology. 2004;62(10):1668-1681.
    • (2004) Neurology , vol.62 , Issue.10 , pp. 1668-1681
    • Mackay, M.T.1    Weiss, S.K.2    Adams-Webber, T.3
  • 33
    • 0018972198 scopus 로고
    • ACTH therapy in infantile spasms: Side effects
    • Riikonen R, Donner M. ACTH therapy in infantile spasms: side effects. Arch Dis Child. 1980;55(9):664-672.
    • (1980) Arch Dis Child , vol.55 , Issue.9 , pp. 664-672
    • Riikonen, R.1    Donner, M.2
  • 34
    • 0020581090 scopus 로고
    • A prospective study of infantile spasms: Clinical and therapeutic correlations
    • Lombroso CT. A prospective study of infantile spasms: clinical and therapeutic correlations. Epilepsia. 1983;24(2):135-158.
    • (1983) Epilepsia , vol.24 , Issue.2 , pp. 135-158
    • Lombroso, C.T.1
  • 35
    • 8944250671 scopus 로고    scopus 로고
    • Vigabatrin as initial therapy for infantile spasms: A European retrospective survey. Sabril IS Investigator and Peer Review Groups
    • Aicardi J, Mumford JP, Dumas C, Wood S. Vigabatrin as initial therapy for infantile spasms: a European retrospective survey. Sabril IS Investigator and Peer Review Groups. Epilepsia. 1996;37(7):638-642.
    • (1996) Epilepsia , vol.37 , Issue.7 , pp. 638-642
    • Aicardi, J.1    Mumford, J.P.2    Dumas, C.3    Wood, S.4
  • 36
    • 84873629600 scopus 로고    scopus 로고
    • Vigabatrin for partial-onset seizure treatment in patients with tuberous sclerosis complex
    • Friedman D, Bogner M, Parker-Menzer K, Devinsky O. Vigabatrin for partial-onset seizure treatment in patients with tuberous sclerosis complex. Epilepsy Behav. 2013;27(1):118-120.
    • (2013) Epilepsy Behav , vol.27 , Issue.1 , pp. 118-120
    • Friedman, D.1    Bogner, M.2    Parker-Menzer, K.3    Devinsky, O.4
  • 37
    • 0026010310 scopus 로고
    • Mumford J. Therapeutic trial of vigabatrin in refractory infantile spasms
    • Chiron C, Dulac O, Beaumont D, Palacios L, Pajot N, Mumford J. Therapeutic trial of vigabatrin in refractory infantile spasms. J Child Neurol. 1991;Suppl 2:S52-S59.
    • (1991) J Child Neurol , Issue.2 , pp. S52-S59
    • Chiron, C.1    Dulac, O.2    Beaumont, D.3    Palacios, L.4    Pajot, N.5
  • 38
    • 0035940574 scopus 로고    scopus 로고
    • US Infantile Spasms Vigabatrin Study Group. Randomized trial of vigabatrin in patients with infantile spasms
    • Elterman RD, Shields WD, Mansfield KA, Nakagawa J; US Infantile Spasms Vigabatrin Study Group. Randomized trial of vigabatrin in patients with infantile spasms. Neurology. 2001;57(8):1416-1421.
    • (2001) Neurology , vol.57 , Issue.8 , pp. 1416-1421
    • Elterman, R.D.1    Shields, W.D.2    Mansfield, K.A.3    Nakagawa, J.4
  • 41
    • 58849147016 scopus 로고    scopus 로고
    • Cerebral MRI abnormalities associated with vigabatrin therapy
    • Pearl PL, Vezina LG, Saneto RP, et al. Cerebral MRI abnormalities associated with vigabatrin therapy. Epilepsia. 2009;50(2):184-194.
    • (2009) Epilepsia , vol.50 , Issue.2 , pp. 184-194
    • Pearl, P.L.1    Vezina, L.G.2    Saneto, R.P.3
  • 42
    • 58849112158 scopus 로고    scopus 로고
    • Magnetic resonance imaging abnormalities associated with vigabatrin in patients with epilepsy
    • Wheless JW, Carmant L, Bebin M, et al. Magnetic resonance imaging abnormalities associated with vigabatrin in patients with epilepsy. Epilepsia. 2009;50(2):195-205.
    • (2009) Epilepsia , vol.50 , Issue.2 , pp. 195-205
    • Wheless, J.W.1    Carmant, L.2    Bebin, M.3
  • 43
    • 0034690601 scopus 로고    scopus 로고
    • Guideline for prescribing vigabatrin in children has been revised
    • Guideline for prescribing vigabatrin in children has been revised. Vigabatrin Paediatric Advisory Group. BMJ. 2000;320(7246):1404-1405.
    • (2000) BMJ , vol.320 , Issue.7246 , pp. 1404-1405
  • 44
    • 33847683434 scopus 로고    scopus 로고
    • Severe relapse of epilepsy after vigabatrin withdrawal: For how long should we treat symptomatic infantile spasms?
    • Kröll-Seger J, Kaminska A, Moutard ML, et al. Severe relapse of epilepsy after vigabatrin withdrawal: for how long should we treat symptomatic infantile spasms? Epilepsia. 2007;48(3):612-613.
    • (2007) Epilepsia , vol.48 , Issue.3 , pp. 612-613
    • Kröll-Seger, J.1    Kaminska, A.2    Moutard, M.L.3
  • 45
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng LH, Xu L, Gutmann DH, Wong M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol. 2008;63(4):444-453.
    • (2008) Ann Neurol , vol.63 , Issue.4 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 46
    • 49149088555 scopus 로고    scopus 로고
    • Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis
    • Ehninger D, Han S, Shilyansky C, et al. Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis. Nat Med. 2008;14(8):843-848.
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 843-848
    • Ehninger, D.1    Han, S.2    Shilyansky, C.3
  • 47
    • 64249118425 scopus 로고    scopus 로고
    • Rapamycin reduces seizure frequency in tuberous sclerosis complex
    • Muncy J, Butler IJ, Koenig MK. Rapamycin reduces seizure frequency in tuberous sclerosis complex. J Child Neurol. 2009;24(4):477.
    • (2009) J Child Neurol , vol.24 , Issue.4 , pp. 477
    • Muncy, J.1    Butler, I.J.2    Koenig, M.K.3
  • 48
    • 84655166921 scopus 로고    scopus 로고
    • Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex
    • Perek-Polnik M, Jóźwiak S, Jurkiewicz E, Perek D, Kotulska K. Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex. Eur J Paediatr Neurol. 2012;16(1):83-85.
    • (2012) Eur J Paediatr Neurol , vol.16 , Issue.1 , pp. 83-85
    • Perek-Polnik, M.1    Jóźwiak, S.2    Jurkiewicz, E.3    Perek, D.4    Kotulska, K.5
  • 49
    • 53549125236 scopus 로고    scopus 로고
    • Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex
    • Koenig MK, Butler IJ, Northrup H. Regression of subependymal giant cell astrocytoma with rapamycin in tuberous sclerosis complex. J Child Neurol. 2008;23(10):1238-1239.
    • (2008) J Child Neurol , vol.23 , Issue.10 , pp. 1238-1239
    • Koenig, M.K.1    Butler, I.J.2    Northrup, H.3
  • 50
    • 33644827461 scopus 로고    scopus 로고
    • Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    • Franz DN, Leonard J, Tudor C, et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol. 2006;59(3):490-498.
    • (2006) Ann Neurol , vol.59 , Issue.3 , pp. 490-498
    • Franz, D.N.1    Leonard, J.2    Tudor, C.3
  • 51
    • 78049510428 scopus 로고    scopus 로고
    • Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
    • Krueger DA, Care MM, Holland K, et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med. 2010;363(19):1801-1811.
    • (2010) N Engl J Med , vol.363 , Issue.19 , pp. 1801-1811
    • Krueger, D.A.1    Care, M.M.2    Holland, K.3
  • 52
    • 84872088946 scopus 로고    scopus 로고
    • Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): A multicentre, randomised, placebo-controlled phase 3 trial
    • Franz DN, Belousova E, Sparagana S, et al. Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial. Lancet. 2013;381(9861):125-132.
    • (2013) Lancet , vol.381 , Issue.9861 , pp. 125-132
    • Franz, D.N.1    Belousova, E.2    Sparagana, S.3
  • 53
    • 84873548352 scopus 로고    scopus 로고
    • Predictors of seizure outcomes in children with tuberous sclerosis complex and intractable epilepsy undergoing resective epilepsy surgery: An individual participant data meta-analysis
    • Fallah A, Guyatt GH, Snead OC, et al. Predictors of seizure outcomes in children with tuberous sclerosis complex and intractable epilepsy undergoing resective epilepsy surgery: an individual participant data meta-analysis. PLoS One. 2013;8(2):e53565.
    • (2013) PLoS One , vol.8 , Issue.2
    • Fallah, A.1    Guyatt, G.H.2    Snead, O.C.3
  • 54
    • 14944366525 scopus 로고    scopus 로고
    • Our experience with pediatric epilepsy surgery focusing on corpus callosotomy and hemispherotomy
    • Shimizu H. Our experience with pediatric epilepsy surgery focusing on corpus callosotomy and hemispherotomy. Epilepsia. 2005;46(Suppl 1):30-31.
    • (2005) Epilepsia , vol.46 , pp. 30-31
    • Shimizu, H.1
  • 57
    • 46849084358 scopus 로고    scopus 로고
    • Changing the paradigm of 1-stage total callosotomy for the treatment of pediatric generalized epilepsy
    • Shim KW, Lee YM, Kim HD, Lee JS, Choi JU, Kim DS. Changing the paradigm of 1-stage total callosotomy for the treatment of pediatric generalized epilepsy. JNeurosurg Pediatr. 2008;2(1):29-36.
    • (2008) JNeurosurg Pediatr , vol.2 , Issue.1 , pp. 29-36
    • Shim, K.W.1    Lee, Y.M.2    Kim, H.D.3    Lee, J.S.4    Choi, J.U.5    Kim, D.S.6
  • 58
    • 0037167532 scopus 로고    scopus 로고
    • Therapeutic mechanisms of vagus nerve stimulation
    • Henry TR. Therapeutic mechanisms of vagus nerve stimulation. Neurology. 2002;59(6 Suppl 4):S3-S14.
    • (2002) Neurology , vol.59 , Issue.6 , pp. S3-S14
    • Henry, T.R.1
  • 59
    • 0027373370 scopus 로고
    • Suppression of interictal spikes and seizures by stimulation of the vagus nerve
    • McLachlan RS. Suppression of interictal spikes and seizures by stimulation of the vagus nerve. Epilepsia. 1993;34(5):918-923.
    • (1993) Epilepsia , vol.34 , Issue.5 , pp. 918-923
    • McLachlan, R.S.1
  • 60
    • 0025258928 scopus 로고
    • Effects of vagal stimulation on experimentally induced seizures in rats
    • Woodbury DM, Woodbury JW. Effects of vagal stimulation on experimentally induced seizures in rats. Epilepsia. 1990;31(Suppl 2): S7-S19.
    • (1990) Epilepsia , vol.31 , Issue.2 , pp. S7-S19
    • Woodbury, D.M.1    Woodbury, J.W.2
  • 61
    • 0027062798 scopus 로고
    • Inhibition of experimental seizures in canines by repetitive vagal stimulation
    • Zabara J. Inhibition of experimental seizures in canines by repetitive vagal stimulation. Epilepsia. 1992;33(6):1005-1012.
    • (1992) Epilepsia , vol.33 , Issue.6 , pp. 1005-1012
    • Zabara, J.1
  • 62
    • 0025250512 scopus 로고
    • Feasibility and safety of vagal stimulation in monkey model
    • Lockard JS, Congdon WC, DuCharme LL. Feasibility and safety of vagal stimulation in monkey model. Epilepsia. 1990;31(Suppl 2): S20-S26.
    • (1990) Epilepsia , vol.31 , Issue.2 , pp. S20-S26
    • Lockard, J.S.1    Congdon, W.C.2    Ducharme, L.L.3
  • 63
    • 0029824494 scopus 로고    scopus 로고
    • Vagus nerve stimulation induces a sustained anticonvulsant effect
    • Takaya M, Terry WJ, Naritoku DK. Vagus nerve stimulation induces a sustained anticonvulsant effect. Epilepsia. 1996;37(11):1111-1116.
    • (1996) Epilepsia , vol.37 , Issue.11 , pp. 1111-1116
    • Takaya, M.1    Terry, W.J.2    Naritoku, D.K.3
  • 64
    • 0033011096 scopus 로고    scopus 로고
    • Vagus nerve prolonged stimulation in cats: Effects on epileptogenesis (amygdala electrical kindling): Behavioral and electrographic changes
    • Fernandez-Guardiola A, Martinez A, Valdes-Cruz A, Magdaleno- Madrigal VM, Martinez D, Fernandez-Mas R. Vagus nerve prolonged stimulation in cats: effects on epileptogenesis (amygdala electrical kindling): behavioral and electrographic changes. Epilepsia. 1999; 40(7):822-829.
    • (1999) Epilepsia , vol.40 , Issue.7 , pp. 822-829
    • Fernandez-Guardiola, A.1    Martinez, A.2    Valdes-Cruz, A.3    Magdaleno-Madrigal, V.M.4    Martinez, D.5    Fernandez-Mas, R.6
  • 65
    • 0036711779 scopus 로고    scopus 로고
    • Effect of electrical stimulation of the nucleus of the solitary tract on the development of electrical amygdaloid kindling in the cat
    • Magdaleno-Madrigal VM, Valdes-Cruz A, Martinez-Vargas D, et al. Effect of electrical stimulation of the nucleus of the solitary tract on the development of electrical amygdaloid kindling in the cat. Epilepsia. 2002;43(9):964-969.
    • (2002) Epilepsia , vol.43 , Issue.9 , pp. 964-969
    • Magdaleno-Madrigal, V.M.1    Valdes-Cruz, A.2    Martinez-Vargas, D.3
  • 66
    • 70350617952 scopus 로고    scopus 로고
    • Refractory epilepsy in tuberous sclerosis: Vagus nerve stimulation with or without subsequent resective surgery
    • Elliott RE, Carlson C, Kalhorn SP, et al. Refractory epilepsy in tuberous sclerosis: vagus nerve stimulation with or without subsequent resective surgery. Epilepsy Behav. 2009;16(3):454-460.
    • (2009) Epilepsy Behav , vol.16 , Issue.3 , pp. 454-460
    • Elliott, R.E.1    Carlson, C.2    Kalhorn, S.P.3
  • 67
    • 45549122258 scopus 로고    scopus 로고
    • Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex
    • Major P, Thiele EA. Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex. Epilepsy Behav. 2008;13(2):357-360.
    • (2008) Epilepsy Behav , vol.13 , Issue.2 , pp. 357-360
    • Major, P.1    Thiele, E.A.2
  • 70
    • 27644549124 scopus 로고    scopus 로고
    • Vagus nerve stimulation in 15 children with therapy resistant epilepsy; its impact on cognition, quality of life, behaviour and mood
    • Hallbook T, Lundgren J, Stjernqvist K, Blennow G, Stromblad LG, Rosen I. Vagus nerve stimulation in 15 children with therapy resistant epilepsy; its impact on cognition, quality of life, behaviour and mood. Seizure. 2005;14(7):504-513.
    • (2005) Seizure , vol.14 , Issue.7 , pp. 504-513
    • Hallbook, T.1    Lundgren, J.2    Stjernqvist, K.3    Blennow, G.4    Stromblad, L.G.5    Rosen, I.6
  • 71
    • 0035216684 scopus 로고    scopus 로고
    • Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: Retrospective study
    • Helmers SL, Wheless JW, Frost M, et al. Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy: retrospective study. J Child Neurol. 2001;16(11):843-848.
    • (2001) J Child Neurol , vol.16 , Issue.11 , pp. 843-848
    • Helmers, S.L.1    Wheless, J.W.2    Frost, M.3
  • 72
    • 33846250398 scopus 로고    scopus 로고
    • Anticonvulsant mechanisms of the ketogenic diet
    • Bough KJ, Rho JM. Anticonvulsant mechanisms of the ketogenic diet. Epilepsia. 2007;48(1):43-58.
    • (2007) Epilepsia , vol.48 , Issue.1 , pp. 43-58
    • Bough, K.J.1    Rho, J.M.2
  • 73
    • 33746848935 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    • Bough KJ, Wetherington J, Hassel B, et al. Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet. Ann Neurol. 2006;60(2):223-235.
    • (2006) Ann Neurol , vol.60 , Issue.2 , pp. 223-235
    • Bough, K.J.1    Wetherington, J.2    Hassel, B.3
  • 74
    • 84879699812 scopus 로고    scopus 로고
    • How does the ketogenic diet work? Four potential mechanisms
    • Danial NN, Hartman AL, Stafstrom CE, Thio LL. How does the ketogenic diet work? Four potential mechanisms. J Child Neurol. 2013;28(8):1027-1033.
    • (2013) J Child Neurol , vol.28 , Issue.8 , pp. 1027-1033
    • Danial, N.N.1    Hartman, A.L.2    Stafstrom, C.E.3    Thio, L.L.4
  • 75
    • 0001544644 scopus 로고
    • The effects of ketonemia on the course of epilepsy
    • Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clin Proc. 1921;2:307-308.
    • (1921) Mayo Clin Proc , vol.2 , pp. 307-308
    • Wilder, R.M.1
  • 76
    • 79952570329 scopus 로고    scopus 로고
    • The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway
    • McDaniel SS, Rensing NR, Thio LL, Yamada KA, Wong M. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia. 2011;52(3):e7-e11.
    • (2011) Epilepsia , vol.52 , Issue.3 , pp. e7-e11
    • McDaniel, S.S.1    Rensing, N.R.2    Thio, L.L.3    Yamada, K.A.4    Wong, M.5
  • 77
  • 79
    • 33745280939 scopus 로고    scopus 로고
    • A systematic review of the use of the ketogenic diet in childhood epilepsy
    • Keene DL. A systematic review of the use of the ketogenic diet in childhood epilepsy. Pediatr Neurol. 2006;35(1):1-5.
    • (2006) Pediatr Neurol , vol.35 , Issue.1 , pp. 1-5
    • Keene, D.L.1
  • 80
    • 33745162585 scopus 로고    scopus 로고
    • Efficacy of the ketogenic diet as a treatment option for epilepsy: Meta-analysis
    • Henderson CB, Filloux FM, Alder SC, Lyon JL, Caplin DA. Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis. J Child Neurol. 2006;21(3):193-198.
    • (2006) J Child Neurol , vol.21 , Issue.3 , pp. 193-198
    • Henderson, C.B.1    Filloux, F.M.2    Alder, S.C.3    Lyon, J.L.4    Caplin, D.A.5
  • 82
    • 33745902533 scopus 로고    scopus 로고
    • The effects of the ketogenic diet in refractory partial seizures with reference to tuberous sclerosis
    • Coppola G, Klepper J, Ammendola E, et al. The effects of the ketogenic diet in refractory partial seizures with reference to tuberous sclerosis. Eur JPaediatrNeurol. 2006;10(3):148-151.
    • (2006) Eur JPaediatrNeurol , vol.10 , Issue.3 , pp. 148-151
    • Coppola, G.1    Klepper, J.2    Ammendola, E.3
  • 83
    • 43249084958 scopus 로고    scopus 로고
    • The ketogenic diet for the treatment of childhood epilepsy: A randomised controlled trial
    • Neal EG, Chaffe H, Schwartz RH, et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol. 2008;7(6):500-506.
    • (2008) Lancet Neurol , vol.7 , Issue.6 , pp. 500-506
    • Neal, E.G.1    Chaffe, H.2    Schwartz, R.H.3
  • 84
    • 33947132079 scopus 로고    scopus 로고
    • The ketogenic diet: One decade later
    • Freeman JM, Kossoff EH, Hartman AL. The ketogenic diet: one decade later. Pediatrics. 2007;119(3):535-543.
    • (2007) Pediatrics , vol.119 , Issue.3 , pp. 535-543
    • Freeman, J.M.1    Kossoff, E.H.2    Hartman, A.L.3
  • 85
    • 0020559177 scopus 로고
    • Double-blind study of ACTH vs prednisone therapy in infantile spasms
    • Hrachovy RA, Frost JD, Kellaway P, Zion TE. Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr. 1983; 103(4):641-645.
    • (1983) J Pediatr , vol.103 , Issue.4 , pp. 641-645
    • Hrachovy, R.A.1    Frost, J.D.2    Kellaway, P.3    Zion, T.E.4
  • 86
    • 0029916006 scopus 로고    scopus 로고
    • High-dose corticotropin (ACTH) versus prednisone for infantile spasms: A prospective, randomized, blinded study
    • Baram TZ, Mitchell WG, Tournay A, Snead OC, Hanson RA, Horton EJ. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics. 1996;97(3):375-379.
    • (1996) Pediatrics , vol.97 , Issue.3 , pp. 375-379
    • Baram, T.Z.1    Mitchell, W.G.2    Tournay, A.3    Snead, O.C.4    Hanson, R.A.5    Horton, E.J.6
  • 87
    • 77952484854 scopus 로고    scopus 로고
    • Three-week combination treatment with ACTH + magnesium sulfate versus ACTH monotherapy for infantile spasms: A 24-week, randomized, open-label, follow-up study in China
    • Zou LP, Wang X, Dong CH, Chen CH, Zhao W, Zhao RY. Three-week combination treatment with ACTH + magnesium sulfate versus ACTH monotherapy for infantile spasms: a 24-week, randomized, open-label, follow-up study in China. Clin Ther. 2010;32(4):692-700.
    • (2010) Clin Ther , vol.32 , Issue.4 , pp. 692-700
    • Zou, L.P.1    Wang, X.2    Dong, C.H.3    Chen, C.H.4    Zhao, W.5    Zhao, R.Y.6
  • 88
    • 0030931268 scopus 로고    scopus 로고
    • Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis
    • Chiron C, Dumas C, Jambaque I, Mumford J, Dulac O. Randomized trial comparing vigabatrin and hydrocortisone in infantile spasms due to tuberous sclerosis. Epilepsy Res. 1997;26(2):389-395.
    • (1997) Epilepsy Res , vol.26 , Issue.2 , pp. 389-395
    • Chiron, C.1    Dumas, C.2    Jambaque, I.3    Mumford, J.4    Dulac, O.5
  • 89
    • 0031468870 scopus 로고    scopus 로고
    • Vigabatrin versus ACTH as first-line treatment for infantile spasms: A randomized, prospective study
    • Vigevano F, Cilio MR. Vigabatrin versus ACTH as first-line treatment for infantile spasms: a randomized, prospective study. Epilepsia. 1997;38(12):1270-1274.
    • (1997) Epilepsia , vol.38 , Issue.12 , pp. 1270-1274
    • Vigevano, F.1    Cilio, M.R.2
  • 90
    • 0033021878 scopus 로고    scopus 로고
    • Treatment of infantile spasms: Results of a population-based study with vigabatrin as the first drug for spasms
    • Granstrom ML, Gaily E, Liukkonen E. Treatment of infantile spasms: results of a population-based study with vigabatrin as the first drug for spasms. Epilepsia. 1999;40(7):950-957.
    • (1999) Epilepsia , vol.40 , Issue.7 , pp. 950-957
    • Granstrom, M.L.1    Gaily, E.2    Liukkonen, E.3


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