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Volumn 31, Issue 4, 2014, Pages 1761-1767

Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma cells

Author keywords

Apoptosis; Bcl 2; Beclin 1; Glioblastoma; LC3

Indexed keywords

BECLIN 1; CASPASE 3; CASPASE 9; CYTOCHROME C; PROTEIN BCL 2; PROTEIN BCL XL;

EID: 84908133229     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3015     Document Type: Article
Times cited : (57)

References (45)
  • 1
    • 10744225487 scopus 로고    scopus 로고
    • A unified nomenclature for yeast autophagy-related genes
    • Klionsky DJ, Cregg JM, Dunn WA Jr, et al: A unified nomenclature for yeast autophagy-related genes. Dev Cell 5: 539-545, 2003.
    • (2003) Dev Cell , vol.5 , pp. 539-545
    • Klionsky, D.J.1    Cregg, J.M.2    Dunn Jr., W.A.3
  • 2
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • Levine B and Yuan J: Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 3
    • 0025283961 scopus 로고
    • Developmental cell death: Morphological diversity and multiple mechanisms
    • Clarke PG: Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl) 181: 195-213, 1990.
    • (1990) Anat Embryol (Berl) , vol.181 , pp. 195-213
    • Clarke, P.G.1
  • 4
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang XH, Jackson S, Seaman M, et al: Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676, 1999.
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 5
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue Z, Jin S, Yang C, Levine AJ and Heintz N: Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100: 15077-15082, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 6
    • 32244442749 scopus 로고    scopus 로고
    • Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
    • Zeng X, Overmeyer JH and Maltese WA: Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci 119: 259-270, 2006.
    • (2006) J Cell Sci , vol.119 , pp. 259-270
    • Zeng, X.1    Overmeyer, J.H.2    Maltese, W.A.3
  • 7
    • 79952628267 scopus 로고    scopus 로고
    • The Beclin 1 network regulates autophagy and apoptosis
    • Kang R, Zeh HJ, Lotze MT and Tang D: The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 18: 571-580, 2011.
    • (2011) Cell Death Differ , vol.18 , pp. 571-580
    • Kang, R.1    Zeh, H.J.2    Lotze, M.T.3    Tang, D.4
  • 8
    • 19544373434 scopus 로고    scopus 로고
    • Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity
    • Furuya D, Tsuji N, Yagihashi A and Watanabe N: Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity. Exp Cell Res 307: 26-40, 2005.
    • (2005) Exp Cell Res , vol.307 , pp. 26-40
    • Furuya, D.1    Tsuji, N.2    Yagihashi, A.3    Watanabe, N.4
  • 9
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu X, Yu J, Bhagat G, et al: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112: 1809-1820, 2003.
    • (2003) J Clin Invest , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 10
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams JM and Cory S: The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998.
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 11
    • 35848962530 scopus 로고    scopus 로고
    • Differential interactions between Beclin 1 and Bcl-2 family members
    • Erlich S, Mizrachy L, Segev O, et al: Differential interactions between Beclin 1 and Bcl-2 family members. Autophagy 3: 561-568, 2007.
    • (2007) Autophagy , vol.3 , pp. 561-568
    • Erlich, S.1    Mizrachy, L.2    Segev, O.3
  • 12
    • 84874589230 scopus 로고    scopus 로고
    • Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth
    • Trisciuoglio D, De Luca T, Desideri M, et al: Removal of the BH4 domain from Bcl-2 protein triggers an autophagic process that impairs tumor growth. Neoplasia 15: 315-327, 2013.
    • (2013) Neoplasia , vol.15 , pp. 315-327
    • Trisciuoglio, D.1    De Luca, T.2    Desideri, M.3
  • 13
    • 79951607477 scopus 로고    scopus 로고
    • Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis
    • Oh S, Xiaofei E, Ni D, et al: Downregulation of autophagy by Bcl-2 promotes MCF7 breast cancer cell growth independent of its inhibition of apoptosis. Cell Death Differ 18: 452-464, 2011.
    • (2011) Cell Death Differ , vol.18 , pp. 452-464
    • Oh, S.1    Xiaofei, E.2    Ni, D.3
  • 14
    • 84875533402 scopus 로고    scopus 로고
    • Decreased expression of autophagic beclin 1 protein in idiopathic pulmonary fibrosis fibroblasts
    • Ricci A, Cherubini E, Scozzi D, et al: Decreased expression of autophagic beclin 1 protein in idiopathic pulmonary fibrosis fibroblasts. J Cell Physiol 28: 1516-1524, 2012.
    • (2012) J Cell Physiol , vol.28 , pp. 1516-1524
    • Ricci, A.1    Cherubini, E.2    Scozzi, D.3
  • 15
    • 34848845834 scopus 로고    scopus 로고
    • Beclin 1-mediated macroautophagy involves regulation of caspase-9 expression in cervical cancer HeLa cells
    • Wang ZH, Xu L, Duan ZL, Zeng LQ, Yan NH and Peng ZL: Beclin 1-mediated macroautophagy involves regulation of caspase-9 expression in cervical cancer HeLa cells. Gynecol Oncol 107: 107-113, 2007.
    • (2007) Gynecol Oncol , vol.107 , pp. 107-113
    • Zh, W.1    Xu, L.2    Duan, Z.L.3    Zeng, L.Q.4    Yan, N.H.5    Peng, Z.L.6
  • 16
    • 40549085336 scopus 로고    scopus 로고
    • Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes
    • Trincheri NF, Follo C, Nicotra G, Peracchio C, Castino R and Isidoro C: Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes. Carcinogenesis 29: 381-389, 2008.
    • (2008) Carcinogenesis , vol.29 , pp. 381-389
    • Trincheri, N.F.1    Follo, C.2    Nicotra, G.3    Peracchio, C.4    Castino, R.5    Isidoro, C.6
  • 17
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen PY and Kesari S: Malignant gliomas in adults. N Engl J Med 359: 492-507, 2008.
    • (2008) N Engl J Med , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 18
    • 35949002429 scopus 로고    scopus 로고
    • Malignant astrocytic glioma: Genetics, biology, and paths to treatment
    • Furnari FB, Fenton T, Bachoo RM, et al: Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 21: 2683-2710, 2007.
    • (2007) Genes Dev , vol.21 , pp. 2683-2710
    • Furnari, F.B.1    Fenton, T.2    Bachoo, R.M.3
  • 19
    • 34047271129 scopus 로고    scopus 로고
    • Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours
    • Miracco C, Cosci E, Oliveri G, et al: Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol 30: 429-436, 2007.
    • (2007) Int J Oncol , vol.30 , pp. 429-436
    • Miracco, C.1    Cosci, E.2    Oliveri, G.3
  • 20
    • 78049460392 scopus 로고    scopus 로고
    • Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors
    • Huang X, Bai HM, Chen L, Li B and Lu YC: Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors. J Clin Neurosci 17: 1515-1519, 2010.
    • (2010) J Clin Neurosci , vol.17 , pp. 1515-1519
    • Huang, X.1    Bai, H.M.2    Chen, L.3    Li, B.4    Lu, Y.C.5
  • 21
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp TR, Bernards R and Agami R: A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553, 2002.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 22
    • 0032542505 scopus 로고    scopus 로고
    • BCL-2 family protein expression in human malignant glioma: A clinical-pathological correlative study
    • Rieger L, Weller M, Bornemann A, Schabet M, Dichgans J and Meyermann R: BCL-2 family protein expression in human malignant glioma: a clinical-pathological correlative study. J Neurol Sci 155: 68-75, 1998.
    • (1998) J Neurol Sci , vol.155 , pp. 68-75
    • Rieger, L.1    Weller, M.2    Bornemann, A.3    Schabet, M.4    Dichgans, J.5    Meyermann, R.6
  • 23
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky DJ, Abeliovich H, Agostinis P, et al: Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4: 151-175, 2008.
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3
  • 24
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross A, McDonnell JM and Korsmeyer SJ: BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13: 1899-1911, 1999.
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 25
    • 0034192467 scopus 로고    scopus 로고
    • Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-xL
    • Hausmann G, O'Reilly LA, van Driel R, et al: Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-xL. J Cell Biol 149: 623-634, 2000.
    • (2000) J Cell Biol , vol.149 , pp. 623-634
    • Hausmann, G.1    O'Reilly, L.A.2    Van Driel, R.3
  • 26
    • 0142117313 scopus 로고    scopus 로고
    • The Bcl-2 family: Roles in cell survival and oncogenesis
    • Cory S, Huang DC and Adams JM: The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590-8607, 2003.
    • (2003) Oncogene , vol.22 , pp. 8590-8607
    • Cory, S.1    Huang, D.C.2    Adams, J.M.3
  • 27
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • Shintani T and Klionsky DJ: Autophagy in health and disease: a double-edged sword. Science 306: 990-995, 2004.
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 28
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X, et al: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122: 927-939, 2005.
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3
  • 29
    • 34248998801 scopus 로고    scopus 로고
    • Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1
    • Maiuri MC, Le Toumelin G, Criollo A, et al: Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1. EMBO J 26: 2527-2539, 2007.
    • (2007) EMBO J , vol.26 , pp. 2527-2539
    • Maiuri, M.C.1    Le Toumelin, G.2    Criollo, A.3
  • 30
    • 23944448372 scopus 로고    scopus 로고
    • Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C elegans
    • Takacs-Vellai K, Vellai T, Puoti A, et al: Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Curr Biol 15: 1513-1517, 2005.
    • (2005) Curr Biol , vol.15 , pp. 1513-1517
    • Takacs-Vellai, K.1    Vellai, T.2    Puoti, A.3
  • 31
    • 0001488499 scopus 로고    scopus 로고
    • Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
    • Liang XH, Kleeman LK, Jiang HH, et al: Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 72: 8586-8596, 1998.
    • (1998) J Virol , vol.72 , pp. 8586-8596
    • Liang, X.H.1    Kleeman, L.K.2    Jiang, H.H.3
  • 32
    • 34547689505 scopus 로고    scopus 로고
    • Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1
    • Feng W, Huang S, Wu H and Zhang M: Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1. J Mol Biol 372: 223-235, 2007.
    • (2007) J Mol Biol , vol.372 , pp. 223-235
    • Feng, W.1    Huang, S.2    Wu, H.3    Zhang, M.4
  • 33
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • Kroemer G, Galluzzi L and Brenner C: Mitochondrial membrane permeabilization in cell death. Physiol Rev 87: 99-163, 2007.
    • (2007) Physiol Rev , vol.87 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 34
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H, Henzel WJ, Liu X, Lutschg A and Wang X: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413, 1997.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 35
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, et al: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 36
    • 0029991311 scopus 로고    scopus 로고
    • Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells
    • Okazawa H, Shimizu J, Kamei M, Imafuku I, Hamada H and Kanazawa I: Bcl-2 inhibits retinoic acid-induced apoptosis during the neural differentiation of embryonal stem cells. J Cell Biol 132: 955-968, 1996.
    • (1996) J Cell Biol , vol.132 , pp. 955-968
    • Okazawa, H.1    Shimizu, J.2    Kamei, M.3    Imafuku, I.4    Hamada, H.5    Kanazawa, I.6
  • 37
    • 2542418036 scopus 로고    scopus 로고
    • The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression
    • Orelio C, Harvey KN, Miles C, Oostendorp RA, van der Horn K and Dzierzak E: The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression. Blood 103: 4084-4092, 2004.
    • (2004) Blood , vol.103 , pp. 4084-4092
    • Orelio, C.1    Harvey, K.N.2    Miles, C.3    Oostendorp, R.A.4    Van Der Horn, K.5    Dzierzak, E.6
  • 38
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum JJ, Bauer DE, Kong M, et al: Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248, 2005.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3
  • 39
    • 10344262564 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
    • Shimizu S, Kanaseki T, Mizushima N, et al: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6: 1221-1228, 2004.
    • (2004) Nat Cell Biol , vol.6 , pp. 1221-1228
    • Shimizu, S.1    Kanaseki, T.2    Mizushima, N.3
  • 40
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    • Yu L, Alva A, Su H, et al: Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502, 2004.
    • (2004) Science , vol.304 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3
  • 41
    • 27144503701 scopus 로고    scopus 로고
    • Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death
    • Hoyer-Hansen M, Bastholm L, Mathiasen IS, Elling F and Jaattela M: Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ 12: 1297-1309, 2005.
    • (2005) Cell Death Differ , vol.12 , pp. 1297-1309
    • Hoyer-Hansen, M.1    Bastholm, L.2    Mathiasen, I.S.3    Elling, F.4    Jaattela, M.5
  • 42
  • 43
    • 1442286330 scopus 로고    scopus 로고
    • The role of Bcl-2 family members in tumorigenesis
    • Kirkin V, Joos S and Zornig M: The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta 1644: 229-249, 2004.
    • (2004) Biochim Biophys Acta , vol.1644 , pp. 229-249
    • Kirkin, V.1    Joos, S.2    Zornig, M.3
  • 44
    • 0035863399 scopus 로고    scopus 로고
    • A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
    • Paglin S, Hollister T, Delohery T, et al: A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 61: 439-444, 2001.
    • (2001) Cancer Res , vol.61 , pp. 439-444
    • Paglin, S.1    Hollister, T.2    Delohery, T.3
  • 45
    • 58149084586 scopus 로고    scopus 로고
    • Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer
    • Shen Y, Li DD, Wang LL, Deng R and Zhu XF: Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy 4: 1067-1068, 2008.
    • (2008) Autophagy , vol.4 , pp. 1067-1068
    • Shen, Y.1    Li, D.D.2    Wang, L.L.3    Deng, R.4    Zhu, X.F.5


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